| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suzanne M Cloonan, John J Keating, Stephen G Butler, Andrew J S Knox, Anne M Jørgensen, Günther H Peters, Dilip Rai, Desmond Corrigan, David G Lloyd, D Clive Williams, Mary J Meega. Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. European journal of medicinal chemistry. vol 44. issue 12. 2010-03-16. PMID:19717215. |
synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. |
2010-03-16 |
2023-08-12 |
Not clear |
| Ryan Hewton, Abdallah Salem, Rodney J Irvin. Potentiation of 3,4-methylenedioxymethamphetamine-induced 5-HT release in the rat substantia nigra by clorgyline, a monoamine oxidase A inhibitor. Clinical and experimental pharmacology & physiology. vol 34. issue 10. 2007-10-03. PMID:17714093. |
however, coadministration of these substituted amphetamines with an mao-a inhibitor causes significant potentiation in the ability to increase extracellular levels of 5-ht for mdma, but not pma. |
2007-10-03 |
2023-08-12 |
rat |
| Pablo R Moya, Kelly A Berg, Manuel A Gutiérrez-Hernandez, Patricio Sáez-Briones, Miguel Reyes-Parada, Bruce K Cassels, William P Clark. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17337633. |
2,5-dimethoxy-4-substituted phenylisopropylamines and phenethylamines are 5-hydroxytryptamine (serotonin) (5-ht)(2a/2c) agonists. |
2007-07-30 |
2023-08-12 |
human |
| Pablo R Moya, Kelly A Berg, Manuel A Gutiérrez-Hernandez, Patricio Sáez-Briones, Miguel Reyes-Parada, Bruce K Cassels, William P Clark. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17337633. |
we compared two homologous series of phenylisopropylamines and phenethylamines measuring both pla(2) and plc responses in chinese hamster ovary-k1 cells expressing human 5-ht(2a) or 5-ht(2c) receptors. |
2007-07-30 |
2023-08-12 |
human |
| Noriyuki Kato, Takashi Kojima, Shinji Yoshiyagawa, Hikoto Ohta, Akira Toriba, Hideo Nishimura, Kazuichi Hayakaw. Rapid and sensitive determination of tryptophan, serotonin and psychoactive tryptamines by thin-layer chromatography/fluorescence detection. Journal of chromatography. A. vol 1145. issue 1-2. 2007-05-21. PMID:17292904. |
rapid and sensitive determination of tryptophan, serotonin and psychoactive tryptamines by thin-layer chromatography/fluorescence detection. |
2007-05-21 |
2023-08-12 |
Not clear |
| Noriyuki Kato, Takashi Kojima, Shinji Yoshiyagawa, Hikoto Ohta, Akira Toriba, Hideo Nishimura, Kazuichi Hayakaw. Rapid and sensitive determination of tryptophan, serotonin and psychoactive tryptamines by thin-layer chromatography/fluorescence detection. Journal of chromatography. A. vol 1145. issue 1-2. 2007-05-21. PMID:17292904. |
a rapid, sensitive and selective method for the determination of tryptophan (trp), serotonin (5-ht) and psychoactive tryptamines (pats) by thin-layer chromatography (tlc) with fluorescence detection is proposed. |
2007-05-21 |
2023-08-12 |
Not clear |
| Michael R Braden, Jason C Parrish, John C Naylor, David E Nichol. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular pharmacology. vol 70. issue 6. 2007-01-30. PMID:17000863. |
experiments were conducted to examine the molecular basis for the high affinity and potency of a new class of 5-ht(2a) receptor agonists, n-benzyl phenethylamines. |
2007-01-30 |
2023-08-12 |
human |
| Michael R Braden, Jason C Parrish, John C Naylor, David E Nichol. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular pharmacology. vol 70. issue 6. 2007-01-30. PMID:17000863. |
pi hydrolysis functional assays confirmed that these n-benzyl phenethylamines are potent and highly efficacious agonists at the rat 5-ht(2a) receptor. |
2007-01-30 |
2023-08-12 |
human |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
loss of serotonin transporter protein after mdma and other ring-substituted amphetamines. |
2007-01-05 |
2023-08-12 |
Not clear |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
we studied in vivo expression of the serotonin transporter (sert) protein after 3,4-methylenedioxymethamphetamine (mdma), p-chloroamphetamine (pca), or fenfluramine (fen) treatments, and compared the effects of substituted amphetamines to those of 5,7-dihydroxytryptamine (5,7-dht), an established serotonin (5-ht) neurotoxin. |
2007-01-05 |
2023-08-12 |
Not clear |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
