| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cindy Achat-Mendes, Syed F Ali, Yossef Itzha. Differential effects of amphetamines-induced neurotoxicity on appetitive and aversive Pavlovian conditioning in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 6. 2005-07-11. PMID:15688084. |
the abuse of substituted amphetamines such as methamphetamine (meth) and 3,4-methylenedioxymethamphetamine (mdma/ecstasy) can result in neurotoxicity, manifested as the depletion of dopamine (da) and 5-hydroxytriptamine (5-ht; serotonin) axon terminal markers in humans and animal models. |
2005-07-11 |
2023-08-12 |
mouse |
| Richard B Rothman, Subramaniam Jayanthi, Jean L Cadet, Xiaoying Wang, Christina M Dersch, Michael H Bauman. Substituted amphetamines that produce long-term serotonin depletion in rat brain ("neurotoxicity") do not decrease serotonin transporter protein expression. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542713. |
substituted amphetamines that produce long-term serotonin depletion in rat brain ("neurotoxicity") do not decrease serotonin transporter protein expression. |
2005-02-18 |
2023-08-12 |
rat |
| Twum-Ampofo Ansah, Sammanda Ramamoorthy, Sylvia Montañez, Lynette C Daws, Randy D Blakel. Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). The Journal of pharmacology and experimental therapeutics. vol 305. issue 3. 2003-07-07. PMID:12626658. |
termination of serotonergic transmission is the function of the plasma membrane 5-hydroxytryptamine (serotonin, 5-ht) transporter (sert), which is also a high-affinity target in vivo for antidepressants, amphetamines, and cocaine. |
2003-07-07 |
2023-08-12 |
mouse |
| J B JEPSON, B J STEVEN. A fluorescence test for serotonin and other tryptamines. Nature. vol 172. issue 4382. 2003-05-01. PMID:13111187. |
a fluorescence test for serotonin and other tryptamines. |
2003-05-01 |
2023-08-12 |
Not clear |
| F HALBER. Eosinopenic effects of tryptamines in mice; synergism of effects of cortisone and serotonin. The American journal of physiology. vol 179. issue 2. 2003-05-01. PMID:13218165. |
eosinopenic effects of tryptamines in mice; synergism of effects of cortisone and serotonin. |
2003-05-01 |
2023-08-12 |
mouse |
| Jie Yuan, Branden J Cord, Una D McCann, Brian T Callahan, George A Ricaurt. Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388670. |
effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines. |
2002-11-22 |
2023-08-12 |
rat |
| Jay C Albretse. Oral medications. The Veterinary clinics of North America. Small animal practice. vol 32. issue 2. 2002-06-28. PMID:12012745. |
the medications reviewed include selective serotonin reuptake inhibitors, benzodiazepines, amphetamines or amphetamine like drugs, carprofen, cyclooxygenase-2 inhibitors, pseudoephedrine, calcium channel blockers, and baclofen. |
2002-06-28 |
2023-08-12 |
Not clear |
| A K Halladay, E Kirschner, K Hesse, H Fisher, G C Wagne. Role of monoamine oxidase inhibition and monoamine depletion in fenfluramine-induced neurotoxicity and serotonin release. Pharmacology & toxicology. vol 89. issue 5. 2002-05-22. PMID:11881977. |
these results indicate that the rapid increase in dopamine activity induced by fenfluramine is partially dependent on serotonin concentration and release and that the mechanism of fenfluramine-induced toxicity is unlike that of the other substituted amphetamines. |
2002-05-22 |
2023-08-12 |
Not clear |
| Jean Chang-Fong, James Addo, Małgorzata Dukat, Carol Smith, Nicholas A Mitchell, Katharine Herrick-Davis, Milt Teitler, Richard A Glenno. Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorganic & medicinal chemistry letters. vol 12. issue 2. 2002-03-22. PMID:11755343. |
on the basis that meta-chlorophenylpiperazine (mcpp; 1) is a nonselective 5-ht(2c) agonist, that benz-fused tryptamines (e.g., 5) display enhanced 5-ht(2) affinity, and that certain isotryptamines 3 reportedly bind with enhanced affinity and selectivity at 5-ht(2c) receptors, we prepared and examined a series of isotryptamine-related analogues as potentially selective 5-ht(2c) agonists. |
2002-03-22 |
2023-08-12 |
Not clear |
| Y Ramamoorthy, R F Tyndale, E M Seller. Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics. vol 11. issue 6. 2001-10-11. PMID:11505218. |
cyp2d6 is involved in the metabolism of several classes of drugs, including tricyclic antidepressants, selective serotonin reuptake inhibitors and various amphetamines. |
