| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F I Tarazi, K Zhang, R J Baldessarin. Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303062. |
changes in members of the dopamine (da) d(1)-like (d(1), d(5)) and d(2)-like (d(2), d(3), d(4)) receptor families in rat forebrain regions were compared by quantitative in vitro receptor autoradiography after prolonged treatment (28 days) with the atypical antipsychotics olanzapine, risperidone, and quetiapine. |
2001-05-21 |
2023-08-12 |
rat |
| M J Byerly, M T Weber, D L Brooks, L R Snow, M A Worley, E Lescouflai. Antipsychotic medications and the elderly: effects on cognition and implications for use. Drugs & aging. vol 18. issue 1. 2001-05-17. PMID:11232738. |
clozapine and quetiapine), for example, would theoretically have a cognitive profile superior to that of agents with higher degrees of dopaminergic inhibition (all traditional agents, risperidone, olanzapine and ziprasidone) when used for conditions associated with diminished dopamine function (e.g. |
2001-05-17 |
2023-08-12 |
Not clear |
| J Ichikawa, H Ishii, S Bonaccorso, W L Fowler, I A O'Laughlin, H Y Meltze. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238736. |
the present study tested the hypothesis that clozapine, olanzapine, risperidone, and perhaps other atypical apds, increase dopamine release in rat medial prefrontal cortex (mpfc) via 5-ht(1a) receptor activation, as a result of the blockade of 5-ht(2a) and d(2) receptors. |
2001-04-05 |
2023-08-12 |
rat |
| J Ichikawa, H Ishii, S Bonaccorso, W L Fowler, I A O'Laughlin, H Y Meltze. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238736. |
way100635 (0.2 mg/kg) also reversed the ability of clozapine (20 mg/kg), olanzapine (1 mg/kg), risperidone (1 mg/kg), and the r:(+)-8-oh-dpat (0.2 mg/kg) to increase mpfc dopamine release. |
2001-04-05 |
2023-08-12 |
rat |
| S R Tolli. Use of the dopamine agonists bromocriptine and cabergoline in the management of risperidone-induced hyperprolactinemia in patients with psychotic disorders. Journal of endocrinological investigation. vol 23. issue 11. 2001-03-22. PMID:11194712. |
in these 4 patients, risperidone therapy was continued and the dopamine agonists bromocriptine or cabergoline were added. |
2001-03-22 |
2023-08-12 |
Not clear |
| S R Tolli. Use of the dopamine agonists bromocriptine and cabergoline in the management of risperidone-induced hyperprolactinemia in patients with psychotic disorders. Journal of endocrinological investigation. vol 23. issue 11. 2001-03-22. PMID:11194712. |
if risperidone therapy must be continued in such patients, addition of the dopamine agonists bromocriptine or cabergoline may successfully alleviate hyperprolactinemia and the associated manifestations without worsening psychotic symptoms. |
2001-03-22 |
2023-08-12 |
Not clear |
| J Cartmell, C R Salhoff, K W Perry, J A Monn, D D Schoep. Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134627. |
here, we have compared the effects of ly379268 with clozapine as well as risperidone on ex vivo tissue levels of dopamine, dopac, hva, 5-ht and 5-hiaa in multiple brain regions. |
2001-02-15 |
2023-08-12 |
rat |
| J Cartmell, C R Salhoff, K W Perry, J A Monn, D D Schoep. Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134627. |
clozapine (10 mg/kg s.c.) and risperidone (1 mg/kg s. c.) also increased levels of the dopamine metabolites to a similar extent but were without significant effect on tissue levels of 5-hiaa. |
2001-02-15 |
2023-08-12 |
rat |
| E Richelson, T Soude. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life sciences. vol 68. issue 1. 2001-01-11. PMID:11132243. |
using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (k(d)s) for nine new antipsychotic drugs (iloperidone, melperone, olanzapine, org 5222, quetiapine, risperidone, sertindole, ziprasidone, and zotepine), one metabolite of a new drug (9-oh-risperidone), and three older antipsychotics (clozapine, haloperidol, and pimozide) at nine different receptors (alpha1-adrenergic, alpha2-adrenergic, dopamine d2, histamine h1, muscarinic, and serotonin 5-ht1a, 5-ht1d, 5-ht2a, and 5-ht2c receptors). |
2001-01-11 |
2023-08-12 |
human |
| S N Wu, C R Jan, H F Li, H T Chian. Characterization of inhibition by risperidone of the inwardly rectifying K(+) current in pituitary GH(3) cells. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 6. 2001-01-04. PMID:11063923. |
the present study provides evidence that risperidone, in addition to the blockade of dopamine receptors, can produce a depressant effect on i(k(ir)) and bk(ca) channels, and implies that the blockade of these ionic currents by risperidone may affect membrane excitability and prolactin secretion in gh(3) cells. |
