| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Glennon, M Lee, J B Rangisetty, M Dukat, B L Roth, J E Savage, A McBride, L Rauser, S Hufeisen, D K Le. 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. Journal of medicinal chemistry. vol 43. issue 5. 2000-04-13. PMID:10715164. |
2-substituted tryptamines: agents with selectivity for 5-ht(6) serotonin receptors. |
2000-04-13 |
2023-08-12 |
human |
| R A Glennon, M Lee, J B Rangisetty, M Dukat, B L Roth, J E Savage, A McBride, L Rauser, S Hufeisen, D K Le. 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. Journal of medicinal chemistry. vol 43. issue 5. 2000-04-13. PMID:10715164. |
2-substituted tryptamines, then, might allow entry to a novel class of 5-ht(6) agonists and antagonists. |
2000-04-13 |
2023-08-12 |
human |
| P Brown, M E Mollive. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-03-09. PMID:10684896. |
the results demonstrate that two functionally different 5-ht projections innervate separate regions of the nac and that selective vulnerability to amphetamines may result from differential expression of sert. |
2000-03-09 |
2023-08-12 |
rat |
| U E Busto, L A Zawertailo, H L Kaplan, E M Seller. Identifying appropriate subjects for abuse liability studies using prestudy pharmacological testing. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique. vol 6. issue 2. 1999-11-22. PMID:10519736. |
using this prescreening methodology has allowed sensitive and reliable data on the abuse liability of benzodiazepine agonists and partial agonists, barbiturates, carbamate compounds, amphetamines, selective serotonin reuptake inhibitors and prescription opiate compounds to be generated using a nondrug abusing population. |
1999-11-22 |
2023-08-12 |
human |
| D S Segal, R Kuczensk. Escalating dose-binge treatment with methylphenidate: role of serotonin in the emergent behavioral profile. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490882. |
in the present study, we explored the generality of these effects by using an escalating-dose, multibinge treatment with methylphenidate (mp), a stimulant that, unlike the amphetamines, produces no increase in serotonin transmission. |
1999-10-12 |
2023-08-12 |
rat |
| S Ramamoorthy, R D Blakel. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science (New York, N.Y.). vol 285. issue 5428. 1999-08-16. PMID:10427004. |
ligands that can permeate the transporter, such as serotonin or the amphetamines, prevented pkc-dependent sert phosphorylation. |
1999-08-16 |
2023-08-12 |
Not clear |
| X Wu, H H G. Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. Gene. vol 233. issue 1-2. 1999-08-05. PMID:10375632. |
cocaine and amphetamines, widely used drugs of abuse, bind to dopamine (da), serotonin, and norepinephrine transporters with high affinity and block their functions. |
1999-08-05 |
2023-08-12 |
mouse |
| R D Blakely, S Ramamoorthy, S Schroeter, Y Qian, S Apparsundaram, A Galli, L J DeFelic. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biological psychiatry. vol 44. issue 3. 1998-11-06. PMID:9693389. |
although we have been aware for decades that sert-mediated 5-ht clearance can be modulated by exogenous agents including serotonin-selective reuptake inhibitors, amphetamines, and cocaine, we have had little reason to speculate that sert activity was actively controlled through endogenous pathways. |
1998-11-06 |
2023-08-12 |
Not clear |
| G Huether, D Zhou, E Rüthe. Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451711. |
the severity of these acute systemic responses is closely related to the severity of the long-term damage to 5-ht axon terminals caused by the administration of substituted amphetamines. |
1998-02-26 |
2023-08-12 |
human |
| G Huether, D Zhou, E Rüthe. Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451711. |
substituted amphetamines selectively tax energy metabolism in 5-ht presynapses through their ability to exchange with 5-ht and to dissipate transmembrane ion gradients. |
1998-02-26 |
2023-08-12 |
human |
| G Huether, D Zhou, E Rüthe. Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451711. |
the resulting energy deficit can no longer adequately restored by the 5-ht presynapses when their availability of substrates for atp production is additionally reduced by the hyperthermic and other energy consuming reactions which are elicited by the systemic administration of substituted amphetamines. |
