| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerard W O'Keeffe, Michael Hanke, Jens Pohl, Aideen M Sulliva. Expression of growth differentiation factor-5 in the developing and adult rat brain. Brain research. Developmental brain research. vol 151. issue 1-2. 2004-09-27. PMID:15246706. |
expression of the dopaminergic neurotrophin gdf-5 in developing rat ventral mesencephalon (vm) was found to begin at embryonic day (e) 12 and peak on e14, when dopaminergic neurones undergo terminal differentiation. |
2004-09-27 |
2023-08-12 |
rat |
| Björn H Schott, Daniela B Sellner, Corinna-J Lauer, Reza Habib, Julietta U Frey, Sebastian Guderian, Hans-Jochen Heinze, Emrah Düze. Activation of midbrain structures by associative novelty and the formation of explicit memory in humans. Learning & memory (Cold Spring Harbor, N.Y.). vol 11. issue 4. 2004-09-23. PMID:15254215. |
recent evidence suggests a close functional relationship between memory formation in the hippocampus and dopaminergic neuromodulation originating in the ventral tegmental area and medial substantia nigra of the midbrain. |
2004-09-23 |
2023-08-12 |
human |
| David Gourion, Sophie Leroy, Marie-Chantal Bourdel, Céline Goldberger, Marie-France Poirier, Jean-Pierre Olié, Marie-Odile Kreb. Cerebellum development and schizophrenia: an association study of the human homeogene Engrailed 2. Psychiatry research. vol 126. issue 2. 2004-09-21. PMID:15123388. |
the homeogene engrailed 2 (en2) is specifically involved in patterning the region that gives rise to the cerebellum and controls the plasticity of midbrain dopaminergic neurons. |
2004-09-21 |
2023-08-12 |
human |
| Beth-Anne Sieber, Alexander Kuzmin, Josep M Canals, Anne Danielsson, Gustavo Paratcha, Ernest Arenas, Jordi Alberch, Sven Ove Ogren, Carlos F Ibáñe. Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine. Molecular and cellular neurosciences. vol 26. issue 3. 2004-09-17. PMID:15234346. |
together, these results reveal an unexpected role for epha/ephrin-a signaling in the normal connectivity and function of midbrain dopaminergic neurons. |
2004-09-17 |
2023-08-12 |
mouse |
| Tatiana M Korotkova, Alexei A Ponomarenko, Ritchie E Brown, Helmut L Haa. Functional diversity of ventral midbrain dopamine and GABAergic neurons. Molecular neurobiology. vol 29. issue 3. 2004-09-16. PMID:15181237. |
the electrophysiological properties of subgroups of gabaergic midbrain neurons, patterns of expression of protein markers and receptors, possible involvement of gabaergic neurons in a number of processes that are usually attributed exclusively to dopaminergic neurons, and the characteristics of a subgroup of neurons that contains both dopamine and gaba are also discussed. |
2004-09-16 |
2023-08-12 |
Not clear |
| David A Ballok, Aoife M Earls, Catherine Krasnik, Steven A Hoffman, Boris Saki. Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice. Journal of neuroimmunology. vol 152. issue 1-2. 2004-09-16. PMID:15223241. |
autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice. |
2004-09-16 |
2023-08-12 |
mouse |
| David A Ballok, Aoife M Earls, Catherine Krasnik, Steven A Hoffman, Boris Saki. Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice. Journal of neuroimmunology. vol 152. issue 1-2. 2004-09-16. PMID:15223241. |
damage of dopaminergic neurons was assessed by tyrosine-hydroxylase (th) staining of the midbrain. |
2004-09-16 |
2023-08-12 |
mouse |
| Yen Kuang Yang, Lung Yu, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, I Hui Le. Associated alterations of striatal dopamine D2/D3 receptor and transporter binding in drug-naive patients with schizophrenia: a dual-isotope SPECT study. The American journal of psychiatry. vol 161. issue 8. 2004-09-09. PMID:15285982. |
in vivo imaging studies have revealed deregulated presynaptic or postsynaptic function of the midbrain dopaminergic system in patients with schizophrenia. |
2004-09-09 |
2023-08-12 |
Not clear |
| Floriana Volpicelli, Claudia Consales, Massimiliano Caiazzo, Luca Colucci-D'Amato, Carla Perrone-Capano, Umberto di Porzi. Enhancement of dopaminergic differentiation in proliferating midbrain neuroblasts by sonic hedgehog and ascorbic acid. Neural plasticity. vol 11. issue 1-2. 2004-09-07. PMID:15303305. |
enhancement of dopaminergic differentiation in proliferating midbrain neuroblasts by sonic hedgehog and ascorbic acid. |
2004-09-07 |
2023-08-12 |
rat |
