| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shyamal H Mehta, John C Morgan, Kapil D Seth. Neuroimaging and transcranial ultrasonography in Parkinson's disease. Current neurology and neuroscience reports. vol 8. issue 4. 2008-10-09. PMID:18590613. |
parkinson's disease is a progressive, widespread, neurodegenerative disease in which the involvement of the dopaminergic neurons of the substantia nigra results in significant dopamine depletion in the striatum. |
2008-10-09 |
2023-08-12 |
Not clear |
| Nobuhisa Ohtsuka, Morris F Tansky, Hui Kuang, Saïd Kourrich, Mark J Thomas, John L R Rubenstein, Marc Ekker, Susan E Leeman, Joe Z Tsie. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 35. 2008-10-06. PMID:18728179. |
to study the role of nmda receptors in dopamine signaling of the striatum, the brain area that receives glutamatergic inputs from various cortical areas and most dopaminergic inputs, we generated striatum-specific nmda receptor-deficient mice. |
2008-10-06 |
2023-08-12 |
mouse |
| M Fedi, S F Berkovic, I E Scheffer, G O'Keefe, C Marini, R Mulligan, S Gong, H Tochon-Danguy, D C Reuten. Reduced striatal D1 receptor binding in autosomal dominant nocturnal frontal lobe epilepsy. Neurology. vol 71. issue 11. 2008-10-03. PMID:18685138. |
as activation of presynaptic nicotinic receptors augments the release of dopamine in the striatum and the prefrontal regions, we tested the hypothesis that that the alpha4-ser248phe mutation affects dopaminergic transmission. |
2008-10-03 |
2023-08-12 |
Not clear |
| Yael Niv, Geoffrey Schoenbau. Dialogues on prediction errors. Trends in cognitive sciences. vol 12. issue 7. 2008-09-30. PMID:18567531. |
neural correlates of such prediction-error signals have been observed now in midbrain dopaminergic neurons, striatum, amygdala and even prefrontal cortex, and models incorporating prediction errors have been invoked to explain complex phenomena such as the transition from goal-directed to habitual behavior. |
2008-09-30 |
2023-08-12 |
Not clear |
| Nico J Diederich, Christopher G Goet. The placebo treatments in neurosciences: New insights from clinical and neuroimaging studies. Neurology. vol 71. issue 9. 2008-09-26. PMID:18725593. |
in pd, objective clinical improvements in parkinsonism correlate with dopaminergic activation of the striatum, documented by pet and with changes in cell firings of the subthalamic nucleus documented by single cell recordings. |
2008-09-26 |
2023-08-12 |
Not clear |
| Evan D Morris, Marc D Normandin, Wynne K Schiffe. Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data. Molecular imaging and biology. vol 10. issue 2. 2008-09-25. PMID:18176804. |
in this study, we apply our model-based method, "ntpet", to (11)c-raclopride pet scans of rats in which the dopaminergic response to a microinfusion of methamphetamine in one striatum was assayed simultaneously by microdialysis and pet. |
2008-09-25 |
2023-08-12 |
human |
| Gang Wang, Jing Pan, Yu-Yan Tan, Xiao-Kang Sun, Yong-Fang Zhang, Hai-Yan Zhou, Ru-Jing Ren, Xi-Jin Wang, Sheng-Di Che. Neuroprotective effects of PACAP27 in mice model of Parkinson's disease involved in the modulation of K(ATP) subunits and D2 receptors in the striatum. Neuropeptides. vol 42. issue 3. 2008-09-19. PMID:18440632. |
our findings suggest that the benefit of pacap may accompany with changes not only in dopaminergic neurotransmission, but also in cholinergic neurotransmission that are relatively associated with the k(atp) subunits and d2 receptors in the striatum. |
2008-09-19 |
2023-08-12 |
mouse |
| Clement A Gautier, Tohru Kitada, Jie She. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 32. 2008-09-16. PMID:18687901. |
functional assays showed impaired mitochondrial respiration in the striatum but not in the cerebral cortex at 3-4 months of age, suggesting specificity of this defect for dopaminergic circuitry. |
2008-09-16 |
2023-08-12 |
mouse |
| Monique Lavialle, Gaëlle Champeil-Potokar, Jean Marc Alessandri, Laure Balasse, Philippe Guesnet, Catherine Papillon, Paul Pévet, Sylvie Vancassel, Berthe Vivien-Roels, Isabelle Deni. An (n-3) polyunsaturated fatty acid-deficient diet disturbs daily locomotor activity, melatonin rhythm, and striatal dopamine in Syrian hamsters. The Journal of nutrition. vol 138. issue 9. 2008-09-16. PMID:18716175. |
to assess the possible relationship between voluntary wheel running activity and dopaminergic neurotransmission, we also measured endogenous monoamine concentrations in the striatum. |
2008-09-16 |
2023-08-12 |
Not clear |
| Lachlan H Thompson, Deniz Kirik, Anders Björklun. Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain. Experimental neurology. vol 213. issue 1. 2008-09-15. PMID:18602916. |
