| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dali Yang, Zhi-Jian Zhang, Michael Oldenburg, Melvin Ayala, Su-Chun Zhan. Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats. Stem cells (Dayton, Ohio). vol 26. issue 1. 2008-03-25. PMID:17951220. |
we show that human embryonic stem cell-derived dopaminergic neurons survived transplantation to the neurotoxin 6-hydroxydopamine-lesioned rat striatum and, in combination with the cells newly differentiated from their progenitors, contributed to locomotive function recovery at 5 months. |
2008-03-25 |
2023-08-12 |
human |
| Masaya Hashimoto, Keiichi Kawasaki, Masahiko Suzuki, Kazuko Mitani, Shigeo Murayama, Masahiro Mishina, Keiichi Oda, Yuichi Kimura, Kiichi Ishiwata, Kenji Ishii, Kiyoharu Inou. Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy. Neuroreport. vol 19. issue 2. 2008-03-24. PMID:18185098. |
both presynaptic and postsynaptic markers were revealed to have declined in such a manner that they kept strong positive correlation throughout the striatum of all patients, suggesting that the degeneration process in the striatum may involve the entire structure of the dopaminergic synapse. |
2008-03-24 |
2023-08-12 |
Not clear |
| Khaled Radad, Gabriele Gille, Wolf-Dieter Rausc. Dopaminergic neurons are preferentially sensitive to long-term rotenone toxicity in primary cell culture. Toxicology in vitro : an international journal published in association with BIBRA. vol 22. issue 1. 2008-03-20. PMID:17923380. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra pars compacta (snpc) and the subsequent decrease of dopamine levels in the striatum. |
2008-03-20 |
2023-08-12 |
mouse |
| M Quinn, K Mukhida, D Sadi, M Hong, I Mende. Adjunctive use of the non-ionic surfactant Poloxamer 188 improves fetal dopaminergic cell survival and reinnervation in a neural transplantation strategy for Parkinson's disease. The European journal of neuroscience. vol 27. issue 1. 2008-03-18. PMID:18093176. |
fetal rat dopaminergic tissue was dissociated in media with or without p188 and then cultured for 1 week or transplanted into the striatum of rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopaminergic pathway. |
2008-03-18 |
2023-08-12 |
rat |
| M Quinn, K Mukhida, D Sadi, M Hong, I Mende. Adjunctive use of the non-ionic surfactant Poloxamer 188 improves fetal dopaminergic cell survival and reinnervation in a neural transplantation strategy for Parkinson's disease. The European journal of neuroscience. vol 27. issue 1. 2008-03-18. PMID:18093176. |
in conclusion, p188 protects fetal dopaminergic cells from mechanical injury by increasing cell survival and enhances dopaminergic fibre outgrowth into the transplanted striatum. |
2008-03-18 |
2023-08-12 |
rat |
| Jason T Moyer, John A Wolf, Leif H Finke. Effects of dopaminergic modulation on the integrative properties of the ventral striatal medium spiny neuron. Journal of neurophysiology. vol 98. issue 6. 2008-03-05. PMID:17913980. |
dopaminergic modulation produces a variety of functional changes in the principal cell of the striatum, the medium spiny neuron (msn). |
2008-03-05 |
2023-08-12 |
Not clear |
| Jia Liu, Hong-Yun Huan. How to improve the survival of the fetal ventral mesencephalic cell transplanted in Parkinson's disease? Neuroscience bulletin. vol 23. issue 6. 2008-03-04. PMID:18064069. |
the major limitations are the poor survival of grafted dopamine (da) neurons and restricted dopaminergic reinnervation of host striatum. |
2008-03-04 |
2023-08-12 |
Not clear |
| Hebert L Hernández-Montiel, Elisa Tamariz, M Teresa Sandoval-Minero, Alfredo Varela-Echavarrí. Semaphorins 3A, 3C, and 3F in mesencephalic dopaminergic axon pathfinding. The Journal of comparative neurology. vol 506. issue 3. 2008-02-28. PMID:18041777. |
by analyzing the mechanisms that govern dopaminergic axon pathfinding from the midbrain to the striatum in embryonic rat brains, we identified neuroepithelial regions that exert chemotropic effects on mesencephalic dopaminergic axons. |
2008-02-28 |
2023-08-12 |
rat |
| Hebert L Hernández-Montiel, Elisa Tamariz, M Teresa Sandoval-Minero, Alfredo Varela-Echavarrí. Semaphorins 3A, 3C, and 3F in mesencephalic dopaminergic axon pathfinding. The Journal of comparative neurology. vol 506. issue 3. 2008-02-28. PMID:18041777. |
expression of semaphorin (sema) 3c and sema3f in the pretectum and of sema3a in the striatum suggested a role for these axon guidance molecules in dopaminergic axon pathfinding. |
2008-02-28 |
2023-08-12 |
rat |
| Hebert L Hernández-Montiel, Elisa Tamariz, M Teresa Sandoval-Minero, Alfredo Varela-Echavarrí. Semaphorins 3A, 3C, and 3F in mesencephalic dopaminergic axon pathfinding. The Journal of comparative neurology. vol 506. issue 3. 2008-02-28. PMID:18041777. |
these results suggest that semaphorins may help to establish the dopaminergic projection from the midbrain to the striatum during embryonic development. |
