| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arianna Bellucci, Francesca Longhena, Maria Grazia Spillantin. The Role of Rab Proteins in Parkinson's Disease Synaptopathy. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009486. |
in patients affected by parkinson's disease (pd), the most common neurodegenerative movement disorder, the brain is characterized by the loss of dopaminergic neurons in the nigrostriatal system, leading to dyshomeostasis of the basal ganglia network activity that is linked to motility dysfunction. |
2022-08-26 |
2023-08-14 |
Not clear |
| Elissavet Akrioti, Timokratis Karamitros, Panagiotis Gkaravelas, Georgia Kouroupi, Rebecca Matsas, Era Taoufi. Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883433. |
neurodegeneration of dopamine neurons leads to a prominent dopaminergic deficiency in the basal ganglia, responsible for motor disturbances. |
2022-07-27 |
2023-08-14 |
Not clear |
| Winston W Liu, Diego V Bohórque. The neural basis of sugar preference. Nature reviews. Neuroscience. 2022-07-25. PMID:35879409. |
based on these and other data, we propose a model in which specific populations of vagal neurons relay these sensory cues to distinct sets of neurons in the brain, including neurons in the caudal nucleus of the solitary tract, dopaminergic reward circuits in the basal ganglia and homeostatic feeding circuits in the hypothalamus, that alter current and future sugar consumption. |
2022-07-25 |
2023-08-14 |
Not clear |
| Rosa Mastrogiacomo, Gabriella Trigilio, Céline Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A Rothmond, John L Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S Weickert, Francesca Managò, Francesco Papale. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular psychiatry. 2022-07-13. PMID:35821415. |
in agreement, dys1a disruption only in astrocytes resulted in decreased motivation and sensorimotor gating deficits, increased astrocytic dopamine d2 receptors and decreased dopaminergic tone within basal ganglia. |
2022-07-13 |
2023-08-14 |
mouse |
| Rosa Mastrogiacomo, Gabriella Trigilio, Céline Devroye, Daniel Dautan, Valentina Ferretti, Gabriele Losi, Lucia Caffino, Genny Orso, Roberto Marotta, Federica Maltese, Enrica Vitali, Gessica Piras, Alessia Forgiarini, Giada Pacinelli, Annamaria Lia, Debora A Rothmond, John L Waddington, Filippo Drago, Fabio Fumagalli, Maria Antonietta De Luca, Gian Marco Leggio, Giorgio Carmignoto, Cynthia S Weickert, Francesca Managò, Francesco Papale. Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular psychiatry. 2022-07-13. PMID:35821415. |
therefore, we started to show a hitherto unknown role for the dys1a isoform in astrocytic-related modulation of basal ganglia behavioral and dopaminergic phenotypes, with relevance to schizophrenia. |
2022-07-13 |
2023-08-14 |
mouse |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus. vol 14. issue 5. 2022-06-20. PMID:35719816. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-08-14 |
Not clear |
| Naohisa Ueda, Yuichi Higashiyama, Asami Saito, Katsuo Kimura, Yoshiharu Nakae, Masanao Endo, Hideto Joki, Chiharu Kugimoto, Hitaru Kishida, Hiroshi Doi, Hideyuki Takeuchi, Shigeru Koyano, Fumiaki Tanak. Relationship between motor learning and gambling propensity in Parkinson's disease. Journal of clinical and experimental neuropsychology. 2022-06-06. PMID:35658796. |
the basal ganglia and related dopaminergic cortical areas are important neural systems underlying motor learning and are also implicated in impulse control disorders (icds). |
2022-06-06 |
2023-08-14 |
Not clear |
| Miriam Schirru, Florence Véronneau-Veilleux, Fahima Nekka, Mauro Ursin. Phasic Dopamine Changes and Hebbian Mechanisms during Probabilistic Reversal Learning in Striatal Circuits: A Computational Study. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408811. |
the basal ganglia (bg) dopaminergic system, under a top-down control of the pre-frontal cortex, is known to be involved in flexible action selection through reinforcement learning. |
2022-04-12 |
2023-08-13 |
Not clear |
| Xiaodong Wang, Yinhao Wang, Jian Chen, Juan Li, Yang Liu, Wei Che. Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease. Experimental brain research. 2022-04-06. PMID:35384454. |
in parkinson's disease (pd) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (da) and glutamate (glu) levels change, resulting in dysfunction of basal ganglia motor regulation. |
2022-04-06 |
2023-08-13 |
mouse |
| Mehmet Nuri Kocak, Orhan Ates, Ahmet Hacımuftuoglu, Irem Ates, Erdal Tekin, Onur Ceylan, Ufuk Okka. Does Intravitreal Dopamine Agonist and Antagonist Administration Have Effects on the Brain? An Experimental Study in Rats. The Eurasian journal of medicine. vol 54. issue 1. 2022-03-21. PMID:35307630. |
in this context, the study was aimed to investigate the possible interaction between the retina and basal ganglia through the dopaminergic system. |
2022-03-21 |
2023-08-13 |
rat |
