| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie W. Double target concept for smoking cessation. Acta pharmacologica Sinica. vol 31. issue 9. 2011-01-04. PMID:20711220. |
dysfunction of nachrs (antagonism or desensitization) is crucial to abolish nicotine dependence and the maintenance of an appropriate level of extracellular dopamine eliminates nicotine withdrawal syndromes. |
2011-01-04 |
2023-08-12 |
Not clear |
| Ming Gao, Yu Jin, Kechun Yang, Die Zhang, Ronald J Lukas, Jie W. Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 41. 2010-11-04. PMID:20943922. |
systemic exposure to nicotine induces glutamatergic synaptic plasticity on dopamine (da) neurons in the ventral tegmental area (vta), but mechanisms are largely unknown. |
2010-11-04 |
2023-08-12 |
mouse |
| Andrew T Seipel, Jerrel L Yake. The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptor. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20598018. |
voltammetric analyses show that low (100-500 nm) doses of nicotine regulate striatal dopamine by inhibiting release evoked by a single stimulation to a greater extent than release evoked by high frequency stimulations. |
2010-10-19 |
2023-08-12 |
Not clear |
| Andrew T Seipel, Jerrel L Yake. The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptor. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20598018. |
surprisingly, a high dose of nicotine (2 μm; capable of interacting with additional nachr subtypes) produced an inhibition of dopamine evoked by high frequency stimulation, an effect that was not seen with the low dose of nicotine or the β2 antagonist, dihydro-β-erythroidine hydrobromide. |
2010-10-19 |
2023-08-12 |
Not clear |
| Vincenzo Di Matteo, Massimo Pierucci, Arcangelo Benigno, Ennio Esposito, Giuseppe Crescimanno, Giuseppe Di Giovann. Critical role of nitric oxide on nicotine-induced hyperactivation of dopaminergic nigrostriatal system: Electrophysiological and neurochemical evidence in rats. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20345972. |
nicotine, the main psychoactive ingredient in tobacco, stimulates dopamine (da) function, increasing da neuronal activity and da release. |
2010-09-22 |
2023-08-12 |
rat |
| Benoit Forget, Carrie Wertheim, Paola Mascia, Abhiram Pushparaj, Steven R Goldberg, Bernard Le Fol. Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 8. 2010-09-17. PMID:20357760. |
although dopamine has been extensively implicated in the rewarding effects of nicotine, noradrenergic systems may have a larger role than previously suspected. |
2010-09-17 |
2023-08-12 |
rat |
| Benoit Forget, Carrie Wertheim, Paola Mascia, Abhiram Pushparaj, Steven R Goldberg, Bernard Le Fol. Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 8. 2010-09-17. PMID:20357760. |
this study evaluated the role of noradrenergic alpha(1) receptors in nicotine and food self-administration and relapse, nicotine discrimination, and nicotine-induced dopamine release in the nucleus accumbens in rats. |
2010-09-17 |
2023-08-12 |
rat |
| Benoit Forget, Carrie Wertheim, Paola Mascia, Abhiram Pushparaj, Steven R Goldberg, Bernard Le Fol. Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 8. 2010-09-17. PMID:20357760. |
prazosin also decreased reinstatement of extinguished nicotine seeking induced by either a nicotine prime (0.15 mg/kg) or nicotine-associated cues, but not food-induced reinstatement of food-seeking, and decreased nicotine-induced (0.15 mg/kg) dopamine release in the nucleus accumbens shell. |
2010-09-17 |
2023-08-12 |
rat |
| Darlene H Brunzell, Karen E Boschen, Elizabeth S Hendrick, Patrick M Beardsley, J Michael McIntos. Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19890263. |
beta2 subunit containing nicotinic acetylcholine receptors (beta2(*)nachrs; asterisk ((*)) denotes assembly with other subunits) are critical for nicotine self-administration and nicotine-associated dopamine (da) release that supports nicotine reinforcement. |
2010-09-07 |
2023-08-12 |
rat |
| K Rintakoski, J Ahlberg, C Hublin, F Lobbezoo, R J Rose, H Murtomaa, J Kapri. Tobacco use and reported bruxism in young adults: a nationwide Finnish Twin Cohort Study. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 12. issue 6. 2010-09-02. PMID:20427458. |
higher levels of smoking, leading to increased levels of nicotine and dopamine release, may be more strongly related to bruxism, although this relationship has remained unclear. |
