| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Vivian Allahyari, Nicolette M Heinsinger, Daniel Hwang, David A Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J Thomas, Theodore J Price, Abdolmohamad Rostami, Angelo C Lepor. Response of Astrocyte Subpopulations Following Spinal Cord Injury. Cells. vol 11. issue 4. 2022-02-25. PMID:35203371. |
finally, we confirmed these astrocyte subpopulations are also present in the human spinal cord in a similar distribution as mouse, suggesting possible conservation of spinal cord astrocyte heterogeneity across species. |
2022-02-25 |
2023-08-13 |
mouse |
| Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Ghazal Haghi, Anna Kristyna Franco Flores, Guy Rouleau, Thomas M Durcan, Stefano Stifan. Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease. Cells. vol 11. issue 3. 2022-02-15. PMID:35159209. |
human ipsc-derived astrocytes with ventral spinal cord features offer advantages over more generic astrocyte preparations for the study of both ventral spinal cord astrocyte biology and the involvement of astrocytes in mechanisms of lower motor neuron degeneration in als. |
2022-02-15 |
2023-08-13 |
human |
| Hai-Yang Liao, Zhi-Qiang Wang, Chao-Ming Da, Kai-Sheng Zhou, Hai-Hong Zhan. Ski regulates proliferation and migration of reactive astrocytes induced by lipopolysaccharide (LPS) through PI3K/Akt pathway. Journal of neuroimmunology. vol 364. 2022-01-10. PMID:35007896. |
ski is a novel molecule that regulates the biological characteristics of astrocytes after spinal cord injury, but its function and the exact mechanism of its overexpression in reactive astrocyte proliferation and migration after sci remain unclear. |
2022-01-10 |
2023-08-13 |
Not clear |
| Chao-Ming Da, Hai-Yang Liao, Yin-Shuan Deng, Guang-Hai Zhao, Lin Ma, Hai-Hong Zhan. Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro. Neuroscience. vol 479. 2021-12-07. PMID:34687796. |
the upstream regulation mechanism of astrocyte proliferation was explored to further regulate the formation of glial scar in specific time and space after spinal cord injury. |
2021-12-07 |
2023-08-13 |
Not clear |
| Ekin Su Akdemir, Junsung Woo, Navish A Bosquez Huerta, Brittney Lozzi, Andrew K Groves, Akdes Serin Harmanci, Benjamin Denee. Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021-12-07. PMID:34872929. |
here we show that the lunatic fringe-gfp (lfng-gfp) bacteria artificial chromosome mouse line from both sexes specifically labels astrocyte populations within lamina iii and iv of the dorsal spinal cord. |
2021-12-07 |
2023-08-13 |
mouse |
| Xiaowei Qian, Ge Lin, Junpei Wang, Siming Zhang, Jingyi Ma, Bin Yu, Ronghua Wu, Mei Li. CircRNA_01477 influences axonal growth via regulating miR-3075/FosB/Stat3 axis. Experimental neurology. vol 347. 2021-12-03. PMID:34699790. |
we investigated the differential expression profiles of circrna induced by spinal cord injury and reported that circrna_01477 facilitates spinal astrocyte proliferation and migration after injury in rats. |
2021-12-03 |
2023-08-13 |
rat |
| Bailey Balouch, Jessica L Funnell, Alexis M Ziemba, Devan L Puhl, Kathy Lin, Manoj K Gottipati, Ryan J Gilber. Conventional immunomarkers stain a fraction of astrocytes in vitro: A comparison of rat cortical and spinal cord astrocytes in naïve and stimulated cultures. Journal of neuroscience research. vol 99. issue 3. 2021-11-23. PMID:33295039. |
we found that only sox9 in cortical cultures and aldh1l1 in spinal cord cultures labeled more than 75% of the cells in naïve and stimulated astrocyte cultures and stained less than 5% of the cells in microglia and oligodendrocyte cultures. |
2021-11-23 |
2023-08-13 |
rat |
| Reza Nasrnezhad, Sohrab Halalkhor, Farzin Sadeghi, Fereshteh Pourabdolhossei. Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34338970. |
luxol fast blue and h&e staining and immunostaining of lumbar spinal cord cross sections confirmed that piperine significantly reduced the extent of demyelination, inflammation, immune cell infiltration, microglia, and astrocyte activation. |
2021-11-18 |
2023-08-13 |
rat |
| Ruihua Fan, Yong Zhang, Benson O A Botchway, Xuehong Li. Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34410605. |
resveratrol can attenuate astrocyte activation to treat spinal cord injury by inhibiting inflammatory responses. |
2021-11-18 |
2023-08-13 |
Not clear |
| Giulia Panattoni, Roberta Amoriello, Christian Memo, Agnes Thalhammer, Clara Ballerini, Laura Ballerin. Diverse inflammatory threats modulate astrocytes Ca Molecular brain. vol 14. issue 1. 2021-11-18. PMID:34696792. |
to explore spinal cord astrocyte reactivity to inflammatory threats we focused our study on the effects of local inflammation in a controlled micro-environment, the organotypic spinal slices, developed from the spinal cord of mouse embryos. |
2021-11-18 |
2023-08-13 |
mouse |
| Orest Tsymbalyuk, Volodymyr Gerzanich, Aaida Mumtaz, Sanketh Andhavarapu, Svetlana Ivanova, Tapas K Makar, Charles A Sansur, Asaf Keller, Yumiko Nakamura, Joseph Bryan, J Marc Simar. SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury. Molecular pain. vol 17. 2021-11-17. PMID:33788643. |
