| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Merja H Voutilainen, Susanne Bäck, Eeva Pörsti, Liisa Toppinen, Lauri Lindgren, Päivi Lindholm, Johan Peränen, Mart Saarma, Raimo K Tuomine. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641128. |
intrastriatally injected manf protected nigrostriatal dopaminergic nerves from 6-ohda-induced degeneration as evaluated by counting tyrosine hydroxylase (th)-positive cell bodies in the substantia nigra (sn) and th-positive fibers in the striatum. |
2009-08-19 |
2023-08-12 |
rat |
| Merja H Voutilainen, Susanne Bäck, Eeva Pörsti, Liisa Toppinen, Lauri Lindgren, Päivi Lindholm, Johan Peränen, Mart Saarma, Raimo K Tuomine. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641128. |
more importantly, manf also restored the function of the nigrostriatal dopaminergic system when administered either 6 h before or 4 weeks after 6-ohda administration in the striatum. |
2009-08-19 |
2023-08-12 |
rat |
| Shin-Ichi Muramatsu, Tsuyoshi Okuno, Yutaka Suzuki, Takashi Nakayama, Takeharu Kakiuchi, Naomi Takino, Asako Iida, Fumiko Ono, Keiji Terao, Nobuo Inoue, Imaharu Nakano, Yasushi Kondo, Hideo Tsukad. Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease. Synapse (New York, N.Y.). vol 63. issue 7. 2009-08-13. PMID:19253400. |
as the primary purpose of cell transplantation in pd is restoration of dopaminergic neurotransmission in the striatum, in vivo assessment of da function after grafting is necessary to achieve better therapeutic effects. |
2009-08-13 |
2023-08-12 |
monkey |
| Jason B Tatom, David B Wang, Robert D Dayton, Omar Skalli, Michael L Hutton, Dennis W Dickson, Ronald L Klei. Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 4. 2009-08-05. PMID:19223871. |
tdp-43 gene transfer caused loss of dopaminergic neurons in the sn and their axons in the striatum. |
2009-08-05 |
2023-08-12 |
human |
| Brandon K Harvey, Jenny Chou, Hui Shen, Barry J Hoffer, Yun Wan. Diadenosine tetraphosphate reduces toxicity caused by high-dose methamphetamine administration. Neurotoxicology. vol 30. issue 3. 2009-08-04. PMID:19442829. |
previous studies have shown that ap(4)a reduced neurodegeneration caused by the dopaminergic neurotoxin 6-hydroxydopamine in rat striatum and substantia nigra. |
2009-08-04 |
2023-08-12 |
rat |
| Xinhua Zhang, Zheng Zhou, Dakui Wang, Aiqun Li, Yanqing Yin, Xiaosong Gu, Fei Ding, Xuechu Zhen, Jiawei Zho. Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 24. 2009-07-17. PMID:19535588. |
moreover, intraperitoneal administration of skf83959 reversed l-methyl-4-phenyl-l,2,3,6-tetrahydropypridine (mptp)-induced reduction in fgf-2 expression in both the striatum and ventral midbrain and resulted in marked protection of dopaminergic neurons from mptp-induced neurotoxicity. |
2009-07-17 |
2023-08-12 |
Not clear |
| Ronald L Klein, Robert D Dayton, Tracee L Terry, Chris Vascoe, John J Sunderland, Kerrie H Tainte. PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models. Brain research. vol 1259. 2009-07-02. PMID:19368808. |
the amplitude of the loss of fmt uptake in striatum at 4 weeks with either model was subtle relative to the postmortem histological analysis of the tissue, but the multi-modal imaging analysis yielded statistical effects that matched well with the histology in terms of the timing of the loss of dopaminergic markers. |
2009-07-02 |
2023-08-12 |
rat |
| Mati Joshua, Avital Adler, Yifat Prut, Eilon Vaadia, Jeffery R Wickens, Hagai Bergma. Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events. Neuron. vol 62. issue 5. 2009-06-26. PMID:19524528. |
dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. |
2009-06-26 |
2023-08-12 |
monkey |
| Anna Nilsson, Maria Fälth, Xiaoqun Zhang, Kim Kultima, Karl Sköld, Per Svenningsson, Per E André. Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease. Molecular & cellular proteomics : MCP. vol 8. issue 5. 2009-06-24. PMID:19131325. |
the principal causative pathology of parkinson disease is the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta projecting to the striatum in the brain. |
2009-06-24 |
2023-08-12 |
mouse |
| Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, Yumi Suzuki, Satoshi Maesawa, Yasukazu Kajita, Masaaki Hirayama, Ikuroh Ohsawa, Shigeo Ohta, Kinji Ohn. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neuroscience letters. vol 453. issue 2. 2009-06-12. PMID:19356598. |
tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. |
2009-06-12 |
2023-08-12 |
human |
| Florence Sotty, Liliana P Montezinho, Björn Steiniger-Brach, Jacob Nielse. Phosphodiesterase 10A inhibition modulates the sensitivity of the mesolimbic dopaminergic system to D-amphetamine: involvement of the D1-regulated feedback control of midbrain dopamine neurons. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19236563. |
phosphodiesterase (pde) 10a is highly expressed in medium spiny neurons of the striatum, at the confluence of the corticostriatal glutamatergic and the midbrain dopaminergic pathways, both believed to be involved in the physiopathology of schizophrenia. |
