| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuejun Chen, Man Xiong, Yi Dong, Alexander Haberman, Jingyuan Cao, Huisheng Liu, Wenhao Zhou, Su-Chun Zhan. Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease. Cell stem cell. vol 18. issue 6. 2017-07-19. PMID:27133795. |
here, we show tunable rescue of motor function in a mouse model of pd, following transplantation of human midbrain dopaminergic (mda) neurons differentiated from hpscs engineered to express dreadds (designer receptors exclusively activated by designer drug). |
2017-07-19 |
2023-08-13 |
mouse |
| Junghyun Jo, Yixin Xiao, Alfred Xuyang Sun, Engin Cukuroglu, Hoang-Dai Tran, Jonathan Göke, Zi Ying Tan, Tzuen Yih Saw, Cheng-Peow Tan, Hidayat Lokman, Younghwan Lee, Donghoon Kim, Han Seok Ko, Seong-Oh Kim, Jae Hyeon Park, Nam-Joon Cho, Thomas M Hyde, Joel E Kleinman, Joo Heon Shin, Daniel R Weinberger, Eng King Tan, Hyunsoo Shawn Je, Huck-Hui N. Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons. Cell stem cell. vol 19. issue 2. 2017-07-19. PMID:27476966. |
recent advances in 3d culture systems have led to the generation of brain organoids that resemble different human brain regions; however, a 3d organoid model of the midbrain containing functional midbrain dopaminergic (mda) neurons has not been reported. |
2017-07-19 |
2023-08-13 |
mouse |
| Henrik H Hansen, Katrine Fabricius, Pernille Barkholt, Jens D Mikkelsen, Jacob Jelsing, Charles Pyke, Lotte Bjerre Knudsen, Niels Vran. Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease. Brain research. vol 1646. 2017-07-18. PMID:27233809. |
quantitative stereology was applied to assess the total number of midbrain tyrosine hydroxylase (th) positive dopaminergic neurons. |
2017-07-18 |
2023-08-13 |
rat |
| Henrik H Hansen, Katrine Fabricius, Pernille Barkholt, Jens D Mikkelsen, Jacob Jelsing, Charles Pyke, Lotte Bjerre Knudsen, Niels Vran. Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease. Brain research. vol 1646. 2017-07-18. PMID:27233809. |
in conclusion, liraglutide showed no neuroprotective effects in the context of moderate or substantial midbrain dopaminergic neuronal loss and associated functional motor deficits in the rat 6-ohda lesion model of pd. |
2017-07-18 |
2023-08-13 |
rat |
| Fabian Philippart, Geoffrey Destreel, Paulina Merino-Sepúlveda, Pablo Henny, Dominique Engel, Vincent Seuti. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 27. 2017-07-18. PMID:27383597. |
differential somatic ca2+ channel profile in midbrain dopaminergic neurons. |
2017-07-18 |
2023-08-13 |
rat |
| Fabian Philippart, Geoffrey Destreel, Paulina Merino-Sepúlveda, Pablo Henny, Dominique Engel, Vincent Seuti. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 27. 2017-07-18. PMID:27383597. |
dopaminergic (da) neurons located in the ventral midbrain continuously generate a slow endogenous pacemaker activity, the mechanism of which is still debated. |
2017-07-18 |
2023-08-13 |
rat |
| Daniela Maria Vogt Weisenhorn, Florian Giesert, Wolfgang Wurs. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:27206718. |
diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to parkinson's disease. |
2017-07-14 |
2023-08-13 |
Not clear |
| Daniela Maria Vogt Weisenhorn, Florian Giesert, Wolfgang Wurs. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:27206718. |
dopaminergic neurons in the ventral mesencephalon (the ventral mesencephalic dopaminergic complex) are known for their role in a multitude of behaviors, including cognition, reward, addiction and voluntary movement. |
2017-07-14 |
2023-08-13 |
Not clear |
| Daniela Maria Vogt Weisenhorn, Florian Giesert, Wolfgang Wurs. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:27206718. |
however, only a subset of dopaminergic neurons in the ventral mesencephalon is highly vulnerable to the disease process. |
2017-07-14 |
2023-08-13 |
Not clear |
| J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon Rw Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arena. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. The EMBO journal. vol 35. issue 18. 2017-06-28. PMID:27354364. |
pre-b-cell leukemia homeobox (pbx) transcription factors are known to regulate organogenesis, but their molecular targets and function in midbrain dopaminergic neurons (mdan) as well as their role in neurodegenerative diseases are unknown. |
2017-06-28 |
2023-08-13 |
human |
| J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon Rw Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arena. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. The EMBO journal. vol 35. issue 18. 2017-06-28. PMID:27354364. |
