| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reza Sedaghat, Mehrdad Roghani, Mohsen Khalil. Neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model. Iranian journal of pharmaceutical research : IJPR. vol 13. issue 1. 2014-04-15. PMID:24734075. |
parkinson disease (pd) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. |
2014-04-15 |
2023-08-13 |
rat |
| Laura E Been, Nancy A Staffend, Avery Tucker, Robert L Meise. Vesicular glutamate transporter 2 and tyrosine hydroxylase are not co-localized in Syrian hamster nucleus accumbens afferents. Neuroscience letters. vol 550. 2014-04-11. PMID:23850605. |
afferents to the nac can be divided into two anatomically segregated neurochemical phenotypes: dopaminergic inputs, primarily from the midbrain ventral tegmental area (vta) and glutamatergic inputs from several cortical and sub-cortical structures. |
2014-04-11 |
2023-08-12 |
mouse |
| Tae Eun Kim, Ji-Seon Seo, Ji Sun Seo, Jae Won Yang, Min Woong Kim, Rukhsana Kausar, Eunhye Joe, Bo Yeon Kim, Myung Ae Le. Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977047. |
nurr1 is an orphan nuclear receptor best known for its essential role in the development and maintenance of midbrain dopaminergic (da) neurons. |
2014-04-08 |
2023-08-12 |
human |
| Rumana Chowdhury, Marc Guitart-Masip, Christian Lambert, Raymond J Dolan, Emrah Düze. Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals. Neurobiology of aging. vol 34. issue 10. 2014-03-25. PMID:23623600. |
the precise contribution of dopaminergic midbrain regions (substantia nigra/ventral tegmental area [sn/vta]) to this form of behavioral adaptation remains unclear. |
2014-03-25 |
2023-08-12 |
human |
| E M Müller-Oehring, Y-C Jung, E V Sullivan, W C Hawkes, A Pfefferbaum, T Schult. Midbrain-driven emotion and reward processing in alcoholism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 10. 2014-03-24. PMID:23615665. |
enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. |
2014-03-24 |
2023-08-12 |
Not clear |
| Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Vahid Sheibani, Mehdi Abbasnejad, Anahita Mehdizadeh, Mohammad Mehdi Yaghoob. Inhibition of 6-hydroxydopamine-induced PC12 cell apoptosis by olive (Olea europaea L.) leaf extract is performed by its main component oleuropein. Rejuvenation research. vol 16. issue 2. 2014-03-21. PMID:23394606. |
parkinson disease (pd) is the most common progressive neurodegenerative disorder characterized by progressive death of midbrain dopaminergic neurons. |
2014-03-21 |
2023-08-12 |
rat |
| Janice M Beit. Parkinson's disease: a review. Frontiers in bioscience (Scholar edition). vol 6. 2014-03-21. PMID:24389262. |
resulting from a pathophysiologic loss or degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the development of neuronal lewy bodies, idiopathic parkinson's disease is associated with risk factors including aging, family history, pesticide exposure and environmental chemicals (e.g., synthetic heroin use). |
2014-03-21 |
2023-08-12 |
Not clear |
| Coraline D Metzger, Martin Walter, Heiko Graf, Birgit Able. SSRI-related modulation of sexual functioning is predicted by pre-treatment resting state functional connectivity in healthy men. Archives of sexual behavior. vol 42. issue 6. 2014-03-20. PMID:23771550. |
data from a 10 min eyes-closed resting state scan were used to analyze functional connectivity under placebo in previously identified brain regions, focussing on the sublenticular extended amygdala (slea), dopaminergic midbrain, and anterior cingulate cortex. |
2014-03-20 |
2023-08-12 |
human |
| Rumana Chowdhury, Christian Lambert, Raymond J Dolan, Emrah Düze. Parcellation of the human substantia nigra based on anatomical connectivity to the striatum. NeuroImage. vol 81. 2014-03-17. PMID:23684858. |
we show that tractography can be used to parcellate the sn/vta into anatomically plausible and behaviourally meaningful compartments, an approach that may help future studies to provide a more fine-grained synopsis of pathological changes in the dopaminergic midbrain and their functional impact. |
2014-03-17 |
2023-08-12 |
human |
| Li-Li Sun, Yan Zhang, Jian-feng Liu, Jun Wang, Wei-li Zhu, Li-yan Zhao, Yan-xue Xue, Lin Lu, Jie Sh. Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine. The international journal of neuropsychopharmacology. vol 16. issue 8. 2014-03-14. PMID:23449013. |
mch has been suggested to regulate the rewarding and reinforcing effects of psychostimulants by potentiating the dopaminergic system within the midbrain. |
