| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Rao, A Deister, A Rot. Lymphocytes of healthy subjects and schizophrenic patients possess no high-affinity binding sites for spiroperidol. Pharmacopsychiatry. vol 23. issue 4. 1990-09-11. PMID:2381986. |
we investigated 3h- and 125i-spiroperidol binding to lymphocytes from healthy subjects and schizophrenic patients and compared it with that to a porcine striatum dopaminergic d2-receptor preparation using identical conditions. |
1990-09-11 |
2023-08-11 |
human |
| J J Fernández-Ruiz, R de Miguel, M L Hernández, J A Ramo. Time-course of the effects of ovarian steroids on the activity of limbic and striatal dopaminergic neurons in female rat brain. Pharmacology, biochemistry, and behavior. vol 36. issue 3. 1990-09-05. PMID:2377660. |
this paper studies the time-course of the effects of pharmacological administrations of ovarian steroids on the functional state of dopaminergic terminals in the striatum and the limbic forebrain, using the ratio between the contents of dopamine (da) and its metabolite, l-3,4 dihydroxyphenylacetic acid (dopac), as an index of nerve activity. |
1990-09-05 |
2023-08-11 |
rat |
| A D Smith, J P Bola. The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones. Trends in neurosciences. vol 13. issue 7. 1990-08-23. PMID:1695400. |
in this way, dopaminergic afferents can directly modulate the flow of information from cortical areas through the striatum to the 'premotor' areas of the brainstem and to the thalamus. |
1990-08-23 |
2023-08-11 |
Not clear |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
after physical (knife-cut) or chemically-mediated (tetrodotoxin 300 nm, 1.5 microliters; 1.0 microliters min-1) interruption of nerve conduction in the nigrostriatal tract, there was a marked increase in the synthesis and metabolism of dopamine in the isolated dopaminergic nerve terminals of the striatum. |
1990-08-08 |
2023-08-11 |
rat |
| J W Commissiong, C Slimovitch, G Toffan. Regulation of the synthesis and metabolism of striatal dopamine after disruption of nerve conduction in the medial forebrain bundle. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361171. |
(b) after degeneration of the striatal dopaminergic nerves, the denervated striatum retains the ability to synthesize (from l-dopa) and metabolize dopamine, to the same degree as the intact, innervated, contralateral striatum. |
1990-08-08 |
2023-08-11 |
rat |
| A S Undie, E Friedma. Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:1972756. |
on examining the effect of skf38393 in several brain regions, the highest dopaminergic stimulation of inositol phosphates formation was obtained in the amygdala, followed by the hippocampus and then the striatum and frontal cortex. |
1990-07-31 |
2023-08-11 |
rat |
| E C Hirsch, C Duyckaerts, F Javoy-Agid, J J Hauw, Y Agi. Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease? Annals of neurology. vol 27. issue 6. 1990-07-31. PMID:2360804. |
it suggests, however, that adrenal medulla grafts may stimulate the sprouting of striatal dopaminergic fibers in a limited zone of the grafted striatum. |
1990-07-31 |
2023-08-11 |
human |
| M Valchár, J J Bonnet, J Costenti. Chronic modification of dopaminergic transmission and its effects on binding characteristics of dopamine transporter ligand 3H-GBR 12783 in the striatum. Activitas nervosa superior. vol 31. issue 4. 1990-07-24. PMID:2561622. |
chronic modification of dopaminergic transmission and its effects on binding characteristics of dopamine transporter ligand 3h-gbr 12783 in the striatum. |
1990-07-24 |
2023-08-11 |
Not clear |
| J F Marshall, A J Rosenstei. Age-related decline in rat striatal dopamine metabolism is regionally homogeneous. Neurobiology of aging. vol 11. issue 2. 1990-07-11. PMID:2348901. |
however, for none of these measures was the age x region interaction significant, suggesting that the decline in these markers of presynaptic dopaminergic function occurs uniformly throughout the striatum. |
1990-07-11 |
2023-08-11 |
rat |
| S E Lindley, K J Lookingland, K E Moor. Activation of tuberoinfundibular but not tuberohypophysial dopaminergic neurons following intracerebroventricular administration of alpha-melanocyte-stimulating hormone. Neuroendocrinology. vol 51. issue 4. 1990-07-05. PMID:2161087. |
the effect of alpha-melanocyte-stimulating hormone (alpha msh) on the activity of different central dopaminergic neurons in the male rat was determined by measuring the concentration of 3,4-dihydroxyphenylacetic acid (dopac) and the accumulation of 3,4-dihydroxyphenylalanine (dopa) following the administration of a decarboxylase inhibitor in brain regions that contain terminals of nigrostriatal (striatum), mesolimbic (nucleus accumbens), tuberoinfundibular (median eminence) and tuberohypophysial (neural and intermediate lobe of the pituitary) dopaminergic neurons. |
1990-07-05 |
2023-08-11 |
rat |
| Y G Gao, R J Baldessarini, N S Kula, J L Neumeye. Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. Journal of medicinal chemistry. vol 33. issue 6. 1990-06-28. PMID:1971309. |