2001-10-11 |
2023-08-12 |
Not clear |
| J B Blair, D Kurrasch-Orbaugh, D Marona-Lewicka, M G Cumbay, V J Watts, E L Barker, D E Nichol. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of medicinal chemistry. vol 43. issue 24. 2001-08-23. PMID:11101361. |
one of the tryptamines, 4-fluoro-5-methoxy-dmt (6), displayed high 5-ht(1a) agonist activity, with potency greater than that of the 5-ht(1a) agonist 8-oh-dpat. |
2001-08-23 |
2023-08-12 |
rat |
| J B Blair, D Kurrasch-Orbaugh, D Marona-Lewicka, M G Cumbay, V J Watts, E L Barker, D E Nichol. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of medicinal chemistry. vol 43. issue 24. 2001-08-23. PMID:11101361. |
the results indicate that fluorination of hallucinogenic tryptamines generally has little effect on 5-ht(2a/2c) receptor affinity or intrinsic activity. |
2001-08-23 |
2023-08-12 |
rat |
| J B Blair, D Kurrasch-Orbaugh, D Marona-Lewicka, M G Cumbay, V J Watts, E L Barker, D E Nichol. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of medicinal chemistry. vol 43. issue 24. 2001-08-23. PMID:11101361. |
although it is generally considered that hallucinogenic activity results from 5-ht(2a) receptor activation, the present results suggest a possible role for involvement of the 5-ht(1a) receptor with tryptamines. |
2001-08-23 |
2023-08-12 |
rat |
| M H Baumann, M A Ayestas, C M Dersch, R B Rothma. 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 5. 2001-07-12. PMID:11282249. |
our data support the notion that 5-ht release per se may not be sufficient to produce the long-term 5-ht deficits associated with d-fenfluramine and other amphetamines. |
2001-07-12 |
2023-08-12 |
rat |
| B T Callahan, B J Cord, G A Ricaurt. Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamine. Synapse (New York, N.Y.). vol 40. issue 2. 2001-07-05. PMID:11252022. |
to further evaluate the serotonin (5-ht) neurotoxic potential of substituted amphetamines, we used tritiated proline to examine anterograde transport along ascending axonal projections originating in the rostral raphe nuclei of animals treated 3 weeks previously with (+/-)fenfluramine (fen, 10 mg/kg, every 2 h x 4 injections; i.p.) |
2001-07-05 |
2023-08-12 |
Not clear |
| R Legutko, R L Ganno. Serotonin transporter localization in the hamster suprachiasmatic nucleus. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11222995. |
amphetamines and certain antidepressants may serve as substrates for this transporter and elicit chronopharmacological activity by elevating serotonin levels in the suprachiasmatic nucleus. |
2001-06-21 |
2023-08-12 |
Not clear |
| J J Chambers, D M Kurrasch-Orbaugh, M A Parker, D E Nichol. Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists. Journal of medicinal chemistry. vol 44. issue 6. 2001-05-03. PMID:11300881. |
the affinity of ligands for either the 5-ht(2a) or 5-ht(2c) agonist binding site was enhanced by modification of the 2,5-oxygen substituents that are found in typical hallucinogenic amphetamines such as 4b (dob). |
2001-05-03 |
2023-08-12 |
Not clear |
| B T Callahan, J Yuan, G A Ricaurt. Fluoxetine increases the anorectic and long-term dopamine-depleting effects of phentermine. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044894. |
fluoxetine, in addition to inhibiting serotonin reuptake, inhibits hepatic mixed function oxidase, which plays an important role in the metabolic degradation of amphetamines. |
2000-12-14 |
2023-08-12 |
mouse |
| G Bringmann, R Brückner, R Mössner, D Feineis, A Heils, K P Lesc. Effect of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on human serotonergic cells. Neurochemical research. vol 25. issue 6. 2000-12-07. PMID:10944002. |
in contrast to well-known serotonergic neurotoxins such as amphetamines, however, taclo toxicity is not mediated by the 5-ht transporter (5-htt). |
2000-12-07 |
2023-08-12 |
human |
| K Kristiansen, W K Kroeze, D L Willins, E I Gelber, J E Savage, R A Glennon, B L Rot. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism. The Journal of pharmacology and experimental therapeutics. vol 293. issue 3. 2000-07-14. PMID:10869371. |
a highly conserved aspartic acid (asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-ht(2a) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism. |
2000-07-14 |
2023-08-12 |
Not clear |