| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Pozzi, Silvana Bertella, Erika Gatti, Gabriëlla G A M Peeters, Carla Carnovale, Stefania Zambrano, Maria Nobil. Emerging drugs for the treatment of attention-deficit hyperactivity disorder (ADHD). Expert opinion on emerging drugs. vol 25. issue 4. 2021-03-16. PMID:32938246. |
current pharmacological treatments for adhd are based on stimulant or non-stimulant medications, targeting dopaminergic and noradrenergic systems in the frontal cortex and dopaminergic system in the basal ganglia. |
2021-03-16 |
2023-08-13 |
Not clear |
| Tapan Behl, Gagandeep Kaur, Simona Bungau, Rishabh Jhanji, Arun Kumar, Vineet Mehta, Gokhan Zengin, Roxana Brata, Syed Shams Ul Hassan, Ovidiu Fratil. Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson's Disease: A Perspective on Associated Therapeutic Interventions. International journal of molecular sciences. vol 21. issue 17. 2021-02-24. PMID:32872273. |
endocannabinoids regulate the basal ganglia neuronal circuit pathways, synaptic plasticity, and motor functions via communication with dopaminergic, glutamatergic, and gabaergic signalling systems bidirectionally in pd. |
2021-02-24 |
2023-08-13 |
Not clear |
| Rafal Bogac. Dopamine role in learning and action inference. eLife. vol 9. 2021-02-22. PMID:32633715. |
in this framework, dopaminergic neurons projecting to different parts of the striatum encode errors in predictions made by the corresponding systems within the basal ganglia. |
2021-02-22 |
2023-08-13 |
Not clear |
| Ronghui Li, Xuxia Wang, Fuchun Lin, Tao Song, Xutao Zhu, Hao Le. Mapping accumulative whole-brain activities during environmental enrichment with manganese-enhanced magnetic resonance imaging. NeuroImage. vol 210. 2021-02-19. PMID:32004718. |
relative to the mice residing in a standard environment (se), the mice subjected to ee treatment had significantly enhanced regional memri signal intensities in the prefrontal cortex, somatosensory cortices, basal ganglia, amygdala, motor thalamus, lateral hypothalamus, ventral hippocampus and midbrain dopaminergic areas at the end of the 7-day exposure, likely attributing to enhanced mn |
2021-02-19 |
2023-08-13 |
mouse |
| Dimitri Ryczko, Swantje Grätsch, Michael H Alpert, Jackson J Cone, Jacquelin Kasemir, Angelina Ruthe, Philippe-Antoine Beauséjour, François Auclair, Mitchell F Roitman, Simon Alford, Réjean Dubu. Descending Dopaminergic Inputs to Reticulospinal Neurons Promote Locomotor Movements. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 44. 2021-02-01. PMID:32998974. |
meso-diencephalic dopaminergic neurons are known to modulate locomotor behaviors through their ascending projections to the basal ganglia, which in turn project to the mesencephalic locomotor region, known to control locomotion in vertebrates. |
2021-02-01 |
2023-08-13 |
Not clear |
| Fumiaki Yokoi, Janneth Oleas, Hong Xing, Yuning Liu, Kelly M Dexter, Carly Misztal, Melinda Gerard, Iakov Efimenko, Patrick Lynch, Matthew Villanueva, Raul Alsina, Shiv Krishnaswamy, David E Vaillancourt, Yuqing L. Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice. Neurobiology of disease. vol 134. 2021-01-13. PMID:31618684. |
d2r-expressing cells, such as the medium spiny neurons in the indirect pathway, striatal cholinergic interneurons, and dopaminergic neurons in the basal ganglia circuits, contribute to motor performance. |
2021-01-13 |
2023-08-13 |
mouse |
| Samuel Alberquilla, Aldo Gonzalez-Granillo, Eduardo Daniel Martín, Rosario Moratall. Dopamine regulates spine density in striatal projection neurons in a concentration-dependent manner. Neurobiology of disease. vol 134. 2021-01-13. PMID:31682992. |
dopaminergic afferents innervate spiny projection neurons (spns) in the striatum, maintaining basal ganglia activity. |
2021-01-13 |
2023-08-13 |
mouse |
| Qi-Wen Han, Yu-He Yuan, Nai-Hong Che. The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31442553. |
factors of the endocannabinoid system (ecs) are abundantly expressed in the neural circuits of basal ganglia, where they interact interactively with glutamatergic, γ-aminobutyric acid-ergic (gabaergic), and dopaminergic signaling systems. |
2021-01-04 |
2023-08-13 |
Not clear |
| Fillipe M de Araújo, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Silvia L Costa, Victor Diogenes A Silva, Maria Trinidad Herrer. Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy. Cellular and molecular neurobiology. 2021-01-02. PMID:33387119. |
parkinson's disease (pd) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the substantia nigra pars compacta (snpc) and deficit of dopamine in the basal ganglia. |
2021-01-02 |
2023-08-13 |
Not clear |
| Amnon A Berger, Ariel Winnick, Alexandra Welschmeyer, Alicia Kaneb, Kevin Berardino, Elyse M Cornett, Alan D Kaye, Omar Viswanath, Ivan Urit. Istradefylline to Treat Patients with Parkinson's Disease Experiencing "Off" Episodes: A Comprehensive Review. Neurology international. vol 12. issue 3. 2020-12-29. PMID:33302331. |
