| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
the microenvironment of the midbrain dopaminergic neurogenic niche was detected as hypoxic with oxygen tensions below 1.1%. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
fetal midbrain hypoxia hampered the generation of dopaminergic neurons and is accompanied with restricted fetal midbrain development. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
our study provides the initial framework for future studies on molecular mechanisms mediating oxygen regulation of dopaminergic neurogenesis within the fetal midbrain as its natural environment. |
2016-10-20 |
2023-08-13 |
Not clear |
| Ting-Yi Wang, Kiara F Bruggeman, Jessica A Kauhausen, Alexandra L Rodriguez, David R Nisbet, Clare L Paris. Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease. Biomaterials. vol 74. 2016-10-19. PMID:26454047. |
in vitro we confirmed the ability of the scaffolds to support ventral midbrain (vm) dopamine progenitors, and provide sustained delivery of gdnf - capable of eliciting effects on cell survival and dopaminergic axon growth. |
2016-10-19 |
2023-08-13 |
mouse |
| Venissa Machado, Tanja Zöller, Abdelraheim Attaai, Björn Spitta. Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821015. |
parkinson's disease (pd) is a neurodegenerative disease characterised by histopathological and biochemical manifestations such as loss of midbrain dopaminergic (da) neurons and decrease in dopamine levels accompanied by a concomitant neuroinflammatory response in the affected brain regions. |
2016-10-19 |
2023-08-13 |
mouse |
| Venissa Machado, Tanja Zöller, Abdelraheim Attaai, Björn Spitta. Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821015. |
moreover, we highlight the contribution of neurotrophic factors as endogenous and/or exogenous molecules to slow the progression of midbrain dopaminergic (mda) neurons and further discuss the potential of combined therapeutic approaches employing neuroinflammation modifying agents and neurotrophic factors. |
2016-10-19 |
2023-08-13 |
mouse |
| R Rumpel, O Baron, A Ratzka, M-L Schröder, M Hohmann, A Effenberg, P Claus, C Groth. Increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of FGF-2. Neuroscience. vol 314. 2016-10-13. PMID:26642808. |
increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of fgf-2. |
2016-10-13 |
2023-08-13 |
mouse |
| R Rumpel, O Baron, A Ratzka, M-L Schröder, M Hohmann, A Effenberg, P Claus, C Groth. Increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of FGF-2. Neuroscience. vol 314. 2016-10-13. PMID:26642808. |
fgf-2 is essential for survival of midbrain dopaminergic (da) neurons and is responsible for their dysplasia and disease-related degeneration. |
2016-10-13 |
2023-08-13 |
mouse |
| Shi-Bin Li, Dan Du, Mazahir T Hasan, Georg Köh. D4 Receptor Activation Differentially Modulates Hippocampal Basal and Apical Dendritic Synapses in Freely Moving Mice. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 2. 2016-10-11. PMID:25270308. |
furthermore, cell type-specific expression of mcherry in datcre mice generated fluorescence in dorsal ca1 that was highest in lacunosum moleculare and similar in or/rad, indicating that midbrain dopaminergic fibers distribute evenly in or/rad. |
2016-10-11 |
2023-08-13 |
mouse |
| G van der Plasse, R van Zessen, M C M Luijendijk, H Erkan, G D Stuber, G M J Ramakers, R A H Ada. Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin. International journal of obesity (2005). vol 39. issue 12. 2016-09-27. PMID:26183405. |
midbrain dopaminergic activity in response to reward-predicting environmental stimuli drives reward-seeking and motivated behavior for food rewards. |
2016-09-27 |
2023-08-13 |
human |
| Carmen Cavada Martíne. [THE THALAMIC DOPAMINERGIC SYSTEM. A NOVEL SYSTEM IN THE PRIMATE BRAIN]. Anales de la Real Academia Nacional de Medicina. vol 131. issue 1. 2016-09-15. PMID:27386678. |
the origin of thalamic dopamine is multiple; it includes dopaminergic nuclei in the hypothalamus, periaqueductal gray, ventral mesencephalon and lateral parabrachial nucleus. |
2016-09-15 |
2023-08-13 |
human |
| Jessica A Kauhausen, Lachlan H Thompson, Clare L Paris. Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice. Molecular and cellular neurosciences. vol 69. 2016-09-12. PMID:26463051. |