neuropathic pain following peripheral nerve injury (pni) is linked to neuroinflammation in the spinal cord marked by astrocyte activation and upregulation of interleukin 6 (il |
2021-11-17 |
2023-08-13 |
mouse |
| Malte Borggrewe, Corien Grit, Ilia D Vainchtein, Nieske Brouwer, Evelyn M Wesseling, Jon D Laman, Bart J L Eggen, Susanne M Kooistra, Erik W G M Boddek. Regionally diverse astrocyte subtypes and their heterogeneous response to EAE. Glia. vol 69. issue 5. 2021-11-16. PMID:33332631. |
to extensively characterize astrocyte subtypes, we facs-isolated and gene expression profiled distinct astrocyte subtypes from three central nervous system regions; forebrain, hindbrain and spinal cord. |
2021-11-16 |
2023-08-13 |
mouse |
| Yining Zhang, Tingting Meng, Jianan Chen, Ying Zhang, Jianning Kang, Xinyu Li, Guilian Yu, Lige Tian, Zhengxin Jin, Hui Dong, Xiaodi Zhang, Bin Nin. miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway. International journal of biological sciences. vol 17. issue 11. 2021-11-12. PMID:34345208. |
mir-21a-5p promotes inflammation following traumatic spinal cord injury through upregulation of neurotoxic reactive astrocyte (a1) polarization by inhibiting the cntf/stat3/nkrf pathway. |
2021-11-12 |
2023-08-13 |
Not clear |
| Yining Zhang, Tingting Meng, Jianan Chen, Ying Zhang, Jianning Kang, Xinyu Li, Guilian Yu, Lige Tian, Zhengxin Jin, Hui Dong, Xiaodi Zhang, Bin Nin. miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway. International journal of biological sciences. vol 17. issue 11. 2021-11-12. PMID:34345208. |
previous studies demonstrated that microrna(mir)-21a-5p was up-regulated in spinal cord tissue after tsci; however, it is not clear whether this affected reactive astrocyte polarization. |
2021-11-12 |
2023-08-13 |
Not clear |
| Christian König, Enrique Vazquez, Sabrina Eß, Matthias Ebbinghaus, Björn Vorpahl, Andrea Ebersberger, Hans-Georg Schaibl. Spinal interleukin-1β induces mechanical spinal hyperexcitability in rats: Interactions and redundancies with TNF and IL-6. Journal of neurochemistry. vol 158. issue 4. 2021-11-11. PMID:34050952. |
we recorded the responses of spinal cord neurons to mechanical stimulation of the knee joint in vivo and used cellular approaches on microglial and astroglial cell lines to identify interactions of il-1β, tnf, and il-6. |
2021-11-11 |
2023-08-13 |
rat |
| Yupeng Wang, Jia Ma, Haoxiao Chang, Xinghu Zhang, Linlin Yi. Efficacy of mycophenolate mofetil in the treatment of neuromyelitis optica spectrum disorders: An update systematic review and meta -analysis. Multiple sclerosis and related disorders. vol 55. 2021-10-19. PMID:34365314. |
neuromyelitis optica spectrum disorders (nmosd) is an autoimmune astrocyte disease that mainly affects the optic nerve and spinal cord resulting in blindness or paralysis. |
2021-10-19 |
2023-08-13 |
Not clear |
| Arens Taga, Christa W Habela, Alexandra Johns, Shiyu Liu, Mollie O'Brien, Nicholas J Maragaki. Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons. Journal of visualized experiments : JoVE. issue 174. 2021-10-15. PMID:34515684. |
it was previously demonstrated that the presence of hipsc-a that are differentiated using techniques to promote a spinal cord astrocyte phenotype improved maturation and electrophysiological activity of regionally specific spinal cord hipsc-motor neurons (mn) when compared to those cultured without hipsc-a or in the presence of rodent astrocytes. |
2021-10-15 |
2023-08-13 |
human |
| Jian Li, Zhiqiang Jia, Qiangqiang Zhang, Junyu Dai, Jundong Kong, Zhongkai Fan, Gang L. Inhibition of ERK1/2 phosphorylation attenuates spinal cord injury induced astrocyte activation and inflammation through negatively regulating aquaporin-4 in rats. Brain research bulletin. vol 170. 2021-10-07. PMID:33592275. |
inhibition of erk1/2 phosphorylation attenuates spinal cord injury induced astrocyte activation and inflammation through negatively regulating aquaporin-4 in rats. |
2021-10-07 |
2023-08-13 |
rat |
| Sudhirkumar Yanpallewar, Gianluca Fulgenzi, Francesco Tomassoni-Ardori, Colleen Barrick, Lino Tessaroll. Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous. Experimental neurology. vol 337. 2021-09-13. PMID:33359475. |
here we show that trkb.t1 is expressed ubiquitously in the spinal cord and its deletion does not change the sod1 mutant spinal cord inflammatory state suggesting that trkb.t1 does not influence microglia or astrocyte activation. |
2021-09-13 |
2023-08-13 |
human |
| Pengzhi Li, Yawei Li, Yuliang Dai, Bing Wang, Lei Li, Bin Jiang, Pengfei Wu, Jietao X. The LncRNA H19/miR-1-3p/CCL2 axis modulates lipopolysaccharide (LPS) stimulation-induced normal human astrocyte proliferation and activation. Cytokine. vol 131. 2021-09-08. PMID:32371379. |
reactive astrocyte proliferation post sci (spinal cord injury) leads to the formation of glial scars, thus hindering axon regeneration and sci repair, during which the activation of astrocytes plays a central role. |
2021-09-08 |
2023-08-13 |
human |