| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marla K Perna, Yoko O Henderson, Christopher L Bruner, Russell W Brow. An analysis of nicotine conditioned place conditioning in early postweanling and adolescent rats neonatally treated with quinpirole. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21315765. |
this study investigated nicotine place conditioning in early postweanling and adolescent male and female rats neonatally treated with quinpirole, a dopamine d(2)/d(3) agonist. |
2011-07-15 |
2023-08-12 |
rat |
| Richard Exley, Nicolas Maubourguet, Vincent David, Raphaël Eddine, Alexis Evrard, Stéphanie Pons, Fabio Marti, Sarah Threlfell, Pierre Cazala, J Michael McIntosh, Jean-Pierre Changeux, Uwe Maskos, Stephanie J Cragg, Philippe Faur. Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 18. 2011-07-15. PMID:21502501. |
using subunit-specific knockout mice and targeted lentiviral re-expression, we have determined the subunit dependence of intracranial nicotine self-administration (icsa) into the vta and the effects of nicotine on dopamine (da) neuron excitability in the vta and on da transmission in the nucleus accumbens (nac). |
2011-07-15 |
2023-08-12 |
mouse |
| R C Jiloh. Biological basis of tobacco addiction: Implications for smoking-cessation treatment. Indian journal of psychiatry. vol 52. issue 4. 2011-07-14. PMID:21267362. |
nicotine acts on these receptors to facilitate neurotransmitter release (dopamine and others), producing pleasure and mood modulation. |
2011-07-14 |
2023-08-12 |
Not clear |
| Valeria Tronci, David J K Balfou. The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on the stimulation of dopamine release evoked by nicotine in the rat brain. Behavioural brain research. vol 219. issue 2. 2011-07-13. PMID:21216262. |
the effects of the mglur5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (mpep) on the stimulation of dopamine release evoked by nicotine in the rat brain. |
2011-07-13 |
2023-08-12 |
rat |
| Valeria Tronci, David J K Balfou. The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on the stimulation of dopamine release evoked by nicotine in the rat brain. Behavioural brain research. vol 219. issue 2. 2011-07-13. PMID:21216262. |
this study employed in vivo microdialysis to test the hypothesis that the prior administration of the mglur5 receptor antagonist, mpep, inhibits a neural response to nicotine, increased dopamine (da) overflow in the nucleus accumbens, implicated in directly in nicotine reinforcement. |
2011-07-13 |
2023-08-12 |
rat |
| Luping Z Huang, Carla Campos, Jason Ly, F Ivy Carroll, Maryka Qui. Nicotinic receptor agonists decrease L-dopa-induced dyskinesias most effectively in partially lesioned parkinsonian rats. Neuropharmacology. vol 60. issue 6. 2011-07-12. PMID:21232546. |
these findings suggest that presynaptic dopamine terminal α4β2* and α6β2* nachrs are critical for nicotine's antidyskinetic action. |
2011-07-12 |
2023-08-12 |
rat |
| F Ivy Carroll, Ana Z Muresan, Bruce E Blough, Hernán A Navarro, S Wayne Mascarella, J Brek Eaton, Xiaodong Huang, M Imad Damaj, Ronald J Luka. Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine. Journal of medicinal chemistry. vol 54. issue 5. 2011-06-06. PMID:21319801. |
toward development of smoking cessation aids superior to bupropion (2), we describe synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues 5a-5h and their effects on inhibition of dopamine, norepinephrine, and serotonin uptake, nicotinic acetylcholine receptor (nachr) function, acute actions of nicotine, and nicotine-conditioned place preference (cpp). |
2011-06-06 |
2023-08-12 |
Not clear |
| Gabriela Novak, Philip Seeman, Bernard Le Fol. Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity. The International journal of neuroscience. vol 120. issue 11. 2011-05-19. PMID:20942582. |
exposure to nicotine produces an increase in dopamine d2(high) receptors: a possible mechanism for dopamine hypersensitivity. |
2011-05-19 |
2023-08-12 |
rat |
| Gabriela Novak, Philip Seeman, Bernard Le Fol. Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity. The International journal of neuroscience. vol 120. issue 11. 2011-05-19. PMID:20942582. |
we suggest that nicotine-induced elevation in d2(high) levels could be participating in hypersensitivity to dopamine following nicotine exposure. |
2011-05-19 |
2023-08-12 |