| Mengya Wang, Huayuan Liu, Zegang M. Roles of the Cannabinoid System in the Basal Ganglia in Parkinson's Disease. Frontiers in cellular neuroscience. vol 16. 2022-03-10. PMID:35264932. |
however, ecb regulation is complex, with diverse cannabinoid receptor functions and the presence of dopaminergic, glutamatergic, and γ-aminobutyric signals interacting with cannabinoid signaling in the basal ganglia region. |
2022-03-10 |
2023-08-13 |
Not clear |
| Michiel F Dirkx, Matteo Bologn. The pathophysiology of Parkinson's disease tremor. Journal of the neurological sciences. vol 435. 2022-03-03. PMID:35240491. |
clinical and experimental observations suggest that tremor in pd cannot be interpreted merely as an expression of dopaminergic denervation of the basal ganglia. |
2022-03-03 |
2023-08-13 |
Not clear |
| Patricia Rodrigo Armenteros, Solange Kapetanovic, Sonia Gonzalez Lopez, Enrique Vazquez-Lorenzo, Lander Anton Mendez, Juan Jose Gomez Muga, Edison Santos Morales Deza, Markel Erburu Iriarte, Juan Carlos Garcia-Monc. Pearls & Oy-sters: Arteriovenous Malformation With Sinus Thrombosis and Thalamic Hemorrhage: Unusual Cause of Parkinsonism and Dementia. Neurology. 2022-02-05. PMID:35121672. |
parkinsonism occasionally occurs when there is basal ganglia involvement.we report a case of a 78-year-old male who presented with a rapidly progressive parkinsonism with poor response to dopaminergic therapy. |
2022-02-05 |
2023-08-13 |
Not clear |
| Débora Masini, Ole Kieh. Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism. Nature communications. vol 13. issue 1. 2022-01-27. PMID:35082287. |
these motor actions are deficient in parkinson's disease (pd), where dopaminergic neurodegeneration alters basal ganglia activity. |
2022-01-27 |
2023-08-13 |
mouse |
| Dorota Frydecka, Błażej Misiak, Patryk Piotrowski, Tomasz Bielawski, Edyta Pawlak, Ewa Kłosińska, Maja Krefft, Kamila Al Noaimy, Joanna Rymaszewska, Ahmed A Moustafa, Jarosław Drapał. The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders. Brain sciences. vol 12. issue 1. 2022-01-21. PMID:35053751. |
schizophrenia spectrum disorders (sz) are characterized by impairments in probabilistic reinforcement learning (rl), which is associated with dopaminergic circuitry encompassing the prefrontal cortex and basal ganglia. |
2022-01-21 |
2023-08-13 |
human |
| Sandeep Sathyanandan Nair, Vignayanandam Ravindernath Muddapu, V Srinivasa Chakravarth. A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions. Frontiers in computational neuroscience. vol 15. 2022-01-20. PMID:35046787. |
the model demonstrates how differential dopaminergic axonal degeneration in basal ganglia results in various cardinal symptoms of pd. |
2022-01-20 |
2023-08-13 |
Not clear |
| Robert Lalonde, Catherine Straziell. Neurochemical anatomy of dorsal and tonic immobility responses. Pharmacology, biochemistry, and behavior. 2022-01-13. PMID:35026175. |
the neurochemical basis of the dir appears to pass through the basal ganglia via dopaminergic fibers, while the neurochemical basis of the tir appears to include a circuit comprising the amygdala, the periaqueductal gray (pag), the dorsal raphe, and the nucleus magnus raphe (nmr) via glutamatergic, serotonergic, cholinergic, gabaergic, and opioid fibers. |
2022-01-13 |
2023-08-13 |
Not clear |
| Aviv D Mizrahi-Kliger, Lucia K Feldmann, Andrea A Kuhn, Hagai Bergma. Etiologies of insomnia in Parkinson's disease - Lessons from human studies and animal models. Experimental neurology. 2022-01-13. PMID:35026228. |
we start by outlining the phenomenology of pd insomnia and continue to analyze the evidence supporting insomnia as emanating from four distinct subdivisions of etiologies - the symptoms and comorbidities of the disease, the medical therapy, the degeneration of non-dopaminergic cell groups and subsequent alterations in circadian rhythms, and the degeneration of dopaminergic neurons in the brainstem and its resulting effect on the basal ganglia. |
2022-01-13 |
2023-08-13 |
human |
| Patrick D Skelton, Valerie Tokars, Loukia Parisiado. LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights. Cells. vol 11. issue 1. 2022-01-11. PMID:35011731. |
the lessons learned from improving our understanding of the pathogenic effects of lrrk2 mutations in striatal neurons will be applicable to both dissecting the cell-type specificity of lrrk2 function in the transcriptionally diverse subtypes of dopaminergic neurons and also increasing our understanding of basal ganglia development and biology. |
2022-01-11 |
2023-08-13 |
Not clear |
| Lan-Hsin Nancy Lee, Chen-Syuan Huang, Hsiang-Hao Chuang, Hsing-Jung Lai, Cheng-Kai Yang, Ya-Chin Yang, Chung-Chin Ku. An electrophysiological perspective on Parkinson's disease: symptomatic pathogenesis and therapeutic approaches. Journal of biomedical science. vol 28. issue 1. 2021-12-10. PMID:34886870. |
parkinson's disease (pd), or paralysis agitans, is a common neurodegenerative disease characterized by dopaminergic deprivation in the basal ganglia because of neuronal loss in the substantia nigra pars compacta. |
2021-12-10 |
2023-08-13 |
Not clear |