| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Uriya Bekenstein, Nibha Mishra, Dan Z Milikovsky, Geula Hanin, Daniel Zelig, Liron Sheintuch, Amit Berson, David S Greenberg, Alon Friedman, Hermona Sore. Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 25. 2018-05-04. PMID:28584127. |
dynamic changes in murine forebrain mir-211 expression associate with cholinergic imbalances and epileptiform activity. |
2018-05-04 |
2023-08-13 |
mouse |
| Uriya Bekenstein, Nibha Mishra, Dan Z Milikovsky, Geula Hanin, Daniel Zelig, Liron Sheintuch, Amit Berson, David S Greenberg, Alon Friedman, Hermona Sore. Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 25. 2018-05-04. PMID:28584127. |
here, we report that dynamic changes in forebrain microrna (mir)-211 in the mouse brain shift the threshold for spontaneous and pharmacologically induced seizures alongside changes in the cholinergic pathway genes, implicating this mir in the avoidance of seizures. |
2018-05-04 |
2023-08-13 |
mouse |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
in alzheimer's disease there is an extensive loss of forebrain cholinergic neurons accompanied by a reduction of the cholinergic fiber network of the cortical mantel and hippocampus. |
2018-04-26 |
2023-08-13 |
Not clear |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
conversely, in parkinson's disease, the midpontine nuclei degenerate, together with the dopaminergic nuclei, reducing the cholinergic input to thalamus and forebrain whereas the forebrain cholinergic neurons are spared. |
2018-04-26 |
2023-08-13 |
Not clear |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
in parkinson's disease with dementia, lewis body dementia and parkinsonian syndromes both groups of forebrain and midpontine cholinergic nuclei degenerate. |
2018-04-26 |
2023-08-13 |
Not clear |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
evidences indicate that β-amyloid disrupts ngf metabolism causing the degeneration of the cholinergic neurons which depend on ngf for their survival, namely the forebrain cholinergic neurons, sparing the midpontine and striatal neurons which express no specific ngf receptors. |
2018-04-26 |
2023-08-13 |
Not clear |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
attention and learning and memory impairment are the functional consequences of the forebrain cholinergic neuron dysfunction, whereas the loss of midpontine cholinergic neurons results primarily in motor and sleep disturbances. |
2018-04-26 |
2023-08-13 |
Not clear |
| A Diez-Garcia, M Garzo. [Regulation of the phases of the sleep-wakefulness cycle with histamine]. Revista de neurologia. vol 64. issue 6. 2018-04-17. PMID:28272728. |
interactions among histaminergic axons and cholinergic nuclei within forebrain and brainstem are particularly important for cortical activation. |
2018-04-17 |
2023-08-13 |
mouse |
| Glenn R Yamakawa, Priyoneel Basu, Filomeno Cortese, Johanna MacDonnell, Danica Whalley, Victoria M Smith, Michael C Antl. The cholinergic forebrain arousal system acts directly on the circadian pacemaker. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 47. 2018-03-30. PMID:27821764. |
the cholinergic forebrain arousal system acts directly on the circadian pacemaker. |
2018-03-30 |
2023-08-13 |
Not clear |
| Mohammed A Al-Onaizi, Gustavo M Parfitt, Benjamin Kolisnyk, Clayton S H Law, Monica S Guzman, Daniela Martí Barros, L Stan Leung, Marco A M Prado, Vania F Prad. Regulation of Cognitive Processing by Hippocampal Cholinergic Tone. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 2. 2018-03-06. PMID:26803167. |
disrupted forebrain cholinergic signaling also affected working memory, a result reproduced by selectively decreasing vacht in the hippocampus. |
2018-03-06 |
2023-08-13 |
mouse |
| Aaron Kucinski, Inge E M de Jong, Martin Sarte. Reducing falls in Parkinson's disease: interactions between donepezil and the 5-HT The European journal of neuroscience. vol 45. issue 2. 2018-02-06. PMID:27469080. |
falling in pd has been attributed to degeneration of forebrain cholinergic neurons that, in interaction with striatal dopamine losses, impairs the cognitive control of balance, gait, and movement. |
2018-02-06 |
2023-08-13 |
rat |
| Kristen A McLaurin, Rosemarie M Booze, Charles F Mactutu. Selective developmental alterations in The HIV-1 transgenic rat: Opportunities for diagnosis of pediatric HIV-1. Journal of neurovirology. vol 23. issue 1. 2018-02-06. PMID:27538996. |
hiv-1 tg animals exhibited a shift in the development of locomotor activity implicating alterations in the maturation of the forebrain cholinergic inhibitory system. |
