| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akhmad Kharis Nugroho, Stefan G Romeijn, Raphaël Zwier, Jan B de Vries, Durk Dijkstra, Håkan Wikström, Oscar Della-Pasqua, Meindert Danhof, Joke A Bouwstr. Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: in vitro-in vivo correlation. Journal of pharmaceutical sciences. vol 95. issue 7. 2006-09-29. PMID:16732562. |
pharmacokinetics and dopaminergic effect of dopamine agonist 5-oh-dpat in vivo were determined following transdermal iontophoresis in rats based on drug concentration in plasma (c(p)) and dopamine levels in striatum (c(da)). |
2006-09-29 |
2023-08-12 |
rat |
| Satoshi Ohashi, Atsushi Mori, Naoki Kurihara, Yasuhide Mitsumoto, Masami Naka. Age-related severity of dopaminergic neurodegeneration to MPTP neurotoxicity causes motor dysfunction in C57BL/6 mice. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16581184. |
an extensive dopaminergic cell loss was found in both the striatum and substantia nigra of older mice given one and two injections of mptp with marked decrease in striatal dopamine (da) levels, but not young mice. |
2006-09-28 |
2023-08-12 |
mouse |
| C Winkler, B Georgievska, T Carlsson, B Lacar, D Kiri. Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats. Neuroscience. vol 141. issue 1. 2006-09-28. PMID:16697115. |
functional recovery following intrastriatal transplantation of fetal dopaminergic neurons in animal models of parkinson's disease is, at least in part, dependent on the number of surviving dopaminergic neurons and the degree of graft-derived dopaminergic reinnervation of the host striatum. |
2006-09-28 |
2023-08-12 |
human |
| Fengming Yue, Li Cui, Kohei Johkura, Naoko Ogiwara, Katsunori Sasak. Induction of midbrain dopaminergic neurons from primate embryonic stem cells by coculture with sertoli cells. Stem cells (Dayton, Ohio). vol 24. issue 7. 2006-09-27. PMID:16822882. |
when transplanted into a 6-hydroxydopamine-treated parkinson's disease model, primate-derived dopaminergic neurons integrated into the mouse striatum. |
2006-09-27 |
2023-08-12 |
mouse |
| J P Q Zhu, W Xu, J A Angul. Methamphetamine-induced cell death: selective vulnerability in neuronal subpopulations of the striatum in mice. Neuroscience. vol 140. issue 2. 2006-09-25. PMID:16650608. |
in the striatum, meth has been shown to cause long lasting neurotoxic damage to dopaminergic nerve terminals and recently, the degeneration and death of striatal cells. |
2006-09-25 |
2023-08-12 |
mouse |
| Aya Sasaki, Tatyana D Sotnikova, Raul R Gainetdinov, Erich D Jarvi. Social context-dependent singing-regulated dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 35. 2006-09-21. PMID:16943558. |
like the mammalian striatum, the songbird striatum receives dense dopaminergic input from the midbrain ventral tegmental area-substantia nigra pars compacta complex. |
2006-09-21 |
2023-08-12 |
Not clear |
| Ana Muñoz, Pablo Rey, Maria J Guerra, Estefania Mendez-Alvarez, Ramon Soto-Otero, Jose L Labandeira-Garci. Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism. Neuropharmacology. vol 51. issue 1. 2006-09-11. PMID:16678218. |
pre-treatment with captopril induced a significant reduction in the mptp-induced loss of dopaminergic neurons in the substantia nigra and a significant reduction in the loss of dopaminergic terminals in the striatum. |
2006-09-11 |
2023-08-12 |
mouse |
| Sang Eun Kim, Insop Shim, June-Key Chung, Myung Chul Le. Effect of ginseng saponins on enhanced dopaminergic transmission and locomotor hyperactivity induced by nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 8. 2006-08-31. PMID:16251992. |
in an attempt to investigate whether the effect of ginseng saponins is through their inhibitory action on the enhanced dopaminergic transmission by psychomotor stimulants, we examined the effects of ginseng total saponin (gts) presynaptically on nicotine-induced dopamine (da) release in the striatum of freely moving rats using in vivo microdialysis technique and postsynaptically on the in vitro and in vivo binding of [3h]raclopride to da d2 receptors. |
2006-08-31 |
2023-08-12 |
rat |
| Sang Eun Kim, Insop Shim, June-Key Chung, Myung Chul Le. Effect of ginseng saponins on enhanced dopaminergic transmission and locomotor hyperactivity induced by nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 8. 2006-08-31. PMID:16251992. |
gts decreased nicotine-induced fos protein expression in the nucleus accumbens and striatum, reflecting the inhibition by gts of nicotine-induced enhancement of dopaminergic transmission. |
2006-08-31 |
2023-08-12 |
rat |
| Aideen M Sullivan, Gerard W O'Keeff. The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment. Journal of anatomy. vol 207. issue 3. 2006-08-21. PMID:16185246. |
