| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tae-Kyeong Lee, Sung-Su Kim, Ji-Won Lee, Dae Won Kim, Jae-Chul Lee, Jong-Dai Kim, Soo Young Choi, Seongkweon Hong, Moo-Ho Won, Yang Hee Ki. Brain Factor-7® Improves Cognitive Impairment Following Transient Ischemia and Reperfusion Injury in Gerbil Forebrain through Promoting Remyelination and Restoring Cholinergic and Glutamatergic Neurotransmission in the Hippocampus. Frontiers in bioscience (Landmark edition). vol 27. issue 12. 2023-01-10. PMID:36624955. |
brain factor-7® improves cognitive impairment following transient ischemia and reperfusion injury in gerbil forebrain through promoting remyelination and restoring cholinergic and glutamatergic neurotransmission in the hippocampus. |
2023-01-10 |
2023-08-14 |
Not clear |
| Xinyan Li, Hongyan Yu, Bing Zhang, Lanfang Li, Wenting Chen, Quntao Yu, Xian Huang, Xiao Ke, Yunyun Wang, Wei Jing, Huiyun Du, Hao Li, Tongmei Zhang, Liang Liu, Ling-Qiang Zhu, Youming L. Molecularly defined and functionally distinct cholinergic subnetworks. Neuron. 2022-09-21. PMID:36130594. |
cholinergic neurons in the medial septum (ms) constitute a major source of cholinergic input to the forebrain and modulate diverse functions, including sensory processing, memory, and attention. |
2022-09-21 |
2023-08-14 |
Not clear |
| Andres Carrasco, Dorothy E Oorschot, Paolo Barzaghi, Jeffery R Wicken. Three-Dimensional Spatial Analyses of Cholinergic Neuronal Distributions Across The Mouse Septum, Nucleus Basalis, Globus Pallidus, Nucleus Accumbens, and Caudate-Putamen. Neuroinformatics. 2022-07-06. PMID:35792992. |
despite robust evidence of functional implications in the modulation of cognition, little is known about the three-dimensional internal organization of cholinergic networks in the forebrain. |
2022-07-06 |
2023-08-14 |
mouse |
| Andres Carrasco, Dorothy E Oorschot, Paolo Barzaghi, Jeffery R Wicken. Three-Dimensional Spatial Analyses of Cholinergic Neuronal Distributions Across The Mouse Septum, Nucleus Basalis, Globus Pallidus, Nucleus Accumbens, and Caudate-Putamen. Neuroinformatics. 2022-07-06. PMID:35792992. |
cholinergic networks in the forebrain primarily occur in subcortical nuclei, specifically the septum, nucleus basalis, globus pallidus, nucleus accumbens, and the caudate-putamen. |
2022-07-06 |
2023-08-14 |
mouse |
| Andres Carrasco, Dorothy E Oorschot, Paolo Barzaghi, Jeffery R Wicken. Three-Dimensional Spatial Analyses of Cholinergic Neuronal Distributions Across The Mouse Septum, Nucleus Basalis, Globus Pallidus, Nucleus Accumbens, and Caudate-Putamen. Neuroinformatics. 2022-07-06. PMID:35792992. |
therefore, the present investigation analyzed the three-dimensional spatial organization of 14,000 cholinergic neurons that expressed choline acetyltransferase (chat) in these subcortical nuclei of the mouse forebrain. |
2022-07-06 |
2023-08-14 |
mouse |
| Andres Carrasco, Dorothy E Oorschot, Paolo Barzaghi, Jeffery R Wicken. Three-Dimensional Spatial Analyses of Cholinergic Neuronal Distributions Across The Mouse Septum, Nucleus Basalis, Globus Pallidus, Nucleus Accumbens, and Caudate-Putamen. Neuroinformatics. 2022-07-06. PMID:35792992. |
this information is important for future digital cellular atlases and computational models of the forebrain cholinergic system enabling models based on actual spatial geometry. |
2022-07-06 |
2023-08-14 |
mouse |
| Sudhirkumar Yanpallewar, Francesco Tomassoni-Ardori, Mary Ellen Palko, Zhenyi Hong, Erkan Kiris, Jodi Becker, Gianluca Fulgenzi, Lino Tessaroll. TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior. Translational psychiatry. vol 12. issue 1. 2022-03-18. PMID:35301275. |