2014-03-14 |
2023-08-12 |
rat |
| Einat Nissim-Eliraz, Sophie Zisman, Omri Schatz, Nissim Ben-Ari. Nato3 integrates with the Shh-Foxa2 transcriptional network regulating the differentiation of midbrain dopaminergic neurons. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23254923. |
nato3 integrates with the shh-foxa2 transcriptional network regulating the differentiation of midbrain dopaminergic neurons. |
2014-03-12 |
2023-08-12 |
Not clear |
| Einat Nissim-Eliraz, Sophie Zisman, Omri Schatz, Nissim Ben-Ari. Nato3 integrates with the Shh-Foxa2 transcriptional network regulating the differentiation of midbrain dopaminergic neurons. Journal of molecular neuroscience : MN. vol 51. issue 1. 2014-03-12. PMID:23254923. |
mesencephalic dopaminergic (mesda) neurons originate from the floor plate of the midbrain, a transient embryonic organizing center located at the ventral-most midline. |
2014-03-12 |
2023-08-12 |
Not clear |
| Amparo Tolosa, Xiaolai Zhou, Björn Spittau, Kerstin Krieglstei. Establishment of a survival and toxic cellular model for Parkinson's disease from chicken mesencephalon. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23238634. |
the objective of this study was to establish and characterize a survival and toxic cellular model for pd by culturing dopaminergic neurons from embryonic chicken ventral midbrain. |
2014-03-03 |
2023-08-12 |
chicken |
| Amparo Tolosa, Xiaolai Zhou, Björn Spittau, Kerstin Krieglstei. Establishment of a survival and toxic cellular model for Parkinson's disease from chicken mesencephalon. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23238634. |
we show that as in rodents, the common neurotrophic factors--brain-derived neurotrophic factor (bdnf), glial cell line-derived neurotrophic factor (gdnf), and fibroblast growth factor 2 (fgf2)--are able to support the survival of chicken midbrain dopaminergic neurons. |
2014-03-03 |
2023-08-12 |
chicken |
| Y Qian, M Chen, H Forssberg, R Diaz Heijt. Genetic variation in dopamine-related gene expression influences motor skill learning in mice. Genes, brain, and behavior. vol 12. issue 6. 2014-02-25. PMID:23819855. |
gene expression analysis of midbrain, frontal cortex and striatum showed significant differences in the expression of presynaptic and postsynaptic dopaminergic (daergic) markers (e.g. |
2014-02-25 |
2023-08-12 |
mouse |
| Supriti Samantaray, Varduhi H Knaryan, Donald C Shields, Naren L Bani. Critical role of calpain in spinal cord degeneration in Parkinson's disease. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:23875735. |
while multiple molecular mechanisms contribute to midbrain nigrostriatal dopaminergic degeneration in parkinson's disease (pd), the mechanism of damage in non-dopaminergic sites within the central nervous system, including the spinal cord, is not well-understood. |
2014-02-18 |
2023-08-12 |
human |
| Mehmet Ozansoy, A Nazli Başa. The central theme of Parkinson's disease: α-synuclein. Molecular neurobiology. vol 47. issue 2. 2014-02-13. PMID:23180276. |
pd is characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta of the midbrain. |
2014-02-13 |
2023-08-12 |
Not clear |
| Jie Zhang, Na Niu, Mingyu Wang, Michael A McNutt, Donghong Zhang, Baogang Zhang, Shijun Lu, Yuqing Liu, Zhihui Li. Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the FcγR I and TLR4 pathways. The international journal of biochemistry & cell biology. vol 45. issue 8. 2014-02-11. PMID:23791745. |
in this study, extensive expression of neuron-derived igg was demonstrated in dopaminergic neurons of human and rat mesencephalon. |
2014-02-11 |
2023-08-12 |
human |
| E Hensleigh, L M Pritchar. Glucocorticoid receptor expression and sub-cellular localization in dopamine neurons of the rat midbrain. Neuroscience letters. vol 556. 2014-02-10. PMID:24121048. |
though glucocorticoid receptor expression in midbrain dopaminergic neurons has been examined in previous studies, results have been somewhat equivocal. |
2014-02-10 |
2023-08-12 |
rat |
| Brette D Blakely, Christopher R Bye, Chathurini V Fernando, Asheeta A Prasad, R Jeroen Pasterkamp, Maria L Macheda, Steven A Stacker, Clare L Paris. Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. Stem cells and development. vol 22. issue 15. 2014-02-05. PMID:23517308. |
ryk, a receptor regulating wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. |
2014-02-05 |
2023-08-12 |
mouse |