| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel Cyr, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 14. 2007-01-01. PMID:17065224. |
however, the mutant huntingtin protein aggregated much earlier and to a greater extent in the striatum and other dopaminergic brain regions in the hyperdopaminergic mouse model of hd. |
2007-01-01 |
2023-08-12 |
mouse |
| Maria Lindskog, MyungSook Kim, Martin A Wikström, Kim T Blackwell, Jeanette Hellgren Kotalesk. Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation. PLoS computational biology. vol 2. issue 9. 2006-12-22. PMID:16965177. |
reinforcement learning theorizes that strengthening of synaptic connections in medium spiny neurons of the striatum occurs when glutamatergic input (from cortex) and dopaminergic input (from substantia nigra) are received simultaneously. |
2006-12-22 |
2023-08-12 |
Not clear |
| Leonid Yavich, Pekka Jäkälä, Heikki Tanil. Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16824047. |
the effects are essentially the same as previously reported for dopaminergic terminals in the striatum, indicating that the important role of alpha-synuclein in neurotransmitter mobilization is not limited to dopaminergic terminals. |
2006-12-20 |
2023-08-12 |
mouse |
| Jörn Schmaljohann, Daniela Gündisch, Martina Minnerop, Jan Bucerius, Alexius Joe, Michael Reinhardt, Stefan Guhlke, Hans-Jürgen Biersack, Ullrich Wüllne. In vitro evaluation of nicotinic acetylcholine receptors with 2-[18F]F-A85380 in Parkinson's disease. Nuclear medicine and biology. vol 33. issue 3. 2006-12-18. PMID:16631078. |
2-[18f]f-a85380 binding was significantly reduced in the striatum ipsilateral to the lesion side (to 64% of the contralateral side), indicating that a fraction of alpha4beta2 nachrs is located on dopaminergic terminals, whereas another fraction resides on striatal interneurons or cortical afferents. |
2006-12-18 |
2023-08-12 |
human |
| Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Shigeo Nakamura, Soichi Itoh, Akemichi Baba, Toshio Matsud. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. European journal of pharmacology. vol 542. issue 1-3. 2006-12-14. PMID:16784740. |
protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. |
2006-12-14 |
2023-08-12 |
mouse |
| Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Shigeo Nakamura, Soichi Itoh, Akemichi Baba, Toshio Matsud. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. European journal of pharmacology. vol 542. issue 1-3. 2006-12-14. PMID:16784740. |
methamphetamine treatment (4 mg/kg, s.c. x 4 with 2 h intervals) showed striatal dopaminergic degeneration as observed by decreases in dopamine levels and tyrosine hydroxylase immunoreactivity in the striatum. |
2006-12-14 |
2023-08-12 |
mouse |
| Catarina A R V Gomes, Sandra H Vaz, Joaquim A Ribeiro, Ana M Sebastiã. Glial cell line-derived neurotrophic factor (GDNF) enhances dopamine release from striatal nerve endings in an adenosine A2A receptor-dependent manner. Brain research. vol 1113. issue 1. 2006-12-13. PMID:16935271. |
both glial cell line-derived neurotrophic factor (gdnf) and adenosine influence dopaminergic function in the striatum. |
2006-12-13 |
2023-08-12 |
rat |
| Bernardette T Saunier-Rébori, Jorge H Paz. Inhibition of jaw opening reflex and single neurons in the trigeminal subnucleus caudalis by activation of striatal D2 dopamine receptors. Neuropharmacology. vol 51. issue 2. 2006-12-04. PMID:16697016. |
the influence of striatal dopaminergic receptors on the inhibitory action of the striatum on the jaw opening reflex (jor) was studied in anesthetized rats. |
2006-12-04 |
2023-08-12 |
rat |
| Jordi Camarasa, David Pubill, Elena Escubed. Association of caffeine to MDMA does not increase antinociception but potentiates adverse effects of this recreational drug. Brain research. vol 1111. issue 1. 2006-11-24. PMID:16889759. |
this mdma toxicity in rats was accompanied by a transient dopaminergic impairment in the striatum, measured as decreased [(3)h]win35428 binding sites, by 31% 3 days after treatment, which was not modified by caffeine. |
2006-11-24 |
2023-08-12 |
rat |
| Suhail Kasim, Bonita L Blake, Xueliang Fan, Elena Chartoff, Kiyoshi Egami, George R Breese, Ellen J Hess, H A Jinna. The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents. Developmental neuroscience. vol 28. issue 6. 2006-11-24. PMID:17028428. |
prior studies have linked both of these behaviors to dysfunction of dopaminergic transmission in the striatum. |
2006-11-24 |
2023-08-12 |
mouse |
