| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiah Shin Chin, Ulla Milbreta, David L Becker, Sing Yian Che. Targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury. Journal of tissue engineering. vol 14. 2023-02-17. PMID:36798907. |
targeting connexin 43 expression via scaffold mediated delivery of antisense oligodeoxynucleotide preserves neurons, enhances axonal extension, reduces astrocyte and microglial activation after spinal cord injury. |
2023-02-17 |
2023-08-14 |
rat |
| Ji Hyeon Ahn, Tae-Kyeong Lee, Dae Won Kim, Myoung Cheol Shin, Jun Hwi Cho, Jae-Chul Lee, Hyun-Jin Tae, Joon Ha Park, Seongkweon Hong, Choong-Hyun Lee, Moo-Ho Won, Yang Hee Ki. Therapeutic Hypothermia after Cardiac Arrest Attenuates Hindlimb Paralysis and Damage of Spinal Motor Neurons and Astrocytes through Modulating Nrf2/HO-1 Signaling Pathway in Rats. Cells. vol 12. issue 3. 2023-02-11. PMID:36766758. |
taken together, our results indicate that hypothermic therapy after ca/rosc attenuates ca-induced hindlimb paralysis by protecting motor neurons in the lumbar spinal cord via activating the nrf2/ho-1 signaling pathway and attenuating pro-inflammation and astrocyte damage (reactive astrogliosis). |
2023-02-11 |
2023-08-14 |
rat |
| Xin Lin, Yang Yang, Ye Ji, Guangxi Wang, Wenbo Xu, Bo Wang, Hangyu Guo, Jiyu Ren, Jinglong Yan, Nanxiang Wan. MiR-135a-5p/SP1 axis regulates spinal astrocyte proliferation and migration. Neuroscience. 2023-02-10. PMID:36764602. |
following spinal cord injury (sci), astrocyte activation and proliferation result in the development of glial scars, which impede axonal growth and neurological recovery. |
2023-02-10 |
2023-08-14 |
Not clear |
| Shuai Ouyang, Xianbin Wang, Yan Chen, Luoyi Deng, Xianglian Yang, Shouxing Hu, Shuang W. Swimming training combined with fecal microbial transplantation protects motor functions in rats with spinal cord injury by improving the intestinal system. Neuroscience letters. 2023-02-09. PMID:36758789. |
in addition, combined interventions significantly suppressed inflammatory factor levels (p<0.05) in the colon and spinal cords and significantly protected forefoot motor neurons (neun) in the spinal cord injury area, inhibiting astrocyte activation and reducing the expressions of the signature glial fibrillary acidic protein (gfap) and markers of microglia (iba-1) at the lesion site(p<0.05). |
2023-02-09 |
2023-08-14 |
rat |
| Liming He, Qiang Chang, Yannan Zhang, Xiaoming Guan, Zhuo Ma, Xu Chen, Wenbo Liu, Yakun Li, Haoyu Fen. MiR-155-5p Aggravated Astrocyte Activation and Glial Scarring in a Spinal Cord Injury Model by Inhibiting Ndfip1 Expression and PTEN Nuclear Translocation. Neurochemical research. 2023-02-07. PMID:36750528. |
mir-155-5p aggravated astrocyte activation and glial scarring in a spinal cord injury model by inhibiting ndfip1 expression and pten nuclear translocation. |
2023-02-07 |
2023-08-14 |
rat |
| Katarzyna Pawlik, Katarzyna Ciapała, Agata Ciechanowska, Klaudia Kwiatkowski, Joanna Mik. Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain. Cells. vol 12. issue 1. 2023-01-08. PMID:36611891. |
in the present comprehensive behavioral and biochemical study, we detected significant time-dependent and long-lasting increases in the mrna levels of ccr1 and/or ccr3 ligands, such as ccl2/3/4/5/6/7/8/9, in the murine spinal cord after chronic constriction injury of the sciatic nerve, and these increases were accompanied by changes in the levels of microglial/macrophage, astrocyte and neutrophil cell markers. |
2023-01-08 |
2023-08-14 |
mouse |
| Tingting Fan, Ying Yu, Yong-Long Chen, Pan Gu, Stanley Wong, Zheng-Yuan Xia, Jessica Aijia Liu, Chi-Wai Cheun. Histone deacetylase 5-induced deficiency of signal transducer and activator of transcription-3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy. Glia. 2022-12-29. PMID:36579750. |
our work identifies the inhibitory axis of hdac5-stat3 induced astrocyte deficiency as a key mechanism underlying the pathogenesis of the diabetic spinal cord that paves the way for potential therapy development for pdn. |
2022-12-29 |
2023-08-14 |
rat |
| Maria Pechlivanidou, Ioanna Kousiappa, Stella Angeli, Irene Sargiannidou, Andreas M Koupparis, Savvas S Papacostas, Kleopas A Kleop. Glial Gap Junction Pathology in the Spinal Cord of the 5xFAD Mouse Model of Early-Onset Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555237. |
the aim of this study was to examine the alterations in astrocyte and related oligodendrocyte gjs in association with aβ plaques in the spinal cord of the 5xfad mouse model of ad. |
2022-12-23 |
2023-08-14 |
mouse |
| Chen Chen, Huiyuan Ji, Nan Jiang, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu, Yongjun Wang, Aihong Li, Aisong Gu. Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury. Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453421. |
however, whether the abnormal astrocyte cholesterol metabolism induced by spinal cord injury contributes to the production of 25-hc, as well as the resulting pathological effects, remain unclear. |
2022-12-01 |
2023-08-14 |
rat |
