| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanna Janhunen, Anna Linnervuo, Minna Svensk, Liisa Ahte. Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats. Pharmacology, biochemistry, and behavior. vol 82. issue 4. 2006-05-09. PMID:16413603. |
both acutely and after the repeated administration, epibatidine enhanced the locomotor activity of rats clearly less than nicotine agreeing with its previously reported lesser effects on accumbal dopamine output. |
2006-05-09 |
2023-08-12 |
rat |
| Sanna Janhunen, Anna Linnervuo, Minna Svensk, Liisa Ahte. Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats. Pharmacology, biochemistry, and behavior. vol 82. issue 4. 2006-05-09. PMID:16413603. |
thus, while nicotine elicits cpp at doses (0.5 and 0.8 mg/kg) equal to those that increase accumbal dopamine output and locomotor activity, epibatidine seems to be aversive at the dose (3.0 microg/kg) that enhances accumbal dopamine output and increases locomotor activity. |
2006-05-09 |
2023-08-12 |
rat |
| R Christopher Pierce, Vidhya Kumaresa. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neuroscience and biobehavioral reviews. vol 30. issue 2. 2006-05-05. PMID:16099045. |
for the other four classes of abused substances, self-administration experiments suggest that although increasing mesolimbic dopamine transmission plays an important role in the reinforcing effects of opiates, ethanol, cannabinoids and nicotine, there are also dopamine-independent processes that contribute significantly to the reinforcing effects of these compounds. |
2006-05-05 |
2023-08-12 |
Not clear |
| N P Visanji, S N Mitchell, M J O'Neill, S Dut. Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat. Neuropharmacology. vol 50. issue 1. 2006-05-01. PMID:16153666. |
chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mrna in the substantia nigra pars compacta of the rat. |
2006-05-01 |
2023-08-12 |
rat |
| N P Visanji, S N Mitchell, M J O'Neill, S Dut. Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat. Neuropharmacology. vol 50. issue 1. 2006-05-01. PMID:16153666. |
whilst local intrastriatal infusion of nicotine consistently elicits striatal dopamine release, systemic administration often fails to do so. |
2006-05-01 |
2023-08-12 |
rat |
| N P Visanji, S N Mitchell, M J O'Neill, S Dut. Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat. Neuropharmacology. vol 50. issue 1. 2006-05-01. PMID:16153666. |
in vivo microdialysis studies in male sprague-dawley rats revealed that following 4 days pre-treatment with nicotine (0.8 mg kg(-1)s.c.), local intrastriatal nicotine infusion (3 mm) elicited significantly higher dopamine efflux compared to vehicle pre-treated controls (peak release: 1273 +/- 199% basal versus 731 +/- 113% basal), whereas systemic nicotine challenge (0.8 mg kg(-1)s.c.) elicited no response. |
2006-05-01 |
2023-08-12 |
rat |
| N P Visanji, S N Mitchell, M J O'Neill, S Dut. Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat. Neuropharmacology. vol 50. issue 1. 2006-05-01. PMID:16153666. |
in contrast, following 8 days pre-treatment with nicotine (0.8 mg kg(-1)s.c.), systemic nicotine challenge (0.8 mg kg(-1)s.c.) now produced significantly higher dopamine efflux than that of vehicle pre-treated controls (147 +/- 30% basal versus 91 +/- 5% basal). |
2006-05-01 |
2023-08-12 |
rat |
| N P Visanji, S N Mitchell, M J O'Neill, S Dut. Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat. Neuropharmacology. vol 50. issue 1. 2006-05-01. PMID:16153666. |
eight days pre-treatment with nicotine also significantly elevated the levels of alpha6 (approximately 55%) and beta3 (approximately 43%) nachr subunit mrna in the snc, suggesting that up-regulation of these nachr subunit genes in the nigrostriatal tract may contribute to the enhanced nicotine-evoked striatal dopamine release. |
2006-05-01 |
2023-08-12 |
rat |
| Sanna Janhunen, Paula Mielikäinen, Päivi Paldánius, Raimo K Tuominen, Liisa Ahtee, Seppo Kaakkol. The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 371. issue 6. 2006-04-28. PMID:16012872. |
the effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats. |
2006-04-28 |
2023-08-12 |
rat |
| Sanna Janhunen, Paula Mielikäinen, Päivi Paldánius, Raimo K Tuominen, Liisa Ahtee, Seppo Kaakkol. The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 371. issue 6. 2006-04-28. PMID:16012872. |
we used brain microdialysis to study the effects of nicotine on extracellular levels of dopamine (da) and its metabolites in the rat dorsal striatum in combination with drugs inhibiting either da uptake (nomifensine), catechol-o-methyltransferase (comt; tolcapone), monoamine oxidase b (mao-b; selegiline) or da receptors (haloperidol). |
