| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianjun Wu, Wenbo Yu, Yan Chen, Yaru Su, Zhengtong Ding, Huimin Ren, Yuping Jiang, Jian Wan. Intrastriatal transplantation of GDNF-engineered BMSCs and its neuroprotection in lactacystin-induced Parkinsonian rat model. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19894114. |
we observed that the intrastriatal transplantation of gdnf-bmscs could significantly rescue the dopaminergic neurons from lactacystin-induced neurotoxicity with regard to behavioral recovery, tyrosine hydroxylase level in nigra and striatum, and striatal dopamine level. |
2010-04-30 |
2023-08-12 |
rat |
| Jorge Mendoza, Daniel Clesse, Paul Pévet, Etienne Challe. Food-reward signalling in the suprachiasmatic clock. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20067576. |
in addition, an increase in the dopamine content and period genes expression in the forebrain of mice was observed, concomitant with a c-fos activation in dopaminergic and orexinergic neurons, suggesting that the effects of a palatable snack on the scn clock are mediated by the reward/arousal central systems. |
2010-04-30 |
2023-08-12 |
mouse |
| Jacob Eriksen, Trine Nygaard Jørgensen, Ulrik Gethe. Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20085610. |
the dopamine transporter (dat) plays a key role in regulating dopaminergic signalling in the brain by mediating rapid clearance of dopamine from the synaptic clefts. |
2010-04-30 |
2023-08-12 |
Not clear |
| Fleur L Warton, Fleur M Howells, Vivienne A Russel. Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate. Metabolic brain disease. vol 24. issue 4. 2010-04-29. PMID:19821016. |
there is considerable evidence to suggest that dopamine release is impaired at mesolimbic and nigrostriatal dopaminergic terminals. |
2010-04-29 |
2023-08-12 |
rat |
| Mirthe M Ponsen, Diederick Stoffers, Erik Ch Wolters, Jan Booij, Henk W Berends. Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 4. 2010-04-26. PMID:19965851. |
methods in a cohort of 361 non-parkinsonian, non-demented first-degree relatives of pd patients, a combination of olfactory processing tasks was used to select groups of hyposmic (n=40) and normosmic (n=38) individuals for a 5-year clinical follow-up evaluation and sequential spect scanning, using a dopamine transporter ligand to assess nigrostriatal dopaminergic function at baseline and 5 years from baseline. |
2010-04-26 |
2023-08-12 |
Not clear |
| Elise T Courtois, Claudia G Castillo, Emma G Seiz, Milagros Ramos, Carlos Bueno, Isabel Liste, Alberto Martínez-Serran. In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL. The Journal of biological chemistry. vol 285. issue 13. 2010-04-26. PMID:20106970. |
the expression of key genes directly involved in vm/snpc dopaminergic patterning, differentiation, and maturation (en1, lmx1b, pitx3, nurr1, vmat2, girk2, and dopamine transporter) is thus enhanced by bcl-x(l). |
2010-04-26 |
2023-08-12 |
human |
| Chihiro It. Histamine H3-receptor inverse agonists as novel antipsychotics. Central nervous system agents in medicinal chemistry. vol 9. issue 2. 2010-04-23. PMID:20021346. |
schizophrenia (sz) that is resistant to treatment with dopamine (da) d2 antagonists may involve changes other than those in the dopaminergic system. |
2010-04-23 |
2023-08-12 |
human |
| John W Cave, Yosuke Akiba, Kasturi Banerjee, Shivraj Bhosle, Roseann Berlin, Harriet Bake. Differential regulation of dopaminergic gene expression by Er81. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 13. 2010-04-22. PMID:20357122. |
a recent study proposed that differentiation of dopaminergic neurons requires a conserved "dopamine motif" (da-motif) that functions as a binding site for ets dna binding domain transcription factors. |
2010-04-22 |
2023-08-12 |
mouse |
| Dirk Taubert, Gundula Grimberg, Werner Stenzel, Edgar Schömi. Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. PloS one. vol 2. issue 4. 2010-04-19. PMID:17460754. |
current hypotheses suggest an abnormal function of the neuronal sodium-dependent dopamine transporter dat to contribute to cell death in the dopaminergic system, but it has not been investigated whether sodium-independent amine transporters are implicated in the pathogenesis of parkinson's disease. |
2010-04-19 |
2023-08-12 |
human |
| Naila Rasheed, Ausaf Ahmad, Chandra Prakash Pandey, Rajnish Kumar Chaturvedi, Mohtashim Lohani, Gautam Pali. Differential response of central dopaminergic system in acute and chronic unpredictable stress models in rats. Neurochemical research. vol 35. issue 1. 2010-04-19. PMID:19568932. |
we aimed to evaluate the response of dopaminergic system in acute stress (as) and chronic unpredictable stress (cus) by measuring dopamine (da) levels, its receptor densities in the frontal cortex, striatum, hippocampus, amygdala and orbito-frontal cortex regions of rat brain, and investigated the corresponding behavioral locomotor changes. |
