| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiomara A Perez, J Michael McIntosh, Maryka Qui. Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:23992036. |
long-term nicotine treatment selectively decreased stimulated α6β2* nachr-mediated dopamine release compared with vehicle-treated rats. |
2014-02-18 |
2023-08-12 |
rat |
| Xiomara A Perez, J Michael McIntosh, Maryka Qui. Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:23992036. |
as long-term nicotine modifies dopamine release by decreasing α6β2* nachrs and their function, these data suggest that interventions that target this subtype may be useful for treating nicotine dependence. |
2014-02-18 |
2023-08-12 |
rat |
| Xiomara A Perez, J Michael McIntosh, Maryka Qui. Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:23992036. |
long-term nicotine treatment decreases dopamine (da) transmission in the mesolimbic dopaminergic system. |
2014-02-18 |
2023-08-12 |
rat |
| Oguz Gozen, Burcu Balkan, Emre Yildirim, Ersin O Koylu, Sakire Pogu. The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex. Synapse (New York, N.Y.). vol 67. issue 9. 2014-02-13. PMID:23447334. |
the epigenetic effect of nicotine on dopamine d1 receptor expression in rat prefrontal cortex. |
2014-02-13 |
2023-08-12 |
rat |
| Oguz Gozen, Burcu Balkan, Emre Yildirim, Ersin O Koylu, Sakire Pogu. The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex. Synapse (New York, N.Y.). vol 67. issue 9. 2014-02-13. PMID:23447334. |
nicotine is a highly addictive drug and exerts its effect partially through causing dopamine release, thereby increasing intrasynaptic dopamine levels in the brain reward systems. |
2014-02-13 |
2023-08-12 |
rat |
| M R Lee, C L Gallen, T J Ross, P Kurup, B J Salmeron, C A Hodgkinson, D Goldman, E A Stein, M A Enoc. A preliminary study suggests that nicotine and prefrontal dopamine affect cortico-striatal areas in smokers with performance feedback. Genes, brain, and behavior. vol 12. issue 5. 2014-01-27. PMID:23433232. |
a preliminary study suggests that nicotine and prefrontal dopamine affect cortico-striatal areas in smokers with performance feedback. |
2014-01-27 |
2023-08-12 |
human |
| M R Lee, C L Gallen, T J Ross, P Kurup, B J Salmeron, C A Hodgkinson, D Goldman, E A Stein, M A Enoc. A preliminary study suggests that nicotine and prefrontal dopamine affect cortico-striatal areas in smokers with performance feedback. Genes, brain, and behavior. vol 12. issue 5. 2014-01-27. PMID:23433232. |
nicotine and tonic dopamine (da) levels [as inferred by catechol-o-methyl tranferase (comt) val158met genotype] interact to affect prefrontal processing. |
2014-01-27 |
2023-08-12 |
human |
| John A Dani, Mariella De Bias. Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. Cold Spring Harbor perspectives in medicine. vol 3. issue 6. 2014-01-24. PMID:23732854. |
mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. |
2014-01-24 |
2023-08-12 |
Not clear |
| John A Dani, Mariella De Bias. Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. Cold Spring Harbor perspectives in medicine. vol 3. issue 6. 2014-01-24. PMID:23732854. |
furthermore, withdrawal from nicotine induces a hypodopaminergic state, but there is a relative increase in the sensitivity to phasic dopamine release that is caused by nicotine. |
2014-01-24 |
2023-08-12 |
Not clear |
| Pedro Lorenzo Fernánde. [Treatment and prevention of tobacco addiction. Antinicotinic vaccine]. Anales de la Real Academia Nacional de Medicina. vol 129. issue 1. 2014-01-09. PMID:24294730. |
the addictive mechanism of nicotine is the stimulus of nicotinic cholinergic receptors at the mesolimbic areas of the brain, which in turn stimulate dopamine release in the brain centres of reward (mainly n. accumbens). |
2014-01-09 |
2023-08-12 |
Not clear |
| John D Eicher, Natalie R Powers, Kelly Cho, Laura L Miller, Kathryn L Mueller, Susan M Ring, J Bruce Tomblin, Jeffrey R Grue. Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. PloS one. vol 8. issue 5. 2014-01-07. PMID:23691092. |
