| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Prasad, H Ikegami, I Shimizu, E S Onaiv. Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons. Life sciences. vol 54. issue 16. 1994-05-12. PMID:8152341. |
we have evaluated the effect of chronic nicotine intake on the age-associated loss of nigrostriatal dopaminergic neurons. |
1994-05-12 |
2023-08-12 |
Not clear |
| S A Richardson, Y Tizab. Hyperactivity in the offspring of nicotine-treated rats: role of the mesolimbic and nigrostriatal dopaminergic pathways. Pharmacology, biochemistry, and behavior. vol 47. issue 2. 1994-05-02. PMID:8146225. |
to evaluate the involvement of the mesolimbic and nigrostriatal dopaminergic systems in hyperactivity in offspring of nicotine-treated dams, timed-pregnant sprague-dawley rats were implanted sc on gestational day 4 with osmotic minipumps to receive saline or nicotine (3 or 6 mg/kg/day) for 16 days. |
1994-05-02 |
2023-08-12 |
rat |
| S N Mitchell, K M Smith, M H Joseph, J A Gra. Increases in tyrosine hydroxylase messenger RNA in the locus coeruleus after a single dose of nicotine are followed by time-dependent increases in enzyme activity and noradrenaline release. Neuroscience. vol 56. issue 4. 1994-02-14. PMID:7904333. |
we have found that a single systemic injection of nicotine (0.8 mg/kg) increases messenger rna for the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase, two to six days later in the noradrenergic cell body region, the locus coeruleus (and not in the dopaminergic cell body regions, substantia nigra and ventral tegmental area). |
1994-02-14 |
2023-08-12 |
rat |
| D Huston-Lyons, M Sarkar, C Kornetsk. Nicotine and brain-stimulation reward: interactions with morphine, amphetamine and pimozide. Pharmacology, biochemistry, and behavior. vol 46. issue 2. 1994-01-27. PMID:8265701. |
these data suggest that the same dopaminergic substrate that supports the positive reinforcing effects of other drugs of abuse also supports nicotine reward. |
1994-01-27 |
2023-08-12 |
rat |
| M D Schechter, S M Meeha. Dopaminergic mediation of the stimulant generalization of nicotine. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 5. 1994-01-13. PMID:7902994. |
dopaminergic mediation of the stimulant generalization of nicotine. |
1994-01-13 |
2023-08-12 |
rat |
| Y Pang, H Kiba, A Jayarama. Acute nicotine injections induce c-fos mostly in non-dopaminergic neurons of the midbrain of the rat. Brain research. Molecular brain research. vol 20. issue 1-2. 1994-01-11. PMID:8255178. |
the psychomotor stimulant and positive reinforcing effects of nicotine have been speculated to be mediated by the dopaminergic neurons of the ventral tegmental area (vta). |
1994-01-11 |
2023-08-12 |
rat |
| K Suemaru, Y Gomita, K Furuno, Y Arak. Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats. Pharmacology, biochemistry, and behavior. vol 46. issue 1. 1994-01-10. PMID:7902980. |
chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats. |
1994-01-10 |
2023-08-12 |
rat |
| K Suemaru, Y Gomita, K Furuno, Y Arak. Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats. Pharmacology, biochemistry, and behavior. vol 46. issue 1. 1994-01-10. PMID:7902980. |
these results suggest that chronic nicotine treatment may increase the susceptibility of the dopaminergic system to dopaminergic drugs. |
1994-01-10 |
2023-08-12 |
rat |
| A Ishikawa, T Miyatak. Effects of smoking in patients with early-onset Parkinson's disease. Journal of the neurological sciences. vol 117. issue 1-2. 1993-11-01. PMID:8410063. |
nicotine is thought to activate the nigrostriatal dopaminergic pathway and increase the release of dopamine in the striatum, and this can explain the effects of smoking in these patients. |
1993-11-01 |
2023-08-12 |
Not clear |
| A M Montgomery, I C Rose, L J Herber. The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission. Journal of neural transmission. General section. vol 91. issue 1. 1993-04-22. PMID:8383982. |
these results support the proposal that 5-ht3 receptors, normally quiescent under basal conditions, mediate the excitatory effect of compounds acting upstream from the da neuron, such as nicotine, but do not affect the dopaminergic synapse directly. |
1993-04-22 |
2023-08-12 |
rat |
