| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren C Smith, Olivier Georg. Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models. Neuropharmacology. vol 178. 2021-08-12. PMID:32758566. |
cannabinoid receptor agonists and antagonists interact with the dopamine reward pathway and show efficacy in reducing nicotine addiction-like behaviors in preclinical studies. |
2021-08-12 |
2023-08-13 |
Not clear |
| Cristina Cadoni, Marta De Felice, Silvia Corongiu, Christian Dessì, Elena Espa, Miriam Melis, Sandro Fen. Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31342609. |
role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission. |
2021-08-11 |
2023-08-13 |
rat |
| Cristina Cadoni, Marta De Felice, Silvia Corongiu, Christian Dessì, Elena Espa, Miriam Melis, Sandro Fen. Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31342609. |
here, we investigated the influence of both genetic background and age at first nicotine exposure in the long-lasting effects on mesolimbic dopamine transmission including the increased cocaine-rewarding effect. |
2021-08-11 |
2023-08-13 |
rat |
| Cristina Cadoni, Marta De Felice, Silvia Corongiu, Christian Dessì, Elena Espa, Miriam Melis, Sandro Fen. Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31342609. |
nicotine pre-exposure differentially changed mesolimbic dopamine transmission depending on strain and age of pre-exposure. |
2021-08-11 |
2023-08-13 |
rat |
| Cristina Cadoni, Marta De Felice, Silvia Corongiu, Christian Dessì, Elena Espa, Miriam Melis, Sandro Fen. Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission. Addiction biology. vol 25. issue 5. 2021-08-11. PMID:31342609. |
a potentiation of dopamine response to nicotine was observed in nucleus accumbens (nac) core of both strains and age groups, whereas dopamine response in nac shell was enhanced exclusively in lewis rats exposed to nicotine during adolescence. |
2021-08-11 |
2023-08-13 |
rat |
| Angela M Lee, Mohammad Shahid Mansuri, Rashaun S Wilson, TuKiet T Lam, Angus C Nairn, Marina R Picciott. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers in molecular neuroscience. vol 14. 2021-08-03. PMID:34335180. |
despite differences by sex, strain, and nicotine exposure parameters, glial fibrillary acidic protein (gfap) and dopamine and camp-regulated phosphoprotein of 32 kda (darpp-32, ppp1r1b) were repeatedly identified as significantly altered proteins, especially in the vta. |
2021-08-03 |
2023-08-13 |
mouse |
| Surya P Aryal, Xu Fu, Joree N Sandin, Khaga R Neupane, Jourdan E Lakes, Martha E Grady, Christopher I Richard. Nicotine induces morphological and functional changes in astrocytes via nicotinic receptor activity. Glia. vol 69. issue 8. 2021-08-02. PMID:33851731. |
nicotine is a highly addictive compound present in tobacco, which causes the release of dopamine in different regions of the brain. |
2021-08-02 |
2023-08-13 |
mouse |
| Maria Paula Faillace, Ramón O Bernabe. Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish. Current neuropharmacology. 2021-07-19. PMID:34279203. |
the hypothesis discussed here proposed that epigenetic regulation participates in installing persistent adaptations and long-lasting synaptic plasticity generated by nicotine action on the mesolimbic dopamine neurons of zebrafish. |
2021-07-19 |
2023-08-13 |
zebrafish |
| Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Kenji Mandai, Miwako Yamasaki, Masahiko Watanabe, Kiyohito Mizutani, Yoshimi Taka. Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula. The Journal of comparative neurology. vol 529. issue 2. 2021-07-13. PMID:32452538. |
the medial habenula (mhb) receives afferents from the triangular septum and the medial septal complex, projects efferents to the interpeduncular nucleus (ipn) in the midbrain to regulate dopamine and serotonin levels, and is implicated in stress, depression, memory, and nicotine withdrawal syndrome. |
2021-07-13 |
2023-08-13 |
Not clear |
| Nailyam Nasirova, Lely A Quina, Shoshana Novik, Eric E Turne. Genetically Targeted Connectivity Tracing Excludes Dopaminergic Inputs to the Interpeduncular Nucleus from the Ventral Tegmentum and Substantia Nigra. eNeuro. vol 8. issue 3. 2021-07-02. PMID:34088738. |
a working model has emerged in which nicotine use may be determined by the balance of reinforcement mediated in part by nicotine effects on dopamine reward pathways, and an aversive "brake" on nicotine consumption encoded in the mhb-ip pathway. |
2021-07-02 |
2023-08-13 |
