| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Ren, Jinghan Sun, Yunpeng Zhang, Tong Liu, Qingzhong Ren, Yan Li, Aike Gu. Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. PloS one. vol 7. issue 12. 2013-07-02. PMID:23300696. |
studies in mammalian systems have revealed some key factors involved in the effects of nicotine, including nicotinic acetylcholine receptors (nachrs), dopamine and other neurotransmitters. |
2013-07-02 |
2023-08-12 |
drosophila_melanogaster |
| Maryka Quik, Tanuja Bordia, Luping Huang, Xiomara Pere. Targeting nicotinic receptors for Parkinson's disease therapy. CNS & neurological disorders drug targets. vol 10. issue 6. 2013-06-17. PMID:21838678. |
recent work indicates that a potential novel therapeutic application is the use of nicotine to reduce levodopa-induced dyskinesias, a side effect of dopamine replacement therapy for parkinson's disease. |
2013-06-17 |
2023-08-12 |
Not clear |
| José-Rubén García-Montes, Alejandra Boronat-García, Ana-María López-Colomé, José Bargas, Magdalena Guerra-Crespo, René Drucker-Colí. Is nicotine protective against Parkinson's disease? An experimental analysis. CNS & neurological disorders drug targets. vol 11. issue 7. 2013-06-13. PMID:23131151. |
however, the mechanisms underlying the effects of nicotine in the dopamine (da) depleted striatum remain elusive. |
2013-06-13 |
2023-08-12 |
rat |
| Maryka Quik, Archana Mallela, Matthew Chin, J Michael McIntosh, Xiomara A Perez, Tanuja Bordi. Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function. Neurobiology of disease. vol 50. 2013-05-31. PMID:23009753. |
we next determined how nicotine's ability to reduce lids correlated with lesion-induced changes in the striatal dopamine transporter and (3)h-dopamine release in these two groups of monkeys. |
2013-05-31 |
2023-08-12 |
monkey |
| Maryka Quik, Archana Mallela, Matthew Chin, J Michael McIntosh, Xiomara A Perez, Tanuja Bordi. Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function. Neurobiology of disease. vol 50. 2013-05-31. PMID:23009753. |
thus, nicotine best improves lids in lesioned monkeys in which striatal dopamine transmission is still relatively intact. |
2013-05-31 |
2023-08-12 |
monkey |
| Jun Zhu, Michael T Bardo, Linda P Dwoski. Distinct effects of enriched environment on dopamine clearance in nucleus accumbens shell and core following systemic nicotine administration. Synapse (New York, N.Y.). vol 67. issue 2. 2013-05-29. PMID:23065942. |
distinct effects of enriched environment on dopamine clearance in nucleus accumbens shell and core following systemic nicotine administration. |
2013-05-29 |
2023-08-12 |
rat |
| Jun Zhu, Michael T Bardo, Linda P Dwoski. Distinct effects of enriched environment on dopamine clearance in nucleus accumbens shell and core following systemic nicotine administration. Synapse (New York, N.Y.). vol 67. issue 2. 2013-05-29. PMID:23065942. |
the current study evaluated dopamine (da) clearance (cl(da) ) in the nac shell and core using in vivo voltammetry in rats raised in an enriched condition (ec) or an impoverished condition (ic) and determined the effect of nicotine (0.4 mg/kg) on cl(da) . |
2013-05-29 |
2023-08-12 |
rat |
| Paul R Sanberg, Cecilia Vindrola-Padros, R Douglas Shytl. Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond. Physiology & behavior. vol 107. issue 5. 2013-05-17. PMID:22776623. |
these early rodent studies with nicotine and dopamine antagonists formed the basis for investigating a potentially improved treatment for children suffering from tourette's syndrome (ts). |
2013-05-17 |
2023-08-12 |
Not clear |
| Xiaojing Di, Jingqi Yan, Yan Zhao, Yanzhong Chang, Baolu Zha. L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway. Science China. Life sciences. vol 55. issue 12. 2013-05-17. PMID:23233221. |
l-theanine treatment also reduced the upregulation of the α(4), β(2) and α(7) nicotine acetylcholine receptor (nachr) subunits induced by nicotine in mouse brain regions that related to the dopamine reward pathway, thus decreasing the number of cells that could react to nicotine. |
2013-05-17 |
2023-08-12 |
mouse |
| Srinivasa Rao Ch, Emmanuel Subash . The effect of chronic tobacco smoking and chewing on the lipid profile. Journal of clinical and diagnostic research : JCDR. vol 7. issue 1. 2013-05-01. PMID:23449989. |
nicotine is highly addictive, it raises the brain levels of dopamine and it produces withdrawal symptoms on its discontinuation. |
2013-05-01 |
2023-08-12 |
Not clear |
| Sandra M Boy. Individual phenotype predicts nicotine-haloperidol interaction in catalepsy: possible implication for the therapeutic efficacy of nicotine in Tourette's syndrome. Behavioural brain research. vol 236. issue 1. 2013-04-23. PMID:22947904. |