we report here that while dopaminergic outgrowth was predominately confined to the striatum, there was also a significant degree of non-dopaminergic outgrowth to extra-striatal structures including the thalamus, cortex and midbrain. |
2008-09-15 |
2023-08-12 |
mouse |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
the current transplantation paradigm for parkinson's disease that places foetal dopaminergic cells in the striatum neither normalizes neuronal activity in basal ganglia structures such as the substantia nigra (sn) and subthalamic nucleus (stn) nor leads to complete functional recovery. |
2008-09-15 |
2023-08-12 |
human |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
it was hypothesized that restoration of parkinsonian deficits requires inhibition of the pathological overactivity of the stn and sn in addition to restoration of dopaminergic activity in the striatum. |
2008-09-15 |
2023-08-12 |
human |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
in hemiparkinsonian rats, transplantation of foetal rat dopaminergic cells in the striatum in conjunction with gabaergic grafts in the stn and/or sn promoted significant improvement in forelimb akinesia and motor function compared to transplantation of intrastriatal dopaminergic grafts alone or in conjunction with undifferentiated hnpcs. |
2008-09-15 |
2023-08-12 |
human |
| K Mukhida, M Hong, G B Miles, T Phillips, B A Baghbaderani, M McLeod, N Kobayashi, A Sen, L A Behie, R M Brownstone, I Mende. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a journal of neurology. vol 131. issue Pt 8. 2008-09-15. PMID:18669492. |
thus, restoration of dopaminergic activity to the striatum in concert with inhibition of the stn and sn by gabaergic grafts may be beneficial for improving clinical outcomes in patients with parkinson's disease and potential clinical application of this strategy may be enhanced by the use of differentiated hnpcs. |
2008-09-15 |
2023-08-12 |
human |
| Sietske M Schotanus, Karima Chergu. NR2A-containing NMDA receptors depress glutamatergic synaptic transmission and evoked-dopamine release in the mouse striatum. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18540994. |
in this study, we have examined the involvement of nr2b and nr2a in the modulatory effect of nmda on glutamatergic and dopaminergic synaptic transmission in the striatum. |
2008-09-12 |
2023-08-12 |
mouse |
| Malcolm K Horne, Joohyung Lee, Feng Chen, Katherine Lanning, Doris Tomas, Andrew J Lawrenc. Long-term administration of cocaine or serotonin reuptake inhibitors results in anatomical and neurochemical changes in noradrenergic, dopaminergic, and serotonin pathways. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18624911. |
this study demonstrates that administering rats either cocaine or a selective serotonin (or 5-hydroxytryptamine; 5-ht) reuptake inhibitor (ssri) for 16 weeks results in reduced density of dopaminergic and noradrenergic terminals in the striatum and olfactory bulb, respectively, reflecting pruning of the terminal arbor of ventral midbrain dopaminergic and locus coeruleus noradrenergic neurones. |
2008-09-12 |
2023-08-12 |
rat |
| Paul F Smit. Inflammation in Parkinson's disease: an update. Current opinion in investigational drugs (London, England : 2000). vol 9. issue 5. 2008-09-05. PMID:18465657. |
the loss of the dopaminergic projection from the snpc deprives the striatum of dopamine and results in a myriad of motor signs, including tremor, rigidity and ataxia. |
2008-09-05 |
2023-08-12 |
Not clear |
| András Csillag, Eszter Bálint, Agota Adám, Gergely Zacha. The organisation of the basal ganglia in the domestic chick (Gallus domesticus): anatomical localisation of DARPP-32 in relation to glutamate. Brain research bulletin. vol 76. issue 3. 2008-09-04. PMID:18498930. |
coincidence between glutamatergic and dopaminergic synaptic activities in the ventral/medial striatum, including the ac, is required for memory to be formed for a given pairing of stimulus and a hedonic quality or behavioural salience. |
2008-09-04 |
2023-08-12 |
chicken |
| Feng Ding, Liming Luan, Yi Ai, Ashley Walton, Greg A Gerhardt, Don M Gash, Richard Grondin, Zhiming Zhan. Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkeys. Experimental neurology. vol 212. issue 2. 2008-09-02. PMID:18547564. |
compared with late-stage pd animals, postmortem analysis demonstrated that more dopaminergic neurons remained in the substantia nigra pars compacta, and more fibers were found in the striatum. |
2008-09-02 |
2023-08-12 |
monkey |
| Hong Jiang, Lin-Jing Li, Jun Wang, Jun-Xia Xi. Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Experimental neurology. vol 212. issue 2. 2008-09-02. PMID:18577498. |
we observed that ghrelin, acting through ghs-r 1a, inhibited mptp-induced dopaminergic neuronal loss in the snpc as well as dopamine depletion in the striatum. |
2008-09-02 |
2023-08-12 |
mouse |