| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oliver Cooper, Ole Isacso. Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 41. 2005-01-12. PMID:15483111. |
consequently, no evidence of dopaminergic (da) neurogenesis was found in the striatum or substantia nigra in any experimental group, and amphetamine-induced behavioral rotations did not improve. |
2005-01-12 |
2023-08-12 |
rat |
| Rumiko Kurosaki, Yasuko Muramatsu, Hiroyuki Kato, Tsutomu Arak. Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 78. issue 1. 2005-01-07. PMID:15159144. |
the immunohistochemical study has shown that the acute treatment with mptp caused severe loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-immunoreactive dopaminergic neurons and marked increase in glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the striatum and the substantia nigra. |
2005-01-07 |
2023-08-12 |
mouse |
| Malgorzata Chalimoniuk, Józef Langfort, Nadezda Lukacova, Józef Marsal. Upregulation of guanylyl cyclase expression and activity in striatum of MPTP-induced parkinsonism in mice. Biochemical and biophysical research communications. vol 324. issue 1. 2004-12-28. PMID:15464991. |
these data suggest that no/cgmp signaling pathway may at least partially contribute to dopaminergic fiber degeneration in the striatum, the damage attributed to pd. |
2004-12-28 |
2023-08-12 |
mouse |
| E Bálint, T Kitka, G Zachar, A Adám, H C Hemmings, A Csilla. Abundance and location of DARPP-32 in striato-tegmental circuits of domestic chicks. Journal of chemical neuroanatomy. vol 28. issue 1-2. 2004-12-22. PMID:15363488. |
the striatum is reciprocally connected to the brainstem dopaminergic nuclei and receives a strong dopaminergic input. |
2004-12-22 |
2023-08-12 |
chicken |
| Eilís Dowd, Stephen B Dunnet. Deficits in a lateralized associative learning task in dopamine-depleted rats with functional recovery by dopamine-rich transplants. The European journal of neuroscience. vol 20. issue 7. 2004-12-22. PMID:15380018. |
transplantation of fetal dopaminergic neurons to the striatum led to a marked improvement in specific parameters and a more modest improvement in others. |
2004-12-22 |
2023-08-12 |
human |
| Davor Stanic, Wanida Tripanichkul, John Drago, David I Finkelstein, Malcolm K Horn. Glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra. Brain research. vol 1023. issue 1. 2004-12-21. PMID:15364022. |
following partial snpc lesions, density of dopamine transporter (dat) immunoreactive (-ir) terminals in the dorsal striatum returned to normal within 16 weeks of injury, suggesting that dopaminergic reinnervation of the striatum was complete. |
2004-12-21 |
2023-08-12 |
rat |
| Martine Cossette, André Parent, Daniel Lévesqu. Tyrosine hydroxylase-positive neurons intrinsic to the human striatum express the transcription factor Nurr1. The European journal of neuroscience. vol 20. issue 8. 2004-12-21. PMID:15450088. |
the putative dopaminergic (da) neurons intrinsic to human striatum were studied to determine their similarity with da neurons of the substantia nigra pars compacta (snpc). |
2004-12-21 |
2023-08-12 |
human |
| Lichuan Yang, Shuei Sugama, Ronald P Mischak, Mahmoud Kiaei, Nicolas Bizat, Emmanuel Brouillet, Tong H Joh, M Flint Bea. A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. Neurobiology of disease. vol 17. issue 2. 2004-12-21. PMID:15474362. |
q-vd-oph significantly reduced dopamine depletion in striatum produced by mptp administration and prevented mptp-induced loss of dopaminergic neurons in the substantia nigra. |
2004-12-21 |
2023-08-12 |
Not clear |
| Nathalie Bock, Gunther H Moll, Maike Wicker, Jürgen Pilz, Eckart Rüther, Tobias Banaschewski, Gerald Huether, Aribert Rothenberge. Early administration of tiapride to young rats without long-lasting changes in the development of the dopaminergic system. Pharmacopsychiatry. vol 37. issue 4. 2004-12-14. PMID:15467972. |
therefore, this study in rats describes tiapride's effects on several parameters of dopaminergic activity (dopamine transporter, d2 receptor, dopamine, dopac, and homovanillic acid in the striatum) seen after tiapride administration (30 mg/kg/day) to prepubertal (from day 25-39) and postpubertal (from day 50-64) rats. |
2004-12-14 |
2023-08-12 |
rat |
| Laura M Borland, Adrian C Michae. Voltammetric study of the control of striatal dopamine release by glutamate. Journal of neurochemistry. vol 91. issue 1. 2004-11-29. PMID:15379902. |
the striatum of the rat receives both dopaminergic and glutamatergic projections that synaptically target striatal neurons but not each other. |
2004-11-29 |
2023-08-12 |
human |
