| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Maria Vogt Weisenhorn, Florian Giesert, Wolfgang Wurs. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease. Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:27206718. |
however, only a subset of dopaminergic neurons in the ventral mesencephalon is highly vulnerable to the disease process. |
2017-07-14 |
2023-08-13 |
Not clear |
| J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon Rw Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arena. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. The EMBO journal. vol 35. issue 18. 2017-06-28. PMID:27354364. |
pre-b-cell leukemia homeobox (pbx) transcription factors are known to regulate organogenesis, but their molecular targets and function in midbrain dopaminergic neurons (mdan) as well as their role in neurodegenerative diseases are unknown. |
2017-06-28 |
2023-08-13 |
human |
| J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon Rw Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna-Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, Ernest Arena. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. The EMBO journal. vol 35. issue 18. 2017-06-28. PMID:27354364. |
notably, pbx1 and nfe2l1 levels are severely reduced in dopaminergic neurons of the substantia nigra of parkinson's disease (pd) patients and decreased nfe2l1 levels increases damage by oxidative stress in human midbrain cells. |
2017-06-28 |
2023-08-13 |
human |
| Eva Rodríguez-Traver, Oscar Solís, Eva Díaz-Guerra, Óscar Ortiz, Eva Vergaño-Vera, Héctor R Méndez-Gómez, Patricia García-Sanz, Rosario Moratalla, Carlos Vicario-Abejó. Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:26678495. |
nurr1 is an essential transcription factor for the differentiation, maturation, and maintenance of midbrain dopaminergic neurons (da neurons) as it has been demonstrated using knock-out mice. |
2017-06-26 |
2023-08-13 |
mouse |
| Douglas A Grow, DeNard V Simmons, Jorge A Gomez, Matthew J Wanat, John R McCarrey, Carlos A Paladini, Christopher S Navar. Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells. Stem cells translational medicine. vol 5. issue 9. 2017-06-22. PMID:27343168. |
we confirmed that bipsc-derived dopaminergic neurons resemble those found in the human midbrain based on cell type-specific expression of dopamine markers th and girk2. |
2017-06-22 |
2023-08-13 |
human |
| Li-Ping Liang, Jie Huang, Ruth Fulton, Jennifer N Pearson-Smith, Brian J Day, Manisha Pate. Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease. Toxicology and applied pharmacology. vol 326. 2017-06-06. PMID:28400118. |
all of these compounds protected against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity, including dopamine depletion in the striatum, dopaminergic neuronal loss in the substantial nigra, and increased oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain of the mice without inhibiting mptp metabolism. |
2017-06-06 |
2023-08-13 |
mouse |
| Ewa B Romuk, Wioletta Szczurek, Przemysław G Nowak, Edyta Hudziec, Ewa Chwalińska, Ewa Birkne. Effects of Propofol on the Liver Oxidative-Antioxidant Balance in a Rat Model of Parkinson's Disease. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 25. issue 5. 2017-06-01. PMID:28028942. |
parkinson's disease is caused by the destruction of dopaminergic neurons in the substantia nigra of the midbrain. |
2017-06-01 |
2023-08-13 |
rat |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
here we used rat foetal midbrain progenitors at two developmental stages corresponding to a peak in either a9 or a10 neurogenesis and examined their commitment to respective dopaminergic phenotypes by grafting cells into different forebrain regions that contain targets of either nigral a9 dopamine innervation (dorsal striatum), ventral tegmental area a10 dopamine innervation (nucleus accumbens and prefrontal cortex), or only sparse dopamine but rich noradrenaline innervation (hippocampus). |
2017-05-16 |
2023-08-13 |
rat |
| Jari Willing, Christine K Wagne. Progesterone Receptor Expression in the Developing Mesocortical Dopamine Pathway: Importance for Complex Cognitive Behavior in Adulthood. Neuroendocrinology. vol 103. issue 3-4. 2017-05-15. PMID:26065828. |
numerous psychiatric and behavioral disorders such as autism, attention deficit disorder and schizophrenia may involve disruptions in the development of the mesocortical dopamine pathway, consisting of dopaminergic projections from the midbrain ventral tegmental area (vta) to the medial prefrontal cortex (mpfc). |
2017-05-15 |
2023-08-13 |
Not clear |
| Venissa Machado, Ralf Gilsbach, Richa Das, Andreas Schober, Lioudmila Bogatyreva, Dieter Hauschke, Kerstin Krieglstein, Klaus Unsicker, Björn Spitta. Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. Cell and tissue research. vol 365. issue 2. 2017-05-15. PMID:27115420. |
