| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas E Wooters, Andrew M Smith, Marharyta Pivavarchyk, Kiran B Siripurapu, J Michael McIntosh, Zhenfa Zhang, Peter A Crooks, Michael T Bardo, Linda P Dwoski. bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse. British journal of pharmacology. vol 163. issue 2. 2011-11-01. PMID:21232049. |
previous results show that the α6β2* nachr antagonist, n,n'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bpiddb) inhibits nicotine-evoked dopamine release from dorsal striatum and decreases nicotine self-administration in rats. |
2011-11-01 |
2023-08-12 |
rat |
| Mariella De Biasi, John A Dan. Reward, addiction, withdrawal to nicotine. Annual review of neuroscience. vol 34. 2011-10-25. PMID:21438686. |
acting mainly through nicotinic receptors containing the α4 and β2 subunits, often in combination with the α6 subunit, nicotine increases the firing rate and the phasic bursts by midbrain dopamine neurons. |
2011-10-25 |
2023-08-12 |
Not clear |
| Wei Li, William M Doyon, John A Dan. Acute in vivo nicotine administration enhances synchrony among dopamine neurons. Biochemical pharmacology. vol 82. issue 8. 2011-10-21. PMID:21684263. |
acute in vivo nicotine administration enhances synchrony among dopamine neurons. |
2011-10-21 |
2023-08-12 |
rat |
| Dena Kota, Sarah Sanjakdar, Michael J Marks, Omar Khabour, Karem Alzoubi, M Imad Dama. Exploring behavioral and molecular mechanisms of nicotine reward in adolescent mice. Biochemical pharmacology. vol 82. issue 8. 2011-10-21. PMID:21708139. |
levels of striatal dopamine release were measured in both age groups using a dopamine release assay over a range of nicotine doses, which also resulted in no significant differences. |
2011-10-21 |
2023-08-12 |
mouse |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic ca2+. |
2011-10-14 |
2023-08-12 |
mouse |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
epidemiological and experimental evidence indicates that nicotine is protective for parkinson disease vulnerable dopamine neurons, but the underlying mechanism of this effect remains only partly characterized. |
2011-10-14 |
2023-08-12 |
mouse |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
we report here that nicotine afforded neuroprotection to dopamine neurons (ec(50)=0.32 μm) but only in a situation where cytosolic ca(2+) (ca(2+)(cyt)) was slightly and chronically elevated above control levels by concurrent depolarizing treatments. |
2011-10-14 |
2023-08-12 |
mouse |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
by a pharmacological approach, we demonstrated that the rise in ca(2+)(cyt) was necessary to sensitize dopamine neurons to the action of nicotine through a mechanism involving α-bungarotoxin-sensitive (presumably α7) nicotinic acetylcholine receptors (nachrs) and secondarily t-type voltage-gated calcium channels. |
2011-10-14 |
2023-08-12 |
mouse |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
collectively, our data support the idea that the protective action of nicotine for dopamine neurons is activity-dependent and gated by ca(2+)(cyt). |
2011-10-14 |
2023-08-12 |
mouse |
| Price E Dickson, Tiffany D Rogers, Deranda B Lester, Mellessa M Miller, Shannon G Matta, Elissa J Chesler, Dan Goldowitz, Charles D Blaha, Guy Mittlema. Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine. Psychopharmacology. vol 215. issue 4. 2011-09-19. PMID:21212937. |
genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine. |
2011-09-19 |
2023-08-12 |
mouse |
| Kenneth Blum, Yijun Liu, Richard Shriner, Mark S Gol. Reward circuitry dopaminergic activation regulates food and drug craving behavior. Current pharmaceutical design. vol 17. issue 12. 2011-08-30. PMID:21492092. |
individuals possessing a paucity of serotonergic and/or dopaminergic receptors and an increased rate of synaptic dopamine catabolism, due to high catabolic genotype of the comt gene, are predisposed to self-medicating any substance or behavior that will activate dopamine release including alcohol, opiates, psychostimulants, nicotine, glucose, gambling, sex, and even excessive internet gaming, among others. |
2011-08-30 |
2023-08-12 |
human |