2006-04-28 |
2023-08-12 |
rat |
| Yen Kuang Yang, Wei Jen Yao, Joseph P McEvoy, Ching Lin Chu, I Hui Lee, Po See Chen, Tzung Lieh Yeh, Nan Tsing Chi. Striatal dopamine D2/D3 receptor availability in male smokers. Psychiatry research. vol 146. issue 1. 2006-04-25. PMID:16343861. |
it has been reported that the activation of the nicotine receptor evokes central endogenous dopamine release. |
2006-04-25 |
2023-08-12 |
Not clear |
| Anne Tammimäki, Kirsi Pietilä, Helena Raattamaa, Liisa Ahte. Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European journal of pharmacology. vol 531. issue 1-3. 2006-04-18. PMID:16442094. |
the effect of chronic oral nicotine treatment which in its intermittent delivery resembles human smoking was studied on the sensitivity of dopamine autoreceptors in mice. |
2006-04-18 |
2023-08-12 |
mouse |
| Anne Tammimäki, Kirsi Pietilä, Helena Raattamaa, Liisa Ahte. Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European journal of pharmacology. vol 531. issue 1-3. 2006-04-18. PMID:16442094. |
on the 50th day of nicotine administration in the drinking water or after 23-25 h withdrawal quinpirole (d2/d3 agonist, 0.01-0.1 mg/kg s.c.) was given, and accumbal and dorsal striatal dopamine outflow, locomotor activity and body temperature were measured. |
2006-04-18 |
2023-08-12 |
mouse |
| Anne Tammimäki, Kirsi Pietilä, Helena Raattamaa, Liisa Ahte. Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European journal of pharmacology. vol 531. issue 1-3. 2006-04-18. PMID:16442094. |
dorsal striatal extracellular dopamine concentration and locomotor activity were found to be elevated during nicotine administration. |
2006-04-18 |
2023-08-12 |
mouse |
| Anne Tammimäki, Kirsi Pietilä, Helena Raattamaa, Liisa Ahte. Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European journal of pharmacology. vol 531. issue 1-3. 2006-04-18. PMID:16442094. |
chronic nicotine did not alter the effects of small, autoreceptor preferring doses of quinpirole on accumbal or dorsal striatal dopamine, locomotor activity or body temperature. |
2006-04-18 |
2023-08-12 |
mouse |
| Anne Tammimäki, Kirsi Pietilä, Helena Raattamaa, Liisa Ahte. Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European journal of pharmacology. vol 531. issue 1-3. 2006-04-18. PMID:16442094. |
thus, although repeated nicotine treatment for 5-14 days decreases dopamine autoreceptor sensitivity, after long-term oral nicotine treatment such a decrease is not seen. |
2006-04-18 |
2023-08-12 |
mouse |
| Anne Tammimäki, Kirsi Pietilä, Helena Raattamaa, Liisa Ahte. Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European journal of pharmacology. vol 531. issue 1-3. 2006-04-18. PMID:16442094. |
thus, the changes occurring in the sensitivity of d2-like dopamine receptors probably play a minor role in regulating the dopaminergic transmission during long-term nicotine administration. |
2006-04-18 |
2023-08-12 |
mouse |
| Sarah E McCallum, Neeraja Parameswaran, Tanuja Bordia, Hong Fan, Rachel F Tyndale, J William Langston, J Michael McIntosh, Maryka Qui. Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment. Journal of neurochemistry. vol 96. issue 4. 2006-04-06. PMID:16412091. |
chronic nicotine treatment (> 6 months) enhanced alpha4* nachr-evoked [(3)h]dopamine release in striatal subregions, with an overall pattern of increase throughout the striatum when normalized to uptake. |
2006-04-06 |
2023-08-12 |
Not clear |
| Sarah E McCallum, Neeraja Parameswaran, Tanuja Bordia, Hong Fan, Rachel F Tyndale, J William Langston, J Michael McIntosh, Maryka Qui. Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment. Journal of neurochemistry. vol 96. issue 4. 2006-04-06. PMID:16412091. |
these divergent actions of chronic nicotine treatment on alpha4* versus alpha6* nachrs, as well as effects on dopamine uptake, allow for a complex control of striatal activity to maintain dopaminergic function. |
2006-04-06 |
2023-08-12 |
Not clear |
| Rong Jie Zhao, Byung Soo Koo, Geun Woo Kim, Eun Young Jang, Jong Rok Lee, Mi Ryeo Kim, Sang Chan Kim, Young Kyu Kwon, Kwang Joong Kim, Tae-lin Huh, Dae-Hyun Kim, Insop Shim, Chae Ha Yan. The essential oil from Angelica gigas NAKAI suppresses nicotine sensitization. Biological & pharmaceutical bulletin. vol 28. issue 12. 2006-03-09. PMID:16327174. |
a direct local challenge of 3 mm nicotine via a microdialysis probe also induced a larger increase in dopamine release in nicotine-pretreated rats than in saline-pretreated rats. |
2006-03-09 |
2023-08-12 |
rat |