| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Menza, K R Kaufman, A Castellano. Modafinil augmentation of antidepressant treatment in depression. The Journal of clinical psychiatry. vol 61. issue 5. 2000-06-21. PMID:10847314. |
the mechanism of action of modafinil is unknown, but, unlike other stimulants, the drug is highly selective for the central nervous system, has little effect on dopaminergic activity in the striatum, and appears to have a lower abuse potential. |
2000-06-21 |
2023-08-12 |
Not clear |
| L R Faro, J L do Nascimento, J M San José, M Alfonso, R Durá. Intrastriatal administration of methylmercury increases in vivo dopamine release. Neurochemical research. vol 25. issue 2. 2000-06-14. PMID:10786706. |
in the present work, we have studied the effects of intrastriatal administration of different doses (40 microm, 400 microm, and 4 mm) of organic mercury (methyl-mercury, mehg) on the dopaminergic system of rat striatum, in conscious and freely-moving animals, using microdialysis coupled to liquid chromatography. |
2000-06-14 |
2023-08-12 |
rat |
| K Tanaka, N Wada, N Ogaw. Chronic cerebral hypoperfusion induces transient reversible monoaminergic changes in the rat brain. Neurochemical research. vol 25. issue 2. 2000-06-14. PMID:10786717. |
dopaminergic changes in the frontal cortex and striatum were observed in hypoperfused rats at 1-3 weeks following occlusion. |
2000-06-14 |
2023-08-12 |
rat |
| C Colosimo, M De Michel. Motor fluctuations in Parkinson's disease: pathophysiology and treatment. European journal of neurology. vol 6. issue 1. 2000-06-06. PMID:10209344. |
two explanations are given: chronic intermittent dopaminergic therapy may lead to postsynaptic receptor downregulation in pd; or, receptor changes in the striatum may occur independently of treatment as a result of structural adaptation of the postsynaptic dopaminergic system to the progressive decline of the nigrostriatal pathway. |
2000-06-06 |
2023-08-12 |
human |
| A Gobert, J M Rivet, F Lejeune, A Newman-Tancredi, A Adhumeau-Auclair, J P Nicolas, L Cistarelli, C Melon, M J Milla. Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse (New York, N.Y.). vol 36. issue 3. 2000-06-06. PMID:10819900. |
the suppressive influence of 5-ht(2c) receptors on da release was also expressed on mesolimbic and nigrostriatal dopaminergic pathways, in that levels of da in nucleus accumbens and striatum were likewise reduced by ro60-0175 and elevated, though less markedly, by sb206,553. |
2000-06-06 |
2023-08-12 |
rat |
| D Frechilla, R Insausti, P Ruiz-Golvano, A García-Osta, M P Rubio, J M Almendral, J Del Rí. Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762706. |
degeneration of serotonergic fibers in the rat striatum was produced by local administration of the serotonergic neurotoxin 5, 7-dihydroxytryptamine (5,7-dht) or the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium (mpp(+)), which is also toxic to serotonergic neurons. |
2000-06-05 |
2023-08-12 |
human |
| D S Schatz, W A Kaufmann, R Schuligoi, C Humpel, A Sari. 3,4-Methylenedioxymetamphetamine (ecstasy) induces c-fos-like protein and mRNA in rat organotypic dorsal striatal slices. Synapse (New York, N.Y.). vol 36. issue 1. 2000-06-02. PMID:10700028. |
the isolated single organotypic slice model allows investigation of the effects of drugs of abuse on the expression of transcription factors in the striatum without dopaminergic and glutamatergic interactions. |
2000-06-02 |
2023-08-12 |
rat |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
these data provide the basis for regarding the period from week 6 to week 10 as optimal for transplantation of dopaminergic neurons into the striatum of patients with parkinson's disease. |
2000-06-02 |
2023-08-12 |
human |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
suspensions of fetal substantia nigra cells enriched with dopaminergic neurons were introduced stereotaxically into a patient's striatum through a cannula. |
2000-06-02 |
2023-08-12 |
human |
| N Nakao, T Itakur. Fetal tissue transplants in animal models of Huntington's disease: the effects on damaged neuronal circuitry and behavioral deficits. Progress in neurobiology. vol 61. issue 3. 2000-05-31. PMID:10727778. |
striatal neurons implanted into the lesioned striatum receive some of the major striatal afferents such as the nigrostriatal dopaminergic inputs and the gluatmatergic afferents from the neocortex and thalamus. |
2000-05-31 |
2023-08-12 |
Not clear |