this strategy leads to increased levels of the marker of cholinergic activation, acetylcholine synthesizing enzyme choline acetyltransferase, in forebrain cholinergic regions and their projection areas such as the hippocampus. |
2022-03-18 |
2023-08-13 |
mouse |
| Donald E Moss, Ruth G Pere. Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: Nexus of cholinergic and nerve growth factor dysfunction. Current Alzheimer research. 2021-12-16. PMID:34911424. |
recent randomized, placebo-controlled studies have shown volume losses of ~0.7% and ~3.5% per year, respectively, in the basal cholinergic forebrain (cbf) and hippocampus in untreated suspected prodromal ad. |
2021-12-16 |
2023-08-13 |
Not clear |
| John F Smiley, Cynthia Bleiwas, Stefanie Canals-Baker, Sharifa Z Williams, Robert Sears, Catia M Teixeira, Donald A Wilson, Mariko Sait. Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals. Alcohol (Fayetteville, N.Y.). vol 97. 2021-12-07. PMID:34464696. |
reduction of cholinergic and gabaergic projection neurons from the basal forebrain that regulate forebrain arousal may contribute to the behavioral and cognitive deficits associated with neonatal ethanol exposure. |
2021-12-07 |
2023-08-13 |
mouse |
| Saravanan Subramaniam, David T Blake, Christos Constantinidi. Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders. Journal of Alzheimer's disease : JAD. vol 83. issue 2. 2021-11-18. PMID:34334401. |
the selection of stimulation target is critical, and structures that have been targeted for memory and cognitive enhancement include the papez circuit, structures projecting to the frontal lobe such as the ventral internal capsule, and the cholinergic forebrain. |
2021-11-18 |
2023-08-13 |
human |
| Saravanan Subramaniam, David T Blake, Christos Constantinidi. Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders. Journal of Alzheimer's disease : JAD. vol 83. issue 2. 2021-11-18. PMID:34334401. |
high-frequency, continuous stimulation is used for movement disorders as a way of inhibiting their output; however, no overexcitation has been hypothesized in alzheimer's disease and lower stimulation frequency or intermittent patterns of stimulation (periods of stimulation interleaved with periods of no stimulation) are likely to be more effective for stimulation of the cholinergic forebrain. |
2021-11-18 |
2023-08-13 |
human |
| Margherita Zaupa, Seyedeh Maryam Alavi Naini, Maroun Abi Younes, Erika Bullier, Erik R Duboué, Hervé Le Corronc, Hédi Soula, Sebastien Wolf, Raphaël Candelier, Pascal Legendre, Marnie E Halpern, Jean-Marie Mangin, Elim Hon. Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway. Current biology : CB. vol 31. issue 21. 2021-11-11. PMID:34529937. |
the evolutionarily conserved forebrain to midbrain habenulo-interpeduncular nucleus (hb-ipn) pathway consists of cholinergic and non-cholinergic neurons, which mediate different aversive behaviors. |
2021-11-11 |
2023-08-13 |
Not clear |
| Frances J Northington, Panagiotis Kratimenos, Victoria Turnbill, Debra L Flock, Daniella Asafu-Adjaye, Raul Chavez-Valdez, Lee J Marti. Basal forebrain magnocellular cholinergic systems are damaged in mice following neonatal hypoxia-ischemia. The Journal of comparative neurology. 2021-11-03. PMID:34687459. |
after neonatal hi, abnormalities were found throughout the major cholinergic systems in relationship to amount of forebrain area loss. |
2021-11-03 |
2023-08-13 |
mouse |