| Yu Ohmura, Emily M Jutkiewicz, Edward F Domin. L-DOPA attenuates nicotine withdrawal-induced behaviors in rats. Pharmacology, biochemistry, and behavior. vol 98. issue 4. 2011-08-24. PMID:21354201. |
there is some evidence that during nicotine abstinence brain dopamine levels are reduced. |
2011-08-24 |
2023-08-12 |
rat |
| Danyan Mao, Keith Gallagher, Daniel S McGehe. Nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543600. |
nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons. |
2011-08-05 |
2023-08-12 |
rat |
| Danyan Mao, Keith Gallagher, Daniel S McGehe. Nicotine potentiation of excitatory inputs to ventral tegmental area dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 18. 2011-08-05. PMID:21543600. |
our laboratory previously reported that nicotine facilitates induction of long-term potentiation (ltp) in vta dopamine (da) neurons by increasing glutamate release via activation of α7 nachrs on the glutamate terminals, suggesting a critical presynaptic contribution of nicotine in ltp induction. |
2011-08-05 |
2023-08-12 |
rat |
| A Millar, D Smith, J Choueiry, D Fisher, P Albert, V Knot. The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine. Neuroscience. vol 180. 2011-08-04. PMID:21315807. |
the moderating role of the dopamine transporter 1 gene on p50 sensory gating and its modulation by nicotine. |
2011-08-04 |
2023-08-12 |
Not clear |
| A Millar, D Smith, J Choueiry, D Fisher, P Albert, V Knot. The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine. Neuroscience. vol 180. 2011-08-04. PMID:21315807. |
hypothesizing that individual differences in striatal dopamine levels may moderate auditory gating and its modulation by nicotine, this preliminary study used the mid-latency (p50) auditory event-related potential (erp) to examine the single dose (6 mg) effects of nicotine (vs. placebo) gum on sensory gating in 24 healthy nonsmokers varying in the genetic expression of the dopamine transporter (dat). |
2011-08-04 |
2023-08-12 |
Not clear |
| A Millar, D Smith, J Choueiry, D Fisher, P Albert, V Knot. The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine. Neuroscience. vol 180. 2011-08-04. PMID:21315807. |
consistent with an inverted-u relationship between dopamine level and the drug effects, individuals carrying the 9r (lower gene expression) allele, which is related to greater striatal dopamine levels, tended to evidence increased baseline gating compared to 10r (higher gene expression) allele carriers and showed a reduction in gating with acute nicotine. |
2011-08-04 |
2023-08-12 |
Not clear |
| Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Kosuke Sato, Minoru Hayase, Noboru Otsuka, Ayumi Fukakusa, Nozomi Kumagai, Hyoung-Chun Kim, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. Activation of post-synaptic dopamine D₁ receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling. Journal of neurochemistry. vol 103. issue 6. 2011-07-19. PMID:17944865. |
we have previously demonstrated that tissue plasminogen activator (tpa) plays an important role through the conversion of plasminogen to plasmin in the release of dopamine in the nucleus accumbens (nac) evoked by depolarization or the systemic administration of drugs of abuse such as morphine and nicotine. |
2011-07-19 |
2023-08-12 |
Not clear |
| Jun Zhu, Michael T Bardo, Thomas A Green, Peter J Wedlund, Linda P Dwoski. Nicotine increases dopamine clearance in medial prefrontal cortex in rats raised in an enriched environment. Journal of neurochemistry. vol 103. issue 6. 2011-07-19. PMID:17953677. |
nicotine increases dopamine clearance in medial prefrontal cortex in rats raised in an enriched environment. |
2011-07-19 |
2023-08-12 |
rat |
| Jun Zhu, Michael T Bardo, Thomas A Green, Peter J Wedlund, Linda P Dwoski. Nicotine increases dopamine clearance in medial prefrontal cortex in rats raised in an enriched environment. Journal of neurochemistry. vol 103. issue 6. 2011-07-19. PMID:17953677. |
the present study investigates dopamine clearance (cl(da) ) in striatum and medial prefrontal cortex (mpfc) using in vivo voltammetry in rats raised in enriched (ec) or impoverished conditions (ic) and administered nicotine (0.4 mg/kg) or saline. |
2011-07-19 |
2023-08-12 |
rat |