| L M Ambrose, E M Unterwald, E J Van Bockstael. Ultrastructural evidence for co-localization of dopamine D2 and micro-opioid receptors in the rat dorsolateral striatum. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. vol 279. issue 1. 2004-11-24. PMID:15224400. |
in conclusion, our results indicate that individual neurons in the rat dorsolateral striatum may be directly modulated by both dopaminergic and opioid ligands. |
2004-11-24 |
2023-08-12 |
rat |
| D W Hampton, A Seitz, P Chen, E Heber-Katz, J W Fawcet. Altered CNS response to injury in the MRL/MpJ mouse. Neuroscience. vol 127. issue 4. 2004-11-16. PMID:15312895. |
axon regeneration was examined following a cut lesion to the dopaminergic projection from the substantia nigra to the striatum used in previous regeneration experiments. |
2004-11-16 |
2023-08-12 |
mouse |
| Z U Khan, A Gutierre. Distribution of C-terminal splice variant of G alpha i2 in rat and monkey brain. Neuroscience. vol 127. issue 4. 2004-11-16. PMID:15312896. |
hippocampus, cerebral cortex, amygdala, thalamus, striatum, nucleus accumbens, olfactory tubercle and dopaminergic cell groups of substantia nigra, hypothalamus and olfactory bulb showed strong labeling with anti-sgi2. |
2004-11-16 |
2023-08-12 |
rat |
| O Vegas, G Beitia, J R Sánchez-Martin, A Arregi, A Azpiro. Behavioral and neurochemical responses in mice bearing tumors submitted to social stress. Behavioural brain research. vol 155. issue 1. 2004-11-15. PMID:15325786. |
similarly, an increase was observed in the density of dopamine(2) (d(2))-receptors in the striatum (srt) and an increase in dopaminergic (dopac/da) and serotonergic (5hiaa/5ht) turnover in the hypothalamus. |
2004-11-15 |
2023-08-12 |
mouse |
| Atsumi Nitta, Hirofumi Nishioka, Hidefumi Fukumitsu, Yoshiko Furukawa, Haruo Sugiura, Liya Shen, Shoei Furukaw. Hydrophobic dipeptide Leu-Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis. Journal of neuroscience research. vol 78. issue 2. 2004-11-15. PMID:15378610. |
also, peripheral administration of leu-ile inhibited dopaminergic (da) denervation caused by unilateral injection of 6-hydroxydopamine (6-ohda) into the striatum of mice. |
2004-11-15 |
2023-08-12 |
mouse |
| Etsuro Matsubar. [The recent advance of treatment of Parkinson's disease]. Nihon rinsho. Japanese journal of clinical medicine. vol 62. issue 9. 2004-11-06. PMID:15462392. |
the primary pathology of parkinson's disease is the degeneration of dopaminergic neurons in the nigrostriatal pathway, resulting in a significant reduction in striatum dopamine concentration which is responsible for the altered motor functions. |
2004-11-06 |
2023-08-12 |
Not clear |
| Adam Przybyłkowski, Iwona Kurkowska-Jastrzebska, Ilona Joniec, Agnieszka Ciesielska, Anna Członkowska, Andrzej Członkowsk. Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306248. |
mptp causes an acute damage of dopaminergic neurons especially in the nigrostriatal dopaminergic system, thus diminishing dopamine (da) content in striatum and decreasing the number of dopaminergic cells in the pars compacta of the substantia nigra (sn). |
2004-11-04 |
2023-08-12 |
mouse |
| Akinori Iwashita, Kayoko Mihara, Syunji Yamazaki, Shigeru Matsuura, Junya Ishida, Hirofumi Yamamoto, Kouji Hattori, Nobuya Matsuoka, Seitaro Muto. A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice. The Journal of pharmacology and experimental therapeutics. vol 310. issue 3. 2004-11-01. PMID:15113847. |
in the mouse meth model, meth (15 mg/kg x 2 i.p., 2 h apart) intoxication accelerated da metabolism and oxidation in the striatum, with subsequent cell damage in nigrostriatal dopaminergic neurons after 4 days. |
2004-11-01 |
2023-08-12 |
mouse |
| Ranjita Betarbet, J Timothy Greenamyr. Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP. Experimental neurology. vol 189. issue 2. 2004-10-28. PMID:15380489. |
in this study, we simultaneously analyzed the regulation of d1 and d2 dopamine receptors and levels of the neuropeptides, substance p, and enkephalin (enk) in various basal ganglia nuclei following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic denervation of striatum in nonhuman primates. |
2004-10-28 |
2023-08-12 |
monkey |
| Juan E Ferrario, Irene R E Taravini, Sophie Mourlevat, Andrea Stefano, Marina A Delfino, Rita Raisman-Vozari, M Gustavo Murer, Merle Ruberg, Oscar Gershani. Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system. Journal of neurochemistry. vol 90. issue 6. 2004-10-27. PMID:15341519. |
levodopa, the major treatment for patients with parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. |
2004-10-27 |
2023-08-12 |
rat |