2008-02-28 |
2023-08-12 |
rat |
| Satoshi Ikemot. Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain research reviews. vol 56. issue 1. 2008-02-26. PMID:17574681. |
present experiments suggest that dopaminergic neurons localized in the posteromedial ventral tegmental area (vta) and central linear nucleus raphe selectively project to the ventromedial striatum (medial olfactory tubercle and medial nucleus accumbens shell), whereas the anteromedial vta has few if any projections to the ventral striatum, and the lateral vta largely projects to the ventrolateral striatum (accumbens core, lateral shell and lateral tubercle). |
2008-02-26 |
2023-08-12 |
rat |
| Kevin B Clayton, Aideen M Sulliva. Differential effects of GDF5 on the medial and lateral rat ventral mesencephalon. Neuroscience letters. vol 427. issue 3. 2008-02-25. PMID:17935884. |
one therapy being explored for pd involves transplantation of fetal vm tissue into the striatum in order to replace lost dopaminergic neurones. |
2008-02-25 |
2023-08-12 |
rat |
| I Rite, S Argüelles, J L Venero, S García-Rodriguez, A Ayala, J Cano, A Machad. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. Journal of neuroscience research. vol 85. issue 16. 2008-02-19. PMID:17705290. |
in this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in the substantia nigra and a loss of more than 80% dopamine terminals in the striatum, with a similar diminution of dopamine levels in both structures. |
2008-02-19 |
2023-08-12 |
rat |
| Paola Arlotta, Bradley J Molyneaux, Denis Jabaudon, Yutaka Yoshida, Jeffrey D Mackli. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 3. 2008-02-08. PMID:18199763. |
this is associated with abnormal dopaminergic innervation of the mutant striatum and dramatic changes in gene expression, including dysregulation of molecules involved in cellular repulsion. |
2008-02-08 |
2023-08-12 |
Not clear |
| Oleg S Gorbatyuk, Shoudong Li, Layla F Sullivan, Weijun Chen, Galina Kondrikova, Fredric P Manfredsson, Ronald J Mandel, Nicholas Muzyczk. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 2. 2008-02-06. PMID:18178617. |
there was a significant reduction of dopaminergic neurons in the snc and dopamine (da) and tyrosine hydroxylase (th) levels in the striatum of all s129a-treated rats as early as 4 wk postinjection. |
2008-02-06 |
2023-08-12 |
human |
| Andrej Nikoshkov, Katarina Drakenberg, Xinyu Wang, Monika Cs Horvath, Eva Keller, Yasmin L Hur. Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 2. 2008-02-06. PMID:18184800. |
we examined polymorphisms of proenkephalin (penk) and prodynorphin (pdyn) genes in relation to heroin abuse and gene expression in the human striatum and the relevance of genetic dopaminergic tone, critical for drug reward and striatal function. |
2008-02-06 |
2023-08-12 |
human |
| Kirsten R Müller-Vahl, Georg Berding, Hinderk M Emrich, Thomas Pesche. Chorea-acanthocytosis in monozygotic twins: clinical findings and neuropathological changes as detected by diffusion tensor imaging, FDG-PET and (123)I-beta-CIT-SPECT. Journal of neurology. vol 254. issue 8. 2008-02-01. PMID:17294064. |
our findings suggest that the main neuropathological process in chac is located in the striatum, involving microstructural alterations, and disturbance of metabolism and dopaminergic neurotransmission. |
2008-02-01 |
2023-08-12 |
Not clear |
| Ling T Guo, Theodore Friedmann, Charles C Kin. Partial characterization of the proteome of the mouse striatum. Proteomics. vol 7. issue 21. 2008-01-22. PMID:17922512. |
many diseases of the mammalian cns, including parkinson's (pd) and lesch nyhan disease (lnd), are associated with programmatic neurodegeneration or dysfunction of dopaminergic neurons in the mesencephalon, the nigrostriatal pathway, and its projections in the striatum [1-4]. |
2008-01-22 |
2023-08-12 |
mouse |
| Maryka Quik, Heather Cox, Neeraja Parameswaran, Kathryn O'Leary, J William Langston, Donato Di Mont. Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys. Annals of neurology. vol 62. issue 6. 2008-01-22. PMID:17960553. |
however, the cholinergic system has received little attention despite an extensive overlap between dopaminergic terminals and cholinergic interneurons in the striatum and the well-known ability of nicotine to stimulate striatal dopamine release. |
2008-01-22 |
2023-08-12 |
monkey |
| Daniela V F Rosa, Renan P Souza, Bruno R Souza, Bernardo S Motta, Fernando Caetano, Luciano K Jornada, Gustavo Feier, Marcus V Gomez, João Quevedo, Marco A Romano-Silv. DARPP-32 expression in rat brain after electroconvulsive stimulation. Brain research. vol 1179. 2008-01-17. PMID:17919461. |
the aim of this work was to analyze the expression of darpp-32 (a protein with a central role in dopaminergic signaling) in striatum, cortex, hippocampus and cerebellum of wistar rats subjected to acute or chronic electroconvulsive stimulation (ecs). |
2008-01-17 |
2023-08-12 |
rat |