the dopaminergic receptor affinities of these compounds and their 2-unsubstituted counterparts (r)-(-)-apomorphine (r(-)-apo, r-1), (s)-(+)-apomorphine (s(+)-apo, s-1), and (r)-(-)-n-n-propylnorapomorphine (r(-)-npa, r-2), as well as those of (r)-(-)-2-chloroapomorphine (r(-)-2-cl-apo, r-6), (r)-(-)-2-bromoapomorphine (r(-)-2-br-apo, r-6), were determined with tissue membrane preparations of corpus striatum from rat brain. |
1990-06-28 |
2023-08-11 |
rat |
| F C Liu, A M Graybiel, S B Dunnett, R W Baughma. Intrastriatal grafts derived from fetal striatal primordia: II. Reconstitution of cholinergic and dopaminergic systems. The Journal of comparative neurology. vol 295. issue 1. 1990-06-27. PMID:1971286. |
reconstitution of striatal cholinergic and dopaminergic systems was studied in intrastriatal grafts derived from embryonic day 15 rat striatal primordia and implanted into adult host rats in which unilateral ibotenic acid lesions had previously been made in the striatum. |
1990-06-27 |
2023-08-11 |
rat |
| K Mizukawa, Y H Sora, N Ogaw. Ultrastructural changes of the substantia nigra, ventral tegmental area and striatum in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Research communications in chemical pathology and pharmacology. vol 67. issue 3. 1990-06-26. PMID:2343182. |
thus, the effect of mptp treatment is inhomogenous within the mouse striatum, as would be expected from the appearance of ultrastructural changes in only some of the dopaminergic neurons in the snc. |
1990-06-26 |
2023-08-11 |
mouse |
| P J Fletcher, M Davie. The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. British journal of pharmacology. vol 99. issue 3. 1990-06-06. PMID:2139586. |
increased dopaminergic neurotransmission in the striatum induces a general behavioural activation, which under certain conditions facilitates feeding. |
1990-06-06 |
2023-08-11 |
rat |
| Y Masuo, D Pélaprat, M N Montagne, D Scherman, W Rostèn. Regulation of neurotensin-containing neurons in the rat striatum and substantia nigra. Effects of unilateral nigral lesion with 6-hydroxydopamine on neurotensin content and its binding site density. Brain research. vol 510. issue 2. 1990-06-04. PMID:1970504. |
on the other hand, nt binding sites decreased in the ipsilateral striatum and substantia nigra, which reflected the destruction of dopaminergic elements in these regions. |
1990-06-04 |
2023-08-11 |
rat |
| T Zetterström, M Fillen. Local administration of flurazepam has different effects on dopamine release in striatum and nucleus accumbens: a microdialysis study. Neuropharmacology. vol 29. issue 2. 1990-05-30. PMID:2109839. |
these results suggest that the dopaminergic projection to the nucleus accumbens is more sensitive to benzodiazepine-induced inhibition than the projection to the striatum. |
1990-05-30 |
2023-08-11 |
Not clear |
| J Peris, S J Boyson, W A Cass, P Curella, L P Dwoskin, G Larson, L H Lin, R P Yasuda, N R Zahnise. Persistence of neurochemical changes in dopamine systems after repeated cocaine administration. The Journal of pharmacology and experimental therapeutics. vol 253. issue 1. 1990-05-30. PMID:2329520. |
our neurochemical experiments focused primarily on the striatum; however, quantitative autoradiography was used to measure d-1 and d-2 da receptors in both cell body and terminal regions of the nigrostriatal and mesolimbic dopaminergic pathways. |
1990-05-30 |
2023-08-11 |
rat |
| I Kanazawa, M Kimura, M Murata, Y Tanaka, F Ch. Choreic movements in the macaque monkey induced by kainic acid lesions of the striatum combined with L-dopa. Pharmacological, biochemical and physiological studies on neural mechanisms. Brain : a journal of neurology. vol 113 ( Pt 2). 1990-05-25. PMID:1970271. |
it is, therefore, assumed that certain populations of 'activated' nigrostriatal dopaminergic neurons which innervate the unlesioned area of the striatum may be more likely to attain a level of activity, induced by l-dopa, sufficient to produce choreic movements in the contralateral limbs. |
1990-05-25 |
2023-08-11 |
monkey |
| J A Swart, J F van der Werf, T Wiegman, A M Paans, W Vaalburg, J Kor. In vivo binding of spiperone and N-methylspiperone to dopaminergic and serotonergic sites in the rat brain: multiple modeling and implications for PET scanning. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 10. issue 3. 1990-05-25. PMID:1970341. |
nonlinear regression analysis shows that the in vivo specific binding of 3h-labeled spiperone in the frontal cortex (mainly serotonergic) can be described by a noninteracting sites model, whereas the specific binding in the striatum (mainly dopaminergic) can best be described by models that lead to sigmoid saturation curves. |
1990-05-25 |
2023-08-11 |
rat |
| E Salmon, D J Brooks, K L Leenders, D R Turton, S P Hume, J E Cremer, T Jones, R S Frackowia. A two-compartment description and kinetic procedure for measuring regional cerebral [11C]nomifensine uptake using positron emission tomography. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 10. issue 3. 1990-05-25. PMID:2329119. |
s-[11c]nomifensine (s-[11c]nmf) is a positron-emitting tracer suitable for positron emission tomography, which binds to both dopaminergic and noradrenergic reuptake sites in the striatum and the thalamus. |
1990-05-25 |
2023-08-11 |
human |