| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vincenzo Di Matteo, Marisa Cacchio, Camillo Di Giulio, Giuseppe Di Giovanni, Ennio Esposit. Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888552. |
therefore, the effects of clozapine (5 mg/kg ip), risperidone (0.08 mg/kg ip) and of the typical antipsychotic haloperidol (0.1 mg/kg ip) were studied on the extracellular concentration of dopamine (da) in the nucleus accumbens of chloral hydrate-anesthetized rats, using intracerebral microdialysis. |
2002-09-11 |
2023-08-12 |
human |
| Junji Ichikawa, Jin Dai, Herbert Y Meltze. 5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex. Brain research. vol 939. issue 1-2. 2002-08-28. PMID:12020849. |
the atypical antipsychotic drugs (apds) clozapine, olanzapine, risperidone, and ziprasidone preferentially increase dopamine (da) release in rat medial prefrontal cortex (mpfc). |
2002-08-28 |
2023-08-12 |
rat |
| Gurpreet Kaur, Shrinivas K Kulkarn. Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 2. 2002-07-22. PMID:11817504. |
the aim of this study was to examine the effects of different doses of typical antipsychotics, chlorpromazine (0.25-1 mg/kg) and haloperidol (0.25-1 mg/kg), and atypical antipsychotics, clozapine (0.5-2 mg/kg), olanzapine (0.25-1 mg/kg), risperidone (0.5-2 mg/kg), sulpiride (10-40 mg/kg) and dopamine d1 antagonist, sch 23390 (0.25-1 mg/kg) on feeding behavior at different time intervals after acute administration. |
2002-07-22 |
2023-08-12 |
mouse |
| I Gil-ad, B Shtaif, R Shiloh, A Weizma. Evaluation of the neurotoxic activity of typical and atypical neuroleptics: relevance to iatrogenic extrapyramidal symptoms. Cellular and molecular neurobiology. vol 21. issue 6. 2002-06-25. PMID:12043843. |
perphenazine, haloperidol, clozapine, sulpiride, and risperidone (10-100 microm) were administered, either alone or combined with dopamine, to primary mouse neuronal or intact brain culture and to a human neuroblastoma (nb) cell line (sk-n-sh). |
2002-06-25 |
2023-08-12 |
mouse |
| Daniel Tarsy, Ross J Baldessarini, Frank I Taraz. Effects of newer antipsychotics on extrapyramidal function. CNS drugs. vol 16. issue 1. 2002-03-18. PMID:11772117. |
for the treatment of psychotic reactions to dopamine agonist therapy in parkinson's disease, clozapine is both effective and relatively well tolerated; quetiapine may be tolerated, olanzapine is not well tolerated, risperidone is poorly tolerated, and amisulpride and ziprasidone have not been well evaluated. |
2002-03-18 |
2023-08-12 |
Not clear |
| Stefan Leucht, Gabi Pitschel-Walz, Rolf R Engel, Werner Kisslin. Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials. The American journal of psychiatry. vol 159. issue 2. 2002-03-06. PMID:11823257. |
the "atypical" profile of the new antipsychotics clozapine, olanzapine, quetiapine, and risperidone has been linked to combined antagonism of serotonin 2 (5-ht(2)) and dopamine 2 (d(2)) receptors. |
2002-03-06 |
2023-08-12 |
Not clear |
| B H Westerink, Y Kawahara, P De Boer, C Geels, J B De Vries, H V Wikström, A Van Kalkeren, B Van Vliet, C G Kruse, S K Lon. Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum. European journal of pharmacology. vol 412. issue 2. 2002-02-21. PMID:11165224. |
dose-effect curves were established for the effects of the antipsychotic drugs haloperidol, clozapine, olanzapine, risperidone and ziprasidone on extracellular levels of dopamine and noradrenaline in the medial prefrontal cortex, and of dopamine in the striatum. |
2002-02-21 |
2023-08-12 |
Not clear |
| F J Jiménez-Jiménez, P J García-Rui. Pharmacological options for the treatment of Tourette's disorder. Drugs. vol 61. issue 15. 2002-02-05. PMID:11772131. |
the potential usefulness of atypical antipsychotic drugs (risperidone, olanzapine, clozapine, ziprasidone) and other dopaminergic drugs (fluphenazine, sulpiride, tiapride, metoclopramide, piquindone, tetrabenazine), clonazepam, calcium channel antagonists, botulinum toxin, dopamine agonists, selegiline, and other drugs is discussed. |
2002-02-05 |
2023-08-12 |
Not clear |
| J Mukherjee, B T Christian, T K Narayanan, B Shi, J Manti. Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 4. 2001-11-01. PMID:11557161. |
evaluation of dopamine d-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18f-fallypride. |
2001-11-01 |
2023-08-12 |
monkey |
| J Mukherjee, B T Christian, T K Narayanan, B Shi, J Manti. Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 4. 2001-11-01. PMID:11557161. |
