| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin E Keck, Simone B Sartori, Tobias Welt, Marianne B Müller, Frauke Ohl, Florian Holsboer, Rainer Landgraf, Nicolas Singewal. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715667. |
this effect may be (at least in part) related to a greater down-regulation of hippocampal serotonin transporter binding sites by paroxetine in habs compared with labs, while 5-ht1a receptor expression remained unaffected in this brain area. |
2005-04-28 |
2023-08-12 |
rat |
| J Douglas Bremner, Eric Vermette. Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder. Annals of the New York Academy of Sciences. vol 1032. 2005-04-19. PMID:15677402. |
we found that treatment of ptsd patients for a year with the serotonin reuptake inhibitor (ssri) paroxetine resulted in a 5% increase in hippocampal volume and a 35% improvement in verbal declarative memory function. |
2005-04-19 |
2023-08-12 |
Not clear |
| Philippos Gourzis, Panagiotis Polychronopoulos, Andreas A Argyriou, Constantina Bakalidou, Stavroula Berati. Induction of the rabbit syndrome following coadministration of paroxetine, perphenazine, and amitriptyline. Clinical neuropharmacology. vol 27. issue 6. 2005-04-18. PMID:15613935. |
to their knowledge, this is the first report in the literature describing rabbit syndrome induced by the administration of a selective serotonin reuptake inhibitor-specifically, paroxetine in combination with perphenazine and amitriptyline. |
2005-04-18 |
2023-08-12 |
rabbit |
| Koen Schruers, Eric Grie. The effects of tianeptine or paroxetine on 35% CO2 provoked panic in panic disorder. Journal of psychopharmacology (Oxford, England). vol 18. issue 4. 2005-04-12. PMID:15582922. |
the aim of the present study was to compare the effect of tianeptine with that of paroxetine, a selective 5-ht reuptake inhibitor with demonstrated efficacy in panic disorder, on the vulnerability to a laboratory panic challenge in panic disorder patients. |
2005-04-12 |
2023-08-12 |
Not clear |
| Koen Schruers, Eric Grie. The effects of tianeptine or paroxetine on 35% CO2 provoked panic in panic disorder. Journal of psychopharmacology (Oxford, England). vol 18. issue 4. 2005-04-12. PMID:15582922. |
in spite of their opposite influence on 5-ht uptake, both tianeptine and paroxetine appeared to reduce the reaction to the panic challenge. |
2005-04-12 |
2023-08-12 |
Not clear |
| M Angels Fisas, Antonio Farré, Jorge Camarasa, Elena Escubed. Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors. Pharmacology. vol 72. issue 2. 2005-04-08. PMID:15331910. |
as lesopitron did not affect the binding of [3h]paroxetine, involvement of the serotonin reuptake system in the effects of lesopitron is rejected. |
2005-04-08 |
2023-08-12 |
Not clear |
| Jordanna E Bermack, Nasser Haddjeri, Guy Debonne. Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. The Journal of pharmacology and experimental therapeutics. vol 310. issue 2. 2005-03-28. PMID:15044555. |
furthermore, after 2-day treatments with opc, the 5-ht(1a) autoreceptor response was altered, as demonstrated by the dramatically reduced response to an increase of endogenous 5-ht induced by the acute administration of paroxetine (500 microg/kg, i.v.). |
2005-03-28 |
2023-08-12 |
rat |
| Jordanna E Bermack, Nasser Haddjeri, Guy Debonne. Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. The Journal of pharmacology and experimental therapeutics. vol 310. issue 2. 2005-03-28. PMID:15044555. |
the decreased response of the 5-ht(1a) autoreceptor to paroxetine was not blocked by the coadministration of ne-100 indicating that sigma(1) receptors are not involved in this effect. |
2005-03-28 |
2023-08-12 |
rat |
| D Joel, J Doljansky, N Roz, M Rehav. Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder. Neuroscience. vol 130. issue 1. 2005-03-22. PMID:15561422. |
we found that lesion to the rat orbital cortex led to a selective increase in compulsive lever-pressing that was prevented by the serotonin re-uptake inhibitor, paroxetine, and was paralleled by an increase in the density of the striatal serotonin transporter, assessed using high affinity [3h]imipramine binding. |
2005-03-22 |
2023-08-12 |
rat |
| Nemesio Cedeño, Mary Urbina, Francisco Obregón, Lucimey Lim. Characterization of serotonin transporter in blood lymphocytes of rats. Modulation by in vivo administration of mitogens. Journal of neuroimmunology. vol 159. issue 1-2. 2005-03-18. PMID:15652400. |
the potency order of inhibition of [(3)h]paroxetine binding was imipramine>citalopram>alaproclate>serotonin. |
2005-03-18 |
2023-08-12 |
human |
| A T Strachan, J B Leiper, R J Maugha. Paroxetine administration failed [corrected] to influence human exercise capacity, perceived effort or hormone responses during prolonged exercise in a warm environment. Experimental physiology. vol 89. issue 6. 2005-03-15. PMID:15328306. |
