| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valtteri Kaasinen, Sargo Aalto, Kjell Någren, Juha O Rinn. Dopaminergic effects of caffeine in the human striatum and thalamus. Neuroreport. vol 15. issue 2. 2004-06-10. PMID:15076753. |
the findings indicate that caffeine has effects on dopaminergic neurotransmission in the human brain, which may be differential in the striatum and the thalamus. |
2004-06-10 |
2023-08-12 |
human |
| Emilio Fernandez-Espej. Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies. Molecular neurobiology. vol 29. issue 1. 2004-06-04. PMID:15034220. |
parkinson's disease (pd) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. |
2004-06-04 |
2023-08-12 |
rat |
| F Delis, A Mitsacos, P Giompre. Dopamine receptor and transporter levels are altered in the brain of Purkinje Cell Degeneration mutant mice. Neuroscience. vol 125. issue 1. 2004-06-03. PMID:15051164. |
the dopamine transporters, as determined by [3h]win35428 binding, were increased compared with wild-type mice in the ventral mesencephalic dopaminergic nuclei and in the lateral striatum, motor cortex and septum. |
2004-06-03 |
2023-08-12 |
mouse |
| Wei Zhang, Tongguang Wang, Liya Qin, Hui-Ming Gao, Belinda Wilson, Syed F Ali, Wanqin Zhang, Jau-Shyong Hong, Bin Li. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 3. 2004-06-01. PMID:14734632. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra and depletion of the neurotransmitter dopamine in the striatum. |
2004-06-01 |
2023-08-12 |
mouse |
| Olle Lindval. Stem cells for cell therapy in Parkinson's disease. Pharmacological research. vol 47. issue 4. 2004-05-21. PMID:12644384. |
the grafted dopaminergic neurons can reinnervate the denervated striatum, restore regulated dopamine (da) release and movement-related frontal cortical activation, and give rise to significant symptomatic relief. |
2004-05-21 |
2023-08-12 |
human |
| Sung Tae Kim, Jin Woo Chang, Hea Nam Hong, Onyou Hwan. Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain. Neuroscience letters. vol 359. issue 1-2. 2004-05-21. PMID:15050714. |
we report in the present study that bh4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (th) immunopositive fibers, a decreased amount of th protein, and decreased dopamine content. |
2004-05-21 |
2023-08-12 |
rat |
| Moussa B H Youdim, Galia Stephenson, Dorit Ben Shacha. Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. Annals of the New York Academy of Sciences. vol 1012. 2004-05-19. PMID:15105275. |
all three pretreatment (30 min) doses of desferal prevented the fall in striatal and frontal cortex da, dihydroxyphenylacetic acid, and homovalinic acid, as well as the left and right striatum th activity and da turnover resulting from 6-ohda lesion of dopaminergic neurons. |
2004-05-19 |
2023-08-12 |
human |
| Shridhar Narayanan, Hoa Lam, F Ivy Carroll, Kabirullah Lutf. Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats. Journal of psychiatry & neuroscience : JPN. vol 29. issue 2. 2004-05-17. PMID:15069465. |
thus, the present study used local administration of ofq/n into the ventral tegmental area (vta), the substantia nigra, the nucleus accumbens and the striatum to determine the contribution of cell-body regions and terminal fields of the dopaminergic neurons to the motor-suppressant effect of ofq/n. |
2004-05-17 |
2023-08-12 |
rat |
| Matthew J LaVoie, J Patrick Card, Teresa G Hasting. Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity. Experimental neurology. vol 187. issue 1. 2004-05-10. PMID:15081587. |
previous studies have demonstrated methamphetamine (meth)-induced toxicity to dopaminergic and serotonergic axons in rat striatum. |
2004-05-10 |
2023-08-12 |
rat |
| Matthew J LaVoie, J Patrick Card, Teresa G Hasting. Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity. Experimental neurology. vol 187. issue 1. 2004-05-10. PMID:15081587. |
in this investigation, we characterized the temporal relationship of reactive microgliosis to neuropathological alterations of dopaminergic axons in striatum following exposure to methamphetamine. |
