| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Rudnick, S C Wal. The platelet plasma membrane serotonin transporter catalyzes exchange between neurotoxic amphetamines and serotonin. Annals of the New York Academy of Sciences. vol 648. 1992-08-21. PMID:1637068. |
the platelet plasma membrane serotonin transporter catalyzes exchange between neurotoxic amphetamines and serotonin. |
1992-08-21 |
2023-08-11 |
Not clear |
| U V Berger, X F Gu, J W van Lange, E C Azmiti. Evidence for a common mechanism of serotonin release induced by substituted amphetamines in vitro. Annals of the New York Academy of Sciences. vol 648. 1992-08-21. PMID:1637070. |
evidence for a common mechanism of serotonin release induced by substituted amphetamines in vitro. |
1992-08-21 |
2023-08-11 |
Not clear |
| R Wölfel, K H Graef. Effects of imipramine and some tryptamine derivatives on the efflux of 3H-5-hydroxytryptamine from rabbit platelets. Journal of neural transmission. Supplementum. vol 34. 1992-07-07. PMID:1817167. |
the maximum efflux-accelerating effect (emax) of 5-ht and some other tryptamines (e.g., n-methyl-5-ht, 5-methoxytryptamine) far exceeded that of imipramine, whereas the emax for 2-methyl-5-ht did not. |
1992-07-07 |
2023-08-11 |
rabbit |
| R Wölfel, K H Graef. Effects of imipramine and some tryptamine derivatives on the efflux of 3H-5-hydroxytryptamine from rabbit platelets. Journal of neural transmission. Supplementum. vol 34. 1992-07-07. PMID:1817167. |
it is concluded that tryptamines that are more effective in releasing 3h-5-ht than imipramine have the property of being substrates of the 5-ht transporter. |
1992-07-07 |
2023-08-11 |
rabbit |
| M P Johnson, X M Huang, D E Nichol. Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1726189. |
there is increasing evidence linking dopamine (da) to the long-term serotonergic (5-ht) neurotoxic effects of certain substituted amphetamines such as 3,4-methylenedioxymethamphetamine (mdma). |
1992-06-30 |
2023-08-11 |
rat |
| R Wölfel, K H Graef. Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 2. 1992-05-22. PMID:1570019. |
evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter. |
1992-05-22 |
2023-08-11 |
rabbit |
| K J Axt, M E Mollive. Immunocytochemical evidence for methamphetamine-induced serotonergic axon loss in the rat brain. Synapse (New York, N.Y.). vol 9. issue 4. 1992-02-18. PMID:1722593. |
these data provide morphologic evidence of 5-ht axon loss following methamphetamine administration and further confirm the differential vulnerability of a particular morphological subtype of serotonergic axons to the neurotoxic effects of substituted amphetamines. |
1992-02-18 |
2023-08-11 |
rat |
| J H Kehne, T C McCloskey, V L Taylor, C K Black, G M Fadayel, C J Schmid. Effects of the serotonin releasers 3,4-methylenedioxymethamphetamine (MDMA), 4-chloroamphetamine (PCA) and fenfluramine on acoustic and tactile startle reflexes in rats. The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1731054. |
the substituted amphetamines 4-chloroamphetamine (pca), 3,4-methylenedioxymethamphetamine (mdma) and fenfluramine (fen) share the common neurochemical action of acutely releasing central serotonin (5-ht), and yet their behavioral effects are quite different. |
1992-02-18 |
2023-08-11 |
rat |
| M P Johnson, D E Nichol. Combined administration of a non-neurotoxic 3,4-methylenedioxymethamphetamine analogue with amphetamine produces serotonin neurotoxicity in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1717873. |
these data support the hypothesis that da release plays a critical role in the serotonin neurotoxicity of substituted amphetamines. |
1991-11-04 |
2023-08-11 |
rat |
| M E Molliver, U V Berger, L A Mamounas, D C Molliver, E O'Hearn, M A Wilso. Neurotoxicity of MDMA and related compounds: anatomic studies. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:1979216. |
the substituted amphetamines, mda, mdma, pca, and fenfluramine, all release serotonin and cause acute depletion of 5-ht from most axon terminals in forebrain. |
1991-01-14 |
2023-08-11 |
Not clear |
| G B Kovachich, C E Aronson, D J Brunswic. Effects of high-dose methamphetamine administration on serotonin uptake sites in rat brain measured using [3H]cyanoimipramine autoradiography. Brain research. vol 505. issue 1. 1990-03-01. PMID:2611665. |