the purpose of the experiment was to examine whether selective serotonin (5-ht) re-uptake transporter blockade by paroxetine has any effect on perceived effort (rpe) during exercise or the time to reach volitional fatigue and on the prolactin and cortisol responses during prolonged exercise performed in a warm environment. |
2005-03-15 |
2023-08-12 |
human |
| A T Strachan, J B Leiper, R J Maugha. Paroxetine administration failed [corrected] to influence human exercise capacity, perceived effort or hormone responses during prolonged exercise in a warm environment. Experimental physiology. vol 89. issue 6. 2005-03-15. PMID:15328306. |
in conclusion, acute administration of paroxetine failed to alter rpe, exercise capacity or the response of the determined peripheral hormone markers of central 5-ht activity during prolonged exercise in a warm environment. |
2005-03-15 |
2023-08-12 |
human |
| K Ghos. Tolerance and side-effects of paroxetine in elderly depressed patients. Archives of gerontology and geriatrics. vol 24. issue 1. 2005-03-14. PMID:15374134. |
paroxetine, a selective serotonin reuptake inhibitor (ssri) antidepressant, is considered to have fewer side-effects than a typical tricyclic antidepressant. |
2005-03-14 |
2023-08-12 |
Not clear |
| Caroline E Renard, Eric Dailly, Bríd A Nic Dhonnchadha, Martine Hascoet, Michel Bouri. Is dopamine a limiting factor of the antidepressant-like effect in the mouse forced swimming test? Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 8. 2005-03-07. PMID:15588751. |
to study the role of dopamine (da) in antidepressant-like effect in the forced swimming test (fst), the relationship between the magnitude of the antidepressant-like effect of drugs [citalopram, fluoxetine, paroxetine (selective serotonin reuptake inhibitors), desipramine (tricyclic antidepressant), maprotiline (tetracyclic antidepressant), bupropion (da reuptake inhibitor), and tranylcypromine (inhibitor of monoamine oxidase)] and the corresponding concentration of da in the whole brain of mice was investigated. |
2005-03-07 |
2023-08-12 |
mouse |
| B Aouizerate, C Martin-Guehl, J Tigno. [Neurobiology and pharmacotherapy of social phobia]. L'Encephale. vol 30. issue 4. 2005-03-01. PMID:15538306. |
there is growing evidence for the efficacy of the selective serotonin reuptake inhibitors fluvoxamine, fluoxetine, citalopram, paroxetine and sertraline. |
2005-03-01 |
2023-08-12 |
human |
| Kazufumi Hirano, Yasuhiro Kato, Shinya Uchida, Yumi Sugimoto, Jun Yamada, Keizo Umegaki, Shizuo Yamad. Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice. The Journal of pharmacy and pharmacology. vol 56. issue 12. 2005-03-01. PMID:15563766. |
in in-vitro experiments, st john's wort inhibited brain synaptosomal [(3)h]serotonin uptake in mice with little effect on specific [(3)h]paroxetine binding. |
2005-03-01 |
2023-08-12 |
mouse |
| Kazufumi Hirano, Yasuhiro Kato, Shinya Uchida, Yumi Sugimoto, Jun Yamada, Keizo Umegaki, Shizuo Yamad. Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice. The Journal of pharmacy and pharmacology. vol 56. issue 12. 2005-03-01. PMID:15563766. |
for selective serotonin-reuptake inhibitors (ssris), the ic50 value for [(3)h]serotonin uptake (molar concentration of unlabelled drug necessary to displace 50% of specific uptake) correlated well with the inhibition constant k(i) value for [(3)h]paroxetine binding in mouse brain. |
2005-03-01 |
2023-08-12 |
mouse |
| Kazufumi Hirano, Yasuhiro Kato, Shinya Uchida, Yumi Sugimoto, Jun Yamada, Keizo Umegaki, Shizuo Yamad. Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice. The Journal of pharmacy and pharmacology. vol 56. issue 12. 2005-03-01. PMID:15563766. |
oral administration of st john's wort (900 mg kg(-1)), paroxetine (1 mg kg(-1)) and sertraline (10 mg kg(-1)) brought about significant increases in the k(m) value for [(3)h]serotonin uptake into brain synaptosomes 4 h later, and only ssris suppressed specific [(3)h]paroxetine binding in mouse brain. |
2005-03-01 |
2023-08-12 |
mouse |
| Nasser Haddjeri, Céline Faure, Guillaume Lucas, Ouissame Mnie-Filali, Guy Chouvet, Bernadette Astier, Bernard Renaud, Pierre Blier, Guy Debonne. In-vivo modulation of central 5-hydroxytryptamine (5-HT1A) receptor-mediated responses by the cholinergic system. The international journal of neuropsychopharmacology. vol 7. issue 4. 2005-02-24. PMID:15140278. |
prevented the suppressant effect of the selective serotonin reuptake inhibitor paroxetine (0.5 mg/kg i.v.) |
2005-02-24 |
2023-08-12 |
rat |
| Susan G Ball, Angela Kuhn, Delynda Wall, Anantha Shekhar, Andrew W Goddar. Selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind, prospective comparison between paroxetine and sertraline. The Journal of clinical psychiatry. vol 66. issue 1. 2005-02-24. PMID:15669894. |
selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind, prospective comparison between paroxetine and sertraline. |
2005-02-24 |
2023-08-12 |
Not clear |