| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jelena Mijatovic, Mikko Airavaara, Anu Planken, Petri Auvinen, Atso Raasmaja, T Petteri Piepponen, Frank Costantini, Liisa Ahtee, Mart Saarm. Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 18. 2007-06-06. PMID:17475787. |
we used knock-in men2b mice with the ret-men2b mutation to study the effects of constitutive ret activity on the brain dopaminergic system and found robustly increased concentrations of dopamine (da) and its metabolites in the striatum, cortex, and hypothalamus. |
2007-06-06 |
2023-08-12 |
mouse |
| David A Price, William A Owens, Georgianna G Gould, Alan Frazer, James L Roberts, Lynette C Daws, Andrea Giuffrid. CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum. Journal of neurochemistry. vol 101. issue 2. 2007-06-01. PMID:17250681. |
in this study, we used in vitro and in vivo techniques to investigate whether cannabinoid agonists and antagonist could affect dopaminergic transmission in the striatum by acting at the dopamine transporter. |
2007-06-01 |
2023-08-12 |
mouse |
| Xavier Ligneau, Laurent Landais, David Perrin, Johanne Piriou, Marilyne Uguen, Emmanuel Denis, Philippe Robert, Régis Parmentier, Christelle Anaclet, Jian-Sheng Lin, Aude Burban, Jean-Michel Arrang, Jean-Charles Schwart. Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Biochemical pharmacology. vol 73. issue 8. 2007-05-31. PMID:17343831. |
dopac/dopamine ratios were enhanced in the prefrontal cortex but not in the striatum, indicating a selective activation of a sub-population of dopaminergic neurons. |
2007-05-31 |
2023-08-12 |
mouse |
| Walter Maetzler, Daniela Berg, Natalie Schalamberidze, Arthur Melms, Klaus Schott, Jakob C Mueller, Lucy Liaw, Thomas Gasser, Cordula Nitsc. Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17188882. |
loss of tyrosine-hydroxylase-positive cells in the sn and of dopaminergic fibers in the striatum was reduced 3 weeks after mptp intoxication in opn-null mice. |
2007-05-17 |
2023-08-12 |
mouse |
| E Ch Wolter. PD-related psychosis: pathophysiology with therapeutical strategies. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447413. |
parkinson's disease (pd) is a chronic, neurodegenerative disease with degeneration of the central dopaminergic neurons in the substantia nigra, leading to a depletion of dopamine (da) in the striatum. |
2007-05-17 |
2023-08-12 |
Not clear |
| Li-Ping Liang, Jie Huang, Ruth Fulton, Brian J Day, Manisha Pate. An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 16. 2007-05-07. PMID:17442816. |
aeol11207 administered either by subcutaneous or oral routes protected against mptp-induced dopamine depletion in the striatum as well as dopaminergic neuronal loss, glutathione depletion, lipid peroxidation, and 3-nt formation in the ventral midbrain. |
2007-05-07 |
2023-08-12 |
mouse |
| T Obat. Nitric oxide and MPP+-induced hydroxyl radical generation. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16463115. |
intraneuronal ca(2+) triggered by mpp(+) may be detrimental to the functioning of dopaminergic nerve terminals in the striatum. |
2007-05-02 |
2023-08-12 |
Not clear |
| Elin K I Andersson, Dwain K Irvin, Jessica Ahlsiö, Malin Parma. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Experimental cell research. vol 313. issue 6. 2007-05-02. PMID:17291494. |
parkinson's disease (pd) is a debilitating motor function disorder due primarily to a loss of midbrain dopaminergic neurons and a subsequent reduction in dopaminergic innervation of the striatum. |
2007-05-02 |
2023-08-12 |
mouse |
| Andisheh Eslamboli, Marina Romero-Ramos, Corinna Burger, Tomas Bjorklund, Nicholas Muzyczka, Ronald J Mandel, Harry Baker, Rosalind M Ridley, Deniz Kiri. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain : a journal of neurology. vol 130. issue Pt 3. 2007-04-16. PMID:17303591. |
histological analysis from animals overexpressing either the wt or a53t alpha -syn showed prominent degeneration of dopaminergic fibres in the striatum. |
2007-04-16 |
2023-08-12 |
human |
| Jeffrey N Joyce, Mark J Milla. Dopamine D3 receptor agonists for protection and repair in Parkinson's disease. Current opinion in pharmacology. vol 7. issue 1. 2007-04-12. PMID:17174156. |
parkinson's disease is a severe, age-related neurodegenerative disorder in which a loss of substantia nigra-derived dopaminergic pathways to the striatum triggers profound motor perturbation, as well as cognitive, sensory and mood deficits. |
2007-04-12 |
2023-08-12 |
Not clear |
| S Urakawa, H Hida, T Masuda, S Misumi, T-S Kim, H Nishin. Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats. Neuroscience. vol 144. issue 3. 2007-04-11. PMID:17161913. |
striatal damage was induced at an age of 8 weeks by injection of the neuro-toxins 6-hydroxydopamine (6-ohda) or quinolinic acid (qa) into the striatum, or by injection of 6-ohda into the substantia nigra (sn), which depleted nigrostriatal dopaminergic innervation. |
