| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kasper, J Tauscher, B Küfferle, C Barnas, B Hesselmann, S Asenbaum, I Podreka, T Brück. Sertindole and dopamine D2 receptor occupancy in comparison to risperidone, clozapine and haloperidol - a 123I-IBZM SPECT study. Psychopharmacology. vol 136. issue 4. 1998-08-07. PMID:9600582. |
sertindole and dopamine d2 receptor occupancy in comparison to risperidone, clozapine and haloperidol - a 123i-ibzm spect study. |
1998-08-07 |
2023-08-12 |
Not clear |
| P Seeman, T Talleric. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Molecular psychiatry. vol 3. issue 2. 1998-07-16. PMID:9577836. |
as determined by the new dissociation constants, antipsychotic drugs which elicit parkinsonism (trifluperazine, chlorpromazine, raclopride, haloperidol, fluphenazine, risperidone) bind more tightly than dopamine to d2, while those antipsychotic drugs which elicit little or no parkinsonism (melperone, seroquel, perlapine, clozapine, remoxipride, molindone, sulpiride, olanzapine, sertindole) bind more loosely than dopamine to d2 receptors. |
1998-07-16 |
2023-08-12 |
human |
| K Yoshida, H Higuchi, Y Hishikaw. Marked improvement of tardive dystonia after replacing haloperidol with risperidone in a schizophrenic patient. Clinical neuropharmacology. vol 21. issue 1. 1998-07-01. PMID:9579290. |
the 5-ht2 antagonistic action of risperidone, in addition to its dopamine antagonistic action, may have also lessened psychotic symptoms in the current case. |
1998-07-01 |
2023-08-12 |
Not clear |
| R J Flietstra, B Levan. Comparison of D2 and D3 dopamine receptor affinity of dopaminergic compounds in rat brain. Life sciences. vol 62. issue 20. 1998-06-04. PMID:9600324. |
in contrast, chlorpromazine, risperidone, and domperidone were more potent at striatal dopamine d2 receptors (3.8-, 31-, and 40-fold, respectively). |
1998-06-04 |
2023-08-12 |
rat |
| M J Mijnster, A Schotte, G J Docter, P Voor. Effects of risperidone and haloperidol on tachykinin and opioid precursor peptide mRNA levels in the caudate-putamen and nucleus accumbens of the rat. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517839. |
furthermore, we studied the contribution of the dopamine d2 and serotonin 5-ht2a antagonist components of risperidone in establishing its effects on neuropeptide mrna levels in the striatum. |
1998-04-30 |
2023-08-12 |
rat |
| M J Mijnster, A Schotte, G J Docter, P Voor. Effects of risperidone and haloperidol on tachykinin and opioid precursor peptide mRNA levels in the caudate-putamen and nucleus accumbens of the rat. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517839. |
however, when doses of risperidone and haloperidol were modified to attain comparable dopamine d2 receptor occupancy, the drugs had comparable effects on preproenkephalin-a mrna levels. |
1998-04-30 |
2023-08-12 |
rat |
| B M Cohen, W Wan, M P Froimowitz, D J Ennulat, S Cherkerzian, H Konieczn. Activation of midline thalamic nuclei by antipsychotic drugs. Psychopharmacology. vol 135. issue 1. 1998-04-22. PMID:9489932. |
rats were given single doses of the typical high and low potency neuroleptics haloperidol (1 mg/kg) and chlorpromazine (20 mg/kg), the atypical neuroleptics thiroridazine (20 mg/kg) and clozapine (20 mg/kg), the specific dopamine antagonist raclopride (3 mg/kg), the mixed dopamine/serotonin antagonist risperidone (3 mg/kg) or drug-free vehicle. |
1998-04-22 |
2023-08-12 |
rat |
| G Remington, S Kapur, R Zipursk. The relationship between risperidone plasma levels and dopamine D2 occupancy: a positron emission tomographic study. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472848. |
the relationship between risperidone plasma levels and dopamine d2 occupancy: a positron emission tomographic study. |
1998-04-02 |
2023-08-12 |
Not clear |
| J Arnt, T Skarsfeld. Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 2. 1998-02-12. PMID:9430133. |
however, among the group of novel apds there are many individual differences in models reflecting limbic versus striatal inhibition of dopamine function: clozapine and sertindole show the largest limbic selectivity, followed by quetiapine, ziprasidone, olanzapine and remoxipride, whereas risperidone in many respects has a profile that resembles haloperidol. |
1998-02-12 |
2023-08-12 |
Not clear |
| G Mas. Atypical neuroleptics in the treatment of early onset schizophrenia. Panminerva medica. vol 39. issue 3. 1998-01-13. PMID:9360425. |
the more recently synthesized neuroleptics, with combined action on dopamine and serotonin receptors, have been called atypical neuroleptics; the atypical neuroleptics currently used in clinical practice are clozapine and risperidone. |
1998-01-13 |
2023-08-12 |
Not clear |
