| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Mogi, A Togari, K Tanaka, N Ogawa, H Ichinose, T Nagats. Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction. Neuroscience letters. vol 268. issue 2. 1999-11-22. PMID:10400088. |
the concentrations of tnf-alpha in the dopaminergic regions (striatum and substantia nigra) on the 6-ohda injection side (right side: r) were significantly higher than those in the regions on the control side (left side: l) (wilcoxon's test, p < 0.05). |
1999-11-22 |
2023-08-12 |
mouse |
| M Mogi, A Togari, K Tanaka, N Ogawa, H Ichinose, T Nagats. Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction. Neuroscience letters. vol 268. issue 2. 1999-11-22. PMID:10400088. |
these results show that tnf-alpha is increased in the striatum and substantia nigra in 6-ohda-injected dopaminergic regions in rats, which finding is similar to the increase in the striatal dopaminergic regions in patients with pd. |
1999-11-22 |
2023-08-12 |
mouse |
| R Betarbet, J T Greenamyr. Differential expression of glutamate receptors by the dopaminergic neurons of the primate striatum. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506511. |
differential expression of glutamate receptors by the dopaminergic neurons of the primate striatum. |
1999-11-19 |
2023-08-12 |
Not clear |
| R Betarbet, J T Greenamyr. Differential expression of glutamate receptors by the dopaminergic neurons of the primate striatum. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506511. |
we previously described the presence of dopaminergic cells intrinsic to the primate striatum that increase in number following mptp treatment. |
1999-11-19 |
2023-08-12 |
Not clear |
| R Betarbet, J T Greenamyr. Differential expression of glutamate receptors by the dopaminergic neurons of the primate striatum. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506511. |
in this study we have used double-label immunocytochemistry to analyze the expression of the glutamate receptor subunits glur1, glur2/3, nr1, mglur1, and mglur5 in the dopaminergic cells of the striatum. |
1999-11-19 |
2023-08-12 |
Not clear |
| E Kosno-Kruszewsk. Survival of cryopreserved fetal substantia nigra implanted into the rat brain in the two forms and estimation of the host brain reaction against graft. Folia neuropathologica. vol 37. issue 1. 1999-10-21. PMID:10337058. |
the survival of transplanted dopaminergic cells in rat striatum was evaluated by means of histological and immunocytochemical methods (th-tyrosine hydroxylase) 1, 3, 7, 14 and 21 days after transplantation. |
1999-10-21 |
2023-08-12 |
rat |
| J Han, F C Cheng, Z Yang, G Dryhurs. Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. Journal of neurochemistry. vol 73. issue 4. 1999-10-14. PMID:10501216. |
in this investigation, microdialysis has been used to study the effects of 1-methyl-4-phenylpyridinium (mpp+), an inhibitor of mitochondrial complex i and alpha-ketoglutarate dehydrogenase and the active metabolite of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), on extracellular concentrations of glutathione (gsh) and cysteine (cysh) in the rat striatum and substantia nigra (sn). |
1999-10-14 |
2023-08-12 |
human |
| M Iida, I Miyazaki, K Tanaka, H Kabuto, E Iwata-Ichikawa, N Ogaw. Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain research. vol 838. issue 1-2. 1999-10-07. PMID:10446316. |
administration of ropinirole for 7 days increased gsh, catalase and sod activities in the striatum and protected striatal dopaminergic neurons against 6-hydroxydopamine (6-ohda) in mice. |
1999-10-07 |
2023-08-12 |
mouse |
| A Sánchez-Capelo, O Corti, J Malle. Adenovirus-mediated over-expression of TGFbeta1 in the striatum decreases dopaminergic cell survival in embryonic nigral grafts. Neuroreport. vol 10. issue 10. 1999-09-23. PMID:10424693. |
adenovirus-mediated over-expression of tgfbeta1 in the striatum decreases dopaminergic cell survival in embryonic nigral grafts. |
1999-09-23 |
2023-08-12 |
rat |
| W A Cass, M W Mannin. Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460271. |
these results suggest that presynaptic dopaminergic functioning can recover to normal levels in the striatum of meth-treated rats by 12 months after treatment. |
1999-09-23 |
2023-08-12 |
rat |
| W Quaglia, M Pigini, A Piergentili, M Giannella, G Marucci, E Poggesi, A Leonardi, C Melchiorr. Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes. Journal of medicinal chemistry. vol 42. issue 15. 1999-08-31. PMID:10425105. |
furthermore, receptor selectivity of selected benzodioxan derivatives was further determined in functional experiments in isolated rat vas deferens (alpha(1a)) and aorta (alpha(1d)) and guinea pig spleen (alpha(1b)), in additional receptor binding assays in rat cortex membranes containing alpha(2)-adrenoreceptors and 5-ht(2) serotoninergic receptors, and in rat striatum membranes containing d(2) dopaminergic receptors. |
