| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A W Michell, G K Tofaris, H Gossage, P Tyers, M G Spillantini, R A Barke. The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell transplantation. vol 16. issue 5. 2007-09-07. PMID:17708336. |
when transplanted to the striatum in the unilateral 6-hydroxydopamine-lesioned mouse model of pd, dopaminergic cells derived from transgenic embryonic ventral mesencephala were significantly smaller at 6 weeks, and showed a trend towards being less effective at ameliorating rotational asymmetry than those from control alpha-synuclein null mice. |
2007-09-07 |
2023-08-12 |
mouse |
| Päivi Lindholm, Merja H Voutilainen, Juha Laurén, Johan Peränen, Veli-Matti Leppänen, Jaan-Olle Andressoo, Maria Lindahl, Sanna Janhunen, Nisse Kalkkinen, Tõnis Timmusk, Raimo K Tuominen, Mart Saarm. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. vol 448. issue 7149. 2007-08-27. PMID:17611540. |
a single injection of cdnf before 6-ohda delivery into the striatum significantly reduced amphetamine-induced ipsilateral turning behaviour and almost completely rescued dopaminergic tyrosine-hydroxylase-positive cells in the substantia nigra. |
2007-08-27 |
2023-08-12 |
mouse |
| Michael R Drew, Eleanor H Simpson, Christoph Kellendonk, William G Herzberg, Olga Lipatova, Stephen Fairhurst, Eric R Kandel, Chara Malapani, Peter D Balsa. Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 29. 2007-08-23. PMID:17634367. |
the striatum receives prominent dopaminergic innervation that is integral to appetitive learning, performance, and motivation. |
2007-08-23 |
2023-08-12 |
mouse |
| Janneke Koerts, Klaus L Leenders, Marthe Koning, Axel T Portman, Marije van Beile. Striatal dopaminergic activity (FDOPA-PET) associated with cognitive items of a depression scale (MADRS) in Parkinson's disease. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561826. |
in particular, cognitive symptoms measured with a depression rating scale may be based on the dopaminergic dysfunction of the striatum in pd patients. |
2007-08-17 |
2023-08-12 |
Not clear |
| Philippe Huot, André Paren. Dopaminergic neurons intrinsic to the striatum. Journal of neurochemistry. vol 101. issue 6. 2007-08-16. PMID:17286588. |
dopaminergic neurons intrinsic to the striatum. |
2007-08-16 |
2023-08-12 |
Not clear |
| Philippe Huot, André Paren. Dopaminergic neurons intrinsic to the striatum. Journal of neurochemistry. vol 101. issue 6. 2007-08-16. PMID:17286588. |
the striatum -- the largest integrative component of the basal ganglia -- harbors a population of neurons that express the enzyme tyrosine hydroxylase (th), a faithful marker of dopaminergic neurons. |
2007-08-16 |
2023-08-12 |
Not clear |
| Muzamil Ahmad, Seema Yousuf, M Badruzzaman Khan, Abdullah Shafique Ahmad, Sofiyan Saleem, Md Nasrul Hoda, Fakhrul Isla. Protective effects of ethanolic extract of Delphinium denudatum in a rat model of Parkinson's disease. Human & experimental toxicology. vol 25. issue 7. 2007-08-08. PMID:16898164. |
a significant decrease in the level of dopamine (da) and its metabolites and an increase in the number of dopaminergic d2 receptors in striatum were observed after 6-ohda injection, both parameters were significantly recovered with treatment of the extract. |
2007-08-08 |
2023-08-12 |
rat |
| Andreas Hald, Johan Van Beek, Julie Lothariu. Inflammation in Parkinson's disease: causative or epiphenomenal? Sub-cellular biochemistry. vol 42. 2007-08-06. PMID:17612055. |
not only have activated microglia and increased levels of inflammatory mediators been detected in the striatum of pd patients, but a large body of animal studies points to a contributory role of inflammation in dopaminergic cell loss. |
2007-08-06 |
2023-08-12 |
human |
| Pietro Mazzoni, Anna Hristova, John W Krakaue. Why don't we move faster? Parkinson's disease, movement vigor, and implicit motivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 27. 2007-08-02. PMID:17611263. |
we propose that, analogous to the established role of dopamine in explicit reward-seeking behavior, the dopaminergic projection to the striatum provides a signal for implicit "motor motivation." |
2007-08-02 |
2023-08-12 |
human |
| X Y Chen, J Li, W Q Qi, S H She. Experimental change on dopaminergic neurons in striatum of Parkinson disease rats. Histology and histopathology. vol 22. issue 10. 2007-08-02. PMID:17616935. |