Not clear |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nicotine is transferred through milk and alters the dopaminergic reward system of adult male rats, reducing dopamine action in the nucleus accumbens (nac) and hypothalamic arcuate nucleus. |
2021-06-24 |
2023-08-13 |
rat |
| Alexey Ostroumov, Ruthie E Wittenberg, Blake A Kimmey, Madison B Taormina, William M Holden, Albert T McHugh, John A Dan. Acute Nicotine Exposure Alters Ventral Tegmental Area Inhibitory Transmission and Promotes Diazepam Consumption. eNeuro. vol 7. issue 2. 2021-06-18. PMID:32102779. |
interactions between nicotine and other drugs of abuse may arise from nicotine-induced neural adaptations in the mesolimbic dopamine (da) system, a common pathway for the reinforcing effects of many addictive substances. |
2021-06-18 |
2023-08-13 |
rat |
| Ekaterina Morozova, Philippe Faure, Boris Gutkin, Christoper Lapish, Alexey Kuznetso. Distinct Temporal Structure of Nicotinic ACh Receptor Activation Determines Responses of VTA Neurons to Endogenous ACh and Nicotine. eNeuro. vol 7. issue 4. 2021-06-18. PMID:32737187. |
the β2 subunit-containing nachrs (β2-nachrs) play a crucial role in the rewarding properties of nicotine and are particularly densely expressed in the mesolimbic dopamine (da) system. |
2021-06-18 |
2023-08-13 |
Not clear |
| Skylar Y Cooper, Austin T Akers, Brandon J Henderso. Green Apple e-Cigarette Flavorant Farnesene Triggers Reward-Related Behavior by Promoting High-Sensitivity nAChRs in the Ventral Tegmental Area. eNeuro. vol 7. issue 4. 2021-06-18. PMID:32747456. |
additionally, farnesene enhances nicotine's potency for activating nachrs on vta dopamine neurons. |
2021-06-18 |
2023-08-13 |
mouse |
| Skylar Y Cooper, Austin T Akers, Brandon J Henderso. Green Apple e-Cigarette Flavorant Farnesene Triggers Reward-Related Behavior by Promoting High-Sensitivity nAChRs in the Ventral Tegmental Area. eNeuro. vol 7. issue 4. 2021-06-18. PMID:32747456. |
consequently, these data show that the green apple flavorant, farnesene, causes reward-related behavior without nicotine through changes in nachr stoichiometry that results in an enhanced effect of nicotine on vta dopamine neurons. |
2021-06-18 |
2023-08-13 |
mouse |
| Austin T Akers, Skylar Y Cooper, Zachary J Baumgard, Gabriella P Casinelli, Alicia J Avelar, Brandon J Henderso. Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior. eNeuro. vol 7. issue 5. 2021-06-18. PMID:32988984. |
here, we use male and female mice that contain α4-mcherry and α6-gfp nachr subunits to show that concentrations of nicotine sufficient to evoke reward-related behavior robustly upregulate α4* and α4α6* nachrs on midbrain dopamine (da) and gaba neurons. |
2021-06-18 |
2023-08-13 |
mouse |
| Stefan Ahrens, Joana Laux, Christina Müller, Christiane M Thie. Increased dopamine availability magnifies nicotine effects on cognitive control: A pilot study. Journal of psychopharmacology (Oxford, England). vol 34. issue 5. 2021-06-17. PMID:32133910. |
increased dopamine availability magnifies nicotine effects on cognitive control: a pilot study. |
2021-06-17 |
2023-08-13 |
Not clear |
| Stefan Ahrens, Joana Laux, Christina Müller, Christiane M Thie. Increased dopamine availability magnifies nicotine effects on cognitive control: A pilot study. Journal of psychopharmacology (Oxford, England). vol 34. issue 5. 2021-06-17. PMID:32133910. |
we aimed to test the hypothesis that the effect of the cholinergic agonist nicotine on cognitive control depends on baseline dopamine levels. |
2021-06-17 |
2023-08-13 |
Not clear |
| Andrea Stojakovic, Syed Muzzammil Ahmad, Kabirullah Lutf. Alterations of Amphetamine Reward by Prior Nicotine and Alcohol Treatment: The Role of Age and Dopamine. Brain sciences. vol 11. issue 4. 2021-04-28. PMID:33810331. |
alterations of amphetamine reward by prior nicotine and alcohol treatment: the role of age and dopamine. |
2021-04-28 |
2023-08-13 |
mouse |
| Jordan M Buck, Heidi C O'Neill, Jerry A Stitze. Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice. Epigenetics & chromatin. vol 13. issue 1. 2021-04-21. PMID:32138755. |
modeling the intergenerationally transmissible impacts of smoking during pregnancy, we previously demonstrated that both the first- and second-generation adolescent offspring of nicotine-exposed female mice exhibit enhanced nicotine preference, hyperactivity and risk-taking behaviors, aberrant rhythmicity of home cage activity, nicotinic acetylcholine receptor and dopamine transporter dysfunction, impaired furin-mediated probdnf proteolysis, hypocorticosteronemia-related glucocorticoid receptor hypoactivity, and global dna hypomethylation in the frontal cortices and striata. |
2021-04-21 |
2023-08-13 |
mouse |