in the same animals, tryptophan hydroxylase (tph)-ir axon density was comparably reduced, indicating that serotonergic deficits after substituted amphetamines differ from those in sert-null animals, which have normal tph levels but, in the absence of sert, develop apparent neuroadaptive changes in 5-ht metabolism. |
2007-01-05 |
2023-08-12 |
Not clear |
| Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurt. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 12. 2007-01-05. PMID:16452989. |
together, these results suggest that lasting serotonergic deficits after mdma and related drugs are unlikely to represent neuroadaptive metabolic responses to changes in sert trafficking, and favor the view that substituted amphetamines have the potential to produce a distal axotomy of brain 5-ht neurons. |
2007-01-05 |
2023-08-12 |
Not clear |
| Dorota Zolkowska, Richard B Rothman, Michael H Bauman. Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16644904. |
many abused drugs (e.g., substituted amphetamines) and prescribed medications (e.g., fluoxetine) target 5-ht transporters and could thereby influence circulating 5-ht. |
2006-08-31 |
2023-08-12 |
rat |
| Dorota Zolkowska, Richard B Rothman, Michael H Bauman. Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16644904. |
we evaluated the effects of amphetamines analogs [(+/-)-fenfluramine, (+/-)-3,4-methylenedioxymethamphetamine, (+)-methamphetamine, (+)-amphetamine, phentermine] on extracellular levels (i.e., plasma levels) of 5-ht and 5-hiaa in blood from catheterized rats. |
2006-08-31 |
2023-08-12 |
rat |
| Dorota Zolkowska, Richard B Rothman, Michael H Bauman. Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. The Journal of pharmacology and experimental therapeutics. vol 318. issue 2. 2006-08-31. PMID:16644904. |
additional studies are needed to determine the effects of chronic administration of amphetamines on circulating 5-ht. |
2006-08-31 |
2023-08-12 |
rat |
| B R Russell, R Lavert. Correlation between 5-HT content and uptake site density following (S)-MDMA and dexfenfluramine-induced depletion, and with neuroprotection by the glycine site-specific NMDA antagonist ACEA 1021. Annals of the New York Academy of Sciences. vol 914. 2006-01-04. PMID:11085322. |
depletion caused by these amphetamines is commonly measured by labeling 5-ht uptake sites using 3h-paroxetine combined with autoradiography or, alternatively measuring the concentration of 5-ht in tissue using high-performance liquid chromatography (hplc). |
2006-01-04 |
2023-08-12 |
Not clear |
| Altaf S Darvesh, Gary A Gudelsk. Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT. Brain research. vol 1056. issue 2. 2005-12-07. PMID:16098955. |
although the exact mechanism involved in the long-term depletion of brain serotonin (5-ht) produced by substituted amphetamines is not completely known, evidence suggests that oxidative and/or bioenergetic stress may contribute to 3,4-methylenedioxymethamphetamine (mdma)-induced 5-ht toxicity. |
2005-12-07 |
2023-08-12 |
Not clear |
| D J De Silva, S J French, N Y Cheung, A K Swinson, C Bendotti, M Rattra. Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamine. Neuroscience. vol 134. issue 4. 2005-11-15. PMID:16054768. |
substituted amphetamines such as p-chloroamphetamine and the abused drug methylenedioxymethamphetamine cause selective destruction of serotonin axons in rats, by unknown mechanisms. |
2005-11-15 |
2023-08-12 |
rat |
| Paul D Callaghan, Rodney J Irvine, Lynette C Daw. Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine revealed by chronoamperometry. Neurochemistry international. vol 47. issue 5. 2005-09-08. PMID:15979209. |
to study the effect of these amphetamines on clearance of 5-ht mediated specifically by the sert, clearance of exogenously applied 5-ht was measured in the ca3 region of the hippocampus. |
2005-09-08 |
2023-08-12 |
rat |
| S A van Wolferen, A Vonk Noordegraaf, A Boonstra, P E Postmu. [Pulmonary arterial hypertension due to the use of amphetamines as drugs or doping]. Nederlands tijdschrift voor geneeskunde. vol 149. issue 23. 2005-08-04. PMID:15960135. |
amphetamines may lead to pah due to the release of serotonin, which causes pulmonary vasoconstriction and the proliferation of smooth muscle cells. |
2005-08-04 |
2023-08-12 |
Not clear |