| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S J Peroutka, P J Ison, D U Liu, R W Barret. Artifactual high-affinity and saturable binding of [3H]5-hydroxytryptamine induced by radioligand oxidation. Journal of neurochemistry. vol 47. issue 1. 1986-07-23. PMID:3711910. |
drug competition studies reveal that the apparent specific "[3h]5-ht binding" in the absence of ascorbate appears to be displaced by nanomolar concentrations of hydroxylated tryptamines (5-ht, bufotenine) but not by nonhydroxylated tryptamines (5-methoxytryptamine, tryptamine). |
1986-07-23 |
2023-08-11 |
rat |
| G Ricaurte, G Bryan, L Strauss, L Seiden, C Schuste. Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Science (New York, N.Y.). vol 229. issue 4717. 1985-09-25. PMID:4023719. |
these results show that mda has toxic activity for serotonin neurons in rats and raise the question of whether exposure to mda and related hallucinogenic amphetamines can produce serotonin neurotoxicity in the human brain. |
1985-09-25 |
2023-08-11 |
human |
| D Hoffmann, W Weseman. Characterization of 5-hydroxytryptamine binding sites in the plasma membrane of pig blood platelets. Journal of neural transmission. vol 61. issue 3-4. 1985-06-19. PMID:3157778. |
with the exception of tryptamines little or no (3h)5-ht was displaced by serotonin antagonists and uptake inhibitors suggesting another type of binding than that of 5-ht1. |
1985-06-19 |
2023-08-11 |
rat |
| P Nencini, A M Ahmed, M C Anania, M Moscucci, E Parol. Prolonged analgesia induced by cathinone. The role of stress and opioid and nonopioid mechanisms. Pharmacology. vol 29. issue 5. 1984-12-13. PMID:6093160. |
both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by reserpine or p-chlorophenylalanine, which deplete catecholamines or serotonin, respectively, and by nomifensine, which prevents neuronal uptake of biogenic amines and amphetamines. |
1984-12-13 |
2023-08-12 |
rat |
| G A Ricaurte, L S Seiden, C R Schuste. Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers. Brain research. vol 303. issue 2. 1984-08-30. PMID:6744029. |
dopamine, norepinephrine and serotonin determinations two weeks later indicated that both amphetamines produced a selective striatal dopamine depletion. |
1984-08-30 |
2023-08-12 |
rat |
| A P De Jong, F Huggins, D Fournier, A Makriyanni. Inhibition of [3H]5-HT binding to rat brain membranes by psychotomimetic amphetamines. European journal of pharmacology. vol 83. issue 3-4. 1983-02-14. PMID:7173311. |
inhibition of [3h]5-ht binding to rat brain membranes by psychotomimetic amphetamines. |
1983-02-14 |
2023-08-12 |
rat |
| R A Glennon, J M Jacyno, J J Salle. 2,3-dihydro and carbocyclic analogues of tryptamines: interaction with serotonin receptors. Journal of medicinal chemistry. vol 25. issue 1. 1982-08-07. PMID:7086824. |
2,3-dihydro and carbocyclic analogues of tryptamines: interaction with serotonin receptors. |
1982-08-07 |
2023-08-12 |
rat |
| R R Guio. Possible interactions between alkoxy amphetamines and brain serotonin receptors. Journal of theoretical biology. vol 91. issue 1. 1982-01-28. PMID:7300385. |
possible interactions between alkoxy amphetamines and brain serotonin receptors. |
1982-01-28 |
2023-08-12 |
Not clear |
| P Seeman, K Westman, D Coscina, J J Wars. Serotonin receptors in hippocampus and frontal cortex. European journal of pharmacology. vol 66. issue 2-3. 1981-02-24. PMID:7439270. |
in the calf frontal cortex, serotonin revealed a biphasic inhibition against 3h-d-lsd binding and the tryptamines inhibited over a concentration range of 10 000-fold. |
1981-02-24 |
2023-08-12 |
rat |
| R S Sloviter, J D Connor, B P Damiano, E G Drus. Para-halogenated phenethylamines: similar serotonergic effects in rats by different mechanisms. Pharmacology, biochemistry, and behavior. vol 13. issue 2. 1980-11-24. PMID:6447879. |
the serotonin (5-ht) behavioral syndrome in rats served as a model to test for possible acute serotonergic effects of para-halogenated phenethylamines. |
1980-11-24 |
2023-08-12 |
rat |
| R S Sloviter, J D Connor, B P Damiano, E G Drus. Para-halogenated phenethylamines: similar serotonergic effects in rats by different mechanisms. Pharmacology, biochemistry, and behavior. vol 13. issue 2. 1980-11-24. PMID:6447879. |
