| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Porritt, P E Batchelor, A J Hughes, R Kalnins, G A Donnan, D W Howell. New dopaminergic neurons in Parkinson's disease striatum. Lancet (London, England). vol 356. issue 9223. 2000-08-07. PMID:10892768. |
new dopaminergic neurons in parkinson's disease striatum. |
2000-08-07 |
2023-08-12 |
Not clear |
| M J Porritt, P E Batchelor, A J Hughes, R Kalnins, G A Donnan, D W Howell. New dopaminergic neurons in Parkinson's disease striatum. Lancet (London, England). vol 356. issue 9223. 2000-08-07. PMID:10892768. |
a new population of dopaminergic neurons has been identified in parkinson's disease striatum. |
2000-08-07 |
2023-08-12 |
Not clear |
| M J Porritt, P E Batchelor, A J Hughes, R Kalnins, G A Donnan, D W Howell. New dopaminergic neurons in Parkinson's disease striatum. Lancet (London, England). vol 356. issue 9223. 2000-08-07. PMID:10892768. |
these neurons are sufficiently numerous to have an important effect on dopaminergic function in the striatum. |
2000-08-07 |
2023-08-12 |
Not clear |
| I Mendez, K A Baker, M Hon. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain research. Brain research reviews. vol 32. issue 1. 2000-08-02. PMID:10751681. |
experimental and clinical studies of neural transplantation in parkinson's disease have focused on the placement of fetal dopaminergic grafts not in their ontogenic site (substantia nigra) but in the main nigral target area (striatum). |
2000-08-02 |
2023-08-12 |
rat |
| I Mendez, K A Baker, M Hon. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain research. Brain research reviews. vol 32. issue 1. 2000-08-02. PMID:10751681. |
16 (1996) 7216-7227] using a new transplantation strategy aimed at restoring dopaminergic innervation of the nigra and striatum by simultaneous dopaminergic transplants placed in the substantia nigra and ipsilateral striatum (double grafts) in the 6-hydroxydopamine lesioned adult rat brain. |
2000-08-02 |
2023-08-12 |
rat |
| I Mendez, K A Baker, M Hon. Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain research. Brain research reviews. vol 32. issue 1. 2000-08-02. PMID:10751681. |
injection of the retrograde tracer fluorogold into the striatum and nigra resulted in fluorescent labeled cells within the intranigral graft and the intrastriatal graft and surrounding striatum, respectively suggesting that these double grafts promote at least partial reconstruction of the nigrostriatal dopaminergic pathway. |
2000-08-02 |
2023-08-12 |
rat |
| A M Lin, L T H. Melatonin suppresses iron-induced neurodegeneration in rat brain. Free radical biology & medicine. vol 28. issue 6. 2000-08-02. PMID:10802221. |
an increase in lipid peroxidation in the infused substantia nigra and reductions in dopamine levels and dopaminergic terminals in the ipsilateral striatum were observed 7 d after iron infusion. |
2000-08-02 |
2023-08-12 |
rat |
| A Fernandez-Gonzalez, I Pérez-Otaño, J I Morga. MPTP selectively induces haem oxygenase-1 expression in striatal astrocytes. The European journal of neuroscience. vol 12. issue 5. 2000-07-24. PMID:10792435. |
this response appears to be mediated by molecules released from affected dopaminergic nerve terminals in the striatum acting upon neighbouring astrocytes. |
2000-07-24 |
2023-08-12 |
mouse |
| P Svenningsson, A A Fienberg, P B Allen, C L Moine, M Lindskog, G Fisone, P Greengard, B B Fredhol. Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854268. |
the role of the dopamine- and cyclic amp-regulated phosphoprotein of m(r) 32,000 (darpp-32) in dopaminergic regulation of gene transcription in striatum and globus pallidus was examined. |
2000-07-17 |
2023-08-12 |
mouse |
| K A Reardon, F A Mendelsohn, S Y Chai, M K Horn. The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson's disease. Australian and New Zealand journal of medicine. vol 30. issue 1. 2000-07-14. PMID:10800878. |
animal studies have demonstrated an interaction within the striatum between the angiotensin and dopaminergic systems. |
2000-07-14 |
2023-08-12 |
rat |
| K A Reardon, F A Mendelsohn, S Y Chai, M K Horn. The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson's disease. Australian and New Zealand journal of medicine. vol 30. issue 1. 2000-07-14. PMID:10800878. |