1998-02-26 |
2023-08-12 |
human |
| M P Johnson, D B Wainscott, V L Lucaites, M Baez, D L Nelso. Mutations of transmembrane IV and V serines indicate that all tryptamines do not bind to the rat 5-HT2A receptor in the same manner. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387857. |
two mutations of the rat serotonin 5-ht2a receptor were made, expressed and examined for their ability to bind and be stimulated by certain tryptamines as well as their ability to bind antagonists. |
1998-02-11 |
2023-08-12 |
rat |
| D M Kuhn, R Arthu. Molecular mechanism of the inactivation of tryptophan hydroxylase by nitric oxide: attack on critical sulfhydryls that spare the enzyme iron center. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 19. 1997-10-15. PMID:9295371. |
the results are interpreted with reference to the substituted amphetamines, which are neurotoxic to 5-ht neurons, that inactivate tph in vivo and are now known to produce no and other reactive oxygen species in vivo. |
1997-10-15 |
2023-08-12 |
Not clear |
| J Goldhill, M F Porquet, I Ange. Post-synaptic 5-HT4 receptor modulation of tachykinergic excitation of rat oesophageal tunica muscularis mucosae. European journal of pharmacology. vol 323. issue 2-3. 1997-06-16. PMID:9128843. |
substance p- (in the presence of atropine) and carbachol-precontracted tissue was relaxed by tryptamines and the substituted benzamides with the following rank order of potency: 5-ht > 5-methoxytryptamine > cisapride > (r)-zacopride > lintopride > metoclopramide, consistent with 5-ht4 receptor activation. |
1997-06-16 |
2023-08-12 |
rat |
| D Zhou, M Schreinert, J Pilz, G Huethe. Rat strain differences in the vulnerability of serotonergic nerve endings to neurotoxic damage by p-chloroamphetamine. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 12. 1997-05-15. PMID:9029405. |
substituted amphetamines are known to selectively destroy serotonin (5-ht) nerve endings in distant projection fields of the dorsal raphe nuclei and the systemic administration of these drugs is widely used in investigations of the role of the central 5-ht system and of the mechanisms involved in their toxicity. |
1997-05-15 |
2023-08-12 |
rat |
| M G Reich, D Razav. [Role of amphetamines in cancerology : a review of the literature]. Bulletin du cancer. vol 83. issue 11. 1997-03-06. PMID:9033598. |
amphetamines may also be a therapeutic option, alone or in association with antidepressant drugs, in the pharmacological management of mood disorders unresponsive to tricyclics or selective serotonin reuptake inhibitors. |
1997-03-06 |
2023-08-12 |
Not clear |
| R Luthringer, M Toussaint, N Schaltenbrand, P Bailey, P H Danjou, D Hackett, J Y Guichoux, J P Mache. A double-blind, placebo-controlled evaluation of the effects of orally administered venlafaxine on sleep in inpatients with major depression. Psychopharmacology bulletin. vol 32. issue 4. 1997-02-12. PMID:8993085. |
venlafaxine, a member of a novel chemical class, phenethylamines, is a new antidepressant that inhibits neuronal uptake of serotonin, norepinephrine, and dopamine (in decreasing order of potency) at doses of 75 to 375 mg per day. |
1997-02-12 |
2023-08-12 |
human |
| M Sparago, J Wlos, J Yuan, G Hatzidimitriou, J Tolliver, T A Dal Cason, J Katz, G Ricaurt. Neurotoxic and pharmacologic studies on enantiomers of the N-methylated analog of cathinone (methcathinone): a new drug of abuse. The Journal of pharmacology and experimental therapeutics. vol 279. issue 2. 1996-12-24. PMID:8930215. |
additional studies were done with rats, because mice are often refractory to 5-ht neurotoxicity induced by amphetamines. |
1996-12-24 |
2023-08-12 |
mouse |
| L S Seiden, K E Sabo. Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction. NIDA research monograph. vol 163. 1996-12-10. PMID:8809863. |
methamphetamine and mdma as well as similar substituted phenethylamines are toxic to da and/or 5-ht neurons. |
1996-12-10 |
2023-08-12 |
rat |
| R G TABORSKY, W M MCISAA. THE SYNTHESIS AND PRELIMINARY PHARMACOLOGY OF SOME 9H-PYRIDO(3,4-B)INDOLES (BETA-CARBOLINES) AND TRYPTAMINES RELATED TO SEROTONIN AND MELATONIN. Journal of medicinal chemistry. vol 7. 1996-12-01. PMID:14187363. |
the synthesis and preliminary pharmacology of some 9h-pyrido(3,4-b)indoles (beta-carbolines) and tryptamines related to serotonin and melatonin. |
1996-12-01 |
2023-08-12 |
Not clear |