| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, Yumi Suzuki, Satoshi Maesawa, Yasukazu Kajita, Masaaki Hirayama, Ikuroh Ohsawa, Shigeo Ohta, Kinji Ohn. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neuroscience letters. vol 453. issue 2. 2009-06-12. PMID:19356598. |
tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. |
2009-06-12 |
2023-08-12 |
human |
| Florence Sotty, Liliana P Montezinho, Björn Steiniger-Brach, Jacob Nielse. Phosphodiesterase 10A inhibition modulates the sensitivity of the mesolimbic dopaminergic system to D-amphetamine: involvement of the D1-regulated feedback control of midbrain dopamine neurons. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19236563. |
phosphodiesterase (pde) 10a is highly expressed in medium spiny neurons of the striatum, at the confluence of the corticostriatal glutamatergic and the midbrain dopaminergic pathways, both believed to be involved in the physiopathology of schizophrenia. |
2009-06-09 |
2023-08-12 |
Not clear |
| Nikolaus R McFarland, Jeng-Shin Lee, Bradley T Hyman, Pamela J McLea. Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19250335. |
newer raav serotypes 2/1, 2/5, and 2/8 demonstrated marked increase in transduction and spread of enhanced green fluorescent protein expression in dopaminergic nigrostriatal neurons and projections to the striatum and globus pallidus compared to raav2/2 at 2 weeks post-injection. |
2009-06-09 |
2023-08-12 |
rat |
| Sofía Sánchez-Iglesias, Estefanía Méndez-Alvarez, Javier Iglesias-González, Ana Muñoz-Patiño, Inés Sánchez-Sellero, José Luís Labandeira-García, Ramón Soto-Oter. Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potential effects in a 6-OHDA-induced model of Parkinson's disease. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19425176. |
the potential of aluminium to act as an etiological factor in parkinson's disease (pd) was assessed by studying its ability to increase oxidative stress in ventral midbrain and striatum and the striatal dopaminergic neurodegeneration induced by 6-hydroxydopamine in an experimental model of pd.the results showed that aluminium caused an increase in oxidative stress (tbars, protein carbonyl content, and protein thiol content) for most of the brain regions studied, which was accompanied by a decrease in the activity of some antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase). |
2009-06-09 |
2023-08-12 |
rat |
| J Molina-Vilaplana, J L Contreras-Vidal, M T Herrero-Ezquerro, J Lopez-Coronad. A model for altered neural network dynamics related to prehension movements in Parkinson disease. Biological cybernetics. vol 100. issue 4. 2009-06-05. PMID:19229555. |
these striatal cells, under a strong influence of the dopaminergic system, significantly contribute to the neural processing within the striatum and in the cortico-basal ganglia loops. |
2009-06-05 |
2023-08-12 |
Not clear |
| Takeshi Tsuji, Masato Asanuma, Ikuko Miyazaki, Ko Miyoshi, Norio Ogaw. Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. Neurochemical research. vol 34. issue 4. 2009-06-03. PMID:18946735. |
we examined changes in nuclear peroxisome proliferator-activated receptor gamma (ppar gamma) in the striatum in methamphetamine (meth)-induced dopaminergic neurotoxicity, and also examined effects of treatment with drugs possessing ppar gamma agonistic properties. |
2009-06-03 |
2023-08-12 |
Not clear |
| Valerie B Thompson, Justin Heiman, James B Chambers, Stephen C Benoit, William R Buesing, Mantana K Norman, Andrew B Norman, Jack W Lipto. Long-term behavioral consequences of prenatal MDMA exposure. Physiology & behavior. vol 96. issue 4-5. 2009-05-26. PMID:19162054. |
prenatal mdma exposure results in increased dopaminergic fiber density in the prefrontal cortex, striatum and nucleus accumbens of young rats. |
2009-05-26 |
2023-08-12 |
rat |
| Dara M Cannon, Jacqueline M Klaver, Summer A Peck, Denise Rallis-Voak, Kristine Erickson, Wayne C Drevet. Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 5. 2009-05-07. PMID:18946469. |
finally, d(1) receptor binding was asymmetrical across hemispheres in healthy humans, compatible with evidence that dopaminergic function in the striatum is lateralized during reward processing, voluntary movement, and self-stimulation behavior. |
2009-05-07 |
2023-08-12 |
human |
| Margaret A Cooper, Kazuto Kobayashi, Renping Zho. Ephrin-A5 regulates the formation of the ascending midbrain dopaminergic pathways. Developmental neurobiology. vol 69. issue 1. 2009-04-15. PMID:19003794. |
ephrin-a5 was found in both the dorsolateral and the ventromedial regions of the striatum, suggesting a role in mediating dopaminergic axon-target interactions. |
2009-04-15 |
2023-08-12 |
mouse |
| Margaret A Cooper, Kazuto Kobayashi, Renping Zho. Ephrin-A5 regulates the formation of the ascending midbrain dopaminergic pathways. Developmental neurobiology. vol 69. issue 1. 2009-04-15. PMID:19003794. |