| Luiz M Oliveira, Ana C Takakura, Thiago S Moreir. Forebrain and Hindbrain Projecting-neurons Target the Post-inspiratory Complex Cholinergic Neurons. Neuroscience. vol 476. 2021-11-01. PMID:34582982. |
forebrain and hindbrain projecting-neurons target the post-inspiratory complex cholinergic neurons. |
2021-11-01 |
2023-08-13 |
Not clear |
| N I Bohnen, C W Bogan, M L T M Mülle. Frontal and periventricular brain white matter lesions and cortical deafferentation of cholinergic and other neuromodulatory axonal projections. European neurological journal. vol 1. issue 1. 2021-10-21. PMID:22763426. |
such cognitive symptoms have been explained by strategically located white matter lesions in the deep forebrain that may disrupt cholinergic projection fibers at their proximal origin. |
2021-10-21 |
2023-08-12 |
Not clear |
| N I Bohnen, C W Bogan, M L T M Mülle. Frontal and periventricular brain white matter lesions and cortical deafferentation of cholinergic and other neuromodulatory axonal projections. European neurological journal. vol 1. issue 1. 2021-10-21. PMID:22763426. |
a unique anatomic feature common to all cortical projections from subcortical neuromodulator systems (that not only include the cholinergic but also the monoaminergic systems, such as dopamine, serotonin, and norepinephrine) is that the proximal axons largely pass through the deep forebrain before fanning out to the cortex. |
2021-10-21 |
2023-08-12 |
Not clear |
| Evan P Lebois, Thomas M Bridges, L Michelle Lewis, Eric S Dawson, Alexander S Kane, Zixiu Xiang, Satyawan B Jadhav, Huiyong Yin, J Phillip Kennedy, Jens Meiler, Colleen M Niswender, Carrie K Jones, P Jeffrey Conn, C David Weaver, Craig W Lindsle. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. ACS chemical neuroscience. vol 1. issue 2. 2021-10-20. PMID:21961051. |
cholinergic transmission in the forebrain is mediated primarily by five subtypes of muscarinic acetylcholine receptors (machrs), termed m(1)-m(5). |
2021-10-20 |
2023-08-12 |
Not clear |
| Ornela Kljakic, Mohammed Al-Onaizi, Helena Janíčková, Kevin S Chen, Monica S Guzman, Marco A M Prado, Vania F Prad. Cholinergic transmission from the basal forebrain modulates social memory in male mice. The European journal of neuroscience. vol 54. issue 6. 2021-09-24. PMID:34308559. |
in this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter-the protein that regulates acetylcholine secretion. |
2021-09-24 |
2023-08-13 |
mouse |
| Xue-Lian Qi, Ruifeng Liu, Balbir Singh, David Bestue, Albert Compte, Almira I Vazdarjanova, David T Blake, Christos Constantinidi. Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity. Cell reports. vol 36. issue 5. 2021-08-27. PMID:34348147. |
our results indicate that stimulation of the cholinergic forebrain increases prefrontal neural activity, and this neuromodulatory tone can improve cognitive performance, subject to a stability-accuracy tradeoff. |
2021-08-27 |
2023-08-13 |
human |
| Behroo Mirza Agha, Roya Akbary, Arashk Ghasroddashti, Mojtaba Nazari-Ahangarkolaee, Ian Q Whishaw, Majid H Mohajeran. Cholinergic upregulation by optogenetic stimulation of nucleus basalis after photothrombotic stroke in forelimb somatosensory cortex improves endpoint and motor but not sensory control of skilled reaching in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 7. 2021-08-20. PMID:33103935. |
a network of cholinergic neurons in the basal forebrain innerve the forebrain and are proposed to contribute to a variety of functions including cortical plasticity, attention, and sensorimotor behavior. |
2021-08-20 |
2023-08-13 |
mouse |