| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazufumi Hirano, Syuji Maruyama, Ryohei Kimura, Yoshiyuki Kagawa, Shizuo Yamad. In vivo identification and characterization of binding sites for selective serotonin reuptake inhibitors in mouse brain. Life sciences. vol 75. issue 24. 2004-12-14. PMID:15454344. |
the value of area under the curve (auc) for decrease in [3h]paroxetine binding vs. time in each brain region was largest for fluoxetine among these ssris, due to the relatively longer-lasting occupation of brain serotonin transporter. |
2004-12-14 |
2023-08-12 |
mouse |
| D Joel, E Ben-Amir, J Doljansky, S Flaishe. 'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. Behavioural pharmacology. vol 15. issue 3. 2004-12-08. PMID:15187582. |
'compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. |
2004-12-08 |
2023-08-12 |
rat |
| D Joel, E Ben-Amir, J Doljansky, S Flaishe. 'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. Behavioural pharmacology. vol 15. issue 3. 2004-12-08. PMID:15187582. |
given that one of the most salient features of ocd is its selective response to treatment with serotonin re-uptake inhibitors (sris), the present study compared the effects of the sris paroxetine and fluvoxamine on compulsive lever-pressing, with those of the tricyclic antidepressant, desipramine, and the benzodiazepine, diazepam, which are not effective in the treatment of ocd. |
2004-12-08 |
2023-08-12 |
rat |
| Pal Pacher, Valeria Kecskemet. Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns? Current pharmaceutical design. vol 10. issue 20. 2004-12-07. PMID:15320756. |
to overcome the toxicity of old generation of antidepressants and antipsychotics, selective serotonin reuptake inhibitor antidepressants (ssris: fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, venlafaxin) and several new antipsychotics (e.g. |
2004-12-07 |
2023-08-12 |
human |
| Greer M Murphy, Steven B Hollander, Heidi E Rodrigues, Charlotte Kremer, Alan F Schatzber. Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. Archives of general psychiatry. vol 61. issue 11. 2004-11-24. PMID:15520364. |
effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. |
2004-11-24 |
2023-08-12 |
Not clear |
| H R Sumnall, E O'Shea, C A Marsden, J C Col. The effects of MDMA pretreatment on the behavioural effects of other drugs of abuse in the rat elevated plus-maze test. Pharmacology, biochemistry, and behavior. vol 77. issue 4. 2004-11-16. PMID:15099927. |
mdma pretreatment produced approximately 20-25% decrease in hippocampal 5-ht and 5-hiaa concentrations, and [(3)h]paroxetine binding when analysed 2 weeks later. |
2004-11-16 |
2023-08-12 |
rat |
| Fluvoxamine: new indication. No progress in obsessive-compulsive disorder. Prescrire international. vol 13. issue 73. 2004-10-28. PMID:15499694. |
(1) four drugs are approved in france for patients with obsessive-compulsive disorders, namely clomipramine and three selective serotonin reuptake inhibitors (ssris): fluoxetine, paroxetine and sertraline. |
2004-10-28 |
2023-08-12 |
Not clear |
| Erdem N Duman, Murat Kesim, Mine Kadioglu, Ersin Yaris, Nuri Ihsan Kalyoncu, Nesrin Erciye. Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain. Journal of pharmacological sciences. vol 94. issue 2. 2004-10-20. PMID:14978354. |
in this study, the potential antinociceptive effect of paroxetine and its interaction with opioidergic system and serotonin receptors were evaluated. |
2004-10-20 |
2023-08-12 |
mouse |
| Erdem N Duman, Murat Kesim, Mine Kadioglu, Ersin Yaris, Nuri Ihsan Kalyoncu, Nesrin Erciye. Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain. Journal of pharmacological sciences. vol 94. issue 2. 2004-10-20. PMID:14978354. |
while ondansetron (a 5-ht(3)-receptor antagonist) inhibited the effect of paroxetine, ketanserin (a 5-ht(2)-receptor antagonist) could not. |
2004-10-20 |
2023-08-12 |
mouse |
| Marcel D Waldinger, Berend Olivie. Utility of selective serotonin reuptake inhibitors in premature ejaculation. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 7. 2004-10-18. PMID:15298071. |
a meta-analysis of 35 daily treatment studies with selective serotonin reuptake inhibitors (ssris) and clomipramine demonstrated comparable efficacy of clomipramine with the ssris sertraline and fluoxetine in delaying ejaculation, whereas the efficacy of the ssri paroxetine was greater than all other ssris and clomipramine. |
2004-10-18 |
2023-08-12 |
Not clear |
