| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Athina Markou, Amanda A Harrison, Jessica Chevrette, Daniel Hoye. Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats. Psychopharmacology. vol 178. issue 2-3. 2005-09-12. PMID:15452682. |
paroxetine combined with a 5-ht(1a) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats. |
2005-09-12 |
2023-08-12 |
rat |
| Scott P Runyon, Jason P Burgess, Philip Abraham, Kathryn I Keverline-Frantz, Judy Flippen-Anderson, Jeffrey Deschamps, Anita H Lewin, Hernán A Navarro, John W Boja, Michael J Kuhar, F Ivy Carrol. Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product. Bioorganic & medicinal chemistry. vol 13. issue 7. 2005-09-01. PMID:15755646. |
the structural requirements for high affinity at the serotonin transporter (5-htt) have been investigated through the preparation of rigid paroxetine analogs. |
2005-09-01 |
2023-08-12 |
Not clear |
| Scott P Runyon, Jason P Burgess, Philip Abraham, Kathryn I Keverline-Frantz, Judy Flippen-Anderson, Jeffrey Deschamps, Anita H Lewin, Hernán A Navarro, John W Boja, Michael J Kuhar, F Ivy Carrol. Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product. Bioorganic & medicinal chemistry. vol 13. issue 7. 2005-09-01. PMID:15755646. |
tropane-derived analogs (4a-i) of paroxetine (2) were designed and synthesized as potential inhibitors of serotonin reuptake based on the structural and biological similarity between the two compound classes. |
2005-09-01 |
2023-08-12 |
Not clear |
| Solisbella Peña, Edith Baccichet, Mary Urbina, Isabel Carreira, Lucimey Lim. Effect of mirtazapine treatment on serotonin transporter in blood peripheral lymphocytes of major depression patients. International immunopharmacology. vol 5. issue 6. 2005-08-15. PMID:15829422. |
serotonin transporters were labeled with [3h] paroxetine. |
2005-08-15 |
2023-08-12 |
human |
| Per Plenge, Ove Wibor. High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions. Neuroscience letters. vol 383. issue 3. 2005-08-09. PMID:15955412. |
the other site is a low-affinity allosteric site, which influences the dissociation of uptake inhibitors, such as imipramine, paroxetine, and citalopram from the first site, when occupied by 5-ht and a few uptake inhibitors like paroxetine and citalopram. |
2005-08-09 |
2023-08-12 |
human |
| Masaki Kato, Yuka Ikenaga, Masataka Wakeno, Gaku Okugawa, Kenji Nobuhara, Tsuyoshi Fukuda, Kazuhiro Fukuda, Junichi Azuma, Toshihiko Kinoshit. Controlled clinical comparison of paroxetine and fluvoxamine considering the serotonin transporter promoter polymorphism. International clinical psychopharmacology. vol 20. issue 3. 2005-08-02. PMID:15812265. |
controlled clinical comparison of paroxetine and fluvoxamine considering the serotonin transporter promoter polymorphism. |
2005-08-02 |
2023-08-12 |
Not clear |
| W E Heydor. Paroxetine: a review of its pharmacology, pharmacokinetics and utility in the treatment of a variety of psychiatric disorders. Expert opinion on investigational drugs. vol 8. issue 4. 2005-07-21. PMID:15992089. |
paroxetine is a selective serotonin re-uptake inhibitor (ssri). |
2005-07-21 |
2023-08-12 |
Not clear |
| W E Heydor. Paroxetine: a review of its pharmacology, pharmacokinetics and utility in the treatment of a variety of psychiatric disorders. Expert opinion on investigational drugs. vol 8. issue 4. 2005-07-21. PMID:15992089. |
as with other selective serotonin re-uptake inhibitors, a significant percentage of men under therapy with paroxetine report abnormal ejaculation. |
2005-07-21 |
2023-08-12 |
Not clear |
| Paul Willner, Anthony S Hale, Spilios Argyropoulo. Dopaminergic mechanism of antidepressant action in depressed patients. Journal of affective disorders. vol 86. issue 1. 2005-07-12. PMID:15820269. |
the participants were patients diagnosed with major depressive disorder (n = 8) who had been treated successfully (hamilton depression scale < 10) with selective serotonin uptake inhibitors (fluoxetine, citalopram or paroxetine); and age-matched, non-depressed, untreated volunteers (n = 10). |
2005-07-12 |
2023-08-12 |
human |
| B A Fallon, S J Mathe. Biological therapies for obsessive-compulsive disorder. Journal of psychiatric practice. vol 6. issue 3. 2005-07-12. PMID:15990479. |
the evidence for the efficacy of the serotonin reuptake inhibitors (clomipramine and the five selective serotonin reuptake inhibitors "ssris" fluvoxamine, fluoxetine, paroxetine, sertraline, and citalopram) as monotherapy for ocd is reviewed. |
2005-07-12 |
2023-08-12 |
Not clear |
