| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Berrendero, Ainhoa Plaza-Zabala, Lola Galeote, África Flores, S Andreea Bura, Brigitte L Kieffer, Rafael Maldonad. Influence of δ-opioid receptors in the behavioral effects of nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22669166. |
accordingly, in-vivo microdialysis studies revealed that the enhancement in dopamine extracellular levels induced by nicotine in the nucleus accumbens was reduced in mutant mice. |
2013-01-09 |
2023-08-12 |
mouse |
| Tanuja Bordia, Maya Hrachova, Matthew Chin, J Michael McIntosh, Maryka Qui. Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22550286. |
more recent data suggest that α6β2* nachrs also regulate dopamine release and mediate nicotine reinforcement. |
2012-12-21 |
2023-08-12 |
rat |
| Tanuja Bordia, Maya Hrachova, Matthew Chin, J Michael McIntosh, Maryka Qui. Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22550286. |
however, it acted as a partial agonist on α6β2* and α4β2* nachr-mediated [(3)h]dopamine release with maximal efficacies of 49 and 24%, respectively, compared with nicotine. |
2012-12-21 |
2023-08-12 |
rat |
| Tanuja Bordia, Maya Hrachova, Matthew Chin, J Michael McIntosh, Maryka Qui. Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22550286. |
functionally, it potently stimulated both α6β2* (ec(50) = 0.014 μm) and α4β2* (ec(50) = 0.029 μm) nachr-mediated [(3)h]dopamine release from monkey striatal synaptosomes, again acting as a partial agonist relative to nicotine at both subtypes. |
2012-12-21 |
2023-08-12 |
rat |
| Xiomara A Perez, Jason Ly, J Michael McIntosh, Maryka Qui. Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22562772. |
long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. |
2012-12-21 |
2023-08-12 |
monkey |
| Xiomara A Perez, Jason Ly, J Michael McIntosh, Maryka Qui. Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22562772. |
paired-pulse studies showed that the facilitation of dopamine release with multiple pulsing observed in controls in the presence of nachr antagonist was lost with long-term nicotine treatment. |
2012-12-21 |
2023-08-12 |
monkey |
| Xiomara A Perez, Jason Ly, J Michael McIntosh, Maryka Qui. Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22562772. |
nicotine-evoked [(3)h]dopamine release from nucleus accumbens synaptosomes was similar in nicotine- and vehicle-treated monkeys, indicating that long-term nicotine administration does not directly modify α6β2* nachr-mediated dopamine release. |
2012-12-21 |
2023-08-12 |
monkey |
| Xiomara A Perez, Jason Ly, J Michael McIntosh, Maryka Qui. Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22562772. |
dopamine uptake rates, as well as dopamine transporter and α6β2* nachrs levels, were also not changed with nicotine administration. |
2012-12-21 |
2023-08-12 |
monkey |
| Xiomara A Perez, Jason Ly, J Michael McIntosh, Maryka Qui. Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22562772. |
these data indicate that nicotine exposure, as occurs with smoking, has major effects on cellular mechanisms linked to α6β2* nachr-mediated dopamine release and that this receptor subtype may represent a novel therapeutic target for smoking cessation. |
2012-12-21 |
2023-08-12 |
monkey |
| Luis A Natividad, Matthew W Buczynski, Loren H Parsons, Oscar V Torres, Laura E O'Del. Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal. Journal of neurochemistry. vol 123. issue 4. 2012-12-21. PMID:22905672. |
adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal. |
2012-12-21 |
2023-08-12 |
rat |
| Luis A Natividad, Matthew W Buczynski, Loren H Parsons, Oscar V Torres, Laura E O'Del. Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal. Journal of neurochemistry. vol 123. issue 4. 2012-12-21. PMID:22905672. |
differential dopaminergic responses to nicotine are thought to underlie these age-related effects, as adolescent rats experience lower withdrawal-related deficits in nucleus accumbens (nacc) dopamine versus adults. |
2012-12-21 |
2023-08-12 |
rat |