in humans, angiotensin type 1 receptors have been found on dopaminergic neurons in the substantia nigra and striatum. |
2000-07-14 |
2023-08-12 |
rat |
| S Akhondzadeh, E Shasavand, H Jamilian, O Shabestari, A Kamalipou. Dipyridamole in the treatment of schizophrenia: adenosine-dopamine receptor interactions. Journal of clinical pharmacy and therapeutics. vol 25. issue 2. 2000-07-14. PMID:10849191. |
adenosine plays a role opposite to dopamine in the striatum and adenosine antagonists, like caffeine, produce similar effects to increased dopaminergic neurotransmission in the striatum. |
2000-07-14 |
2023-08-12 |
Not clear |
| M J Millan, A Gobert, A Newman-Tancredi, F Lejeune, D Cussac, J M Rivet, V Audinot, T Dubuffet, G Laviell. S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626. The Journal of pharmacology and experimental therapeutics. vol 293. issue 3. 2000-07-14. PMID:10869410. |
administered alone, s33084 did not modify dialysate levels of da in the frontal cortex, nucleus accumbens, or striatum of freely moving rats, nor the firing rate of ventrotegmental dopaminergic cell bodies. |
2000-07-14 |
2023-08-12 |
human |
| M Tsunoda, V J Johnson, R P Sharm. Increase in dopamine metabolites in murine striatum after oral exposure to inorganic but not organic form of selenium. Archives of environmental contamination and toxicology. vol 39. issue 1. 2000-07-12. PMID:10790499. |
the alterations of da metabolites by inorganic se in da-rich striatum suggested a se-specific increased neural activity of dopaminergic pathways. |
2000-07-12 |
2023-08-12 |
mouse |
| D S Kim, M S Szczypka, R D Palmite. Dopamine-deficient mice are hypersensitive to dopamine receptor agonists. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 12. 2000-06-30. PMID:10844009. |
the acute behavioral response of da-/- mice to a dopamine d1 receptor agonist was correlated with c-fos induction in the striatum, a brain nucleus that receives dense dopaminergic input. |
2000-06-30 |
2023-08-12 |
mouse |
| G Yadid, N Fitoussi, N Kinor, R Geffen, I Gispa. Astrocyte line SVG-TH grafted in a rat model of Parkinson's disease. Progress in neurobiology. vol 59. issue 6. 2000-06-30. PMID:10845756. |
the striatum in pd that lacks the dopaminergic projection from the substantia nigra metabolizes and releases dopamine differently from normal tissue and may react to different factors released by the grafted cells. |
2000-06-30 |
2023-08-12 |
human |
| M Fedrowitz, H Potschka, A Richter, W Lösche. A microdialysis study of striatal dopamine release in the circling rat, a genetic animal model with spontaneous lateralized rotational behavior. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10771340. |
we have previously found that ci2 rats of both genders have a lower tissue content of dopamine in the striatum ipsilateral to the preferred direction of rotation, indicating that the rats turn away from the brain hemisphere with higher striatal dopaminergic activity. |
2000-06-23 |
2023-08-12 |
rat |
| J F Chen, M Beilstein, Y H Xu, T J Turner, R Moratalla, D G Standaert, V J Aloyo, J S Fink, M A Schwarzschil. Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10771351. |
a(2a) adenosine receptors are highly expressed in the striatum where they modulate dopaminergic activity. |
2000-06-23 |
2023-08-12 |
mouse |
| J F Chen, M Beilstein, Y H Xu, T J Turner, R Moratalla, D G Standaert, V J Aloyo, J S Fink, M A Schwarzschil. Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors. Neuroscience. vol 97. issue 1. 2000-06-23. PMID:10771351. |
the extent of dopaminergic innervation and expression of dopamine receptors in the striatum were indistinguishable between a(2a) receptor knockout and wild-type mice. |
2000-06-23 |
2023-08-12 |
mouse |
| M Espejo, B Cutillas, T E Arenas, S Ambrosi. Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor. Cell transplantation. vol 9. issue 1. 2000-06-21. PMID:10784066. |
we studied the effects of neurotrophin-3 (nt-3) or glial cell line-derived neurotrophic factor (gdnf) on the survival of dopaminergic neurons from rat fetal ventral mesencephalic cells (fmcs) implanted into the rat striatum. |
2000-06-21 |
2023-08-12 |
rat |