this is consistent with previous studies indicating that methamphetamine and related amphetamines are neurotoxic to serotonin neurons. |
1990-03-01 |
2023-08-11 |
rat |
| A A Li, G J Marek, G Vosmer, L S Seide. Long-term central 5-HT depletions resulting from repeated administration of MDMA enhances the effects of single administration of MDMA on schedule-controlled behavior of rats. Pharmacology, biochemistry, and behavior. vol 33. issue 3. 1989-12-29. PMID:2573905. |
since the psychomotor stimulant effects of amphetamines appear to be mediated primarily by the dopamine system, these results provide evidence that 5-ht and da may represent opposing systems in the drl schedule-controlled behavior. |
1989-12-29 |
2023-08-11 |
rat |
| M S Kleven, W L Woolverton, L S Seide. Evidence that both intragastric and subcutaneous administration of methylenedioxymethylamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys. Brain research. vol 488. issue 1-2. 1989-08-14. PMID:2472850. |
since evidence of degenerating 5-ht neurons has been observed in the rat brain following mdma injections, it is likely that these depletions are due to neurotoxicity similar to that observed with other substituted amphetamines. |
1989-08-14 |
2023-08-11 |
rat |
| C Waeber, P Schoeffter, J M Palacios, D Hoye. Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:2975354. |
under these conditions, [3h]5-ht labelled a population of "5-ht1-like" sites which display nanomolar affinity for tryptamines (5-carboxamidotryptamine greater than 5-ht greater than or equal to 5-methoxytryptamine greater than tryptamine) and some ergolines (metergoline greater than methysergide). |
1989-03-02 |
2023-08-11 |
human |
| D E Nichols, D H Lloyd, M P Johnson, A J Hoffma. Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. Journal of medicinal chemistry. vol 31. issue 7. 1988-08-05. PMID:3385733. |
synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-ht1b receptors. |
1988-08-05 |
2023-08-11 |
rat |
| D Hoyer, C Waeber, A Pazos, A Probst, J M Palacio. Identification of a 5-HT1 recognition site in human brain membranes different from 5-HT1A, 5-HT1B and 5-HT1C sites. Neuroscience letters. vol 85. issue 3. 1988-06-02. PMID:2966310. |
under those conditions, [3h]5-ht labelled an apparently homogeneous population of 5-ht1-like sites which display nanomolar affinity for tryptamines (5-carboxamido-tryptamine, (5-ct) greater than 5-ht greater than or equal to 5-methoxytryptamine (5-meot) greater than tryptamine) and some ergolines (metergoline greater than methysergide). |
1988-06-02 |
2023-08-11 |
human |
| G R Martin, P Leff, D Cambridge, V J Barret. Comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 4. 1988-03-24. PMID:3431594. |
comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines. |
1988-03-24 |
2023-08-11 |
rabbit |
| G R Martin, P Leff, D Cambridge, V J Barret. Comparative analysis of two types of 5-hydroxytryptamine receptor mediating vasorelaxation: differential classification using tryptamines. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 4. 1988-03-24. PMID:3431594. |
when the activities of a single set of tryptamines were compared in endothelium-intact and -denuded jugular vein rings, different affinity and relative efficacy estimates were obtained, confirming that two distinct 5-ht receptors mediate relaxation responses in this tissue. |
1988-03-24 |
2023-08-11 |
rabbit |
| L L Martin, D M Roland, R F Neale, P L Woo. Structural relationships in the inhibition of [3H]tryptamine binding to rat brain membranes in vitro by phenylalkylamines. European journal of pharmacology. vol 132. issue 1. 1987-04-01. PMID:3816964. |
based on the unique structure-activity relationship obtained, it appears that [3h]tryptamine binding sites do not mediate the actions of phenethylamines on serotonin uptake or release. |
1987-04-01 |
2023-08-11 |
rat |
| A I Cohen, C Blazynsk. Tryptamine and some related molecules block the accumulation of a light-sensitive pool of cyclic AMP in the dark-adapted, dark-incubated mouse retina. Journal of neurochemistry. vol 48. issue 3. 1987-03-19. PMID:2433393. |
there is some suggestion that serotonin 5-ht-2 antagonists can partially reverse the action of the tryptamines, but hitherto undescribed receptors may be involved. |
1987-03-19 |
2023-08-11 |
mouse |