| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L de Haan, J Lavalaye, D Linszen, P M Dingemans, J Booi. Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone. The American journal of psychiatry. vol 157. issue 6. 2000-06-29. PMID:10831489. |
the authors' goal was to study the relationship between subjective experience during treatment with olanzapine or risperidone and dopamine d(2) receptor occupancy in stabilized patients with schizophrenia. |
2000-06-29 |
2023-08-12 |
Not clear |
| J Lavalaye, D H Linszen, J Booij, L Reneman, B P Gersons, E A van Roye. Dopamine D2 receptor occupancy by olanzapine or risperidone in young patients with schizophrenia. Psychiatry research. vol 92. issue 1. 2000-03-14. PMID:10688158. |
dopamine d2 receptor occupancy by olanzapine or risperidone in young patients with schizophrenia. |
2000-03-14 |
2023-08-12 |
Not clear |
| S M Dursun, J K Patel, J G Burke, M A Revele. Effects of typical antipsychotic drugs and risperidone on the quality of sleep in patients with schizophrenia: a pilot study. Journal of psychiatry & neuroscience : JPN. vol 24. issue 4. 2000-02-29. PMID:10516800. |
to investigate the effects of a newer antipsychotic drug, risperidone (a potent serotonin 5-ht2a/2c and dopamine d2-receptor blocker), on the quantity and quality of sleep in patients with schizophrenia. |
2000-02-29 |
2023-08-12 |
Not clear |
| I Ninan, S K Kulkarn. Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics. Methods and findings in experimental and clinical pharmacology. vol 21. issue 9. 2000-02-28. PMID:10669905. |
the effect of the selective dopamine d2 receptor agonist quinpirole, the selective 5-ht1a receptor agonist 8-oh-dpat and the selective 5-ht2a receptor antagonist ketanserin on catalepsy induced by atypical antipsychotics clozapine, risperidone, olanzapine and sertindole at higher doses was studied in rats. |
2000-02-28 |
2023-08-12 |
mouse |
| S Oerther, S Ahleniu. Atypical antipsychotics and dopamine D(1) receptor agonism: an in vivo experimental study using core temperature measurements in the rat. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640312. |
the study objectives were to examine the effects of the atypical antipsychotic drugs olanzapine, risperidone, and quetiapine on core temperature in the rat in relation to such effects produced by clozapine and to compare possible in vivo intrinsic efficacy of olanzapine, risperidone, and quetiapine at dopamine (da) d(1) receptors with such effects previously shown for clozapine. |
2000-02-22 |
2023-08-12 |
rat |
| E Carboni, M T Rolando, A Silvagni, G Di Chiar. Increase of dialysate dopamine in the bed nucleus of stria terminalis by clozapine and related neuroleptics. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 2. 2000-02-14. PMID:10649827. |
dopamine output in dialysates was increased dose-dependently by clozapine (max + 158%, 298%, and 461% of basal at 5, 10, and 20 mg/kg i.p., respectively), risperidone (max + 115% and 221% of basal at 1 and 3 mg/kg i.p., respectively), olanzapine (max + 138% and 235% of basal at 3 and 6 mg/kg i.p., respectively), bimg 80 (max + 64% and 164% of basal at 3 and 5 mg/kg i.p., respectively), amperozide (max + 110% and 194% of basal at 3 and 6 mg/kg i.p., respectively). |
2000-02-14 |
2023-08-12 |
rat |
| J Peuskens, P Bech, H J Möller, R Bale, O Fleurot, W Rei. Amisulpride vs. risperidone in the treatment of acute exacerbations of schizophrenia. Amisulpride study group. Psychiatry research. vol 88. issue 2. 2000-02-08. PMID:10622347. |
amisulpride, a substituted benzamide with high selectivity for dopamine d3 and d2 receptors, was compared with the antipsychotic risperidone in patients with acute exacerbations of schizophrenia. |
2000-02-08 |
2023-08-12 |
Not clear |
| S Chaki, T Funakoshi, R Yoshikawa, S Okuyama, T Kumagai, A Nakazato, M Nagamine, K Tomisaw. In vivo receptor occupancy of NRA0045, a putative atypical antipsychotic, in rats. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462131. |
in the present study, in vivo receptor occupancy of 5-ht2a, alpha1, dopamine d2 and d3 receptors by nra0045 was assessed, based on in vivo and ex vivo receptor binding, and findings were compared to reference antipsychotic drugs (haloperidol, risperidone, clozapine). |
1999-10-12 |
2023-08-12 |
rat |
| S Chaki, T Funakoshi, R Yoshikawa, S Okuyama, T Kumagai, A Nakazato, M Nagamine, K Tomisaw. In vivo receptor occupancy of NRA0045, a putative atypical antipsychotic, in rats. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462131. |
clozapine and risperidone also occupied the alpha1 adrenoceptor in the frontal cortex, and clozapine did not occupy the dopamine d3 receptor. |
1999-10-12 |
2023-08-12 |
rat |
| A Ceci, A Brambilla, P Duranti, M Grauert, N Grippa, F Borsin. Effect of antipsychotic drugs and selective dopaminergic antagonists on dopamine-induced facilitatory activity in prelimbic cortical pyramidal neurons. An in vitro study. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430475. |