| Zoë A Hughes, Kathryn R Starr, Christopher J Langmead, Matthew Hill, Gerd D Bartoszyk, James J Hagan, Derek N Middlemiss, Lee A Dawso. Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. European journal of pharmacology. vol 510. issue 1-2. 2005-06-28. PMID:15740724. |
in contrast, administration of 8-oh-dpat (0.3 mg/kg s.c.), either alone or in combination with a serotonin specific reuptake inhibitor (ssri; paroxetine, 3 mg/kg p.o. |
2005-06-28 |
2023-08-12 |
rat |
| Zoë A Hughes, Kathryn R Starr, Christopher J Langmead, Matthew Hill, Gerd D Bartoszyk, James J Hagan, Derek N Middlemiss, Lee A Dawso. Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. European journal of pharmacology. vol 510. issue 1-2. 2005-06-28. PMID:15740724. |
a 2-fold increase in extracellular 5-ht levels (but no change in noradrenaline or dopamine levels) was observed after combination of the 5-ht(1a) receptor antagonist, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(pyridinyl)cyclohexanecarboxamide) (way-100635; 0.3 mg/kg s.c.) and paroxetine (3 mg/kg p.o.). |
2005-06-28 |
2023-08-12 |
rat |
| Steven H Snyderman, Moira A Rynn, Kevin Bellew, Karl Rickel. Paroxetine in the treatment of generalised anxiety disorder. Expert opinion on pharmacotherapy. vol 5. issue 8. 2005-06-27. PMID:15264994. |
paroxetine is a selective serotonin re-uptake inhibitor useful in the treatment of a wide range of psychiatric disorders. |
2005-06-27 |
2023-08-12 |
Not clear |
| Y Hendrix, M S G van Zagte. [Serotonin syndrome as a result of concomitant use of paroxetine and sumatriptan]. Nederlands tijdschrift voor geneeskunde. vol 149. issue 16. 2005-06-09. PMID:15868995. |
[serotonin syndrome as a result of concomitant use of paroxetine and sumatriptan]. |
2005-06-09 |
2023-08-12 |
Not clear |
| Hideaki Obata, Shigeru Saito, Shiro Koizuka, Koichi Nishikawa, Fumio Got. The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain. Anesthesia and analgesia. vol 100. issue 5. 2005-05-26. PMID:15845695. |
a serotonin noradrenaline reuptake inhibitor, milnacipran, a selective serotonin reuptake inhibitor, paroxetine, or a selective noradrenaline reuptake inhibitor, maprotiline, was administered intrathecally via a chronically implanted catheter. |
2005-05-26 |
2023-08-12 |
rat |
| V Valentini, F Cacciapaglia, R Frau, G Di Chiar. Selective serotonin reuptake blockade increases extracellular dopamine in noradrenaline-rich isocortical but not prefrontal areas: dependence on serotonin-1A receptors and independence from noradrenergic innervation. Journal of neurochemistry. vol 93. issue 2. 2005-05-20. PMID:15816860. |
the present study investigated the effects of two serotonin (5-ht) uptake inhibitors, citalopram and paroxetine, and of a non-selective noradrenaline (na) and 5-ht uptake blocker, imipramine, on extracellular na and dopamine (da) in the prefrontal cortex (pfcx), parietal cortex (parcx) and occipital cortex (occcx). |
2005-05-20 |
2023-08-12 |
Not clear |
| V Valentini, F Cacciapaglia, R Frau, G Di Chiar. Selective serotonin reuptake blockade increases extracellular dopamine in noradrenaline-rich isocortical but not prefrontal areas: dependence on serotonin-1A receptors and independence from noradrenergic innervation. Journal of neurochemistry. vol 93. issue 2. 2005-05-20. PMID:15816860. |
paroxetine, a less selective 5-ht uptake inhibitor than citalopram, at the dose of 5 mg/kg, increased da in the occcx but not in the pfcx; however, at doses of 10 mg/kg, which increase pfcx na, paroxetine increased da also in this area. |
2005-05-20 |
2023-08-12 |
Not clear |
| Brian J Piper, Jerrold S Meye. Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. Pharmacology, biochemistry, and behavior. vol 79. issue 4. 2005-04-29. PMID:15582680. |
brain tissues were collected at pd 70 for determination of radiolabeled paroxetine binding to the serotonin transporter (sert) in the neocortex and hippocampus. |
2005-04-29 |
2023-08-12 |
human |
| Martin E Keck, Simone B Sartori, Tobias Welt, Marianne B Müller, Frauke Ohl, Florian Holsboer, Rainer Landgraf, Nicolas Singewal. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715667. |
chronic paroxetine treatment markedly increased the stress-induced rise in hippocampal 5-ht in hab, but not lab rats. |
2005-04-28 |
2023-08-12 |
rat |
| Martin E Keck, Simone B Sartori, Tobias Welt, Marianne B Müller, Frauke Ohl, Florian Holsboer, Rainer Landgraf, Nicolas Singewal. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715667. |
this effect may be (at least in part) related to a greater down-regulation of hippocampal serotonin transporter binding sites by paroxetine in habs compared with labs, while 5-ht1a receptor expression remained unaffected in this brain area. |
2005-04-28 |
2023-08-12 |
rat |