experimental change on dopaminergic neurons in striatum of parkinson disease rats. |
2007-08-02 |
2023-08-12 |
rat |
| Osamu Kitamura, Itsuo Tokunaga, Takako Gotohda, Shin-ichi Kub. Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. International journal of legal medicine. vol 121. issue 3. 2007-07-31. PMID:16622715. |
immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. |
2007-07-31 |
2023-08-12 |
human |
| Osamu Kitamura, Itsuo Tokunaga, Takako Gotohda, Shin-ichi Kub. Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. International journal of legal medicine. vol 121. issue 3. 2007-07-31. PMID:16622715. |
these findings might indicate that dopaminergic terminal degeneration is induced in the striatum of some meth abusers. |
2007-07-31 |
2023-08-12 |
human |
| R E Nordquist, P Voorn, J G de Mooij-van Malsen, R N J M A Joosten, C M A Pennartz, L J M J Vanderschure. Augmented reinforcer value and accelerated habit formation after repeated amphetamine treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 8. 2007-07-30. PMID:17275266. |
augmented dopaminergic neurotransmission in the striatum. |
2007-07-30 |
2023-08-12 |
rat |
| Hiroo Yamaguchi, Jie She. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Molecular neurodegeneration. vol 2. 2007-07-30. PMID:17535435. |
we found that dj-1-/- mice at the age of 24-27 months have normal numbers of dopaminergic neurons in the substantia nigra and normal levels of dopamine and its major metabolites in the striatum. |
2007-07-30 |
2023-08-12 |
mouse |
| Deanna M Marchionini, Elin Lehrmann, Yaping Chu, Bin He, Caryl E Sortwell, Kevin G Becker, William J Freed, Jeffrey H Kordower, Timothy J Collie. Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease. Brain research. vol 1147. 2007-07-16. PMID:17368428. |
examination of gene expression in the developing striatum suggested an important role for the heparin binding growth factor family at time points relevant to establishment of dopaminergic innervation. |
2007-07-16 |
2023-08-12 |
Not clear |
| V Pedersen, W J Schmid. The neuroprotectant properties of glutamate antagonists and antiglutamatergic drugs. Neurotoxicity research. vol 2. issue 2-3. 2007-07-09. PMID:16787840. |
there are recent studies indicating that a transneuronal retrograde degeneration of the substantia nigra pars compacta neurons might be induced by a loss of function of dopaminergic synapses in the striatum. |
2007-07-09 |
2023-08-12 |
Not clear |
| Marine Hovakimyan, Stefan Jean-Pierre Haas, Oliver Schmitt, Bernd Gerber, Andreas Wree, Christian Andresse. Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behaviour. Journal of anatomy. vol 209. issue 6. 2007-07-09. PMID:17118060. |
in the striatum, tyrosine hydroxylase-immunoreactive somata were also found, indicating a dopaminergic differentiation capacity of transplanted hnpcs in vivo. |
2007-07-09 |
2023-08-12 |
human |
| Vincenzo Di Matteo, Massimo Pierucci, Giuseppe Di Giovanni, Arcangelo Benigno, Ennio Esposit. The neurobiological bases for the pharmacotherapy of nicotine addiction. Current pharmaceutical design. vol 13. issue 12. 2007-07-09. PMID:17504235. |
the neurochemical data are consistent with neuroanatomical findings showing the presence of nicotinic acetylcholine receptors (nachrs) in the snc, the vta, and in projection areas of the central dopaminergic system such as the corpus striatum and the nucleus accumbens. |
2007-07-09 |
2023-08-12 |
Not clear |
| Jun Takahash. Stem cell therapy for Parkinson's disease. Expert review of neurotherapeutics. vol 7. issue 6. 2007-07-03. PMID:17563250. |
as an alternative, transplantation of stem cell-derived dopaminergic neurons into the striatum has been attempted, with the aim of stimulating local synapse formation and/or release of dopamine and cytokines from grafted cells. |
2007-07-03 |
2023-08-12 |
Not clear |
| Nathalie Breysse, Thomas Carlsson, Christian Winkler, Anders Björklund, Deniz Kiri. The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 22. 2007-06-13. PMID:17537955. |
here, we report that in animals subjected to an intrastriatal 6-hydroxydopamine lesion of the striatal dopaminergic afferent, the integrity of the host dopaminergic innervation outside the areas innervated by the graft is critical for optimal function of da neurons placed in the striatum. |
2007-06-13 |
2023-08-12 |
human |