2001-01-04 |
2023-08-12 |
rat |
| S Seedat, S Kesler, D J Niehaus, D J Stei. Pathological gambling behaviour: emergence secondary to treatment of Parkinson's disease with dopaminergic agents. Depression and anxiety. vol 11. issue 4. 2000-12-21. PMID:10945141. |
we present a case in which the use of low dose risperidone (a potent d2 and 5-ht2 antagonist) was successful in controlling gambling behaviour secondary to dopamine agonist treatment of parkinson's disease. |
2000-12-21 |
2023-08-12 |
Not clear |
| N Bhana, C M Spence. Risperidone: a review of its use in the management of the behavioural and psychological symptoms of dementia. Drugs & aging. vol 16. issue 6. 2000-11-30. PMID:10939309. |
risperidone has antagonistic activity primarily at serotonin 5-ht2a and dopamine d2 receptors. |
2000-11-30 |
2023-08-12 |
Not clear |
| J F Vanhauwe, K Josson, W H Luyten, A J Driessen, J E Leyse. G-protein sensitivity of ligand binding to human dopamine D(2) and D(3) receptors expressed in Escherichia coli: clues for a constrained D(3) receptor structure. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991990. |
binding affinities of agonists (dopamine, 7-oh-dpat, pd128907, lisuride) and antagonists/inverse agonists (haloperidol, risperidone, domperidone, spiperone, raclopride, nemonapride), measured using [(125)i]iodosulpride and [(3)h]7-oh-dpat, were similar for hd(3) receptors in e. coli and cho cell membranes. |
2000-11-03 |
2023-08-12 |
human |
| K Antoniou, S Bekris, M Saranti, P Stathis, M Rimikis, Z Papadopoulou-Daifot. The effects of antipsychotic drugs on serotonergic activity in the rat hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 5. 2000-10-30. PMID:10974601. |
acute administration of risperidone, the serotonin(2) (5-ht(2)) receptor antagonist ketanserin, and the dopamine (da)-d(2) receptor antagonist raclopride increased the 5-hydroxyindoleacetic acid/serotonin (5-hiaa/5-ht) ratio. |
2000-10-30 |
2023-08-12 |
rat |
| F Angelucci, A A Mathé, L Alo. Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. Journal of neuroscience research. vol 60. issue 6. 2000-09-06. PMID:10861791. |
the former drug mainly acts on the dopamine (da) d(2) receptor whereas risperidone binds to both da and serotonin (5ht) receptors, particularly in the neurons of striatal and limbic structures. |
2000-09-06 |
2023-08-12 |
rat |
| J Grabowski, H Rhoades, P Silverman, J M Schmitz, A Stotts, D Creson, R Baile. Risperidone for the treatment of cocaine dependence: randomized, double-blind trial. Journal of clinical psychopharmacology. vol 20. issue 3. 2000-09-01. PMID:10831016. |
risperidone, a 5-hydroxytryptamine and dopamine d2 antagonist, is an atypical antipsychotic and was a candidate medication for the treatment of cocaine dependence. |
2000-09-01 |
2023-08-12 |
human |
| F I Tarazi, K Zhang, R J Baldessarin. Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain. Neuroscience letters. vol 287. issue 2. 2000-08-17. PMID:10854717. |
we compared labeling of dopamine (dat) and serotonin (sert) transporter proteins in subregions of rat corpus striatum by quantitative autoradiography with [(3)h]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tropane ([(3)h]beta-cit) and [(3)h]paroxetine after 28 days of continuous subcutaneous infusion of olanzapine, quetiapine, risperidone, or vehicle controls. |
2000-08-17 |
2023-08-12 |
rat |
| I Kusumi, Y Takahashi, K Suzuki, K Kameda, T Koyam. Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 3. 2000-08-02. PMID:10821438. |
the effects of 3-week treatment with a typical antipsychotic drug chlorpromazine and three atypical antipsychotic drugs (risperidone, olanzapine and perospirone) on the binding to dopamine d2 and serotonin 5-ht2a receptors were examined in the rat stratum and frontal cortex, respectively. |
2000-08-02 |
2023-08-12 |
rat |
| M Rodríguez-Arias, I Broseta, M A Aguilar, J Miñarr. Lack of specific effects of selective D(1) and D(2) dopamine antagonists vs. risperidone on morphine-induced hyperactivity. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837860. |
lack of specific effects of selective d(1) and d(2) dopamine antagonists vs. risperidone on morphine-induced hyperactivity. |
2000-07-06 |
2023-08-12 |
Not clear |
| L de Haan, J Lavalaye, D Linszen, P M Dingemans, J Booi. Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone. The American journal of psychiatry. vol 157. issue 6. 2000-06-29. PMID:10831489. |
subjective experience and striatal dopamine d(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone. |
2000-06-29 |
2023-08-12 |
Not clear |