notably, pbx1 and nfe2l1 levels are severely reduced in dopaminergic neurons of the substantia nigra of parkinson's disease (pd) patients and decreased nfe2l1 levels increases damage by oxidative stress in human midbrain cells. |
2017-06-28 |
2023-08-13 |
human |
| Eva Rodríguez-Traver, Oscar Solís, Eva Díaz-Guerra, Óscar Ortiz, Eva Vergaño-Vera, Héctor R Méndez-Gómez, Patricia García-Sanz, Rosario Moratalla, Carlos Vicario-Abejó. Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:26678495. |
nurr1 is an essential transcription factor for the differentiation, maturation, and maintenance of midbrain dopaminergic neurons (da neurons) as it has been demonstrated using knock-out mice. |
2017-06-26 |
2023-08-13 |
mouse |
| Douglas A Grow, DeNard V Simmons, Jorge A Gomez, Matthew J Wanat, John R McCarrey, Carlos A Paladini, Christopher S Navar. Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells. Stem cells translational medicine. vol 5. issue 9. 2017-06-22. PMID:27343168. |
we confirmed that bipsc-derived dopaminergic neurons resemble those found in the human midbrain based on cell type-specific expression of dopamine markers th and girk2. |
2017-06-22 |
2023-08-13 |
human |
| Li-Ping Liang, Jie Huang, Ruth Fulton, Jennifer N Pearson-Smith, Brian J Day, Manisha Pate. Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease. Toxicology and applied pharmacology. vol 326. 2017-06-06. PMID:28400118. |
all of these compounds protected against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity, including dopamine depletion in the striatum, dopaminergic neuronal loss in the substantial nigra, and increased oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain of the mice without inhibiting mptp metabolism. |
2017-06-06 |
2023-08-13 |
mouse |
| Ewa B Romuk, Wioletta Szczurek, Przemysław G Nowak, Edyta Hudziec, Ewa Chwalińska, Ewa Birkne. Effects of Propofol on the Liver Oxidative-Antioxidant Balance in a Rat Model of Parkinson's Disease. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 25. issue 5. 2017-06-01. PMID:28028942. |
parkinson's disease is caused by the destruction of dopaminergic neurons in the substantia nigra of the midbrain. |
2017-06-01 |
2023-08-13 |
rat |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
here we used rat foetal midbrain progenitors at two developmental stages corresponding to a peak in either a9 or a10 neurogenesis and examined their commitment to respective dopaminergic phenotypes by grafting cells into different forebrain regions that contain targets of either nigral a9 dopamine innervation (dorsal striatum), ventral tegmental area a10 dopamine innervation (nucleus accumbens and prefrontal cortex), or only sparse dopamine but rich noradrenaline innervation (hippocampus). |
2017-05-16 |
2023-08-13 |
rat |
| Jari Willing, Christine K Wagne. Progesterone Receptor Expression in the Developing Mesocortical Dopamine Pathway: Importance for Complex Cognitive Behavior in Adulthood. Neuroendocrinology. vol 103. issue 3-4. 2017-05-15. PMID:26065828. |
numerous psychiatric and behavioral disorders such as autism, attention deficit disorder and schizophrenia may involve disruptions in the development of the mesocortical dopamine pathway, consisting of dopaminergic projections from the midbrain ventral tegmental area (vta) to the medial prefrontal cortex (mpfc). |
2017-05-15 |
2023-08-13 |
Not clear |
| Venissa Machado, Ralf Gilsbach, Richa Das, Andreas Schober, Lioudmila Bogatyreva, Dieter Hauschke, Kerstin Krieglstein, Klaus Unsicker, Björn Spitta. Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. Cell and tissue research. vol 365. issue 2. 2017-05-15. PMID:27115420. |
growth/differentiation factor-15 (gdf-15) is a member of the transforming growth factor-β (tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (daergic) neurons both in vitro and in vivo. |
2017-05-15 |
2023-08-13 |
mouse |
| Leonardo A Parra, Tracy B Baust, Amanda D Smith, Juliann D Jaumotte, Michael J Zigmond, Soledad Torres, Rehana K Leak, Jose A Pino, Gonzalo E Torre. The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization. The Journal of biological chemistry. vol 291. issue 34. 2017-05-12. PMID:27365397. |
immunocytochemical studies indicated that hsc70 and th co-localize in midbrain dopaminergic neurons. |
2017-05-12 |
2023-08-13 |
mouse |
| Allan K Hansen, Karoline Knudsen, Thea P Lillethorup, Anne M Landau, Peter Parbo, Tatyana Fedorova, Hélène Audrain, Dirk Bender, Karen Østergaard, David J Brooks, Per Borghamme. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190023. |
the tau tangle ligand (18)f-av-1451 ((18)f-t807) binds to neuromelanin in the midbrain, and may therefore be a measure of the pigmented dopaminergic neuronal count in the substantia nigra. |
2017-05-10 |
2023-08-13 |
human |