| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Darvas, Richard D Palmite. Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 34. 2009-09-28. PMID:19667174. |
therefore, dopaminergic signaling in the dorsolateral striatum is sufficient for mice to learn several different cognitive tasks although the rate of learning some of them was reduced. |
2009-09-28 |
2023-08-12 |
mouse |
| Martin Darvas, Richard D Palmite. Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 34. 2009-09-28. PMID:19667174. |
these results indicate that dopaminergic signaling in the ventromedial striatum is not absolutely necessary for mastery of these behaviors, but may facilitate them. |
2009-09-28 |
2023-08-12 |
mouse |
| Fang Zheng, Matthew J McConnell, Chang-Guo Zhan, Linda P Dwoskin, Peter A Crook. QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorganic & medicinal chemistry. vol 17. issue 13. 2009-09-09. PMID:19477134. |
qsar study on maximal inhibition (imax) of quaternary ammonium antagonists for s-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. |
2009-09-09 |
2023-08-12 |
rat |
| Ricarda A Menke, Jan Scholz, Karla L Miller, Sean Deoni, Saad Jbabdi, Paul M Matthews, Mojtaba Zare. MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. NeuroImage. vol 47. issue 2. 2009-09-03. PMID:19447183. |
the substantia nigra contains dopaminergic cells that project to the striatum and are affected by the neurodegenerative process that appears in parkinson's disease (pd). |
2009-09-03 |
2023-08-12 |
human |
| Margarida Castro-Caldas, Andreia Neves Carvalho, Isabel Peixeiro, Elsa Rodrigues, Maria Celeste Lechner, Maria João Gam. GSTpi expression in MPTP-induced dopaminergic neurodegeneration of C57BL/6 mouse midbrain and striatum. Journal of molecular neuroscience : MN. vol 38. issue 2. 2009-08-31. PMID:18792812. |
gstpi expression in mptp-induced dopaminergic neurodegeneration of c57bl/6 mouse midbrain and striatum. |
2009-08-31 |
2023-08-12 |
mouse |
| V P Zykov, A Yu Shcherbina, E B Novikova, T V Shvabrin. Neuroimmune aspects of the pathogenesis of Tourette's syndrome and experience in the use of immunoglobulins in children. Neuroscience and behavioral physiology. vol 39. issue 7. 2009-08-31. PMID:19621268. |
the observation of antibodies to caudate nucleus proteins and the positive effects seen on administration of immunoglobulins to patients with tourette's syndrome support previous data on the possibility of using immunoglobulin therapy in the treatment of tic-type hyperkinesias and provide evidence of the involvement of autoimmune mechanisms inducing damage to the dopaminergic system of the striatum. |
2009-08-31 |
2023-08-12 |
Not clear |
| Nicola Pavese, David J Brook. Imaging neurodegeneration in Parkinson's disease. Biochimica et biophysica acta. vol 1792. issue 7. 2009-08-25. PMID:18992326. |
functional imaging approaches such as positron emission tomography (pet) and single photon emission computerised tomography (spect) have been successfully employed to detect dopaminergic dysfunction in pd, even while at a preclinical stage, and to demonstrate the effects of therapies on function of intact dopaminergic neurons within the affected striatum. |
2009-08-25 |
2023-08-12 |
Not clear |
| Ruwani Wijeyekoon, Roger A Barke. Cell replacement therapy for Parkinson's disease. Biochimica et biophysica acta. vol 1792. issue 7. 2009-08-25. PMID:19007882. |
parkinson's disease (pd) is a progressive neurodegenerative disorder in which the degeneration of dopaminergic neurons projecting from the substantia nigra to the striatum is a key pathological feature of the disease. |
2009-08-25 |
2023-08-12 |
Not clear |
| Robert M Kessler, Neil D Woodward, Patrizia Riccardi, Rui Li, M Sib Ansari, Sharlett Anderson, Benoit Dawant, David Zald, Herbert Y Meltze. Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects. Biological psychiatry. vol 65. issue 12. 2009-08-20. PMID:19251247. |
studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments. |
2009-08-20 |
2023-08-12 |
human |
| P M Pitychoutis, K Nakamura, P A Tsonis, Z Papadopoulou-Daifot. Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed. Neuroscience. vol 159. issue 4. 2009-08-20. PMID:19409213. |
therefore, we investigated the serotonergic and dopaminergic activity of various brain regions implicated in the pathophysiology of affective disorders (hypothalamus, hippocampus, prefrontal cortex, amygdala and striatum) in response to a mild lipopolysaccharide (lps) challenge, in rats of both sexes. |