taken as a group, para-halogenated phenethylamines are short-acting serotonergic compounds which, unlike p-chloroamphetamine, do not produce long-lasting depletion of brain 5-ht. |
1980-11-24 |
2023-08-12 |
rat |
| S B Ross, A L As. Structural requirements for uptake into serotoninergic neurones. Acta pharmacologica et toxicologica. vol 46. issue 4. 1980-06-25. PMID:7368945. |
experiments were performed to examine whether non-hydroxylated tryptamines and 4-chloroamphetamine utilize the membrane 5-hydroxytryptamine carrier to pass into serotoninergic neurones. |
1980-06-25 |
2023-08-12 |
mouse |
| S B Ross, A L As. Structural requirements for uptake into serotoninergic neurones. Acta pharmacologica et toxicologica. vol 46. issue 4. 1980-06-25. PMID:7368945. |
these results do not support the hypothesis that non-hydroxylated tryptamines and 4-chloroamphetamine are transported by the 5-ht carrier. |
1980-06-25 |
2023-08-12 |
mouse |
| H Komulainen, J Tuomisto, M M Airaksinen, I Kari, P Peura, L Pollar. Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin, dopamine and noradrenaline uptake in rat brain synaptosomes. Acta pharmacologica et toxicologica. vol 46. issue 4. 1980-06-25. PMID:7368949. |
tetrahydro-beta-carbolines and corresponding tryptamines: in vitro inhibition of serotonin, dopamine and noradrenaline uptake in rat brain synaptosomes. |
1980-06-25 |
2023-08-12 |
rat |
| H Komulainen, J Tuomisto, M M Airaksinen, I Kari, P Peura, L Pollar. Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin, dopamine and noradrenaline uptake in rat brain synaptosomes. Acta pharmacologica et toxicologica. vol 46. issue 4. 1980-06-25. PMID:7368949. |
the structure activity relationships of tryptolines and some other beta-carbolines and tryptamines as inhibitors of serotonin (5-ht), dopamine (da) and noradrenaline (na) uptake were studied in rat brain synaptosomes. |
1980-06-25 |
2023-08-12 |
rat |
| M M Airaksinen, H Svensk, J Tuomisto, H Komulaine. Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin and dopamine uptake by human blood platelets. Acta pharmacologica et toxicologica. vol 46. issue 4. 1980-06-25. PMID:7368950. |
tetrahydro-beta-carbolines and corresponding tryptamines: in vitro inhibition of serotonin and dopamine uptake by human blood platelets. |
1980-06-25 |
2023-08-12 |
human |
| M M Airaksinen, H Svensk, J Tuomisto, H Komulaine. Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin and dopamine uptake by human blood platelets. Acta pharmacologica et toxicologica. vol 46. issue 4. 1980-06-25. PMID:7368950. |
tetrahydro-beta-carbolines (thbcs), 6-methoxyharmalan and norharman and the corresponding open chain tryptamines studied inhibited t-hydroxytrypere better inhibitors of da than 5-ht uptake but thbcs generally were far more potent inhibitors of 5-ht uptake than of da uptake. |
1980-06-25 |
2023-08-12 |
human |
| D E Nichols, R Woodard, B A Hathaway, M T Lowy, K W Yo. Resolution and absolute configuration of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, a potent hallucinogen analogue. Journal of medicinal chemistry. vol 22. issue 4. 1979-06-29. PMID:430485. |
in view of the stereoselective ability of the (-) isomer to elicit hallucinogen-like behavioral profiles in these animal models, the proof of absolute configuration lends further support to a new model which interrelates the active binding, conformation of phenethylamine hallucinogens to that of serotonin and tryptamines. |
1979-06-29 |
2023-08-11 |
mouse |
| P M Whitaker, P Seema. Selective labeling of serotonin receptors by d-[3H]lysergic acid diethylamide in calf caudate. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 12. 1979-03-13. PMID:32537. |
various ergots had approximately equal ic50 values against [3h]serotonin and [3h]lsd but tryptamines were much more selective against [3h]serotonin; the data may indicate the existence of the two types of serotonin receptors. |
1979-03-13 |
2023-08-11 |
Not clear |
| U H Lindberg, S O Thorberg, A L Renyi, S B Ross, S O Ogre. Inhibitors of neuronal monoamine uptake. I. Selective inhibition of 5-hydroxytryptamine uptake by alpha-aminoacid amides of phenethylamines. Acta pharmaceutica Suecica. vol 15. issue 2. 1978-09-30. PMID:676761. |
selective inhibition of 5-hydroxytryptamine uptake by alpha-aminoacid amides of phenethylamines. |
1978-09-30 |
2023-08-11 |
Not clear |