| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanaa A M Elgayar, Ola A Hussein, Heba A Mubarak, Amany M Ismaiel, Asmaa M S Goma. Nicotine impact on rat substantia nigra compacta. Anatomy & cell biology. vol 54. issue 1. 2021-04-09. PMID:33782217. |
in nicotine group, biochemical analysis revealed reduction in total antioxidant capacity (tac), decrease in dopamine and malondialdehyde (mda) levels. |
2021-04-09 |
2023-08-13 |
rat |
| Melissa Herman, Robert Tarra. E-cigarettes, nicotine, the lung and the brain: multi-level cascading pathophysiology. The Journal of physiology. vol 598. issue 22. 2021-03-01. PMID:32515030. |
nicotine's reinforcing properties are primarily mediated by activation of the brain's mesolimbic reward circuitry and release of the neurotransmitter dopamine that contribute to the development of addiction. |
2021-03-01 |
2023-08-13 |
human |
| Silvia Corongiu, Christian Dessì, Cristina Cadon. Adolescence versus adulthood: Differences in basal mesolimbic and nigrostriatal dopamine transmission and response to drugs of abuse. Addiction biology. vol 25. issue 1. 2021-02-10. PMID:30779271. |
adolescent rats showed greater increase of dopamine in the nac shell following nicotine (0.4 mg/kg), thc (1.0 mg/kg), and morphine (1.0 mg/kg), in the nac core following nicotine and morphine, and in the dls following thc, morphine, and cocaine (10 mg/kg). |
2021-02-10 |
2023-08-13 |
rat |
| Chidera C Chukwueke, William J Kowalczyk, Patricia Di Ciano, Marie Gendy, Richard Taylor, Stephen J Heishman, Bernard Le Fol. Exploring the role of the Ser9Gly (rs6280) Dopamine D3 receptor polymorphism in nicotine reinforcement and cue-elicited craving. Scientific reports. vol 10. issue 1. 2020-11-23. PMID:32139730. |
exploring the role of the ser9gly (rs6280) dopamine d3 receptor polymorphism in nicotine reinforcement and cue-elicited craving. |
2020-11-23 |
2023-08-13 |
Not clear |
| Leanna A Marquart, Matthew W Turner, Owen M McDouga. Qualitative Assay to Detect Dopamine Release by Ligand Action on Nicotinic Acetylcholine Receptors. Toxins. vol 11. issue 12. 2020-11-13. PMID:31757080. |
results are presented for the action of nachr agonists (acetylcholine, nicotine, and cytisine), and antagonists (α-conotoxins (α-ctxs) mii, imi, lvia, and peia) that demonstrate a luminescence response correlating to the increase or decrease of dopamine release. |
2020-11-13 |
2023-08-13 |
rat |
| Ashley M Fennell, Elizabeth G Pitts, Lacey L Sexton, Mark J Ferri. Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:31932634. |
phasic dopamine release magnitude tracks individual differences in sensitization of locomotor response following a history of nicotine exposure. |
2020-11-12 |
2023-08-13 |
rat |
| Ashley M Fennell, Elizabeth G Pitts, Lacey L Sexton, Mark J Ferri. Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:31932634. |
given the role of mesolimbic dopamine projections in motivation, substance use disorder, and drug relapse, we examined the effect of repeated nicotine on rapid dopamine signals in the nucleus accumbens (nac) of rats. |
2020-11-12 |
2023-08-13 |
rat |
| Ashley M Fennell, Elizabeth G Pitts, Lacey L Sexton, Mark J Ferri. Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:31932634. |
nicotine exposure decreased electrically-stimulated dopamine release across a range of stimulation frequencies and decreased α6β2-containing nicotinic receptor control over dopamine release. |
2020-11-12 |
2023-08-13 |
rat |
| Ashley M Fennell, Elizabeth G Pitts, Lacey L Sexton, Mark J Ferri. Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:31932634. |
additionally, nicotine locomotor sensitization correlated with accumbal dopamine modulation by nicotine and mecamylamine. |
2020-11-12 |
2023-08-13 |
rat |
| Ashley M Fennell, Elizabeth G Pitts, Lacey L Sexton, Mark J Ferri. Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:31932634. |
taken together, our study suggests that repeated exposure to nicotine blunts dopamine release in the nac core through changes in α6β2 modulation of dopamine release and individual differences in the sensitivity to this outcome may predict variation in behavioral models of vulnerability to substance use disorder. |
2020-11-12 |
2023-08-13 |
rat |