these observations indicate that the interactions between ephrin-a ligands and epha receptors promote growth and targeting of the midbrain dopaminergic axons to the striatum. |
2009-04-15 |
2023-08-12 |
mouse |
| E Lorenc-Koci, L Antkiewicz-Michaluk, A Kamińska, T Lenda, B Zieba, J Wierońska, M Smiałowska, G Schulze, H Rommelspache. The influence of acute and chronic administration of 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline on the function of the nigrostriatal dopaminergic system in rats. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18809471. |
the contribution of (r)-enantiomer of n-methyl-salsolinol (1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; nmsal) to the degeneration of dopaminergic neurons in the course of parkinson's disease (pd) has been predominantly suggested by in vitro experiments in cell culture and by an in vivo study in which this compound has been directly injected into the rat striatum. |
2009-04-14 |
2023-08-12 |
rat |
| M T Tadaiesky, P A Dombrowski, C P Figueiredo, E Cargnin-Ferreira, C Da Cunha, R N Takahash. Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18817851. |
bilateral infusion of 6-ohda in the striatum of rats caused early (1 week) damage of dopaminergic terminals in striatum and in cell bodies in substantia nigra pars compacta. |
2009-04-14 |
2023-08-12 |
rat |
| M T Tadaiesky, P A Dombrowski, C P Figueiredo, E Cargnin-Ferreira, C Da Cunha, R N Takahash. Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18817851. |
these findings suggest that partial striatal dopaminergic degeneration and parallel dopaminergic, noradrenergic and serotonergic alterations in striatum and prefrontal cortex may have caused the emotional and cognitive deficits observed in this rat model of early phase pd. |
2009-04-14 |
2023-08-12 |
rat |
| Salma Bukhatwa, Mahmoud M Iravani, Bai-Yun Zeng, Jonathan D Cooper, Sarah Rose, Peter Jenne. An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat. Journal of neurochemistry. vol 109. issue 1. 2009-04-13. PMID:19187437. |
to provide a method of marking sn neurones independent of protein expression, fluorogold (fg) was stereotaxically injected bilaterally into the striatum of male wistar rats to retrogradely label nigral dopaminergic neurons. |
2009-04-13 |
2023-08-12 |
rat |
| Ana Saavedra, Graça Baltazar, Emília P Duart. Driving GDNF expression: the green and the red traffic lights. Progress in neurobiology. vol 86. issue 3. 2009-04-09. PMID:18824211. |
in animal models of pd, gdnf delivery to the striatum or the substantia nigra protects dopaminergic neurons against subsequent toxin-induced injury and rescues previously damaged neurons, promoting recovery of the motor function. |
2009-04-09 |
2023-08-12 |
Not clear |
| Hironori Yokoyama, Hayato Kuroiwa, Ryohei Yano, Tsutomu Arak. Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 29. issue 5. 2009-04-09. PMID:18941931. |
the primary pathology of pd is degeneration of dopaminergic neurons in the substantia nigra pars compacta, resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum. |
2009-04-09 |
2023-08-12 |
Not clear |
| Shen-Yang Lim, Michael J Farrell, Stephen J Gibson, Robert D Helme, Anthony E Lang, Andrew H Evan. Do dyskinesia and pain share common pathophysiological mechanisms in Parkinson's disease? Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 12. 2009-04-08. PMID:18709675. |
plastic changes within the striatum resulting from pulsatile dopaminergic stimulation are thought to lead to dyskinesia in patients with parkinson's disease (pd). |
2009-04-08 |
2023-08-12 |
human |
| Rosa M Villalba, Heyne Lee, Yoland Smit. Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeys. Experimental neurology. vol 215. issue 2. 2009-04-08. PMID:18977221. |
dopaminergic denervation and spine loss in the striatum of mptp-treated monkeys. |
2009-04-08 |
2023-08-12 |
human |
| Seema Gulyani, Christopher J Earley, Simonetta Camandola, Stuart Maudsley, Sergi Ferré, Mohamed R Mughal, Bronwen Martin, Aiwu Cheng, Marc Gleichmann, Byron C Jones, Richard P Allen, Mark P Mattso. Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Experimental neurology. vol 215. issue 2. 2009-04-08. PMID:19013457. |
in light of the unknown mechanism for the iron deficiency-dopamine connection and because of the known interplay between adenosinergic and dopaminergic systems in the striatum we examined the effects of iron deficiency on the adenosine system. |
2009-04-08 |
2023-08-12 |
mouse |
| Matthew J Chiocco, Brandon K Harvey, Yun Wang, Barry J Hoffe. Neurotrophic factors for the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267258. |
pathologically, there is a loss of the dopaminergic neurons in the substantia nigra that project to the striatum. |
2009-04-01 |
2023-08-12 |
Not clear |