gdf5 is under investigation as a potential therapeutic agent for parkinson's disease (pd), which is caused by the progressive degeneration of dopaminergic neurones projecting from the substantia nigra (sn) to the striatum. |
2006-08-21 |
2023-08-12 |
rat |
| Daniela C C Gerardin, Maria M Bernardi, Estefânia G Moreira, Oduvaldo C M Pereir. Neuroendocrine and reproductive aspects of adult male rats exposed neonatally to an antiestrogen. Pharmacology, biochemistry, and behavior. vol 83. issue 4. 2006-08-16. PMID:16650888. |
treated rats also showed decreased dopaminergic and serotonergic neurotransmissions in the hypothalamus and decreased dopaminergic neurotransmission in the striatum. |
2006-08-16 |
2023-08-12 |
rat |
| Shaji Theodore, Wayne A Cass, William F Marago. Involvement of cytokines in human immunodeficiency virus-1 protein Tat and methamphetamine interactions in the striatum. Experimental neurology. vol 199. issue 2. 2006-08-11. PMID:16510141. |
in previous studies, we demonstrated that the hiv-1 protein tat and ma interacted to cause enhanced loss of dopamine in the rat striatum via the destruction of dopaminergic terminals. |
2006-08-11 |
2023-08-12 |
mouse |
| Shaji Theodore, Wayne A Cass, William F Marago. Involvement of cytokines in human immunodeficiency virus-1 protein Tat and methamphetamine interactions in the striatum. Experimental neurology. vol 199. issue 2. 2006-08-11. PMID:16510141. |
our findings suggest that hiv-1 infection with concurrent drug abuse might profoundly increase chemokine levels in the striatum resulting in enhanced damage to the dopaminergic system. |
2006-08-11 |
2023-08-12 |
mouse |
| Jun Ding, Jaime N Guzman, Tatiana Tkatch, Songhai Chen, Joshua A Goldberg, Philip J Ebert, Pat Levitt, Charles J Wilson, Heidi E Hamm, D James Surmeie. RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nature neuroscience. vol 9. issue 6. 2006-08-11. PMID:16699510. |
parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. |
2006-08-11 |
2023-08-12 |
Not clear |
| Xuhong Liu, Kelly A Sullivan, James E Madl, Marie Legare, Ronald B Tjalken. Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration. Toxicological sciences : an official journal of the Society of Toxicology. vol 91. issue 2. 2006-08-09. PMID:16551646. |
in contrast, soma and terminals of dopaminergic neurons were morphologically unaltered in either the substantia nigra or striatum, as indicated by immunohistochemical staining for tyrosine hydroxylase. |
2006-08-09 |
2023-08-12 |
mouse |
| Q David Walker, Rupa Ray, Cynthia M Kuh. Sex differences in neurochemical effects of dopaminergic drugs in rat striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 6. 2006-08-07. PMID:16237396. |
sex differences in neurochemical effects of dopaminergic drugs in rat striatum. |
2006-08-07 |
2023-08-12 |
rat |
| H Melrose, S Lincoln, G Tyndall, D Dickson, M Farre. Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience. vol 139. issue 3. 2006-08-03. PMID:16504409. |
we find lrrk2 is highly expressed in the striatum, cortex and olfactory tubercle; however, little or no expression is found in the substantia nigra, where dopaminergic neurons preferentially degenerate in parkinson's disease. |
2006-08-03 |
2023-08-12 |
mouse |
| Yushi U Adachi, Shigeyuki Yamada, Maiko Satomoto, Kazuhiko Watanabe, Hideyuki Higuchi, Tomiei Kazama, Matsuyuki Doi, Shigehito Sat. Pentobarbital inhibits L-DOPA-induced dopamine increases in the rat striatum: An in vivo microdialysis study. Brain research bulletin. vol 69. issue 5. 2006-08-03. PMID:16647588. |
the results of the present investigation demonstrate that administration of pentobarbital might inhibit dopaminergic neural activity not only in the nucleus accumbens but also in the rat striatum. |
2006-08-03 |
2023-08-12 |
rat |
| Khaled Radad, Gabriele Gille, Wolf-Dieter Rausc. Short review on dopamine agonists: insight into clinical and research studies relevant to Parkinson's disease. Pharmacological reports : PR. vol 57. issue 6. 2006-07-21. PMID:16382188. |
parkinson's disease (pd) is a chronic and progressive neurological disorder characterized by selective degeneration of dopaminergic neurons (daergic) in the substantia nigra pars compacta (snpc) and subsequent decrease in dopamine (da) levels in the striatum. |
2006-07-21 |
2023-08-12 |
Not clear |
| Sara González, Camila Scorticati, Moisés García-Arencibia, Rosario de Miguel, José A Ramos, Javier Fernández-Rui. Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease. Brain research. vol 1073-1074. 2006-07-19. PMID:16412990. |
in summary, rimonabant may have potential antihypokinetic activity in moderate parkinsonism at low doses, but this effect is not related to changes in dopaminergic, gabaergic, or glutamatergic transmission in the striatum. |
2006-07-19 |
2023-08-12 |
rat |