| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng-Ming Ding, Simon N Katner, Zachary A Rodd, William Truitt, Sheketha R Hauser, Gerald A Deehan, Eric A Engleman, William J McBrid. Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 46. issue 3. 2012-07-30. PMID:22449786. |
another experiment tested the effects of challenge microinjections of 200 μm nicotine in the pvta on extracellular dopamine levels in the nacsh following 7 daily pretreatments with 200 mg% ethanol in the pvta. |
2012-07-30 |
2023-08-12 |
rat |
| Zheng-Ming Ding, Simon N Katner, Zachary A Rodd, William Truitt, Sheketha R Hauser, Gerald A Deehan, Eric A Engleman, William J McBrid. Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol. Alcohol (Fayetteville, N.Y.). vol 46. issue 3. 2012-07-30. PMID:22449786. |
the results suggest that repeated exposure of the pvta to nicotine increased the response of local dopamine neurons to the stimulating effects of ethanol, whereas repeated exposure of the pvta to ethanol did not alter the responses of pvta dopamine neurons to nicotine. |
2012-07-30 |
2023-08-12 |
rat |
| Maria Scherma, Zuzana Justinová, Claudio Zanettini, Leigh V Panlilio, Paola Mascia, Paola Fadda, Walter Fratta, Alexandros Makriyannis, Subramanian K Vadivel, Islam Gamaleddin, Bernard Le Foll, Steven R Goldber. The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. British journal of pharmacology. vol 165. issue 8. 2012-07-27. PMID:21557729. |
the anandamide transport inhibitor am404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. |
2012-07-27 |
2023-08-12 |
rat |
| Samuel S Shin, Eric R Bray, C Edward Dixo. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. Journal of neurotrauma. vol 29. issue 5. 2012-07-23. PMID:21815786. |
effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. |
2012-07-23 |
2023-08-12 |
rat |
| Samuel S Shin, Eric R Bray, C Edward Dixo. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. Journal of neurotrauma. vol 29. issue 5. 2012-07-23. PMID:21815786. |
in order to reverse deficits in the activity of tyrosine hydroxylase and dopamine release following tbi, we administered nicotine by intraperitoneal injection into rats for 7 days. |
2012-07-23 |
2023-08-12 |
rat |
| Samuel S Shin, Eric R Bray, C Edward Dixo. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. Journal of neurotrauma. vol 29. issue 5. 2012-07-23. PMID:21815786. |
microdialysis experiments using potassium stimulation to induce dopamine release showed recovery of dopamine release in injured animals receiving nicotine treatment. |
2012-07-23 |
2023-08-12 |
rat |
| Samuel S Shin, Eric R Bray, C Edward Dixo. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. Journal of neurotrauma. vol 29. issue 5. 2012-07-23. PMID:21815786. |
there was no effect of nicotine injection on extracellular dopamine metabolite levels, indicating the specificity of nicotine's effect on dopamine synthesis and release. |
2012-07-23 |
2023-08-12 |
rat |
| Samuel S Shin, Eric R Bray, C Edward Dixo. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in rats. Journal of neurotrauma. vol 29. issue 5. 2012-07-23. PMID:21815786. |
injury reduced pdarpp-32-t34 levels, but nicotine treatment of injured animals did not alter pdarpp-32-t34 levels, indicating that postsynaptic dopamine signaling is complex, and the recovery of dopamine release may not be sufficient for the recovery of darpp-32 activity. |
2012-07-23 |
2023-08-12 |
rat |
| Christie L Burton, Paul J Fletche. Age and sex differences in impulsive action in rats: the role of dopamine and glutamate. Behavioural brain research. vol 230. issue 1. 2012-07-23. PMID:22326372. |
to this end, we examined the effects of increasing the inter-trial interval (iti; 9s) and amphetamine (dopamine releaser; 0, 0.25, 0.5mg/kg; experiment 1), ro 63-1908 (glutamate nmda receptor nr2b subunit antagonist; 0, 0.3, 1.0mg/kg; experiment 2 & 3), and nicotine (nicotinic receptor agonist and indirect dopamine releaser; 0, 0.15, 0.3mg/kg; experiment 3) on premature responding. |
2012-07-23 |
2023-08-12 |
rat |
| Kate Cahill, Lindsay F Stead, Tim Lancaste. Nicotine receptor partial agonists for smoking cessation. The Cochrane database of systematic reviews. issue 4. 2012-07-23. PMID:22513936. |
nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). |
2012-07-23 |
2023-08-12 |
Not clear |
| Joanne Voisey, Christopher Dean Swagell, Ian Paul Hughes, Angela van Daal, Ernest Pascal Noble, Bruce Robert Lawford, Ross McDonald Young, Charles Phillip Morri. A DRD2 and ANKK1 haplotype is associated with nicotine dependence. Psychiatry research. vol 196. issue 2-3. 2012-07-19. PMID:22382052. |
to test the importance of the dopamine d2 receptor (drd2) region in nicotine dependence, 150 smokers and 228 controls were genotyped for the drd2 c957t, -141delc and ankk1 taqia polymorphisms (rs6277, rs1799732 and rs1800497, respectively). |