simultaneous homotopic transplantation of dopaminergic progenitors, into the ventral midbrain of chabc treated pd mice, had no effect on graft survival but resulted in enhanced axonal growth along the nigrostriatal pathway and reinnervation of the striatum, compared to control grafted mice. |
2016-09-12 |
2023-08-13 |
mouse |
| Hao Yang, Yang Liu, Yanan Hai, Ying Guo, Shi Yang, Zheng Li, Wei-Qiang Gao, Zuping H. Efficient Conversion of Spermatogonial Stem Cells to Phenotypic and Functional Dopaminergic Neurons via the PI3K/Akt and P21/Smurf2/Nolz1 Pathway. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25373443. |
parkinson's disease (pd) is a common neurodegenerative syndrome characterized by loss of midbrain dopaminergic (da) neurons. |
2016-08-30 |
2023-08-13 |
Not clear |
| Zhixing Hu, Jiali Pu, Houbo Jiang, Ping Zhong, Jingxin Qiu, Feng Li, Xiaomin Wang, Baorong Zhang, Zhen Yan, Jian Fen. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling. Stem cells and development. vol 24. issue 21. 2016-08-29. PMID:26218671. |
the lack of robust parkinson's disease (pd) phenotype in parkin knockout rodents and the identification of defective dopaminergic (da) neurotransmission in midbrain da neurons derived from induced pluripotent stem cells (ipsc) of pd patients with parkin mutations demonstrate the utility of patient-specific ipscs as an effective system to model the unique vulnerabilities of midbrain da neurons in pd. |
2016-08-29 |
2023-08-13 |
mouse |
| Seon-Heui Cha, Yu Ree Choi, Cheol-Ho Heo, Seo-Jun Kang, Eun-Hye Joe, Ilo Jou, Hwan-Myung Kim, Sang Myun Par. Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease. Molecular neurodegeneration. vol 10. 2016-08-24. PMID:26627850. |
parkinson's disease (pd) is characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor dysfunctions. |
2016-08-24 |
2023-08-13 |
Not clear |
| Celia van der Merwe, Jonathan Carr, Brigitte Glanzmann, Soraya Bardie. Exonic rearrangements in the known Parkinson's disease-causing genes are a rare cause of the disease in South African patients. Neuroscience letters. vol 619. 2016-08-24. PMID:27001088. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2016-08-24 |
2023-08-13 |
Not clear |
| M W Howe, D A Dombec. Rapid signalling in distinct dopaminergic axons during locomotion and reward. Nature. vol 535. issue 7613. 2016-08-24. PMID:27398617. |
dopaminergic projection axons from the midbrain to the striatum are crucial for motor control, as their degeneration in parkinson disease results in profound movement deficits. |
2016-08-24 |
2023-08-13 |
mouse |
| Ryan E Hillmer, Joanne P Boisvert, Monica J Cucciare, Michael B Dwinell, Milan Joksimovi. Generation and characterization of mice harboring a conditional CXCL12 allele. The International journal of developmental biology. vol 59. issue 4-6. 2016-08-23. PMID:26505253. |
as expected from the global mutant phenotype, our mutants were also characterized by highly irregular cerebellar cytoarchitecture of the external granule layer as well as altered radial migration of midbrain dopaminergic neurons. |
2016-08-23 |
2023-08-13 |
mouse |
| S Torii, S Kasai, A Suzuki, Y Todoroki, K Yokozawa, K-I Yasumoto, N Seike, H Kiyonari, Y Mukumoto, A Kakita, K Sogaw. Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease. Cell death discovery. vol 1. 2016-08-23. PMID:27551449. |
ipas was markedly induced in the midbrain following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) administration, and ipas-deficient mice showed resistance to mptp-induced degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2016-08-23 |
2023-08-13 |
mouse |
| Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M Griggs, Laura Zavala-Flores, Elsa M Reyes-Reyes, Javier Seravalli, Lia A Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franc. Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiology of disease. vol 81. 2016-08-22. PMID:25497688. |
short-term overexpression of wild type (wt) or mutant a53t α-synuclein had no toxic effect in human dopaminergic cells and primary midbrain cultures, but it exerted a synergistic effect on cu-induced cell death. |
2016-08-22 |
2023-08-13 |
human |