growth/differentiation factor-15 (gdf-15) is a member of the transforming growth factor-β (tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (daergic) neurons both in vitro and in vivo. |
2017-05-15 |
2023-08-13 |
mouse |
| Leonardo A Parra, Tracy B Baust, Amanda D Smith, Juliann D Jaumotte, Michael J Zigmond, Soledad Torres, Rehana K Leak, Jose A Pino, Gonzalo E Torre. The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization. The Journal of biological chemistry. vol 291. issue 34. 2017-05-12. PMID:27365397. |
immunocytochemical studies indicated that hsc70 and th co-localize in midbrain dopaminergic neurons. |
2017-05-12 |
2023-08-13 |
mouse |
| Allan K Hansen, Karoline Knudsen, Thea P Lillethorup, Anne M Landau, Peter Parbo, Tatyana Fedorova, Hélène Audrain, Dirk Bender, Karen Østergaard, David J Brooks, Per Borghamme. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190023. |
the tau tangle ligand (18)f-av-1451 ((18)f-t807) binds to neuromelanin in the midbrain, and may therefore be a measure of the pigmented dopaminergic neuronal count in the substantia nigra. |
2017-05-10 |
2023-08-13 |
human |
| V L Hewitt, A J Whitwort. Mechanisms of Parkinson's Disease: Lessons from Drosophila. Current topics in developmental biology. vol 121. 2017-05-08. PMID:28057299. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder which results from the relentless degeneration of midbrain dopaminergic neurons. |
2017-05-08 |
2023-08-13 |
human |
| Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin, Byung Tae Cho. Antidepressant Effects of Aripiprazole Augmentation for Cilostazol-Treated Mice Exposed to Chronic Mild Stress after Ischemic Stroke. International journal of molecular sciences. vol 18. issue 2. 2017-04-28. PMID:28208711. |
phosphorylation of the cyclic adenosine monophosphate response element binding protein (creb) was increased in the striatum, hippocampus, and midbrain of mice receiving combined treatment compared to treatment with either drug alone, particularly in the neurons of the striatum and hippocampus, and dopaminergic neurons of the midbrain. |
2017-04-28 |
2023-08-13 |
mouse |
| Magdalena Walczak, Tomasz Błasia. Midbrain dopaminergic neuron activity across alternating brain states of urethane anaesthetized rat. The European journal of neuroscience. vol 45. issue 8. 2017-04-25. PMID:28177164. |
midbrain dopaminergic neurons are implicated in the control of motor functions and reward-driven behaviours. |
2017-04-25 |
2023-08-13 |
rat |
| Nozomi Asaoka, Hiroyuki Kawai, Naoya Nishitani, Haruko Kinoshita, Norihiro Shibui, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kanek. A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons. The Journal of toxicological sciences. vol 41. issue 6. 2017-04-11. PMID:27853110. |
a new designer drug 5f-adb activates midbrain dopaminergic neurons but not serotonergic neurons. |
2017-04-11 |
2023-08-13 |
Not clear |
| Nozomi Asaoka, Hiroyuki Kawai, Naoya Nishitani, Haruko Kinoshita, Norihiro Shibui, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kanek. A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons. The Journal of toxicological sciences. vol 41. issue 6. 2017-04-11. PMID:27853110. |
to investigate the neuronal mechanisms underlying its toxicity, we examined the effects of 5f-adb on midbrain dopaminergic and serotonergic systems, which modulate various basic brain functions such as those in reward-related behavior. |
2017-04-11 |
2023-08-13 |
Not clear |
| Chao Ping Yang, Zhen Hua Zhang, Li Hua Zhang, Han Chen Ru. Neuroprotective Role of MicroRNA-22 in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via Regulation of Its Target Gene TRPM7. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27631550. |
parkinson's disease (pd), the second most prevalent neurodegenerative disorder with only symptomatic treatment available, is characterized by a progressive loss of dopaminergic neurons in the midbrain. |
2017-03-23 |
2023-08-13 |
Not clear |
| Willyan Franco Hilario, Alice Laschuk Herlinger, Lorena Bianchine Areal, Lívia Silveira de Moraes, Tamara Andrea Alarcon Ferreira, Tassiane Emanuelle Servane Andrade, Cristina Martins-Silva, Rita Gomes Wanderley Pire. Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27660217. |
analysis of dopaminergic mrna alterations in the midbrain showed that d1r expression was increased by mptp, while the normal expression level of this receptor was restored by ee. |
2017-03-23 |
2023-08-13 |
mouse |
| Wei Zhu, Jie Li, Yigang Liu, Kun Xie, Le Wang, Jianmin Fan. Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways. Immunopharmacology and immunotoxicology. vol 38. issue 3. 2017-03-21. PMID:27075782. |
mesencephalic astrocyte-derived neurotrophic factor (manf), a new evolutionary conserved neurotrophic factor (ntf), has been reported to protect midbrain dopaminergic neurons of neurodegenerative diseases such as parkinson's disease (pd) model. |
2017-03-21 |
2023-08-13 |
Not clear |