| H Nishino, H Hida, M Kumazaki, Y Shimano, K Nakajima, H Shimizu, T Ooiwa, H Bab. The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: a hypothesis to explain its specific vulnerability. Journal of neurotrauma. vol 17. issue 3. 2000-05-31. PMID:10757330. |
we hypothesize that the striatum-specific lesion by 3-npa is due to cummulative insults characteristic to the striatum including glutamatergic excitotoxicity, dopaminergic toxicity, vulnerability of the lateral striatal artery and high activity in the glutamate-transporter. |
2000-05-31 |
2023-08-12 |
Not clear |
| B P Bejjani, I Arnulf, S Demeret, P Damier, A M Bonnet, J L Houeto, Y Agi. Levodopa-induced dyskinesias in Parkinson's disease: is sensitization reversible? Annals of neurology. vol 47. issue 5. 2000-05-31. PMID:10805339. |
levodopa-induced dyskinesias (lids) in patients with parkinson's disease are considered to result from the severity of dopaminergic denervation in the striatum, which is an irrevocable phenomenon, and sensitization induced by long-term intermittent administration of levodopa. |
2000-05-31 |
2023-08-12 |
Not clear |
| F Noël, M Geurts, J M Maloteau. Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 33. issue 2. 2000-05-18. PMID:10657066. |
selective destruction of nigrostriatal dopaminergic neurons does not alter [3h]-ryanodine binding in rat striatum. |
2000-05-18 |
2023-08-12 |
rat |
| F Noël, M Geurts, J M Maloteau. Selective destruction of nigrostriatal dopaminergic neurons does not alter [3H]-ryanodine binding in rat striatum. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 33. issue 2. 2000-05-18. PMID:10657066. |
the present data indicate that [3h]-ryanodine binding sites present in rat striatum are not preferentially localized in dopaminergic terminals. |
2000-05-18 |
2023-08-12 |
rat |
| E M Unterwald, M Cuntapa. Dopamine-opioid interactions in the rat striatum: a modulatory role for dopamine D1 receptors in delta opioid receptor-mediated signal transduction. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698003. |
dopaminergic and opioidergic systems interact in the striatum to modulate locomotor and motivated behaviors. |
2000-05-16 |
2023-08-12 |
rat |
| P Damier, L Tremblay, J Féger, E C Hirsc. [Development of dyskinesias induced by treatment for Parkinson's disease: potential role of first exposure to L-DOPA (or phenomenon of priming)]. Revue neurologique. vol 156. issue 3. 2000-05-16. PMID:10740093. |
the results of recent experiments have given rise to several different hypothesis for the mechanisms involved in priming: the role of internalization of dopamine receptors after administration of dopaminergic drugs; change in the distribution of d3 dopamine receptor; changes in the expression of peptides (substance p, enkephalin) in efferent neurons of the striatum; and reorganization of connections at the level of the dopaminergic neurons and their target tissue. |
2000-05-16 |
2023-08-12 |
monkey |
| A Pope-Coleman, J P Tinker, J S Schneide. Effects of GM1 ganglioside treatment on pre- and postsynaptic dopaminergic markers in the striatum of parkinsonian monkeys. Synapse (New York, N.Y.). vol 36. issue 2. 2000-05-12. PMID:10767059. |
effects of gm1 ganglioside treatment on pre- and postsynaptic dopaminergic markers in the striatum of parkinsonian monkeys. |
2000-05-12 |
2023-08-12 |
monkey |
| D Joel, I Weine. The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. Neuroscience. vol 96. issue 3. 2000-04-27. PMID:10717427. |
the connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. |
2000-04-27 |
2023-08-12 |
rat |
| D Joel, I Weine. The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. Neuroscience. vol 96. issue 3. 2000-04-27. PMID:10717427. |
this commentary compares the connections of the dopaminergic system with the striatum in rats and primates with respect to two levels of striatal organization: a tripartite functional (motor, associative and limbic) subdivision and a compartmental (patch/striosome-matrix) subdivision. |
2000-04-27 |
2023-08-12 |
rat |
| D Joel, I Weine. The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum. Neuroscience. vol 96. issue 3. 2000-04-27. PMID:10717427. |
(1) the limbic striatum reciprocates its dopaminergic input and in addition innervates most of the dopaminergic neurons projecting to the associative and motor striatum, whereas the motor and associative striatum reciprocate only part of their dopaminergic input. |
2000-04-27 |
2023-08-12 |
rat |