| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Loeffler, P A LeWitt, P L Juneau, D M Camp, L A Arnold, K Hylan. Time-dependent effects of levodopa on regional brain dopamine metabolism and lipid peroxidation. Brain research bulletin. vol 47. issue 6. 1999-05-06. PMID:10078623. |
at 1, 4, 8, and 12 h after levodopa administration (100 mg/kg), dopamine, dihydroxyphenylacetic acid, and homovanillic acid were measured in striatum and ventral midbrain, regions containing marked dopaminergic innervation, and in prefrontal cortex and cerebellum, which possess little dopaminergic innervation. |
1999-05-06 |
2023-08-12 |
rat |
| E López-Martín, H J Caruncho, J Rodríguez-Pallares, M J Guerra, J L Labandeira-Garcí. Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts. The Journal of comparative neurology. vol 406. issue 2. 1999-05-04. PMID:10096606. |
these results demonstrate that gdnf-ir is coincident with that for th and darpp-32, and suggest that gdnf release by fetal striatal neurons both in normal development and in developing striatal grafts may have not only a trophic but also a tropic influence on th-ir fibers and may be one of the factors that regulate dopaminergic innervation of the striatum. |
1999-05-04 |
2023-08-12 |
rat |
| G W Miller, J D Erickson, J T Perez, S N Penland, D C Mash, D B Rye, A I Leve. Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192785. |
the vesicular monoamine transporter (vmat2) has been suggested to be an excellent marker of presynaptic dopaminergic nerve terminals in the striatum of parkinson's disease patients based on its high level of expression and insensitivity to drugs used to treat the disease. |
1999-04-21 |
2023-08-12 |
human |
| P E Batchelor, G T Liberatore, J Y Wong, M J Porritt, F Frerichs, G A Donnan, D W Howell. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 5. 1999-04-20. PMID:10024357. |
activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. |
1999-04-20 |
2023-08-12 |
Not clear |
| W S Joo, B K Jin, C W Park, S H Maeng, Y S Ki. Melatonin increases striatal dopaminergic function in 6-OHDA-lesioned rats. Neuroreport. vol 9. issue 18. 1999-04-13. PMID:9926859. |
the purpose of this study was to assess the in vivo effects of melatonin, as an antioxidant, on striatal dopaminergic function in rats with a unilateral 6-hydroxydopamine (6-ohda) lesion of the striatum. |
1999-04-13 |
2023-08-12 |
rat |
| S F McTavish, P J Cowen, T Shar. Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. Psychopharmacology. vol 141. issue 2. 1999-04-13. PMID:9952043. |
the tyrosine-free amino acid mixture also reduced dopa accumulation: this effect was most marked in striatum (-44%) and nucleus accumbens (-34%), areas with a predominantly dopaminergic innervation. |
1999-04-13 |
2023-08-12 |
rat |
| B M Ross, S Turenne, A Moszczynska, J J Warsh, S J Kis. Differential alteration of phospholipase A2 activities in brain of patients with schizophrenia. Brain research. vol 821. issue 2. 1999-04-13. PMID:10064828. |
studies of the cellular role played by pla2 suggest that decreased calcium-stimulated pla2 activity, as also occurs in striatum of chronic human cocaine users, may be due, in part, to increased dopaminergic activity in the disorder, whereas increased calcium-independent pla2 activity may be related to abnormal fatty acid metabolism and oxidative stress in schizophrenia. |
1999-04-13 |
2023-08-12 |
human |
| M J Wilby, S R Sinclair, E M Muir, R Zietlow, K H Adcock, P Horellou, J H Rogers, S B Dunnett, J W Fawcet. A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 6. 1999-04-13. PMID:10066280. |
we show that such bridge grafts increase the survival of implanted embryonic dopaminergic neurons and promote the growth of axons through the grafts to the striatum. |
1999-04-13 |
2023-08-12 |
rat |
| F Fumagalli, R R Gainetdinov, Y M Wang, K J Valenzano, G W Miller, M G Caro. Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 7. 1999-04-13. PMID:10087057. |
meth-induced dopaminergic neurotoxicity was increased in striatum of vmat2 +/- mice compared with wild-type mice as revealed by a more consistent da and metabolite depletion and a greater decrease in dopamine transporter expression. |
1999-04-13 |
2023-08-12 |
mouse |
| A M Lin, B Y Chyi, S D Wang, H H Yu, P P Kanakamma, T Y Luh, C K Chou, L T H. Carboxyfullerene prevents iron-induced oxidative stress in rat brain. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098871. |