2009-06-09 |
2023-08-12 |
Not clear |
| Nikolaus R McFarland, Jeng-Shin Lee, Bradley T Hyman, Pamela J McLea. Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19250335. |
newer raav serotypes 2/1, 2/5, and 2/8 demonstrated marked increase in transduction and spread of enhanced green fluorescent protein expression in dopaminergic nigrostriatal neurons and projections to the striatum and globus pallidus compared to raav2/2 at 2 weeks post-injection. |
2009-06-09 |
2023-08-12 |
rat |
| Sofía Sánchez-Iglesias, Estefanía Méndez-Alvarez, Javier Iglesias-González, Ana Muñoz-Patiño, Inés Sánchez-Sellero, José Luís Labandeira-García, Ramón Soto-Oter. Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potential effects in a 6-OHDA-induced model of Parkinson's disease. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19425176. |
the potential of aluminium to act as an etiological factor in parkinson's disease (pd) was assessed by studying its ability to increase oxidative stress in ventral midbrain and striatum and the striatal dopaminergic neurodegeneration induced by 6-hydroxydopamine in an experimental model of pd.the results showed that aluminium caused an increase in oxidative stress (tbars, protein carbonyl content, and protein thiol content) for most of the brain regions studied, which was accompanied by a decrease in the activity of some antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase). |
2009-06-09 |
2023-08-12 |
rat |
| J Molina-Vilaplana, J L Contreras-Vidal, M T Herrero-Ezquerro, J Lopez-Coronad. A model for altered neural network dynamics related to prehension movements in Parkinson disease. Biological cybernetics. vol 100. issue 4. 2009-06-05. PMID:19229555. |
these striatal cells, under a strong influence of the dopaminergic system, significantly contribute to the neural processing within the striatum and in the cortico-basal ganglia loops. |
2009-06-05 |
2023-08-12 |
Not clear |
| Takeshi Tsuji, Masato Asanuma, Ikuko Miyazaki, Ko Miyoshi, Norio Ogaw. Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. Neurochemical research. vol 34. issue 4. 2009-06-03. PMID:18946735. |
we examined changes in nuclear peroxisome proliferator-activated receptor gamma (ppar gamma) in the striatum in methamphetamine (meth)-induced dopaminergic neurotoxicity, and also examined effects of treatment with drugs possessing ppar gamma agonistic properties. |
2009-06-03 |
2023-08-12 |
Not clear |
| Valerie B Thompson, Justin Heiman, James B Chambers, Stephen C Benoit, William R Buesing, Mantana K Norman, Andrew B Norman, Jack W Lipto. Long-term behavioral consequences of prenatal MDMA exposure. Physiology & behavior. vol 96. issue 4-5. 2009-05-26. PMID:19162054. |
prenatal mdma exposure results in increased dopaminergic fiber density in the prefrontal cortex, striatum and nucleus accumbens of young rats. |
2009-05-26 |
2023-08-12 |
rat |
| Dara M Cannon, Jacqueline M Klaver, Summer A Peck, Denise Rallis-Voak, Kristine Erickson, Wayne C Drevet. Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 5. 2009-05-07. PMID:18946469. |
finally, d(1) receptor binding was asymmetrical across hemispheres in healthy humans, compatible with evidence that dopaminergic function in the striatum is lateralized during reward processing, voluntary movement, and self-stimulation behavior. |
2009-05-07 |
2023-08-12 |
human |
| Margaret A Cooper, Kazuto Kobayashi, Renping Zho. Ephrin-A5 regulates the formation of the ascending midbrain dopaminergic pathways. Developmental neurobiology. vol 69. issue 1. 2009-04-15. PMID:19003794. |
ephrin-a5 was found in both the dorsolateral and the ventromedial regions of the striatum, suggesting a role in mediating dopaminergic axon-target interactions. |
2009-04-15 |
2023-08-12 |
mouse |
| Margaret A Cooper, Kazuto Kobayashi, Renping Zho. Ephrin-A5 regulates the formation of the ascending midbrain dopaminergic pathways. Developmental neurobiology. vol 69. issue 1. 2009-04-15. PMID:19003794. |
these observations indicate that the interactions between ephrin-a ligands and epha receptors promote growth and targeting of the midbrain dopaminergic axons to the striatum. |
2009-04-15 |
2023-08-12 |
mouse |
| E Lorenc-Koci, L Antkiewicz-Michaluk, A Kamińska, T Lenda, B Zieba, J Wierońska, M Smiałowska, G Schulze, H Rommelspache. The influence of acute and chronic administration of 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline on the function of the nigrostriatal dopaminergic system in rats. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18809471. |
the contribution of (r)-enantiomer of n-methyl-salsolinol (1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; nmsal) to the degeneration of dopaminergic neurons in the course of parkinson's disease (pd) has been predominantly suggested by in vitro experiments in cell culture and by an in vivo study in which this compound has been directly injected into the rat striatum. |
2009-04-14 |
2023-08-12 |
rat |