2012-07-19 |
2023-08-12 |
Not clear |
| Ning Guo, Wei Yao, Shi-Rong Wang, Jun Zhu, Dong Huang, Pan-Li Zuo, Xin-Jiang Kang, Chong-Luo Fu, Zhuan Zhou, Bo Zhan. Nicotine dynamically modulates dopamine clearance in rat striatum in vivo. Neurochemistry international. vol 60. issue 4. 2012-07-05. PMID:22310173. |
nicotine dynamically modulates dopamine clearance in rat striatum in vivo. |
2012-07-05 |
2023-08-12 |
rat |
| Ning Guo, Wei Yao, Shi-Rong Wang, Jun Zhu, Dong Huang, Pan-Li Zuo, Xin-Jiang Kang, Chong-Luo Fu, Zhuan Zhou, Bo Zhan. Nicotine dynamically modulates dopamine clearance in rat striatum in vivo. Neurochemistry international. vol 60. issue 4. 2012-07-05. PMID:22310173. |
nicotine binds to nicotinic acetylcholine receptors on dopaminergic terminals to evoke dopamine (da) release. |
2012-07-05 |
2023-08-12 |
rat |
| Heidi Hartsto. The case for compulsive shopping as an addiction. Journal of psychoactive drugs. vol 44. issue 1. 2012-06-21. PMID:22641966. |
addictive drugs like cocaine, opiates and nicotine, through direct or indirect means, hyperstimulate the dopamine (da) reward system. |
2012-06-21 |
2023-08-12 |
Not clear |
| Manoranjan S D'Souza, Matthias E Liechti, Ana M Ramirez-Niño, Ronald Kuczenski, Athina Marko. The metabotropic glutamate 2/3 receptor agonist LY379268 blocked nicotine-induced increases in nucleus accumbens shell dopamine only in the presence of a nicotine-associated context in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 10. 2012-06-04. PMID:21654734. |
in this study, the effects of ly379268 (1 mg/kg) or saline pretreatment on nicotine-induced increases in nucleus accumbens (nacc) shell dopamine were evaluated using in vivo microdialysis under different experimental conditions: (i) nicotine (0.4 mg/kg, base) was experimenter-administered subcutaneously to nicotine-naïve rats; (ii) nicotine was experimenter-administered either subcutaneously (0.4 mg/kg) or by a single experimenter-administered infusion (0.06 mg/kg, base) in rats with a history of nicotine self-administration (nicotine experienced) in the absence of a nicotine-associated context (ie, context and cues associated with nicotine self-administration); (iii) nicotine (0.06 mg/kg) was self-administered or experimenter-administered in nicotine-experienced rats in the presence of a nicotine-associated context. |
2012-06-04 |
2023-08-12 |
rat |
| Manoranjan S D'Souza, Matthias E Liechti, Ana M Ramirez-Niño, Ronald Kuczenski, Athina Marko. The metabotropic glutamate 2/3 receptor agonist LY379268 blocked nicotine-induced increases in nucleus accumbens shell dopamine only in the presence of a nicotine-associated context in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 10. 2012-06-04. PMID:21654734. |
in saline-pretreated nicotine-naïve and nicotine-experienced rats, nicotine increased nacc shell dopamine regardless of the context used for testing. |
2012-06-04 |
2023-08-12 |
rat |
| Manoranjan S D'Souza, Matthias E Liechti, Ana M Ramirez-Niño, Ronald Kuczenski, Athina Marko. The metabotropic glutamate 2/3 receptor agonist LY379268 blocked nicotine-induced increases in nucleus accumbens shell dopamine only in the presence of a nicotine-associated context in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 10. 2012-06-04. PMID:21654734. |
these intriguing findings suggest that activation of mglu2/3 receptors negatively modulates the combined effects of nicotine and nicotine-associated contexts/cues on nacc dopamine. |
2012-06-04 |
2023-08-12 |
rat |
| Morgane Besson, Vincent David, Mathieu Baudonnat, Pierre Cazala, Jean-Philippe Guilloux, Christelle Reperant, Isabelle Cloez-Tayarani, Jean-Pierre Changeux, Alain M Gardier, Sylvie Grano. Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice. Psychopharmacology. vol 220. issue 1. 2012-06-04. PMID:21901321. |
the mesolimbic dopamine (da) system, where neurons of the ventral tegmental area (vta) project to the nucleus accumbens (acb), is considered a core site for the processing of nicotine's reinforcing properties. |
2012-06-04 |
2023-08-12 |
mouse |
| Lifen Zhang, Yu Dong, William M Doyon, John A Dan. Withdrawal from chronic nicotine exposure alters dopamine signaling dynamics in the nucleus accumbens. Biological psychiatry. vol 71. issue 3. 2012-05-14. PMID:21872847. |
withdrawal from chronic nicotine exposure alters dopamine signaling dynamics in the nucleus accumbens. |
2012-05-14 |
2023-08-12 |
Not clear |
| Lifen Zhang, Yu Dong, William M Doyon, John A Dan. Withdrawal from chronic nicotine exposure alters dopamine signaling dynamics in the nucleus accumbens. Biological psychiatry. vol 71. issue 3. 2012-05-14. PMID:21872847. |
alterations in dopamine (da) signaling correlate with withdrawal from chronic nicotine exposure, but those changes have not been well-characterized. |
2012-05-14 |
2023-08-12 |
Not clear |