| Jeong-Wook Kwon, Kevin L Armbrus. Hydrolysis and photolysis of paroxetine, a selective serotonin reuptake inhibitor, in aqueous solutions. Environmental toxicology and chemistry. vol 23. issue 6. 2004-10-05. PMID:15376524. |
hydrolysis and photolysis of paroxetine, a selective serotonin reuptake inhibitor, in aqueous solutions. |
2004-10-05 |
2023-08-12 |
Not clear |
| Jeong-Wook Kwon, Kevin L Armbrus. Hydrolysis and photolysis of paroxetine, a selective serotonin reuptake inhibitor, in aqueous solutions. Environmental toxicology and chemistry. vol 23. issue 6. 2004-10-05. PMID:15376524. |
the hydrolysis and photolysis of paroxetine hci, a selective serotonin reuptake inhibitor, in aqueous buffer solutions (ph 5, 7, and 9), in synthetic humic water, and in lake water were investigated at 25 degrees c in the dark and in a growth chamber outfitted with fluorescent lamps simulating the ultraviolet (uv) output of sunlight. |
2004-10-05 |
2023-08-12 |
Not clear |
| Robert N Golde. Making advances where it matters: improving outcomes in mood and anxiety disorders. CNS spectrums. vol 9. issue 6 Suppl 4. 2004-09-21. PMID:15181381. |
a controlled-release formulation of paroxetine targets the site of absorption for a more distal region of the small intestine, thereby avoiding the stimulation of upper gastrointestinal serotonin receptors that mediate nausea. |
2004-09-21 |
2023-08-12 |
Not clear |
| Vered Stearns, Charles L Loprinz. New therapeutic approaches for hot flashes in women. The journal of supportive oncology. vol 1. issue 1. 2004-09-21. PMID:15352639. |
newer antidepressants from the selective serotonin or noradrenergic reuptake inhibitor family, such as venlafaxine and paroxetine, appear to be among the most effective nonhormonal agents for the treatment of hot flashes. |
2004-09-21 |
2023-08-12 |
Not clear |
| Javier Angulo, Pedro Cuevas, Begoña Cuevas, Sandeep Gupta, Iñigo Sáenz de Tejad. Mechanisms for the inhibition of genital vascular responses by antidepressants in a female rabbit model. The Journal of pharmacology and experimental therapeutics. vol 310. issue 1. 2004-09-07. PMID:15034084. |
the selective 5-ht reuptake inhibitor (ssri) escitalopram did not modify gvrs, whereas the ssri paroxetine dose-dependently inhibited gvrs in female rabbits (43.3 and 53.1% at 5 mg/kg). |
2004-09-07 |
2023-08-12 |
rabbit |
| Jonathan R T Davidson, Dan J Stein, Arieh Y Shalev, Rachel Yehud. Posttraumatic stress disorder: acquisition, recognition, course, and treatment. The Journal of neuropsychiatry and clinical neurosciences. vol 16. issue 2. 2004-09-07. PMID:15260364. |
mainstay treatments include exposure-based psychosocial therapy and selective serotonin reuptake inhibitors, such as paroxetine and sertraline, both of which have been found to be effective in ptsd. |
2004-09-07 |
2023-08-12 |
Not clear |
| Yanling Xu, Youssef Sari, Feng C Zho. Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development. Brain research. Developmental brain research. vol 150. issue 2. 2004-08-23. PMID:15158078. |
to further investigate the role of the transiently expressed serotonin (5-ht) transporter (5-htt) in the development of thalamic fibers projecting to cortical barrels and the potential developmental changes in neuronal circuitry caused by a selective serotonin reuptake inhibitor (ssri), paroxetine (5 mg/kg, twice daily, s.c.) or saline was administered to rat pups from postnatal day 0 (p0) to p8. |
2004-08-23 |
2023-08-12 |
rat |
| Yanling Xu, Youssef Sari, Feng C Zho. Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development. Brain research. Developmental brain research. vol 150. issue 2. 2004-08-23. PMID:15158078. |
paroxetine treatment completely blocked 5-ht uptake into the thalamocortical fibers as indicated by the negative 5-ht-im in cortical barrel areas. |
2004-08-23 |
2023-08-12 |
rat |
| D J P David, M Bourin, G Jego, C Przybylski, P Jolliet, A M Gardie. Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice. British journal of pharmacology. vol 140. issue 6. 2004-08-17. PMID:14530210. |
effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in swiss mice. |
2004-08-17 |
2023-08-12 |
mouse |
| D J P David, M Bourin, G Jego, C Przybylski, P Jolliet, A M Gardie. Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice. British journal of pharmacology. vol 140. issue 6. 2004-08-17. PMID:14530210. |
of paroxetine, citalopram or venlafaxine may simultaneously increase extracellular levels of 5-ht ([5-ht]ext) and noradrenaline ([na]ext) by using in vivo microdialysis in the frontal cortex (fcx) of awake, freely moving swiss mice. |
2004-08-17 |
2023-08-12 |
mouse |