1999-08-31 |
2023-08-12 |
human |
| b' M D Jovanovi\\xc4\\x87, M Ninkovi\\xc4\\x87, Z Malicevi\\xc4\\x87, R Mihajlovi\\xc4\\x87, M Duki\\xc4\\x87, I Vasiljevi\\xc4\\x87, A Jelenkovi\\xc4\\x87, A Jovici\\xc4\\x8. Oxidative stress in the thalamus of Wistar rats treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Vojnosanitetski pregled. vol 56. issue 2. 1999-08-24. PMID:10437415.' |
mutually depleted glutathione content in the thalamus and contralateral striatum, the structures distant from ipsilateral treated striatum, could indicate on spatial propagation of oxidative stress, not only in the selective vulnerable dopaminergic nigrostriatal neurons, but in the structures included in the motor and cognitive loops of basal ganglia. |
1999-08-24 |
2023-08-12 |
rat |
| M Merino, M L Vizuete, J Cano, A Machad. The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428073. |
in the present study, the possible neuroprotective effect of glutamate receptor antagonists against mpp+ neurotoxicity on dopaminergic terminals of rat striatum was investigated. |
1999-08-13 |
2023-08-12 |
rat |
| M Merino, M L Vizuete, J Cano, A Machad. The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428073. |
different doses of glutamate receptor antagonists were coinfused with 1.5 microg of mpp+ into the striatum; kynurenic acid, a nonselective antagonist of glutamate receptors (30 and 60 nmol), partially protected dopaminergic terminal degeneration in terms of rescue of dopamine levels and tyrosine hydroxylase immunohistochemistry. |
1999-08-13 |
2023-08-12 |
rat |
| A Hein. [Psychopathological correlates of dopaminergic dysfunction in alcoholic and schizophrenic patients]. Der Nervenarzt. vol 70. issue 5. 1999-08-12. PMID:10407835. |
primate studies pointed to the importance of a temporocortical dysfunction in the pathogenesis of phasic dopaminergic dysregulation in the striatum. |
1999-08-12 |
2023-08-12 |
Not clear |
| B Piallat, A Benazzouz, A L Benabi. Neuroprotective effect of chronic inactivation of the subthalamic nucleus in a rat model of Parkinson's disease. Journal of neural transmission. Supplementum. vol 55. 1999-08-03. PMID:10335494. |
as subthalamic nucleus neurons send direct glutamatergic projections to the substantia nigra, we studied the effects of kainic acid lesion of this nucleus on the degeneration of dopaminergic neurons induced by microinjection of 6-hydroxydopamine in the striatum of rat done one week after the first lesion. |
1999-08-03 |
2023-08-12 |
rat |
| B Piallat, A Benazzouz, A L Benabi. Neuroprotective effect of chronic inactivation of the subthalamic nucleus in a rat model of Parkinson's disease. Journal of neural transmission. Supplementum. vol 55. 1999-08-03. PMID:10335494. |
immunohistochemical study showed that lesion of the subthalamic nucleus can prevent the degeneration of substantia nigra dopaminergic somata when carried out one week prior to 6-hydroxydopamine injection in the striatum. |
1999-08-03 |
2023-08-12 |
rat |
| P Foley, P Riedere. Pathogenesis and preclinical course of Parkinson's disease. Journal of neural transmission. Supplementum. vol 56. 1999-08-02. PMID:10370902. |
the progressive and irreversible degeneration of dopaminergic neurons projecting from the substantia nigra pars compacta (snc) to the striatum and the presence of snc lewy bodies are regarded as the essential pathological bases of ip, but neither the initiator(s) nor the nature of the degeneration have been determined, nor its relationship with degenerative changes in other parts of the ip brain. |
1999-08-02 |
2023-08-12 |
Not clear |
| M P Muriel, V Bernard, A I Levey, O Laribi, D N Abrous, Y Agid, B Bloch, E C Hirsc. Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease. Annals of neurology. vol 46. issue 1. 1999-08-02. PMID:10401786. |
this effect was likely the result of the treatment rather than the dopaminergic denervation, as such changes were not observed in the striatum of rats with a unilateral 6-hydroxydopamine nigrostriatal lesion, but were present in normal or lesioned rats treated with a d1 dopamine agonist. |
1999-08-02 |
2023-08-12 |
human |
| A A Harrison, B J Everitt, T W Robbin. Central serotonin depletion impairs both the acquisition and performance of a symmetrically reinforced go/no-go conditional visual discrimination. Behavioural brain research. vol 100. issue 1-2. 1999-07-28. PMID:10212057. |
selective central 5-ht depletion (generally averaging more than 90% in neocortex, hippocampus and striatum) was induced by intracerebroventricular administration of the neurotoxin 5,7-dihydroxytryptamine (5,7-dht) following pretreatment with both a noradrenergic and dopaminergic re-uptake inhibitor. |
1999-07-28 |
2023-08-12 |
human |