2004-05-10 |
2023-08-12 |
rat |
| Takashi Sasaki, Jun Kotera, Kenji Omor. Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons. Journal of neurochemistry. vol 89. issue 2. 2004-05-04. PMID:15056290. |
phosphodiesterase (pde) 7b, a camp-specific pde which is dominantly expressed in striatum, is expected to be involved in dopaminergic signaling in striatal neurons. |
2004-05-04 |
2023-08-12 |
rat |
| Shawn Hayley, Stephen J Crocker, Patrice D Smith, Tanaya Shree, Vernice Jackson-Lewis, Serge Przedborski, Matthew Mount, Ruth Slack, Hymie Anisman, David S Par. Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 8. 2004-04-30. PMID:14985447. |
although critical for degeneration of the soma, fas deficiency did not significantly prevent the reduction of dopaminergic terminal fibers within the striatum or normalize the activation of striatal microglia and elevation of the postsynaptic activity marker deltafosb induced by denervation. |
2004-04-30 |
2023-08-12 |
mouse |
| Kelvin L Chou, Mark S Forman, John Q Trojanowski, Howard I Hurtig, Gordon H Baltuc. Subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive multiple system atrophy. Case report. Journal of neurosurgery. vol 100. issue 3. 2004-04-22. PMID:15035294. |
the authors speculate that the presence of alpha-synuclein in the striatum, combined with the inflammation surrounding the electrodes, contributed to the ineffectiveness of stimulation and dopaminergic medications postoperatively. |
2004-04-22 |
2023-08-12 |
Not clear |
| D C Mathangi, A Namasivaya. Protective effect of diltiazem on cyanide-induced neurotoxicity in Wistar strain rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 42. issue 4. 2004-04-13. PMID:15019184. |
the protective effect of diltiazem pretreatment and diltiazem treatment along with cyanide on the dopaminergic system and the serotonergic system in the corpus striatum were studied. |
2004-04-13 |
2023-08-12 |
rat |
| David Erritzoe, Peter Talbot, W Gordon Frankle, Anissa Abi-Dargha. Positron emission tomography and single photon emission CT molecular imaging in schizophrenia. Neuroimaging clinics of North America. vol 13. issue 4. 2004-04-07. PMID:15024964. |
the most robust set of findings pertains to imaging of presynaptic dopaminergic function in the striatum. |
2004-04-07 |
2023-08-12 |
human |
| D C Mathangi, A Namasivaya. Calcium ions: its role in cyanide neurotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 42. issue 3. 2004-04-06. PMID:14871577. |
this study showed that dil pretreatment prevented cyanide induced changes in the dopaminergic and serotonergic system in the corpus striatum. |
2004-04-06 |
2023-08-12 |
rat |
| Martin Lévesque, Andréanne Bédard, Martine Cossette, André Paren. Novel aspects of the chemical anatomy of the striatum and its efferents projections. Journal of chemical neuroanatomy. vol 26. issue 4. 2004-04-02. PMID:14729129. |
on the other hand, immunostaining studies in humans have shown the presence of several types of putative dopaminergic neurons intrinsic to the striatum. |
2004-04-02 |
2023-08-12 |
rat |
| S D Hurley, M K O'Banion, D D Song, F S Arana, J A Olschowka, S N Habe. Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys. Experimental neurology. vol 184. issue 2. 2004-04-02. PMID:14769357. |
our previous work demonstrated tyrosine hydroxylase (th)-positive fiber sprouting in the striatum in monkeys that had received a partial dopaminergic lesion using a low-dose, chronic mptp administration paradigm. |
2004-04-02 |
2023-08-12 |
mouse |
| Karima Chergui, Per Svenningsson, Paul Greengar. Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 7. 2004-03-16. PMID:14769920. |
cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. |
2004-03-16 |
2023-08-12 |
mouse |
| Karima Chergui, Per Svenningsson, Paul Greengar. Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 7. 2004-03-16. PMID:14769920. |
dopaminergic and glutamatergic neurotransmissions in the striatum play an essential role in motor- and reward-related behaviors. |
2004-03-16 |
2023-08-12 |
mouse |