| Tina Kazemi, Naze G Avci, Renee F Keller, Yasemin M Akay, Metin Aka. Investigating the influence of perinatal nicotine exposure on genetic profiles of neurons in the sub-regions of the VTA. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32051445. |
previously, we investigated the complexity of dopamine (da) neuron firing in the sub-regions of the ventral tegmental area (vta) following perinatal nicotine exposure. |
2020-11-12 |
2023-08-13 |
Not clear |
| Funda Akkus, Sylvia Terbeck, Connor J Haggarty, Valerie Treyer, Janan J Dietrich, Stefanie Hornschuh, Gregor Hasle. The role of the metabotropic glutamate receptor 5 in nicotine addiction. CNS spectrums. 2020-10-07. PMID:32713396. |
previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has provided strong evidence for the involvement of dopaminergic neuronal circuitry in nicotine addiction. |
2020-10-07 |
2023-08-13 |
human |
| Kenneth Blum, Peter K Thanos, Marlene Oscar-Berman, Marcelo Febo, David Baron, Rajendra D Badgaiyan, Eliot Gardner, Zsolt Demetrovics, Claudia Fahlke, Brett C Haberstick, Kristina Dushaj, Mark S Gol. Dopamine in the Brain: Hypothesizing Surfeit or Deficit Links to Reward and Addiction. Journal of reward deficiency syndrome. vol 1. issue 3. 2020-10-01. PMID:27398406. |
david nutt and associates eloquently proposed that dopamine (da) may be central to psycho stimulant dependence and some what important for alcohol, but not important for opiates, nicotine or even cannabis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ashley M Fox-Loe, Linda P Dwoskin, Christopher I Richard. Nicotinic Acetylcholine Receptors as Targets for Tobacco Cessation Therapeutics: Cutting-Edge Methodologies to Understand Receptor Assembly and Trafficking. Neuromethods. vol 117. 2020-10-01. PMID:28025590. |
tobacco dependence is a chronic relapsing disorder and nicotine, the primary alkaloid in tobacco, acts at nicotinic receptors to stimulate dopamine release in brain, which is responsible for the reinforcing properties of nicotine, leading to addiction. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mehmet Atilla Uysal, Ülgen Sever, Ayşe Feyda Nursal, Sacide Pehlİva. Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population. Noro psikiyatri arsivi. vol 56. issue 4. 2020-10-01. PMID:31903031. |
dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| David Miller, Merlene Miller, Kenneth Blum, Rajendra D Badgaiyan, Marcelo Feb. Addiction Treatment in America: After Money or Aftercare? Journal of reward deficiency syndrome. vol 1. issue 3. 2020-09-30. PMID:26835513. |
alcohol, opiates, nicotine) these drugs favor a short-term benefit by blocking dopamine. |
2020-09-30 |
2023-08-13 |
human |
| Ginetta Collo, Laura Cavalleri, Michele Zoli, Uwe Maskos, Emiliangelo Ratti, Emilio Merlo Pic. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:29910731. |
midbrain dopamine (da) neurons are considered a critical substrate for the reinforcing and sensitizing effects of nicotine and tobacco dependence. |
2020-09-30 |
2023-08-13 |
mouse |
| Chao Wei, Xiao Han, Danwei Weng, Qiru Feng, Xiangbing Qi, Jin Li, Minmin Lu. Response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA. Cell discovery. vol 4. 2020-09-30. PMID:30416749. |
response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and mdma. |
2020-09-30 |
2023-08-13 |
Not clear |
| Nicole Petersen, Edythe D Londo. Addiction and Dopamine: Sex Differences and Insights from Studies of Smoking. Current opinion in behavioral sciences. vol 23. 2020-09-30. PMID:30746429. |
findings from research on cigarette smoking reveal sex differences in striatal and midbrain dopamine d2-type receptor availability and striatal dopamine release that suggest mechanisms of nicotine dependence, and stronger subjective responses to nicotine and efficacy of nicotine replacement therapies in male smokers than in their female counterparts. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fawaz Alasmari, Laura E Crotty Alexander, Alaa M Hammad, Christine M Bojanowski, Alex Moshensky, Youssef Sar. Effects of Chronic Inhalation of Electronic Cigarette Vapor Containing Nicotine on Neurotransmitters in the Frontal Cortex and Striatum of C57BL/6 Mice. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31456684. |
we reported here that 6-month e-cig vapor containing nicotine inhalation decreased dopamine concentration only in the str. |
2020-09-29 |
2023-08-13 |
mouse |