associations of prenatal nicotine exposure and the dopamine related genes ankk1 and drd2 to verbal language. |
2014-01-07 |
2023-08-12 |
Not clear |
| Hanane Khalki, Sylvia Navailles, Camille L Piron, Philippe De Deurwaerdèr. A tobacco extract containing alkaloids induces distinct effects compared to pure nicotine on dopamine release in the rat. Neuroscience letters. vol 544. 2014-01-06. PMID:23583588. |
a tobacco extract containing alkaloids induces distinct effects compared to pure nicotine on dopamine release in the rat. |
2014-01-06 |
2023-08-12 |
rat |
| Hanane Khalki, Sylvia Navailles, Camille L Piron, Philippe De Deurwaerdèr. A tobacco extract containing alkaloids induces distinct effects compared to pure nicotine on dopamine release in the rat. Neuroscience letters. vol 544. 2014-01-06. PMID:23583588. |
we hypothesized that these molecules modulate the effect of nicotine on the activity of central dopamine (da) neurons, one of the main cellular targets in addiction to drugs. |
2014-01-06 |
2023-08-12 |
rat |
| F Saint-Preux, L R Bores, I Tulloch, B Ladenheim, R Kim, P K Thanos, N D Volkow, J L Cade. Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats. Neuroscience. vol 243. 2013-12-17. PMID:23562942. |
nicotine and methamphetamine (meth) cause addiction by triggering neuroplastic changes in brain reward pathways though they each engage distinct molecular targets (nicotine receptors and dopamine transporters respectively). |
2013-12-17 |
2023-08-12 |
rat |
| William M Doyon, Alyse M Thomas, Alexey Ostroumov, Yu Dong, John A Dan. Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23876345. |
both nicotine and alcohol activate the mesocorticolimbic dopamine system, producing downstream dopamine signals that promote the drug reinforcement process. |
2013-12-17 |
2023-08-12 |
Not clear |
| Jie Wu, Ming Gao, Jian-Xin Shen, Wei-Xing Shi, Andrew M Oster, Boris S Gutki. Cortical control of VTA function and influence on nicotine reward. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23933294. |
nicotine acts on widely distributed nicotinic acetylcholine receptors (nachrs) in the brain and excites dopamine (da) neurons in the ventral tegmental area (vta). |
2013-12-17 |
2023-08-12 |
Not clear |
| Yu Dong, John A Dani, Randy D Blakel. Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23939187. |
choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. |
2013-12-17 |
2023-08-12 |
mouse |
| Yu Dong, John A Dani, Randy D Blakel. Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23939187. |
dopamine (da) signaling in the central nervous system mediates the addictive capacities of multiple commonly abused substances, including cocaine, amphetamine, heroin and nicotine. |
2013-12-17 |
2023-08-12 |
mouse |
| S de la Salle, D Smith, J Choueiry, D Impey, T Philippe, H Dort, A Millar, P Albert, V Knot. Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors. Neuroscience. vol 241. 2013-12-12. PMID:23535252. |
the results were consistent with the hypothesis that increased dopamine resulting from nicotine stimulation or met allelic activity would benefit gating in low suppressors and impair gating in high suppressors, and that this gating improvement with nicotine would be more evident in val carriers who were low suppressors, while the gating impairment would be more evident in met carriers who were high suppressors. |
2013-12-12 |
2023-08-12 |
Not clear |
| Staci E Engle, Pei-Yu Shih, J Michael McIntosh, Ryan M Drena. α4α6β2* nicotinic acetylcholine receptor activation on ventral tegmental area dopamine neurons is sufficient to stimulate a depolarizing conductance and enhance surface AMPA receptor function. Molecular pharmacology. vol 84. issue 3. 2013-11-26. PMID:23788655. |
nachrs in ventral tegmental area (vta) dopamine (da) neurons are crucial for the rewarding and reinforcing properties of nicotine in rodents, suggesting that they may be key mediators of nicotine's action in humans. |
2013-11-26 |
2023-08-12 |
mouse |