| Sanjay Jain, Judith P Golden, David Wozniak, Elizabeth Pehek, Eugene M Johnson, Jeffrey Milbrand. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 43. 2006-11-24. PMID:17065462. |
a detailed morphometric and biochemical analysis including dopaminergic neuron number and size in snc and vta, and fiber density in the striatum and nucleus accumbens, and dopamine levels indicate that ret is not required for providing global trophic support to midbrain dopaminergic neurons in adult mice. |
2006-11-24 |
2023-08-12 |
mouse |
| Ting-Ting Sun, Ian A Paul, Ing K H. Motor functions but not learning and memory are impaired upon repeated exposure to sub-lethal doses of methyl parathion. Journal of biomedical science. vol 13. issue 4. 2006-10-24. PMID:16645783. |
the motor dysfunctions in mp-treated rats may be mediated via reciprocal balance between cholinergic and dopaminergic systems at striatum following cholinergic over-stimulation. |
2006-10-24 |
2023-08-12 |
rat |
| M Parent, A Paren. Relationship between axonal collateralization and neuronal degeneration in basal ganglia. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017513. |
our results stemmed from single-cell labeling experiments in rodents and primates, immunohistochemical study of the dopaminergic nigrostriatal pathway in parkinsonian monkeys, and immunocytological analysis of the human striatum in normal individuals and in patients with huntington's disease. |
2006-10-24 |
2023-08-12 |
human |
| R M Kostrzewa, J P Kostrzewa, R Brus, R A Kostrzewa, P Nowa. Proposed animal model of severe Parkinson's disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017542. |
proposed animal model of severe parkinson's disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum. |
2006-10-24 |
2023-08-12 |
rat |
| R M Kostrzewa, J P Kostrzewa, R Brus, R A Kostrzewa, P Nowa. Proposed animal model of severe Parkinson's disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017542. |
rats lesioned shortly after birth with 6-hydroxydopamine are posed as a near-ideal model of severe parkinson's disease, because of the non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, near-total dopamine (da)-denervation of striatum, reproducibility of effect, and relative absence of overt behavioral effects--there is no aphasia, no adipsia, and no change in motor activity. |
2006-10-24 |
2023-08-12 |
rat |
| Bin Li. Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease. The AAPS journal. vol 8. issue 3. 2006-10-24. PMID:17025278. |
parkinson's disease (pd) is a debilitating movement disorder resulting from a progressive degeneration of the nigrostriatal dopaminergic pathway and depletion of neurotransmitter dopamine in the striatum. |
2006-10-24 |
2023-08-12 |
Not clear |
| Christian Pifl, Oleh Hornykiewic. Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys. Neurochemistry international. vol 49. issue 5. 2006-10-18. PMID:16698121. |
in parkinson's disease (pd) and experimental parkinsonism, losses of up to 60% and 80%, respectively, of dopaminergic neurons in substantia nigra, and dopamine (da) in striatum remain asymptomatic. |
2006-10-18 |
2023-08-12 |
monkey |
| O von Bohlen Und Halbac. Modeling neurodegenerative diseases in vivo review. Neuro-degenerative diseases. vol 2. issue 6. 2006-10-04. PMID:16909014. |
on the morphological and anatomical level, pd is characterized by massive degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to a severe loss of striatal dopaminergic fibers and to a massive reduction of dopamine levels in the striatum. |
2006-10-04 |
2023-08-12 |
monkey |
| Mathias Pessiglione, Ben Seymour, Guillaume Flandin, Raymond J Dolan, Chris D Frit. Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature. vol 442. issue 7106. 2006-10-02. PMID:16929307. |
here we show that, during instrumental learning, the magnitude of reward prediction error expressed in the striatum is modulated by the administration of drugs enhancing (3,4-dihydroxy-l-phenylalanine; l-dopa) or reducing (haloperidol) dopaminergic function. |
2006-10-02 |
2023-08-12 |
human |
| W Michael Caudle, Jason R Richardson, Kristin C Delea, Thomas S Guillot, Minzheng Wang, Kurt D Pennell, Gary W Mille. Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 92. issue 2. 2006-09-29. PMID:16702228. |
the observed reductions appear to be specific to the dat populations located in the striatum, as no change was observed in other dopaminergic brain regions or to other neurotransmitter transporters present in the striatum. |
2006-09-29 |
2023-08-12 |
human |