| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jari Willing, Christine K Wagne. Progesterone Receptor Expression in the Developing Mesocortical Dopamine Pathway: Importance for Complex Cognitive Behavior in Adulthood. Neuroendocrinology. vol 103. issue 3-4. 2017-05-15. PMID:26065828. |
numerous psychiatric and behavioral disorders such as autism, attention deficit disorder and schizophrenia may involve disruptions in the development of the mesocortical dopamine pathway, consisting of dopaminergic projections from the midbrain ventral tegmental area (vta) to the medial prefrontal cortex (mpfc). |
2017-05-15 |
2023-08-13 |
Not clear |
| Venissa Machado, Ralf Gilsbach, Richa Das, Andreas Schober, Lioudmila Bogatyreva, Dieter Hauschke, Kerstin Krieglstein, Klaus Unsicker, Björn Spitta. Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. Cell and tissue research. vol 365. issue 2. 2017-05-15. PMID:27115420. |
growth/differentiation factor-15 (gdf-15) is a member of the transforming growth factor-β (tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (daergic) neurons both in vitro and in vivo. |
2017-05-15 |
2023-08-13 |
mouse |
| Leonardo A Parra, Tracy B Baust, Amanda D Smith, Juliann D Jaumotte, Michael J Zigmond, Soledad Torres, Rehana K Leak, Jose A Pino, Gonzalo E Torre. The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization. The Journal of biological chemistry. vol 291. issue 34. 2017-05-12. PMID:27365397. |
immunocytochemical studies indicated that hsc70 and th co-localize in midbrain dopaminergic neurons. |
2017-05-12 |
2023-08-13 |
mouse |
| Allan K Hansen, Karoline Knudsen, Thea P Lillethorup, Anne M Landau, Peter Parbo, Tatyana Fedorova, Hélène Audrain, Dirk Bender, Karen Østergaard, David J Brooks, Per Borghamme. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190023. |
the tau tangle ligand (18)f-av-1451 ((18)f-t807) binds to neuromelanin in the midbrain, and may therefore be a measure of the pigmented dopaminergic neuronal count in the substantia nigra. |
2017-05-10 |
2023-08-13 |
human |
| V L Hewitt, A J Whitwort. Mechanisms of Parkinson's Disease: Lessons from Drosophila. Current topics in developmental biology. vol 121. 2017-05-08. PMID:28057299. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder which results from the relentless degeneration of midbrain dopaminergic neurons. |
2017-05-08 |
2023-08-13 |
human |
| Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin, Byung Tae Cho. Antidepressant Effects of Aripiprazole Augmentation for Cilostazol-Treated Mice Exposed to Chronic Mild Stress after Ischemic Stroke. International journal of molecular sciences. vol 18. issue 2. 2017-04-28. PMID:28208711. |
phosphorylation of the cyclic adenosine monophosphate response element binding protein (creb) was increased in the striatum, hippocampus, and midbrain of mice receiving combined treatment compared to treatment with either drug alone, particularly in the neurons of the striatum and hippocampus, and dopaminergic neurons of the midbrain. |
2017-04-28 |
2023-08-13 |
mouse |
| Magdalena Walczak, Tomasz Błasia. Midbrain dopaminergic neuron activity across alternating brain states of urethane anaesthetized rat. The European journal of neuroscience. vol 45. issue 8. 2017-04-25. PMID:28177164. |
midbrain dopaminergic neurons are implicated in the control of motor functions and reward-driven behaviours. |
2017-04-25 |
2023-08-13 |
rat |
| Nozomi Asaoka, Hiroyuki Kawai, Naoya Nishitani, Haruko Kinoshita, Norihiro Shibui, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kanek. A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons. The Journal of toxicological sciences. vol 41. issue 6. 2017-04-11. PMID:27853110. |
a new designer drug 5f-adb activates midbrain dopaminergic neurons but not serotonergic neurons. |
2017-04-11 |
2023-08-13 |
Not clear |
| Nozomi Asaoka, Hiroyuki Kawai, Naoya Nishitani, Haruko Kinoshita, Norihiro Shibui, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kanek. A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons. The Journal of toxicological sciences. vol 41. issue 6. 2017-04-11. PMID:27853110. |
to investigate the neuronal mechanisms underlying its toxicity, we examined the effects of 5f-adb on midbrain dopaminergic and serotonergic systems, which modulate various basic brain functions such as those in reward-related behavior. |
2017-04-11 |
2023-08-13 |
Not clear |
| Chao Ping Yang, Zhen Hua Zhang, Li Hua Zhang, Han Chen Ru. Neuroprotective Role of MicroRNA-22 in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via Regulation of Its Target Gene TRPM7. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27631550. |
parkinson's disease (pd), the second most prevalent neurodegenerative disorder with only symptomatic treatment available, is characterized by a progressive loss of dopaminergic neurons in the midbrain. |
2017-03-23 |
2023-08-13 |
Not clear |