| Chen Chen, Huiyuan Ji, Nan Jiang, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu, Yongjun Wang, Aihong Li, Aisong Gu. Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury. Neural regeneration research. vol 18. issue 6. 2022-12-01. PMID:36453421. |
in the present study, spinal cord injury-induced activation of thrombin was found to increase astrocyte ch25h expression. |
2022-12-01 |
2023-08-14 |
rat |
| Yumeng Ding, Liye Hu, Xiaotong Wang, Qingyu Sun, Tingting Hu, Jing Liu, Danmin Shen, Yurui Zhang, Wen Chen, Chao Wei, Meng Liu, Dianxin Liu, Peipei Wang, Chenguang Zhang, Jiannan Zhang, Qian Li, Fei Yan. The contribution of spinal dorsal horn astrocytes in neuropathic pain at the early stage of EAE. Neurobiology of disease. 2022-11-04. PMID:36332813. |
in this study, we demonstrated that spinal dorsal horn astrocytes were activated in the pre-clinical stage of eae mice, and the inhibition of spinal cord astrocyte reactivity effectively alleviates pain symptoms in eae mice. |
2022-11-04 |
2023-08-14 |
mouse |
| Siyi Liu, Ge Lin, Qiao Yang, Penghui Wang, Chao Ma, Xiaowei Qian, Xiaomei He, Zhangji Dong, Yan Liu, Mei Liu, Ronghua Wu, Liu Yan. Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury. CNS neuroscience & therapeutics. 2022-10-26. PMID:36286186. |
depletion of sash1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury. |
2022-10-26 |
2023-08-14 |
Not clear |
| Dan Zhao, Ye Zhang, Ya Zheng, Xu-Tong Li, Cheng-Cheng Sun, Qi Yang, Qing Xie, Dong-Sheng X. Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254994. |
double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation. |
2022-10-18 |
2023-08-14 |
rat |
| Dan Zhao, Ye Zhang, Ya Zheng, Xu-Tong Li, Cheng-Cheng Sun, Qi Yang, Qing Xie, Dong-Sheng X. Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254994. |
results showed that in the injured spinal cord, the expression of the astrocyte marker glial fibrillary acidic protein and inflammatory factors interleukin 1β, interleukin-6, and tumor necrosis factor-α had decreased, whereas that of neuronal survival marker microtubule-associated protein 2 and synaptic plasticity markers postsynaptic densification protein 95 and synaptophysin protein had increased. |
2022-10-18 |
2023-08-14 |
rat |
| Dan Zhao, Ye Zhang, Ya Zheng, Xu-Tong Li, Cheng-Cheng Sun, Qi Yang, Qing Xie, Dong-Sheng X. Double-target neural circuit-magnetic stimulation improves motor function in spinal cord injury by attenuating astrocyte activation. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254994. |
these findings suggest that double-target neural circuit-magnetic stimulation improves rat motor function by attenuating astrocyte activation, thus providing a theoretical basis for application of double-target neural circuit-magnetic stimulation in the clinical treatment of spinal cord injury. |
2022-10-18 |
2023-08-14 |
rat |
| Gang Chen, Jing Xu, Hao Luo, Xin Luo, Sandeep K Singh, Juan J Ramirez, Michael L James, Joseph P Mathew, Miles Berger, Cagla Eroglu, Ru-Rong J. Sparcl1/Hevin drives pathological pain through spinal cord astrocyte and NMDA receptor signaling. JCI insight. 2022-10-18. PMID:36256481. |
sparcl1/hevin drives pathological pain through spinal cord astrocyte and nmda receptor signaling. |
2022-10-18 |
2023-08-14 |
mouse |
| Yongyuan Zhang, Xiaohui Wang, Chao Jiang, Zhe Chen, Shuangyang Ni, Hong Fan, Zhiyuan Wang, Fang Tian, Jing An, Hao Yang, Dingjun Ha. Correction: Rho Kinase Inhibitor Y27632 Improves Recovery After Spinal Cord Injury by Shifting Astrocyte Phenotype and Morphology via the ROCK/NF-?B/C3 Pathway. Neurochemical research. 2022-10-16. PMID:36244038. |
correction: rho kinase inhibitor y27632 improves recovery after spinal cord injury by shifting astrocyte phenotype and morphology via the rock/nf-?b/c3 pathway. |
2022-10-16 |
2023-08-14 |
Not clear |
| Yong-Long Chen, Xiang-Lan Feng, Chi-Wai Cheung, Jessica Aijia Li. Mode of action of astrocytes in pain: from the spinal cord to the brain. Progress in neurobiology. 2022-10-13. PMID:36228888. |
multiple astrocyte subsets and diversified activation states driven by intrinsic and extrinsic cues have recently been identified in the spinal cord and brain, playing complex roles in pain development and resolution. |
2022-10-13 |
2023-08-14 |
Not clear |
| Jiajun Cai, Jundong Kong, Song Ma, Yaozu Ban, Jian Li, Zhongkai Fa. Upregulation of TRPC6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing AQP4 expression. Brain research bulletin. 2022-09-17. PMID:36115513. |
upregulation of trpc6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing aqp4 expression. |
2022-09-17 |
2023-08-14 |
rat |
| Jiajun Cai, Jundong Kong, Song Ma, Yaozu Ban, Jian Li, Zhongkai Fa. Upregulation of TRPC6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing AQP4 expression. Brain research bulletin. 2022-09-17. PMID:36115513. |
this work investigates the effects and mechanisms of inhibiting trpc6 (a non-selective cation channel) downregulation on rat astrocyte activation and proliferation following spinal cord injury (sci) by suppressing aqp4 expression. |
2022-09-17 |
2023-08-14 |
rat |