in laboratory rats, the dopamine antagonist haloperidol produces catalepsy and nicotine can potentiate it, although this effect is variable and not always observed. |
2013-04-23 |
2023-08-12 |
rat |
| Mohammad Reza Zarrindast, Solmaz Khalifeh, Ameneh Rezayof, Parvin Rostami, Arash Aghamohammadi Sereshki, Maryam Zahmatkes. Involvement of rat dopaminergic system of nucleus accumbens in nicotine-induced anxiogenic-like behaviors. Brain research. vol 1460. 2013-03-25. PMID:22595749. |
the objective of the present study was to investigate the involvement of dopamine d₁ and d₂ receptors of the nucleus accumbens (nac) shell in the anxiogenic-like effect of intra-central amygdala (cea) nicotine administration. |
2013-03-25 |
2023-08-12 |
rat |
| Mohammad Reza Zarrindast, Solmaz Khalifeh, Ameneh Rezayof, Parvin Rostami, Arash Aghamohammadi Sereshki, Maryam Zahmatkes. Involvement of rat dopaminergic system of nucleus accumbens in nicotine-induced anxiogenic-like behaviors. Brain research. vol 1460. 2013-03-25. PMID:22595749. |
these findings may suggest the involvement of dopamine transmission, through d₁ and d₂ receptors of nac shell, in the anxiogenic-like effect of nicotine in the epm task. |
2013-03-25 |
2023-08-12 |
rat |
| Philippe H J Hoogsteder, Daniel Kotz, Paul I van Spiegel, Wolfgang Viechtbauer, Ruth Brauer, Paul D Kessler, Matthew W Kalnik, Raafat E F Fahim, Onno C P van Schayc. The efficacy and safety of a nicotine conjugate vaccine (NicVAX®) or placebo co-administered with varenicline (Champix®) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial. BMC public health. vol 12. 2013-03-06. PMID:23216646. |
the resulting antibody-antigen is too large to cross the blood-brain barrier and is therefore postulated to attenuate the rewarding effect of nicotine by preventing the latter from reaching its receptors in the brain and causing the release of dopamine. |
2013-03-06 |
2023-08-12 |
Not clear |
| Xiang Yang Zhang, Da Chun Chen, Mei Hong Xiu, Li Hui, Haibo Liu, Xingguang Luo, Lingjun Zuo, Huiping Zhang, Therese A Kosten, Thomas R Koste. Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. Schizophrenia research. vol 141. issue 1. 2013-02-13. PMID:22871345. |
recent evidence suggests that a dopamine beta-hydroxylase (dbh) polymorphism may play a role in determining an individual's predisposition to developing nicotine dependence. |
2013-02-13 |
2023-08-12 |
Not clear |
| Xiang Yang Zhang, Da Chun Chen, Mei Hong Xiu, Li Hui, Haibo Liu, Xingguang Luo, Lingjun Zuo, Huiping Zhang, Therese A Kosten, Thomas R Koste. Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. Schizophrenia research. vol 141. issue 1. 2013-02-13. PMID:22871345. |
the mechanism for such an association may reflect nicotine's mediation of drug reward in the brain through actions on dopamine, a key mediator of drug reward. |
2013-02-13 |
2023-08-12 |
Not clear |
| Arik J Hone, Mick'l Scadden, Joanna Gajewiak, Sean Christensen, Jon Lindstrom, J Michael McIntos. α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors. Molecular pharmacology. vol 82. issue 5. 2013-02-12. PMID:22914547. |
nicotinic acetylcholine receptors (nachrs) containing α6 and β2 subunits modulate dopamine release in the basal ganglia and are therapeutically relevant targets for treatment of neurological and psychiatric disorders including parkinson's disease and nicotine dependence. |
2013-02-12 |
2023-08-12 |
xenopus_laevis |
| Mahomi Kuroiwa, Miho Hamada, Eriko Hieda, Takahide Shuto, Naoki Sotogaku, Marc Flajolet, Gretchen L Snyder, Joseph P Hendrick, Allen Fienberg, Akinori Nish. Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons. Neuropharmacology. vol 63. issue 7. 2013-02-12. PMID:22971543. |
the increase in darpp-32 phosphorylation was completely abolished either by a dopamine d(1) receptor antagonist (sch23390), tetrodotoxin, genetic deletion of m5 receptors, muscarinic toxins for m1 and m4 receptors, or 6-hydroxydopamine lesioning of dopaminergic neurons, whereas it was enhanced by nicotine. |
2013-02-12 |
2023-08-12 |
mouse |
| Osamu Uchiumi, Yoshiyuki Kasahara, Asami Fukui, F Scott Hall, George R Uhl, Ichiro Sor. Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. Neuropharmacology. vol 64. 2013-02-11. PMID:22809709. |
serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. |
2013-02-11 |
2023-08-12 |
mouse |
| Massimo Grilli, Maria Summa, Alessia Salamone, Guendalina Olivero, Stefania Zappettini, Silvia Di Prisco, Marco Feligioni, Cesare Usai, Anna Pittaluga, Mario March. In vitro exposure to nicotine induces endocytosis of presynaptic AMPA receptors modulating dopamine release in rat nucleus accumbens nerve terminals. Neuropharmacology. vol 63. issue 5. 2013-01-14. PMID:22771975. |
in vitro exposure to nicotine induces endocytosis of presynaptic ampa receptors modulating dopamine release in rat nucleus accumbens nerve terminals. |
2013-01-14 |
2023-08-12 |
rat |