| Willyan Franco Hilario, Alice Laschuk Herlinger, Lorena Bianchine Areal, Lívia Silveira de Moraes, Tamara Andrea Alarcon Ferreira, Tassiane Emanuelle Servane Andrade, Cristina Martins-Silva, Rita Gomes Wanderley Pire. Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27660217. |
analysis of dopaminergic mrna alterations in the midbrain showed that d1r expression was increased by mptp, while the normal expression level of this receptor was restored by ee. |
2017-03-23 |
2023-08-13 |
mouse |
| Wei Zhu, Jie Li, Yigang Liu, Kun Xie, Le Wang, Jianmin Fan. Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways. Immunopharmacology and immunotoxicology. vol 38. issue 3. 2017-03-21. PMID:27075782. |
mesencephalic astrocyte-derived neurotrophic factor (manf), a new evolutionary conserved neurotrophic factor (ntf), has been reported to protect midbrain dopaminergic neurons of neurodegenerative diseases such as parkinson's disease (pd) model. |
2017-03-21 |
2023-08-13 |
Not clear |
| Valeria D Felice, Eamonn M Quigley, Aideen M Sullivan, Gerard W O'Keeffe, Siobhain M O'Mahon. Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms. Parkinsonism & related disorders. vol 27. 2017-03-16. PMID:27013171. |
the primary neuropathology is the loss of midbrain dopaminergic neurons, resulting in characteristic motor deficits, upon which the clinical diagnosis is based. |
2017-03-16 |
2023-08-13 |
Not clear |
| Noriko Nakano, Satoru Matsuda, Mayuko Ichimura, Akari Minami, Mako Ogino, Toshiyuki Murai, Yasuko Kitagish. PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review). International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28000847. |
parkinson's disease (pd) is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. |
2017-03-16 |
2023-08-13 |
Not clear |
| Veronne de Vrind, Jacqueline Scuvée-Moreau, Guillaume Drion, Cyrine Hmaied, Fabian Philippart, Dominique Engel, Vincent Seuti. Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels. European journal of pharmacology. vol 788. 2017-03-10. PMID:27364758. |
although small-conductance ca(2+)-activated k(+) (sk) channels and various types of voltage-gated ca(2+) (cav) channels have been described in midbrain dopaminergic neurons, the nature of their interactions is unclear. |
2017-03-10 |
2023-08-13 |
rat |
| Veronne de Vrind, Jacqueline Scuvée-Moreau, Guillaume Drion, Cyrine Hmaied, Fabian Philippart, Dominique Engel, Vincent Seuti. Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels. European journal of pharmacology. vol 788. 2017-03-10. PMID:27364758. |
we addressed this question using intracellular and extracellular recordings from substantia nigra, pars compacta (snc), dopaminergic neurons in rat midbrain slices. |
2017-03-10 |
2023-08-13 |
rat |
| Manjula Senthilkumaran, Michaela E Johnson, Larisa Bobrovskay. The Effects of Insulin-Induced Hypoglycaemia on Tyrosine Hydroxylase Phosphorylation in Rat Brain and Adrenal Gland. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:26935743. |
in this study we investigated the effects of insulin-induced hypoglycaemia on tyrosine hydroxylase (th) protein and th phosphorylation in the adrenal gland, c1 cell group, locus coeruleus (lc) and midbrain dopaminergic cell groups that are thought to play a role in response to hypoglycaemia and compared the effects of different concentrations of insulin in rats. |
2017-03-03 |
2023-08-13 |
rat |
| Manjula Senthilkumaran, Michaela E Johnson, Larisa Bobrovskay. The Effects of Insulin-Induced Hypoglycaemia on Tyrosine Hydroxylase Phosphorylation in Rat Brain and Adrenal Gland. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:26935743. |
in the brain, ser19 phosphorylation was limited to certain dopaminergic groups in the midbrain, while ser31 phosphorylation was increased in most catecholaminergic regions at 60 min (1.3-2 fold), suggesting that ser31 phosphorylation may be an important mechanism to maintain catecholamine synthesis in the brain. |
2017-03-03 |
2023-08-13 |
rat |
| Sandra Gómez-López, Ana Valeria Martínez-Silva, Teresa Montiel, Daniel Osorio-Gómez, Federico Bermúdez-Rattoni, Lourdes Massieu, Diana Escalante-Alcald. Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration. Scientific reports. vol 6. 2017-03-02. PMID:27063549. |
parkinson's disease (pd) is a multifactorial neurodegenerative disorder, characterised by the progressive loss of midbrain dopaminergic neurons and a variety of motor symptoms. |
2017-03-02 |
2023-08-13 |
mouse |
| H Chen, Z Song, L Yuan, W Xiong, Z Yang, L Gong, H Den. Genetic analysis of PITX3 variants in patients with essential tremor. Acta neurologica Scandinavica. vol 135. issue 3. 2017-02-27. PMID:27145793. |
the paired-like homeodomain transcription factor 3 gene (pitx3) has been shown to play an important role for the differentiation and survival of midbrain dopaminergic neurons in the substantia nigra pars compacta. |
2017-02-27 |
2023-08-13 |
Not clear |