| M B Knable, A Heinz, T Raedler, D R Weinberge. Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels. Psychiatry research. vol 75. issue 2. 1997-12-16. PMID:9351491. |
risperidone is an antipsychotic drug with high affinity at dopamine d2 and serotonin 5-ht2 receptors. |
1997-12-16 |
2023-08-12 |
human |
| C J McDougl. Update on pharmacologic management of OCD: agents and augmentation. The Journal of clinical psychiatry. vol 58 Suppl 12. 1997-12-15. PMID:9393391. |
however, when drugs affecting dopamine function (e.g., pimozide, haloperidol, risperidone) are added to sri therapy in sri-refractory ocd patients, individuals with either a personal history or family history of tics experience a reduction in their symptoms. |
1997-12-15 |
2023-08-12 |
Not clear |
| C Cohen, D J Sanger, G Perraul. Characterization of the discriminative stimulus produced by the dopamine antagonist tiapride. The Journal of pharmacology and experimental therapeutics. vol 283. issue 2. 1997-12-08. PMID:9353371. |
all dopamine antagonists, including amisulpride (ed50 4 mg/kg), sulpiride (18 mg/kg), sultopride (1.5 mg/kg), clebopride (0.13 mg/kg), raclopride (0.16 mg/kg), metoclopramide (1.4 mg/kg), remoxipride (4.8 mg/kg), pimozide (2.7 mg/kg), thioridazine (3.4 mg/kg), olanzapine (0.97 mg/kg), chlorpromazine (1.9 mg/kg), risperidone (0.22 mg/kg) and haloperidol (0.14 mg/kg), except clozapine (>10 mg/kg), produced dose-dependent substitution for tiapride. |
1997-12-08 |
2023-08-12 |
rat |
| S Schreiber, M M Backer, R Weizman, C G Pic. Augmentation of opioid induced antinociception by the atypical antipsychotic drug risperidone in mice. Neuroscience letters. vol 228. issue 1. 1997-08-28. PMID:9197279. |
risperidone is a novel atypical neuroleptic with a favorable profile of side effects due to its unique pharmacological activity: it exhibits both potent dopamine d2 and 5-ht2 receptor blocking activity, as well as high affinity for alpha1 and alpha2 adrenergic receptors and histamine h1 receptor. |
1997-08-28 |
2023-08-12 |
mouse |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
we have previously shown that risperidone, an antipsychotic drug with high affinity for 5-hydroxytryptamine (5-ht)2a and dopamine (da)2 receptors, as well as for alpha 2- and alpha 2-adrenoceptors, enhances 5-ht metabolism selectively in the rat frontal cortex (fc). |
1997-08-13 |
2023-08-12 |
rat |
| M Volonté, E Monferini, M Cerutti, F Fodritto, F Borsin. BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202309. |
the effect of acute subcutaneous bimg 80, clozapine, haloperidol, risperidone, amperozide, olanzapine, and seroquel was then investigated on dopamine release in medial prefrontal cortex, nucleus accumbens, and striatum in freely moving rats using the microdialysis technique. |
1997-07-24 |
2023-08-12 |
rat |
| M Volonté, E Monferini, M Cerutti, F Fodritto, F Borsin. BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202309. |
(c) risperidone and olanzapine stimulated dopamine release to a similar extent in all brain regions investigated. |
1997-07-24 |
2023-08-12 |
rat |
| J S Silvestre, M F O'Neill, A G Fernandez, J M Palacio. Effects of a range of dopamine receptor agonists and antagonists on ethanol intake in the rat. European journal of pharmacology. vol 318. issue 2-3. 1997-05-29. PMID:9016913. |
the dopamine d1 receptor antagonist sch 23390 (r-(+)-7-chloro-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1h-3-benzazepine-8- ol), dopamine d2/d3 receptor antagonist raclopride and 5-ht2/d2 receptor antagonist risperidone did not affect ethanol consumption, although all at high doses induced a significant decrease in water intake, indicating a non-specific decrease in consummatory behavior with these compounds. |
1997-05-29 |
2023-08-12 |
rat |
| B Küfferle, T Brücke, A Topitz-Schratzberger, J Tauscher, R Gössler, C Vesely, S Asenbaum, I Podreka, S Kaspe. Striatal dopamine-2 receptor occupancy in psychotic patients treated with risperidone. Psychiatry research. vol 68. issue 1. 1997-04-30. PMID:9027930. |
a statistically significant difference was also found concerning these ratios and percentage of dopamine d2 receptor occupancy rates between the treatment groups with lowest ratios and highest percentage of d2 receptor occupancy in the group of patients treated with haloperidol, followed by the group treated with 8 mg of risperidone and the group treated with 3 mg of risperidone. |
1997-04-30 |
2023-08-12 |
human |
| H D Abraham, A Mame. LSD-like panic from risperidone in post-LSD visual disorder. Journal of clinical psychopharmacology. vol 16. issue 3. 1997-03-18. PMID:8784656. |
risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine d2 receptors. |
1997-03-18 |
2023-08-12 |
Not clear |