2009-08-20 |
2023-08-12 |
rat |
| P M Pitychoutis, K Nakamura, P A Tsonis, Z Papadopoulou-Daifot. Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed. Neuroscience. vol 159. issue 4. 2009-08-20. PMID:19409213. |
dopaminergic activation following immune system sensitization with lps was not apparent in male rats and only modest in female rats with the exception of striatum. |
2009-08-20 |
2023-08-12 |
rat |
| Merja H Voutilainen, Susanne Bäck, Eeva Pörsti, Liisa Toppinen, Lauri Lindgren, Päivi Lindholm, Johan Peränen, Mart Saarma, Raimo K Tuomine. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641128. |
intrastriatally injected manf protected nigrostriatal dopaminergic nerves from 6-ohda-induced degeneration as evaluated by counting tyrosine hydroxylase (th)-positive cell bodies in the substantia nigra (sn) and th-positive fibers in the striatum. |
2009-08-19 |
2023-08-12 |
rat |
| Merja H Voutilainen, Susanne Bäck, Eeva Pörsti, Liisa Toppinen, Lauri Lindgren, Päivi Lindholm, Johan Peränen, Mart Saarma, Raimo K Tuomine. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641128. |
more importantly, manf also restored the function of the nigrostriatal dopaminergic system when administered either 6 h before or 4 weeks after 6-ohda administration in the striatum. |
2009-08-19 |
2023-08-12 |
rat |
| Shin-Ichi Muramatsu, Tsuyoshi Okuno, Yutaka Suzuki, Takashi Nakayama, Takeharu Kakiuchi, Naomi Takino, Asako Iida, Fumiko Ono, Keiji Terao, Nobuo Inoue, Imaharu Nakano, Yasushi Kondo, Hideo Tsukad. Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease. Synapse (New York, N.Y.). vol 63. issue 7. 2009-08-13. PMID:19253400. |
as the primary purpose of cell transplantation in pd is restoration of dopaminergic neurotransmission in the striatum, in vivo assessment of da function after grafting is necessary to achieve better therapeutic effects. |
2009-08-13 |
2023-08-12 |
monkey |
| Jason B Tatom, David B Wang, Robert D Dayton, Omar Skalli, Michael L Hutton, Dennis W Dickson, Ronald L Klei. Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 4. 2009-08-05. PMID:19223871. |
tdp-43 gene transfer caused loss of dopaminergic neurons in the sn and their axons in the striatum. |
2009-08-05 |
2023-08-12 |
human |
| Brandon K Harvey, Jenny Chou, Hui Shen, Barry J Hoffer, Yun Wan. Diadenosine tetraphosphate reduces toxicity caused by high-dose methamphetamine administration. Neurotoxicology. vol 30. issue 3. 2009-08-04. PMID:19442829. |
previous studies have shown that ap(4)a reduced neurodegeneration caused by the dopaminergic neurotoxin 6-hydroxydopamine in rat striatum and substantia nigra. |
2009-08-04 |
2023-08-12 |
rat |
| Xinhua Zhang, Zheng Zhou, Dakui Wang, Aiqun Li, Yanqing Yin, Xiaosong Gu, Fei Ding, Xuechu Zhen, Jiawei Zho. Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 24. 2009-07-17. PMID:19535588. |
moreover, intraperitoneal administration of skf83959 reversed l-methyl-4-phenyl-l,2,3,6-tetrahydropypridine (mptp)-induced reduction in fgf-2 expression in both the striatum and ventral midbrain and resulted in marked protection of dopaminergic neurons from mptp-induced neurotoxicity. |
2009-07-17 |
2023-08-12 |
Not clear |
| Ronald L Klein, Robert D Dayton, Tracee L Terry, Chris Vascoe, John J Sunderland, Kerrie H Tainte. PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models. Brain research. vol 1259. 2009-07-02. PMID:19368808. |
the amplitude of the loss of fmt uptake in striatum at 4 weeks with either model was subtle relative to the postmortem histological analysis of the tissue, but the multi-modal imaging analysis yielded statistical effects that matched well with the histology in terms of the timing of the loss of dopaminergic markers. |
2009-07-02 |
2023-08-12 |
rat |
| Mati Joshua, Avital Adler, Yifat Prut, Eilon Vaadia, Jeffery R Wickens, Hagai Bergma. Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events. Neuron. vol 62. issue 5. 2009-06-26. PMID:19524528. |
dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. |
2009-06-26 |
2023-08-12 |
monkey |
| Anna Nilsson, Maria Fälth, Xiaoqun Zhang, Kim Kultima, Karl Sköld, Per Svenningsson, Per E André. Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease. Molecular & cellular proteomics : MCP. vol 8. issue 5. 2009-06-24. PMID:19131325. |
the principal causative pathology of parkinson disease is the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta projecting to the striatum in the brain. |
2009-06-24 |
2023-08-12 |
mouse |