2010-04-19 |
2023-08-12 |
rat |
| David J Brook. Imaging approaches to Parkinson disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 4. 2010-04-19. PMID:20351351. |
demonstrating midbrain structural abnormalities with transcranial sonography or diffusion-weighted mri or showing striatal dopamine terminal dysfunction with pet or spect supports the diagnosis and rationalizes the use of dopaminergic medications. |
2010-04-19 |
2023-08-12 |
Not clear |
| N B Saul'skaya, N V Fofonova, P V Sudorgin. Effects of blockade of dopamine D2 receptors on extracellular citrulline levels in the nucleus accumbens during performance of a conditioned reflex fear response. Neuroscience and behavioral physiology. vol 40. issue 1. 2010-04-16. PMID:20012493. |
these data suggest that the dopaminergic input and dopamine d(2) receptors control the activity of the no-ergic system of the nucleus accumbens during performance of the conditioned reflex fear response and may control "transfer" of fear to another behavioral situation. |
2010-04-16 |
2023-08-12 |
rat |
| Santiago Perez-Lloret, Perez-Lloret Santiago, Malco Rossi, Daniel P Cardinali, Marcelo Merell. Activity-rest rhythm abnormalities in Parkinson's disease patients are related to dopaminergic therapy. The International journal of neuroscience. vol 120. issue 1. 2010-04-16. PMID:20128666. |
to compare going to bed, waking-up, and immobility onset and offset times in parkinson's disease (pd) patients receiving levodopa and/or dopamine agonists (i.e., dopaminergic therapy or dt) with "de novo" patients and healthy controls and to correlate these parameters with self-reported sleep disturbances. |
2010-04-16 |
2023-08-12 |
Not clear |
| Hiroyuki Uchida, David C Mam. Dosing of antipsychotics in schizophrenia across the life-spectrum. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 6. 2010-04-12. PMID:19426777. |
recent data suggest that this increased antipsychotic sensitivity with age comes from age-related functional decline in the dopaminergic system, including endogenous dopamine level and dopamine receptor density. |
2010-04-12 |
2023-08-12 |
Not clear |
| Gabriella Santangelo, Carmine Vitale, Luigi Trojano, Danilo De Gaspari, Leonilda Bilo, Angelo Antonini, Paolo Baron. Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 1. 2010-04-06. PMID:20014112. |
thirty-six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. |
2010-04-06 |
2023-08-12 |
Not clear |
| Anne K Meyer, Martina Maisel, Andreas Hermann, Katja Stirl, Alexander Storc. Restorative approaches in Parkinson's Disease: which cell type wins the race? Journal of the neurological sciences. vol 289. issue 1-2. 2010-04-05. PMID:19733367. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder and is characterized by a continuous and selective loss of dopaminergic neurons in the midbrain with a subsequent reduction of the neurotransmitter dopamine in the striatum. |
2010-04-05 |
2023-08-12 |
Not clear |
| Donald Grosse. Therapy adherence issues in Parkinson's disease. Journal of the neurological sciences. vol 289. issue 1-2. 2010-04-05. PMID:19793590. |
single and multicentre studies of therapy compliance report significant under- and overuse of dopamine replacement therapy resulting in poor symptomatic control, or features of the dopamine dysregulation syndrome or other signs of dopaminergic excess (dyskinesia, confusion, visual hallucinations). |
2010-04-05 |
2023-08-12 |
Not clear |
| Tino Dyhring, Elsebet Ø Nielsen, Clas Sonesson, Fredrik Pettersson, Jonas Karlsson, Peder Svensson, Palle Christophersen, Nicholas Water. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19919834. |
the dopaminergic stabilizers pridopidine (acr16) and (-)-osu6162 display dopamine d(2) receptor antagonism and fast receptor dissociation properties. |
2010-04-05 |
2023-08-12 |
Not clear |
| Tino Dyhring, Elsebet Ø Nielsen, Clas Sonesson, Fredrik Pettersson, Jonas Karlsson, Peder Svensson, Palle Christophersen, Nicholas Water. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19919834. |
the molecular mode-of-action of dopaminergic stabilizers is not yet fully understood, but they are assumed to act via normalization of dopaminergic signaling, through interactions with the dopamine d(2) receptor. |
2010-04-05 |
2023-08-12 |
Not clear |
| Tino Dyhring, Elsebet Ø Nielsen, Clas Sonesson, Fredrik Pettersson, Jonas Karlsson, Peder Svensson, Palle Christophersen, Nicholas Water. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19919834. |
here we have evaluated the dopaminergic stabilizers pridopidine (acr16) and (-)-osu6162, as well as the new compound n-{[(2s)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}ethanamine (ns30678) in a series of cellular in vitro dopamine d(2) receptor functional and binding assays. |
2010-04-05 |
2023-08-12 |
Not clear |