furthermore, tyrosine hydroxylase-immunoreactive staining showed that carboxyfullerene inhibited the iron-induced loss of the dopaminergic nerve terminals in striatum. |
1999-04-13 |
2023-08-12 |
rat |
| G P Reynolds, C F Dalton, C L Tillery, L Mangiarini, S W Davies, G P Bate. Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098889. |
dopamine was decreased in the striatum in older animals, parallelling evidence for diminished dopaminergic activity in hd. |
1999-04-13 |
2023-08-12 |
mouse |
| W Timmerman, F Westerhof, T I van der Wal, B H Westerin. Striatal dopamine-glutamate interactions reflected in substantia nigra reticulata firing. Neuroreport. vol 9. issue 17. 1999-03-24. PMID:9875713. |
to gain insight into the role of striatal dopamine in basal ganglia functioning, dopaminergic drugs alone and in combination with the glutamate receptor agonist kainic acid were infused in the lateral striatum via a microdialysis probe, while single-unit recordings of substantia nigra reticulata neurons were made in chloral hydrate-anaesthetized rats. |
1999-03-24 |
2023-08-12 |
rat |
| O Pogarell, W H Oerte. Neural transplantation in Parkinson's disease and its effects on rest tremor: a review of the literature. Movement disorders : official journal of the Movement Disorder Society. vol 13 Suppl 3. 1999-03-22. PMID:9827603. |
the transplantation of fetal mesencephalic dopaminergic tissue into the striatum of parkinsonian (pd) patients is an experimental therapeutic approach. |
1999-03-22 |
2023-08-12 |
Not clear |
| M Morari, M Marti, S Sbrenna, K Fuxe, C Bianchi, L Bean. Reciprocal dopamine-glutamate modulation of release in the basal ganglia. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874089. |
this topic has been the object of interest since the late 70's, particularly in the striatum and in midbrain dopaminergic areas (substantia nigra and ventral tegmental area). |
1999-03-18 |
2023-08-12 |
rat |
| M Morari, M Marti, S Sbrenna, K Fuxe, C Bianchi, L Bean. Reciprocal dopamine-glutamate modulation of release in the basal ganglia. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874089. |
therefore, glutamatergic modulation of dopamine release has been reviewed by analyzing the effects of glutamatergic selective receptor agonists and antagonists in the striatum (both motor and limbic portions) and in midbrain dopaminergic areas, as revealed by in vitro (slices, cell cultures, synaptosomes) and in vivo (push-pull, microdialysis and voltammetry techniques) experimental approaches. |
1999-03-18 |
2023-08-12 |
rat |
| M Morari, M Marti, S Sbrenna, K Fuxe, C Bianchi, L Bean. Reciprocal dopamine-glutamate modulation of release in the basal ganglia. Neurochemistry international. vol 33. issue 5. 1999-03-18. PMID:9874089. |
in vitro and in vivo experiments in the striatum and midbrain dopaminergic areas mainly depict dopamine as an inhibitory modulator of glutamate release. |
1999-03-18 |
2023-08-12 |
rat |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
loss of regulation by presynaptic dopamine d2 receptors of exogenous l-dopa-derived dopamine release in the dopaminergic denervated striatum. |
1999-03-12 |
2023-08-12 |
rat |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
to determine whether dopamine release derived from exogenous l-dopa is under inhibitory control of presynaptic dopamine d2 receptors in the dopaminergic denervated striatum, extracellular dopamine levels were measured in the striatum of 6-hydroxydopamine-lesioned rats using in vivo brain microdialysis. |
1999-03-12 |
2023-08-12 |
rat |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
quinpirole, a d2 agonist, dose-dependently (0.01-3 mg/kg s.c.) inhibited endogenous dopamine release both in the intact and dopaminergic denervated striatum. |
1999-03-12 |
2023-08-12 |
rat |
| T Maeda, K Kannari, T Suda, M Matsunag. Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum. Brain research. vol 817. issue 1-2. 1999-03-12. PMID:9889362. |
these results suggest that, in the striatum with dopaminergic denervation, regulation by presynaptic d2 receptors is still operative on endogenous dopamine release but it does not work on dopamine release derived from exogenously administered l-dopa. |
1999-03-12 |
2023-08-12 |
rat |