2018-02-06 |
2023-08-13 |
rat |
| Natalia Bobkova, Vasily Vorobyov, Natalia Medvinskaya, Inna Nesterova, Olga Tatarnikova, Pavel Nekrasov, Alexander Samokhin, Alexander Deev, Frank Sengpiel, Dmitry Koroev, Olga Volpin. Immunization Against Specific Fragments of Neurotrophin p75 Receptor Protects Forebrain Cholinergic Neurons in the Olfactory Bulbectomized Mice. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-24. PMID:27163825. |
immunization against specific fragments of neurotrophin p75 receptor protects forebrain cholinergic neurons in the olfactory bulbectomized mice. |
2018-01-24 |
2023-08-13 |
mouse |
| Natalia Bobkova, Vasily Vorobyov, Natalia Medvinskaya, Inna Nesterova, Olga Tatarnikova, Pavel Nekrasov, Alexander Samokhin, Alexander Deev, Frank Sengpiel, Dmitry Koroev, Olga Volpin. Immunization Against Specific Fragments of Neurotrophin p75 Receptor Protects Forebrain Cholinergic Neurons in the Olfactory Bulbectomized Mice. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-24. PMID:27163825. |
obx-mice have been shown in previous studies, and confirmed in the present one, to be characterized by typical behavioral, morphological, and biochemical ad hallmarks, including cholinergic deficits in forebrain neurons. |
2018-01-24 |
2023-08-13 |
mouse |
| Juan Mena-Segovi. Structural and functional considerations of the cholinergic brainstem. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 7. 2018-01-23. PMID:26945862. |
this review focuses on recent findings that suggest an intrinsic functional organization of the cholinergic brainstem that is closely correlated with its connectivity with midbrain and forebrain circuits. |
2018-01-23 |
2023-08-13 |
Not clear |
| Paul M McKeever, TaeHyung Kim, Andrew R Hesketh, Laura MacNair, Denise Miletic, Giorgio Favrin, Stephen G Oliver, Zhaolei Zhang, Peter St George-Hyslop, Janice Robertso. Cholinergic neuron gene expression differences captured by translational profiling in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 57. 2018-01-03. PMID:28628896. |
to explore the molecular basis of this cholinergic dysfunction, we paired translating ribosome affinity purification (trap) with rna sequencing (trap-seq) to identify the actively translating mrnas in anterior forebrain cholinergic neurons in the tgcrnd8 mouse model of ad. |
2018-01-03 |
2023-08-13 |
mouse |
| Linda Patia Spea. Consequences of adolescent use of alcohol and other drugs: Studies using rodent models. Neuroscience and biobehavioral reviews. vol 70. 2017-10-19. PMID:27484868. |
persisting alterations in forebrain systems critical for modulating reward, socioemotional processing and cognition have emerged, including apparent induction of a hyper-dopaminergic state with some drugs and/or attenuations in neurons expressing cholinergic markers. |
2017-10-19 |
2023-08-13 |
Not clear |
| b' Zsuzsanna Bard\\xc3\\xb3czi, Bal\\xc3\\xa1zs P\\xc3\\xa1l, \\xc3\\x81ron K\\xc5\\x91szeghy, Tam\\xc3\\xa1s Wilheim, Masahiko Watanabe, L\\xc3\\xa1szl\\xc3\\xb3 Z\\xc3\\xa1borszky, Zsolt Liposits, Imre Kall\\xc3\\xb. Glycinergic Input to the Mouse Basal Forebrain Cholinergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 39. 2017-10-10. PMID:28874448.' |
the basal forebrain (bf) receives afferents from brainstem ascending pathways, which has been implicated first by moruzzi and magoun (1949) to induce forebrain activation and cortical arousal/waking behavior; however, it is very little known about how brainstem inhibitory inputs affect cholinergic functions. |
2017-10-10 |
2023-08-13 |
mouse |
| Inga Antyborzec, Valerie B O'Leary, James O Dolly, Saak V Ovsepia. Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 13. issue 4. 2017-09-22. PMID:27220617. |
while discriminatory provision of neuroprotective agents and trophic factors to these cells is thought to be of substantial therapeutic potential, the intricate topography and structure of the forebrain cholinergic system imposes a major challenge. |
2017-09-22 |
2023-08-13 |
rat |
| Martin Engel, Dzung Do-Ha, Sonia Sanz Muñoz, Lezanne Oo. Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research. Cellular and molecular life sciences : CMLS. vol 73. issue 19. 2017-08-04. PMID:27154043. |
we have analyzed the literature that describes differentiation of human pluripotent stem cells into three neural cell types that are commonly used to study diseases, including forebrain cholinergic neurons for alzheimer's disease, midbrain dopaminergic neurons for parkinson's disease and cortical astrocytes for neurodegenerative and psychiatric disorders. |
2017-08-04 |
2023-08-13 |
human |