we have used the high-affinity dopamine d-2 receptor radioligand, 18f-fallypride for evaluating receptor occupancy by the antipsychotic drugs, clozapine, risperidone, and haloperidol in rodents and nonhuman primates. |
2001-11-01 |
2023-08-12 |
monkey |
| J Mukherjee, B T Christian, T K Narayanan, B Shi, J Manti. Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 25. issue 4. 2001-11-01. PMID:11557161. |
at therapeutically relevant doses, clozapine, risperidone, and haloperidol were able to compete significantly with the binding of 18f-fallypride in all brain regions in rhesus monkeys, and our analyses indicate that these drugs (clozapine, risperidone, and haloperidol) do not discriminate between the striatal (caudate and putamen) and the extrastriatal (thalamus and cortical regions) dopamine receptors. |
2001-11-01 |
2023-08-12 |
monkey |
| M Markianos, J Hatzimanolis, L Lykoura. Neuroendocrine serotonergic and dopaminergic responsivity in male schizophrenic patients during treatment with neuroleptics and after switch to risperidone. Psychopharmacology. vol 157. issue 1. 2001-10-25. PMID:11512043. |
the pharmacological profile of risperidone is that of an atypical neuroleptic regarding its serotonin 5-ht2a and dopamine d2 receptor blocking properties. |
2001-10-25 |
2023-08-12 |
Not clear |
| O G Heitu. [Risperidone as a tool to control hard aggression]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 121. issue 19. 2001-10-25. PMID:11571877. |
risperidone is an antipsychotic drug with a combined effect as a dopamine antagonist and a 5-ht2a receptor antagonist. |
2001-10-25 |
2023-08-12 |
Not clear |
| N Maneeton, S Intaprasert, M Srisurapanon. Risperidone for controlling aggressive behavior in a mentally retarded child: a case report. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 84. issue 6. 2001-10-04. PMID:11556472. |
risperidone is an atypical antipsychotic agent with dopamine and serotonin antagonistic effects. |
2001-10-04 |
2023-08-12 |
Not clear |
| M Van Bellinghen, C De Troc. Risperidone in the treatment of behavioral disturbances in children and adolescents with borderline intellectual functioning: a double-blind, placebo-controlled pilot trial. Journal of child and adolescent psychopharmacology. vol 11. issue 1. 2001-08-30. PMID:11322745. |
risperidone, an antipsychotic agent with combined serotonin (5-ht2a) and dopamine (d2) receptor-blocking properties, is associated with fewer extrapyramidal side effects in adults than conventional neuroleptics. |
2001-08-30 |
2023-08-12 |
Not clear |
| J Cartmell, K W Perry, C R Salhoff, J A Monn, D D Schoep. Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378155. |
here, we compared the acute effects of ly379268 with those of clozapine and risperidone (atypical antipsychotics) on extracellular levels of both dopamine and 5-ht in the mpfc of freely-moving rats. |
2001-08-09 |
2023-08-12 |
rat |
| J Cartmell, K W Perry, C R Salhoff, J A Monn, D D Schoep. Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378155. |
one hour after injection, ly379268 (10 mg/kg s.c.), clozapine (10 mg/kg s.c.) or risperidone (1 mg/kg s.c.) maximally increased dopamine by 224, 257 and 234% of basal levels. |
2001-08-09 |
2023-08-12 |
rat |
| C Manzanedo, M A Aguilar, M Rodríguez-Arias, J Miñarr. Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice. Behavioural brain research. vol 121. issue 1-2. 2001-06-28. PMID:11275296. |
the effects of dopamine (da) antagonists with different selectivity for the da receptors (sch 23390, 0.5, 0.25, 0.125 mg/kg; haloperidol, 0.2, 0.1 mg/kg; raclopride, 1.2, 0.6, 0.3 mg/kg; risperidone, 0.4, 0.2, 0.1 mg/kg; u-99194a maleate, 40, 20 mg/kg; clozapine, 2.5, 1.25, 0.625 mg/kg) on the acquisition of place conditioning and morphine-induced conditioned place preference (cpp) were explored in male mice. |
2001-06-28 |
2023-08-12 |
mouse |
| J K Buitelaar, R J van der Gaag, P Cohen-Kettenis, C T Melma. A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. The Journal of clinical psychiatry. vol 62. issue 4. 2001-06-14. PMID:11379837. |
risperidone is an atypical antipsychotic drug that blocks dopamine as well as serotonin receptor systems. |
2001-06-14 |
2023-08-12 |
Not clear |
| R Bruggeman, M Heeringa, B H Westerink, W Timmerma. Combined 5-HT2/D2 receptor blockade inhibits the firing rate of SNR neurons in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 4. 2001-05-24. PMID:10958152. |
the aim of the present study was to evaluate the contribution of serotonin (5-ht) and dopamine (da) receptor antagonism to the distinct inhibitory effects of the atypical antipsychotics clozapine and risperidone on snr neurons, we have shown previously. |
2001-05-24 |
2023-08-12 |
rat |