rat |
| Linxiang Tan, Quansheng Tang, Wei Ha. Nicotine dependence and smoking cessation. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 34. issue 11. 2011-05-02. PMID:19952392. |
nicotine, the primary active ingredient of cigarettes that contributes to physical dependence, acts on nicotine receptors in the central nervous system and leads to the release of neurotransmitters (such as dopamine). |
2011-05-02 |
2023-08-12 |
Not clear |
| Mona Boules, Alfredo Oliveros, Yanqi Liang, Katrina Williams, Amanda Shaw, Jessica Robinson, Paul Fredrickson, Elliott Richelso. A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats. Neuropeptides. vol 45. issue 1. 2011-04-18. PMID:21047685. |
additionally, nt69l modulated serum corticosterone; brain norepinephrine serotonin; and dopamine receptors mrna levels altered in the nicotine self-infused rats after a 24h withdrawal period. |
2011-04-18 |
2023-08-12 |
rat |
| Mona Boules, Alfredo Oliveros, Yanqi Liang, Katrina Williams, Amanda Shaw, Jessica Robinson, Paul Fredrickson, Elliott Richelso. A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats. Neuropeptides. vol 45. issue 1. 2011-04-18. PMID:21047685. |
nt69l might modulate dopamine neurotransmission implicated in the reinforcing effects of nicotine by modulating tyrosine hydroxylase and dopamine receptor mrna levels in the pfc and striatum. |
2011-04-18 |
2023-08-12 |
rat |
| Maria Hadjiconstantinou, Anne-Marie Duchemin, Hailing Zhang, Norton H Nef. Enhanced dopamine transporter function in striatum during nicotine withdrawal. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20506223. |
enhanced dopamine transporter function in striatum during nicotine withdrawal. |
2011-04-01 |
2023-08-12 |
mouse |
| Maria Hadjiconstantinou, Anne-Marie Duchemin, Hailing Zhang, Norton H Nef. Enhanced dopamine transporter function in striatum during nicotine withdrawal. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20506223. |
spontaneous and antagonist-precipitated withdrawal from nicotine is characterized by marked deficits in extracellular dopamine (da) in striatum, especially in nucleus accumbens, that have been thought to underlie the affective state associated with drug discontinuation. |
2011-04-01 |
2023-08-12 |
mouse |
| Ting Y Chen, Andrei Dragomir, Die Zhang, Yasemin Akay, Metin Aka. Prefrontal cortex deletion affects the dopaminergic neural firing complexity in nicotine-treated ventral tegmental area. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2010. 2011-03-29. PMID:21095787. |
nicotine, an addictive substance in cigarette, triggers glutamatergic synaptic plasticity on ventral tegmental area (vta) dopamine (da) neurons. |
2011-03-29 |
2023-08-12 |
human |
| Edward D Levin, Susan Slade, Corinne Wells, Margaret Pruitt, Vanessa Cousins, Marty Cauley, Ann Petro, Dawn Hampton, Jed Ros. Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20951696. |
nicotine-induced dopamine release has been shown to play a key role in facilitating nicotine self-administration. |
2011-03-24 |
2023-08-12 |
rat |
| Kate Cahill, Lindsay F Stead, Tim Lancaste. Nicotine receptor partial agonists for smoking cessation. The Cochrane database of systematic reviews. issue 2. 2011-03-23. PMID:21328282. |
nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). |
2011-03-23 |
2023-08-12 |
Not clear |
| Kate Cahill, Lindsay F Stead, Tim Lancaste. Nicotine receptor partial agonists for smoking cessation. The Cochrane database of systematic reviews. issue 12. 2011-02-10. PMID:21154363. |
nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). |
2011-02-10 |
2023-08-12 |
Not clear |
| Kelly P Cosgrov. Imaging receptor changes in human drug abusers. Current topics in behavioral neurosciences. vol 3. 2011-01-20. PMID:21161754. |
specifically, alterations in dopamine, serotonin, opioid, and gaba systems in cocaine, alcohol, nicotine, and heroin dependence have been examined. |
2011-01-20 |
2023-08-12 |
human |
| Jie W. Double target concept for smoking cessation. Acta pharmacologica Sinica. vol 31. issue 9. 2011-01-04. PMID:20711220. |
through the nachrs in brain reward circuits, nicotine alters dopaminergic (da) neuronal function in the ventral tegmental area (vta) and increases dopamine release from vta to nuclear accumbens (na), which leads to nicotine reward, tolerance and dependence. |
2011-01-04 |
2023-08-12 |
Not clear |