2007-04-11 |
2023-08-12 |
rat |
| Erica L Unger, Tessy Paul, Laura E Murray-Kolb, Barbara Felt, Byron C Jones, John L Bear. Early iron deficiency alters sensorimotor development and brain monoamines in rats. The Journal of nutrition. vol 137. issue 1. 2007-04-10. PMID:17182811. |
only g15 iron deficient rats had greater dopaminergic activity than controls as indicated by increased tyrosine hydroxylase levels, phosphorylated tyrosine hydroxylase levels, and cellular dopamine in prefrontal cortex and striatum at p15. |
2007-04-10 |
2023-08-12 |
human |
| Hideki Hida, Tadashi Masuda, Toyohiro Sato, Tae-Sun Kim, Sachiyo Misumi, Hitoo Nishin. Pleiotrophin promotes functional recovery after neural transplantation in rats. Neuroreport. vol 18. issue 2. 2007-04-10. PMID:17301686. |
to investigate whether pleiotrophin promotes survival of grafted dopaminergic neurons in vivo, donor cells from ventral mesencephalon were treated with pleiotrophin (100 ng/ml) during cell preparation and grafted into striatum of hemi-parkinson model rats. |
2007-04-10 |
2023-08-12 |
rat |
| Cindy Achat-Mendes, Karen L Anderson, Yossef Itzha. Impairment in consolidation of learned place preference following dopaminergic neurotoxicity in mice is ameliorated by N-acetylcysteine but not D1 and D2 dopamine receptor agonists. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 3. 2007-04-05. PMID:16760923. |
we have shown that a high dose of meth selectively depleted dopaminergic markers in striatum, frontal cortex and amygdala of swiss webster mice, and impaired learned place preference. |
2007-04-05 |
2023-08-12 |
mouse |
| Gregory D Lyng, Abigail Snyder-Keller, Richard F Seega. Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain research. vol 1133. issue 1. 2007-04-05. PMID:17196555. |
dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. |
2007-04-05 |
2023-08-12 |
rat |
| Alexandre Kreisler, Patrick Gelé, Jean-François Wiart, Michel Lhermitte, Alain Destée, Régis Borde. Lipid-lowering drugs in the MPTP mouse model of Parkinson's disease: fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not. Brain research. vol 1135. issue 1. 2007-04-05. PMID:17196944. |
when orally administered for the week prior to intoxication and a week thereafter, fenofibrate prevented the mptp-induced dopaminergic cell loss in the substantia nigra pars compacta (snpc) and attenuated the loss of tyrosine hydroxylase immunoreactivity in the striatum. |
2007-04-05 |
2023-08-12 |
mouse |
| Meleik Hebert Goodwill, David A Lawrence, Richard F Seega. Polychlorinated biphenyls induce proinflammatory cytokine release and dopaminergic dysfunction: protection in interleukin-6 knockout mice. Journal of neuroimmunology. vol 183. issue 1-2. 2007-04-05. PMID:17229471. |
taken together, these results suggest that: (1) pcb exposure results in a peripheral inflammatory response associated with striatal terminal degeneration; and (2) the absence of il-6 prevents pcb-induced dopaminergic losses in the striatum. |
2007-04-05 |
2023-08-12 |
mouse |
| T Yasuda, S Miyachi, R Kitagawa, K Wada, T Nihira, Y-R Ren, Y Hirai, N Ageyama, K Terao, T Shimada, M Takada, Y Mizuno, H Mochizuk. Neuronal specificity of alpha-synuclein toxicity and effect of Parkin co-expression in primates. Neuroscience. vol 144. issue 2. 2007-03-28. PMID:17101231. |
the serotype-1 raav (raav1) carrying alphasyn cdna (raav1-alphasyn), and a cocktail of raav1-alphasyn and raav1 carrying parkin cdna (raav1-parkin) were unilaterally injected into the striatum of macaque monkeys, resulting in protein expression in striatonigral gabaergic and nigrostriatal dopaminergic neurons. |
2007-03-28 |
2023-08-12 |
rat |
| Yogeshwar V Kalkonde, William W Morgan, Jose Sigala, Shivani K Maffi, Carlo Condello, William Kuziel, Seema S Ahuja, Sunil K Ahuj. Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain research. vol 1128. issue 1. 2007-03-27. PMID:17126305. |
astrocytes were the predominant source of ccl2 and ccl3 in the striatum and the substantia nigra, and dopaminergic neurons in the substantia nigra constitutively expressed these two chemokines. |
2007-03-27 |
2023-08-12 |
mouse |
| Przemysław Nowak, Grazyna Szczerbak, Joanna Dabrowska, Aleksandra Bortel, Izabela Biedka, Richard M Kostrzew. [Molecular mechanisms of levodopa action in animal models of Parkinson's disease]. Neurologia i neurochirurgia polska. vol 40. issue 6. 2007-03-27. PMID:17199178. |
since loss of nigrostriatal dopaminergic function is the basic underlying pathophysiology of this disease, drugs that enhance dopaminergic function in the striatum, including the exogenous precursor levodopa, remain the most effective symptomatic agents in the treatment of parkinson's disease. |
2007-03-27 |
2023-08-12 |
Not clear |