| J D Brioni, S P Arneri. Nicotinic receptor agonists facilitate retention of avoidance training: participation of dopaminergic mechanisms. Behavioral and neural biology. vol 59. issue 1. 1993-03-26. PMID:8442733. |
these results demonstrate that the nicotinic receptor agonists nicotine and cytisine facilitate the retention of avoidance responses and suggest that this effect is mediated through central dopaminergic pathways. |
1993-03-26 |
2023-08-12 |
mouse |
| O Nikodijević, K A Jacobson, J W Dal. Locomotor activity in mice during chronic treatment with caffeine and withdrawal. Pharmacology, biochemistry, and behavior. vol 44. issue 1. 1993-03-09. PMID:7679219. |
there was little or no effect of chronic caffeine on the stimulatory effects of dopaminergic agents (amphetamine, caffeine), while both depressant and stimulatory effects of cholinergic agents (nicotine, oxotremorine, scopolamine) were reduced. |
1993-03-09 |
2023-08-12 |
mouse |
| K P Rajashekhar, J L Wilken. Dopamine and nicotine, but not serotonin, modulate the crustacean ventilatory pattern generator. Journal of neurobiology. vol 23. issue 6. 1992-12-22. PMID:1431839. |
these observations support the hypothesis that dopaminergic pathways are involved in the maintenance of the cpgv rhythm and that the acceleratory effects of nicotine may involve release of da either directly or via stimulation of atypical ach receptors at intraganglionic sites. |
1992-12-22 |
2023-08-11 |
Not clear |
| T Kita, M Okamoto, T Nakashim. [Nicotine-induced ambulatory stimulant effect and its reverse tolerance]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 12. issue 1. 1992-10-29. PMID:1414027. |
these results suggest that the enhancement of nicotine-induced ambulatory stimulant effect by the daily administration of nicotine is concerned with central dopaminergic stimulation through the nicotinic acetylcholine receptor in the rat brain. |
1992-10-29 |
2023-08-11 |
rat |
| A Schiavone, E Giraldo, L Giudici, M Turconi, A Sagrad. DAU 6285: a novel antagonist at the putative 5-HT4 receptor. Life sciences. vol 51. issue 8. 1992-09-01. PMID:1640809. |
moreover, it did not bind to other 5-ht receptor subtypes, or to adrenergic, dopaminergic, benzodiazepine, nicotine, gaba receptors. |
1992-09-01 |
2023-08-11 |
human |
| J H Carlson, S L Foot. Oscillation of interspike interval length in substantia nigra dopamine neurons: effects of nicotine and the dopaminergic D2 agonist LY 163502 on electrophysiological activity. Synapse (New York, N.Y.). vol 11. issue 3. 1992-08-24. PMID:1636152. |
oscillation of interspike interval length in substantia nigra dopamine neurons: effects of nicotine and the dopaminergic d2 agonist ly 163502 on electrophysiological activity. |
1992-08-24 |
2023-08-11 |
rat |
| D G Kirch, T R Taylor, I Creese, S X Xu, R J Wyat. Effect of chronic nicotine treatment and withdrawal on rat striatal D1 and D2 dopamine receptors. The Journal of pharmacy and pharmacology. vol 44. issue 2. 1992-08-19. PMID:1352822. |
although nicotine has been shown to affect nigrostriatal dopamine release, chronic treatment does not appear to alter overall striatal dopaminergic receptor binding parameters. |
1992-08-19 |
2023-08-11 |
rat |
| W A Corrigall, K B Franklin, K M Coen, P B Clark. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1615127. |
the mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. |
1992-07-30 |
2023-08-11 |
rat |
| L G Harsing, H Sershen, A Lajth. Dopamine efflux from striatum after chronic nicotine: evidence for autoreceptor desensitization. Journal of neurochemistry. vol 59. issue 1. 1992-07-24. PMID:1351932. |
we examined the effect of chronic nicotine treatment on dopaminergic activity by measuring the effects of d1 and d2 dopamine (da) receptor agonists and antagonists on tritium release from mouse striatum preloaded with [3h]da. |
1992-07-24 |
2023-08-11 |
mouse |
| N T Sandor, T Zelles, J Kiss, H Sershen, A Torocsik, A Lajtha, E S Viz. Effect of nicotine on dopaminergic-cholinergic interaction in the striatum. Brain research. vol 567. issue 2. 1992-07-10. PMID:1817734. |
since the release of ach in the striatum is tonically inhibited by endogenous dopamine and nicotine enhances the release of dopamine, we studied the release of ach when the dopaminergic input was impaired. |
1992-07-10 |
2023-08-11 |
rat |