| Luis A Natividad, Matthew W Buczynski, Loren H Parsons, Oscar V Torres, Laura E O'Del. Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal. Journal of neurochemistry. vol 123. issue 4. 2012-12-21. PMID:22905672. |
these results indicate that adolescents display resistance to withdrawal-related neurochemical processes that inhibit mesolimbic dopamine function in adults experiencing nicotine withdrawal. |
2012-12-21 |
2023-08-12 |
rat |
| Paul J Fletcher, Zoë Rizos, Kevin Noble, Ashlie D Soko, Leo B Silenieks, Anh Dzung Lê, Guy A Higgin. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22342986. |
the reinforcing effects of nicotine are mediated in part by brain dopamine systems. |
2012-12-20 |
2023-08-12 |
rat |
| Yoan Mihov, René Hurleman. Altered amygdala function in nicotine addiction: insights from human neuroimaging studies. Neuropsychologia. vol 50. issue 8. 2012-11-29. PMID:22575084. |
while current research perspectives on nicotine addiction emphasize the contribution of reward-related mesocorticolimbic dopamine (da) systems, the role of the amygdala remains less well characterized, although it is crucially engaged in the emotional and motivational modulation of cognition and behavior. |
2012-11-29 |
2023-08-12 |
human |
| Bo Söderpalm, Mia Ericso. Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points. Current topics in behavioral neurosciences. vol 13. 2012-11-13. PMID:22094880. |
whereas the mechanisms of actions for central stimulants, opioids and nicotine in their dopamine activating effects are fairly well established, the corresponding mechanisms with respect to ethanol have been elusive. |
2012-11-13 |
2023-08-12 |
Not clear |
| Leigh V Panlilio, Zuzana Justinova, Paola Mascia, Marco Pistis, Antonio Luchicchi, Salvatore Lecca, Chanel Barnes, Godfrey H Redhi, Jordan Adair, Stephen J Heishman, Sevil Yasar, Mano Aliczki, Jozsef Haller, Steven R Goldber. Novel use of a lipid-lowering fibrate medication to prevent nicotine reward and relapse: preclinical findings. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22453137. |
in the central nervous system, clofibrate blocked nicotine's effects on neuronal firing in the ventral tegmental area and on dopamine release in the nucleus accumbens shell. |
2012-11-13 |
2023-08-12 |
human |
| A Drasdo, M Caulfield, D Bertrand, S Bertrand, S Wonnacot. Methyl lycaconitine: A novel nicotinic antagonist. Molecular and cellular neurosciences. vol 3. issue 3. 2012-10-02. PMID:19912865. |
a presynaptic nicotinic receptor mediating dopamine release from rat striatal synaptosomes was blocked by 10 mum mla, in good agreement with its ki of 4 mum for inhibition of [(3)h]nicotine binding to striatal membranes. |
2012-10-02 |
2023-08-12 |
rat |
| A Mills, S Wonnacot. Antibodies to nicotinic acetylcholine receptors used to probe the structural and functional relationships between brain ?-bungarotoxin binding sites and nicotinic receptors. Neurochemistry international. vol 6. issue 2. 2012-10-02. PMID:20488045. |
release of [(3)h]dopamine from striatal synaptosomes could be elicited by nicotine in a dose-dependent manner and the response was prevented by the ganglionic blocker mecamylamine, although antagonism by ?-bungarotoxin was less clearcut. |
2012-10-02 |
2023-08-12 |
rat |
| A Mills, S Wonnacot. Antibodies to nicotinic acetylcholine receptors used to probe the structural and functional relationships between brain ?-bungarotoxin binding sites and nicotinic receptors. Neurochemistry international. vol 6. issue 2. 2012-10-02. PMID:20488045. |
preincubation of the synaptosomes with antiserum m resulted in a statistically significant decrease in the [(3)h]dopamine response to nicotine at all agonist concentrations tested. |
2012-10-02 |
2023-08-12 |
rat |
| C Reavill, I P Stolerma. Interaction of nicotine with dopaminergic mechanisms assessed through drug discrimination and rotational behaviour in rats. Journal of psychopharmacology (Oxford, England). vol 1. issue 4. 2012-10-02. PMID:22159140. |
biochemical and electrophysiological studies have suggested that nicotine may interact with dopaminergic systems so as to enhance the release and utilization of dopamine. |
2012-10-02 |
2023-08-12 |
rat |