2010-09-02 |
2023-08-12 |
Not clear |
| J L Wilkinson, F I Carroll, R A Bevin. An investigation of bupropion substitution for the interoceptive stimulus effects of nicotine. Journal of psychopharmacology (Oxford, England). vol 24. issue 6. 2010-08-20. PMID:19304864. |
we tested the effects of bupropion pretreatment, the nicotine dose-effect function and the ability of dopamine antagonist to block the substitution of bupropion for nicotine. |
2010-08-20 |
2023-08-12 |
rat |
| E Carboni, V G Barros, M Ibba, A Silvagni, C Mura, M C Antonell. Prenatal restraint stress: an in vivo microdialysis study on catecholamine release in the rat prefrontal cortex. Neuroscience. vol 168. issue 1. 2010-08-20. PMID:20353810. |
pns decreased nicotine stimulated noradrenaline (but not dopamine output) in adults, though not in adolescents. |
2010-08-20 |
2023-08-12 |
rat |
| Marcelo O Ortells, Georgina E Barrante. Tobacco addiction: a biochemical model of nicotine dependence. Medical hypotheses. vol 74. issue 5. 2010-08-18. PMID:19962246. |
we propose that negative feedbacks on dopamine release regulated by alpha4beta2 nachrs are disrupted by nicotine. |
2010-08-18 |
2023-08-12 |
Not clear |
| Thomas E Wooters, Rick A Bevins, Michael T Bard. Neuropharmacology of the interoceptive stimulus properties of nicotine. Current drug abuse reviews. vol 2. issue 3. 2010-08-13. PMID:20443771. |
there is now evidence regarding the specific nachr subtypes involved in nicotine discrimination; in addition, there is also evidence suggesting that other systems (i.e., adenosine, cannabinoid, dopamine, glutamate and serotonin) may play a modulatory role. |
2010-08-13 |
2023-08-12 |
Not clear |
| K Kovacs, A Lajtha, H Sershe. Effect of nicotine and cocaine on neurofilaments and receptors in whole brain tissue and synaptoneurosome preparations. Brain research bulletin. vol 82. issue 1-2. 2010-07-19. PMID:20188799. |
the present study examined the effect of repeated nicotine and cocaine administration on the expression of neurofilament proteins (nf-l, -m, and -h), actin, and on alpha-7 nicotinic, dopamine d1 and nmda nr1 receptors in brain. |
2010-07-19 |
2023-08-12 |
mouse |
| Theodore A Slotkin, Frederic J Seidle. Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood. Brain research bulletin. vol 82. issue 1-2. 2010-07-19. PMID:20211707. |
mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood. |
2010-07-19 |
2023-08-12 |
rat |
| Paul W Czoty, Jennifer L Martelle, Michael A Nade. Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology. vol 209. issue 4. 2010-07-08. PMID:20217052. |
agonist medications have been proven effective in treating opioid and nicotine dependence; results from clinical studies suggest that the indirect dopamine agonist d-amphetamine may reduce cocaine abuse. |
2010-07-08 |
2023-08-12 |
monkey |
| Amir Abdolahi, Glen Acosta, Florence J Breslin, Scott E Hemby, Wendy J Lync. Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex. The European journal of neuroscience. vol 31. issue 4. 2010-07-08. PMID:20384816. |
in this study we used an animal model of nicotine addiction to examine the possibility that changes in insular cortex levels of dopamine (da)- and camp-regulated phosphoprotein of 32 kda (darpp-32), a phosphoprotein enriched in da neurons containing da d1 receptors, may be associated with changes in vulnerability to nicotine addiction. |
2010-07-08 |
2023-08-12 |
rat |
| Yue Xue, Mark Morris, Lisong Ni, Sally K Guthrie, Jon-Kar Zubieta, Kimberly Gonzalez, Daniel S McConnell, Edward F Domin. Venous plasma nicotine correlates of hormonal effects of tobacco smoking. Pharmacology, biochemistry, and behavior. vol 95. issue 2. 2010-07-01. PMID:20100507. |
contrary to most abused drugs which release dopamine and decrease prolactin, nicotine concentration correlated with increased prolactin release. |
2010-07-01 |
2023-08-12 |
Not clear |
| Mohammad-Reza Zarrindast, Nima Naghdi-Sedeh, Mohammad Nasehi, Hedayat Sahraei, Farideh Bahrami, Fereshteh Asad. The effects of dopaminergic drugs in the ventral hippocampus of rats in the nicotine-induced anxiogenic-like response. Neuroscience letters. vol 475. issue 3. 2010-06-30. PMID:20363294. |
the results may indicate a modulatory effect for the d(1) and d(2) dopamine receptors of vhc in the anxiogenic-like response induced by nicotine. |
2010-06-30 |
2023-08-12 |
rat |