the facilitatory effect of dopamine in prelimbic cortex was concentration dependently antagonized by haloperidol, risperidone, quetiapine, clozapine and by the selective d4 dopaminergic receptor antagonist l-745,870, but not by the selective d2/d3 dopaminergic receptor antagonist (-)-sulpiride. |
1999-10-08 |
2023-08-12 |
Not clear |
| S Dresel, T Mager, B Rossmüller, E Meisenzahl, K Hahn, H J Möller, K Tatsc. In vivo effects of olanzapine on striatal dopamine D(2)/D(3) receptor binding in schizophrenic patients: an iodine-123 iodobenzamide single-photon emission tomography study. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10436199. |
the specific aims of this study were (a) to assess dopamine d(2)/d(3) receptor availability in patients treated with olanzapine by means of iodine-123 iodobenzamide [(123)i]ibzm single-photon emission tomography (spet), (b) to compare the results with findings of [(123)i]ibzm spet in patients under treatment with risperidone and (c) to correlate the results with the occurrence of extrapyramidal side-effects (epms). |
1999-10-07 |
2023-08-12 |
Not clear |
| H Y Meltze. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432496. |
recent interest in the role of serotonin (5-ht) in antipsychotic drug action is based mainly upon the fact that antipsychotic drugs such as clozapine, olanzapine, quetiapine, risperidone, sertindole, and ziprasidone are potent 5-ht2a receptor antagonists and relatively weaker dopamine d2 antagonists. |
1999-09-17 |
2023-08-12 |
Not clear |
| P B Bergqvist, J Dong, P Blie. Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology. vol 143. issue 1. 1999-07-02. PMID:10227084. |
in contrast, the beneficial effect of low doses of risperidone may be due, in part, to the antagonism of dopamine receptors. |
1999-07-02 |
2023-08-12 |
rat |
| S Nyberg, B Eriksson, G Oxenstierna, C Halldin, L Fard. Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. The American journal of psychiatry. vol 156. issue 6. 1999-06-16. PMID:10360125. |
the aim of this positron emission tomography (pet) study was to suggest a minimal effective dose of risperidone based on measurements of dopamine d2 and serotonin 5-ht2a receptor occupancy. |
1999-06-16 |
2023-08-12 |
Not clear |
| A Breier, T P Su, A K Malhotra, I Elman, C M Adler, N I Weisenfeld, D Picka. Effects of atypical antipsychotic drug treatment on amphetamine-induced striatal dopamine release in patients with psychotic disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088134. |
in this study, we examined the effects of clozapine and risperidone on amphetamine-induced striatal dopamine release in patients with psychotic disorders. |
1999-06-03 |
2023-08-12 |
Not clear |
| A Breier, T P Su, A K Malhotra, I Elman, C M Adler, N I Weisenfeld, D Picka. Effects of atypical antipsychotic drug treatment on amphetamine-induced striatal dopamine release in patients with psychotic disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088134. |
a novel 11c-raclopride/pet paradigm was used to derive estimates of amphetamine-induced changes in striatal synaptic dopamine concentrations and patients were scanned while antipsychotic drug-free and during chronic treatment with either clozapine or risperidone. |
1999-06-03 |
2023-08-12 |
Not clear |
| J W Grimm, R E Se. Unique activation of extracellular striato-pallidal neurotransmitters in rats following acute risperidone. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729373. |
in the striatum, risperidone increased extracellular levels of dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) at all doses and the serotonin (5-ht) metabolite, 5-hydroxyindoleacetic acid (5-hiaa), at the highest dose. |
1999-05-12 |
2023-08-12 |
rat |
| F X Vollenweider, M F Vollenweider-Scherpenhuyzen, A Bäbler, H Vogel, D Hel. Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport. vol 9. issue 17. 1999-03-24. PMID:9875725. |
in healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2a antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. |
1999-03-24 |
2023-08-12 |
human |
| B H Westerink, P de Boer, J B de Vries, C G Kruse, S K Lon. Antipsychotic drugs induce similar effects on the release of dopamine and noradrenaline in the medial prefrontal cortex of the rat brain. European journal of pharmacology. vol 361. issue 1. 1999-03-04. PMID:9851538. |
in the present study we have compared the effects of the classical antipsychotic drug haloperidol and four different atypical antipsychotics (clozapine, risperidone, olanzapine, ziprasidone) on extracellular levels of dopamine and noradrenaline in the medial prefrontal cortex (mpfc) of conscious rats. |
1999-03-04 |
2023-08-12 |
rat |
| S Dresel, K Tatsch, I Dähne, T Mager, J Scherer, K Hah. Iodine-123-iodobenzamide SPECT assessment of dopamine D2 receptor occupancy in riperidone-treated schizophrenic patients. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 39. issue 7. 1998-08-11. PMID:9669383. |
the recently introduced neuroleptic, risperidone, was expected to block fewer dopamine d2 receptors than typical neuroleptics (e.g., haloperidol), but at comparable potency. |
1998-08-11 |
2023-08-12 |
Not clear |