| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S K Chakrabart. Altered regulation of dopaminergic activity and impairment in motor function in rats after subchronic exposure to styrene. Pharmacology, biochemistry, and behavior. vol 66. issue 3. 2000-10-05. PMID:10899365. |
these data imply that despite the dopaminergic neuronal loss due to styrene, dopaminergic transmission was not reduced to a level that would result in an overall development of dopamine receptor supersensitivity in the striatum. |
2000-10-05 |
2023-08-12 |
human |
| J Gross, I Müller, Y Chen, M Elizalde, N Leclere, M Herrera-Marschitz, K Andersso. Perinatal asphyxia induces region-specific long-term changes in mRNA levels of tyrosine hydroxylase and dopamine D(1) and D(2) receptors in rat brain. Brain research. Molecular brain research. vol 79. issue 1-2. 2000-10-04. PMID:10925148. |
to study the effects of neonatal asphyxia on gene expression of the dopaminergic systems, we determined quantitatively the mrna levels of tyrosine hydroxylase, dopamine transporter, dopamine d(1) and d(2) receptors in substantia nigra/ventral tegmental area, striatum and limbic area. |
2000-10-04 |
2023-08-12 |
rat |
| P Izurieta-Sánchez, S Sarre, G Ebinger, Y Michott. Muscarinic antagonists in substantia nigra influence the decarboxylation of L-dopa in striatum. European journal of pharmacology. vol 399. issue 2-3. 2000-09-22. PMID:10884514. |
this in vivo study demonstrates that anticholinergic drugs perfused at the level of the substantia nigra can modulate dopamine and gaba levels and attenuate the l-dopa decarboxylation in the striatum, possibly via modulation of the nigrostriatal dopaminergic system. |
2000-09-22 |
2023-08-12 |
rat |
| M Arvin, L Fedorkova, K A Disshon, D E Dluzen, R E Leipheime. Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924688. |
results of this study demonstrate that: (1) mpp(+) evokes striatal dopamine release and this effect is significantly reduced in the presence of estrogen as determined by both in vivo electrochemistry and in vitro superfusion: (2) similar, albeit attenuated effects are observed in the nucleus accumbens as determined with in vivo electrochemistry; (3) estrogen acts to inhibit the clearance of dopamine in both the striatum and nucleus accumbens; and (4) estrogen may function as a neuroprotectant by reducing the uptake of neurotoxin into dopaminergic neurons. |
2000-09-20 |
2023-08-12 |
rat |
| S Y Si. Dopamine agonists in the treatment of Parkinson s disease past, present and future. Current pharmaceutical design. vol 6. issue 12. 2000-09-14. PMID:10903391. |
the destruction of dopaminergic neurons with projections to the striatum results in the diminishing striatal dopamine levels. |
2000-09-14 |
2023-08-12 |
Not clear |
| M S Saporito, B A Thomas, R W Scot. MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. Journal of neurochemistry. vol 75. issue 3. 2000-09-12. PMID:10936203. |
increased mkk4 phosphorylation, but not jnk phosphorylation, was found in the striatum, suggesting that activation of mkk4 occurs in injured dopaminergic terminals. |
2000-09-12 |
2023-08-12 |
mouse |
| S M Nicola, J Surmeier, R C Malenk. Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annual review of neuroscience. vol 23. 2000-09-08. PMID:10845063. |
dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. |
2000-09-08 |
2023-08-12 |
Not clear |
| I T Uzbay, S E Usanmaz, E E Tapanyigit, S Aynacioglu, E S Akars. Dopaminergic and serotonergic alterations in the rat brain during ethanol withdrawal: association with behavioral signs. Drug and alcohol dependence. vol 53. issue 1. 2000-09-08. PMID:10933339. |
changes in dopaminergic and serotonergic levels and metabolites in cerebral cortex, corpus striatum and hippocampus were investigated during the first 6-h of withdrawal in ethanol-dependent wistar rats. |
2000-09-08 |
2023-08-12 |
rat |
| J C Paterna, T Moccetti, A Mura, J Feldon, H Büele. Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain. Gene therapy. vol 7. issue 15. 2000-08-28. PMID:10918501. |
moreover, the wpre further increased egfp expression, and a raav vector incorporating both the pdgf-beta chain promoter and the wpre resulted in efficient egfp expression in dopaminergic neurons and their projections in the striatum for at least 41 weeks after virus injection. |