pd is caused by a loss of dopaminergic, cholinergic, serotonergic, and noradrenergic neurons in the central nervous system (cns), and peripherally; the syndromic parkinsonism symptoms of movement disorder, gait disorder, rigidity and tremor are mostly driven by the loss of these neurons in the basal ganglia. |
2020-12-29 |
2023-08-13 |
Not clear |
| Amnon A Berger, Ariel Winnick, Alexandra Welschmeyer, Alicia Kaneb, Kevin Berardino, Elyse M Cornett, Alan D Kaye, Omar Viswanath, Ivan Urit. Istradefylline to Treat Patients with Parkinson's Disease Experiencing "Off" Episodes: A Comprehensive Review. Neurology international. vol 12. issue 3. 2020-12-29. PMID:33302331. |
it promotes dopaminergic activity by antagonizing adenosine in the basal ganglia. |
2020-12-29 |
2023-08-13 |
Not clear |
| Hong-Yuan Ch. Synaptic and cellular plasticity in Parkinson's disease. Acta pharmacologica Sinica. vol 41. issue 4. 2020-12-21. PMID:32112041. |
accumulating evidence suggests that both dopaminergic degeneration and the associated abnormal cellular and circuit activity in the basal ganglia drive the motor symptoms of pd. |
2020-12-21 |
2023-08-13 |
Not clear |
| Roger L Albi. Tourette Syndrome as a Disorder of the Social Decision Making Network. Frontiers in psychiatry. vol 10. 2020-12-02. PMID:31649568. |
dopaminergic signaling within the basal ganglia component of the sdm may regulate social act motivation with the sbn component responsible for act expression. |
2020-12-02 |
2023-08-13 |
Not clear |
| Maximilian Kleimaker, Alexander Kleimaker, Anne Weissbach, Lorenza S Colzato, Christian Beste, Tobias Bäumer, Alexander Müncha. Non-invasive Brain Stimulation for the Treatment of Gilles de la Tourette Syndrome. Frontiers in neurology. vol 11. 2020-11-28. PMID:33244309. |
however, there is convincing evidence that structural and functional abnormalities in the basal ganglia, in cortico-striato-thalamo-cortical circuits, and some cortical areas including medial frontal regions and the prefrontal cortex as well as hyperactivity of the dopaminergic system are key findings. |
2020-11-28 |
2023-08-13 |
Not clear |
| Andrew F Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parma. hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease. Cell reports. vol 28. issue 13. 2020-10-19. PMID:31553914. |
hesc-derived dopaminergic transplants integrate into basal ganglia circuitry in a preclinical model of parkinson's disease. |
2020-10-19 |
2023-08-13 |
human |
| Dimitri Ryczko, Réjean Dubu. Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28603482. |
in pathological conditions where dopamine cells are lost, such as in parkinson's disease, locomotor deficits are traditionally associated with the reduced ascending dopaminergic input to the basal ganglia. |
2020-10-01 |
2023-08-13 |
human |
| Abir A Rahman, Nathan K Lai, Joshua E Albright, Paige E Urquhart, Abby R Webb, Brad E Morriso. Nigral dopaminergic neuron replenishment in adult mice through VE-cadherin-expressing neural progenitor cells. Neural regeneration research. vol 12. issue 11. 2020-10-01. PMID:29239333. |
the function of dopaminergic neurons in the substantia nigra is of central importance to the coordination of movement by the brain's basal ganglia circuitry. |
2020-10-01 |
2023-08-13 |
mouse |
| Yannick Vermeiren, Jana Janssens, Debby Van Dam, Peter P De Dey. Serotonergic Dysfunction in Amyotrophic Lateral Sclerosis and Parkinson's Disease: Similar Mechanisms, Dissimilar Outcomes. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29615862. |
similarly, disruption of the organized serotonergic control on complex mesencephalic dopaminergic connections between basal ganglia (bg) nuclei and across the bg-cortico-thalamic circuits, has shown to be closely involved in the onset of parkinsonian symptoms. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shu-Yin Xu, Qi-Lei Zhang, Qi Zhang, Lily Wan, Juan Jiang, Tian Tu, Jim Manavis, Aihua Pan, Yan Cai, Xiao-Xin Ya. Regional and Cellular Mapping of Sortilin Immunoreactivity in Adult Human Brain. Frontiers in neuroanatomy. vol 13. 2020-10-01. PMID:30914927. |
dopaminergic neurons in the substantia nigra, cholinergic neurons in the basal nuclei of meynert and noradrenergic neurons in the locus coeruleus co-expressed strong sortilin ir in double immunofluorescence. |
2020-10-01 |
2023-08-13 |
human |
| Chentao Wen, Yukiko Ogura, Toshiya Matsushim. Striatal and Tegmental Neurons Code Critical Signals for Temporal-Difference Learning of State Value in Domestic Chicks. Frontiers in neuroscience. vol 10. 2020-09-30. PMID:27877100. |
psychological studies of associative learning and neurophysiological analyses of dopaminergic neurons have suggested that this updating process involves the temporal-difference (td) method in the basal ganglia network. |
2020-09-30 |
2023-08-13 |
Not clear |