| Floriana Volpicelli, Claudia Consales, Massimiliano Caiazzo, Luca Colucci-D'Amato, Carla Perrone-Capano, Umberto di Porzi. Enhancement of dopaminergic differentiation in proliferating midbrain neuroblasts by sonic hedgehog and ascorbic acid. Neural plasticity. vol 11. issue 1-2. 2004-09-07. PMID:15303305. |
we analyzed the molecular mechanisms involved in the acquisition and maturation of dopaminergic (da) neurons generated in vitro from rat ventral mesencephalon (mes) cells in the presence of mitogens or specific signaling molecules. |
2004-09-07 |
2023-08-12 |
rat |
| Dong-Wook Ki. Efficient induction of dopaminergic neurons from embryonic stem cells for application to Parkinson's disease. Yonsei medical journal. vol 45 Suppl. 2004-08-17. PMID:15250046. |
for cell replacement therapy of neurodegenerative diseases such as parkinson's disease (pd), methods for efficiently generating midbrain dopaminergic (da) neurons from embryonic stem (es) cells have been investigated. |
2004-08-17 |
2023-08-12 |
Not clear |
| Eleni Roussa, Lilla M Farkas, Kerstin Krieglstei. TGF-beta promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8. Neurobiology of disease. vol 16. issue 2. 2004-08-13. PMID:15193287. |
here we show that transforming growth factor beta (tgf-beta) acts directly on rat e14 midbrain dopaminergic neurons in vitro, its survival-promoting effect being not mediated by bdnf, nt-3, or gdnf. |
2004-08-13 |
2023-08-12 |
rat |
| Eleni Roussa, Lilla M Farkas, Kerstin Krieglstei. TGF-beta promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8. Neurobiology of disease. vol 16. issue 2. 2004-08-13. PMID:15193287. |
neutralization of tgf-beta in vivo during chick e6-10 resulted in reduced number of midbrain dopaminergic neurons. |
2004-08-13 |
2023-08-12 |
rat |
| Ki Sook Park, Rhee Da Lee, Sun-Kyung Kang, Soon Young Han, Kui Lae Park, Ki Hwa Yang, Youn Sook Song, Hye Ji Park, Yoot Mo Lee, Yeo Pyo Yun, Ki Wan Oh, Dae Joong Kim, Young Won Yun, Se Jin Hwang, Sung Eun Lee, Jin Tae Hon. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. Experimental cell research. vol 297. issue 2. 2004-08-03. PMID:15212945. |
to expand our study, the effect of 15-deoxy-pgj(2) on the differentiation of embryonic midbrain cells into dopaminergic neuronal cells was investigated in this study. |
2004-08-03 |
2023-08-12 |
rat |
| Ki Sook Park, Rhee Da Lee, Sun-Kyung Kang, Soon Young Han, Kui Lae Park, Ki Hwa Yang, Youn Sook Song, Hye Ji Park, Yoot Mo Lee, Yeo Pyo Yun, Ki Wan Oh, Dae Joong Kim, Young Won Yun, Se Jin Hwang, Sung Eun Lee, Jin Tae Hon. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. Experimental cell research. vol 297. issue 2. 2004-08-03. PMID:15212945. |
the present results therefore indicate that 15-deoxy-pgj(2) stimulates differentiation of embryonic midbrain cells into dopaminergic neuronal cells, and its effect may be ppar-gamma and jnk signal pathway dependent. |
2004-08-03 |
2023-08-12 |
rat |
| Masami Ishido, Yoshinori Masuo, Manabu Kunimoto, Syuichi Oka, Masatoshi Morit. Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity. Journal of neuroscience research. vol 76. issue 3. 2004-07-29. PMID:15079872. |
we conclude that bisphenol a affected central dopaminergic system activity, resulting in hyperactivity due most likely to a large reduction of tyrosine hydroxylase activity in the midbrain. |
2004-07-29 |
2023-08-12 |
rat |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
nicotine reinforces smoking behaviour by activating nicotinic acetylcholine receptors in the midbrain dopaminergic reward centres. |
2004-07-22 |
2023-08-12 |
Not clear |
| Leu-Fen H Lin, Lee L Rubin, Mei X. A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189341. |
a non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. |
2004-07-22 |
2023-08-12 |
Not clear |
| Leu-Fen H Lin, Lee L Rubin, Mei X. A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189341. |
abstract a small organic molecule (cur-162590) that selectively enhances survival of midbrain dopaminergic neurons was identified by screening small molecule compound libraries. |
2004-07-22 |
2023-08-12 |
Not clear |
| Leu-Fen H Lin, Lee L Rubin, Mei X. A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons. Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189341. |
in embryonic midbrain cultures, cur-162590 increased dopamine uptake and the number of dopaminergic neurons without altering the number of total neurons or astroglia or the uptake of gaba or serotonin. |
2004-07-22 |
2023-08-12 |
Not clear |