2000-08-28 |
2023-08-12 |
rat |
| K S Bankiewicz, J L Eberling, M Kohutnicka, W Jagust, P Pivirotto, J Bringas, J Cunningham, T F Budinger, J Harvey-Whit. Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877910. |
in addition, the imbalance in dopamine production between the nigrostriatal and mesolimbic dopaminergic systems can be corrected by using aadc gene delivery to the striatum. |
2000-08-16 |
2023-08-12 |
monkey |
| S J Cragg, D J Clarke, S A Greenfiel. Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877925. |
thus, these data demonstrate that dopaminergic grafts restore striatal dopaminergic function with extracellular dynamics of da that are different from those of intact striatum but which can normalize ambient da levels and permit transmission over an extended sphere. |
2000-08-16 |
2023-08-12 |
Not clear |
| Z Puschban, R Waldner, K Seppi, N Stefanova, C Humpel, C Scherfler, M Levivier, W Poewe, G K Wennin. Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy). Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877927. |
these findings indicate that beneficial protective effects of striatal grafts implanted into host striatum prior to excitotoxic insults are abolished in the presence of severe dopaminergic denervation. |
2000-08-16 |
2023-08-12 |
rat |
| H Nishino, H Hida, N Takei, M Kumazaki, K Nakajima, H Bab. Mesencephalic neural stem (progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877931. |
mesencephalic neural stem (progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum. |
2000-08-16 |
2023-08-12 |
rat |
| K Tsuboi, T A Kimber, C W Shult. Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825480. |
relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-ohda), a neurotoxin selective for catecholaminergic neurons. |
2000-08-07 |
2023-08-12 |
rat |
| K Tsuboi, T A Kimber, C W Shult. Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion. Brain research. vol 866. issue 1-2. 2000-08-07. PMID:10825480. |
the patches and subcallosal layer of preserved dopaminergic axons in the striatum of rats lesioned with 6-ohda contained cr, a 31-kda calcium-binding protein, but interestingly not cb. |
2000-08-07 |
2023-08-12 |
rat |
| M J Porritt, P E Batchelor, A J Hughes, R Kalnins, G A Donnan, D W Howell. New dopaminergic neurons in Parkinson's disease striatum. Lancet (London, England). vol 356. issue 9223. 2000-08-07. PMID:10892768. |
new dopaminergic neurons in parkinson's disease striatum. |
2000-08-07 |
2023-08-12 |
Not clear |
| M J Porritt, P E Batchelor, A J Hughes, R Kalnins, G A Donnan, D W Howell. New dopaminergic neurons in Parkinson's disease striatum. Lancet (London, England). vol 356. issue 9223. 2000-08-07. PMID:10892768. |
a new population of dopaminergic neurons has been identified in parkinson's disease striatum. |
2000-08-07 |
2023-08-12 |
Not clear |
| M J Porritt, P E Batchelor, A J Hughes, R Kalnins, G A Donnan, D W Howell. New dopaminergic neurons in Parkinson's disease striatum. Lancet (London, England). vol 356. issue 9223. 2000-08-07. PMID:10892768. |
these neurons are sufficiently numerous to have an important effect on dopaminergic function in the striatum. |
2000-08-07 |
2023-08-12 |
Not clear |
| I Mendez, K A Baker, M Hon. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain research. Brain research reviews. vol 32. issue 1. 2000-08-02. PMID:10751681. |
experimental and clinical studies of neural transplantation in parkinson's disease have focused on the placement of fetal dopaminergic grafts not in their ontogenic site (substantia nigra) but in the main nigral target area (striatum). |
2000-08-02 |
2023-08-12 |
rat |
| I Mendez, K A Baker, M Hon. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain research. Brain research reviews. vol 32. issue 1. 2000-08-02. PMID:10751681. |
16 (1996) 7216-7227] using a new transplantation strategy aimed at restoring dopaminergic innervation of the nigra and striatum by simultaneous dopaminergic transplants placed in the substantia nigra and ipsilateral striatum (double grafts) in the 6-hydroxydopamine lesioned adult rat brain. |
2000-08-02 |
2023-08-12 |
rat |